This document discusses Treponema pallidum, the spirochete bacteria that causes syphilis. It describes the morphology and pathogenic species of Treponema, focusing on T. pallidum. The stages of syphilis and correlation with test results are outlined. Antibodies produced during syphilis infection and their development are explained. Treatment of syphilis and its effects on test results are also summarized. Related diseases caused by other Treponema species like yaws are briefly mentioned.
Rickettsiae are obligate intracellular bacteria that can cause diseases like Rocky Mountain spotted fever and typhus. They are transmitted through arthropod bites like ticks, mites and fleas. Common symptoms include fever, headache and rash. Diagnosis involves serologic tests detecting IgM and IgG antibodies. Doxycycline is the treatment of choice. Clinical features along with exposure history and serology can help diagnose rickettsial infections.
This document provides an overview of typhoid fever and salmonella species across 13 chapters. It discusses the history, symptoms, transmission, diagnosis and treatment of typhoid fever. It also covers salmonella nomenclature, structure, habitats and identification. Typhoid fever remains an important cause of illness in developing countries, where it is transmitted through ingestion of food or water contaminated by infected feces. Common symptoms include sustained high fever, abdominal pain, and possible complications like intestinal bleeding or perforation. Proper sanitation and antibiotic treatment have reduced typhoid prevalence in developed nations.
Treponema pallidum is a spirochete bacterium that causes syphilis. It is thin and motile, seen under darkfield microscopy. Syphilis is transmitted sexually or from mother to fetus. It has three stages - primary, secondary, and tertiary - with characteristic lesions developing at each stage like chancres. Diagnosis involves serological tests detecting antibodies like VDRL and RPR. Penicillin is the treatment of choice.
This document defines syphilis as a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. It describes the epidemiology, clinical features, laboratory diagnosis, complications, treatment, and prevention of syphilis. Syphilis presents initially as a chancre sore and progresses through primary, secondary, latent, and tertiary stages if left untreated. Penicillin is the most common treatment, though antibiotics like doxycycline may be used for those allergic to penicillin. Safe sex practices and regular STI screening are important for prevention.
Malaria is a mosquito-borne disease caused by Plasmodium parasites. In 2018, 228 million people were infected globally resulting in over 400,000 deaths. India accounts for 3% of global malaria cases and deaths, with most cases concentrated in 7 states. Malaria is transmitted via the bites of infected female Anopheles mosquitoes. Symptoms include fever, chills, and flu-like illness, with P. falciparum infections potentially causing severe complications like cerebral malaria, severe anemia, or respiratory distress. Proper diagnosis and treatment are needed to prevent mortality from this widespread and potentially deadly disease.
This document discusses Varicella Zoster Virus (VZV) which causes chickenpox (varicella) and shingles (herpes zoster). VZV establishes latency in dorsal root ganglia after primary infection of chickenpox which can later reactivate and cause shingles. Both diseases present with characteristic vesicular rashes but shingles lesions are limited to a single dermatome. Complications of shingles include postherpetic neuralgia. VZV is diagnosed through virus isolation, serology, PCR or antigen detection and treated with antiviral drugs like acyclovir. Vaccination provides effective protection against chickenpox.
Treponema pallidum is a spirochete bacterium that causes syphilis and other diseases. It has a thin, helical shape with periplasmic flagella and tightly coiled cells. Syphilis infection progresses through primary, secondary, latent, and tertiary stages and can involve multiple organ systems if left untreated. Diagnosis involves darkfield microscopy, serological tests like VDRL and RPR, and specific treponemal tests since the bacterium cannot be cultured.
This document summarizes clinical manifestations of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. It describes how dengue is caused by a virus transmitted by Aedes mosquitos. It outlines the disease progression from primary to secondary infection and discusses disease definitions. Key points include four clinical syndromes, hemorrhagic manifestations, thrombocytopenia, and signs of circulatory failure in dengue shock syndrome.
Rickettsiae are obligate intracellular bacteria that can cause diseases like Rocky Mountain spotted fever and typhus. They are transmitted through arthropod bites like ticks, mites and fleas. Common symptoms include fever, headache and rash. Diagnosis involves serologic tests detecting IgM and IgG antibodies. Doxycycline is the treatment of choice. Clinical features along with exposure history and serology can help diagnose rickettsial infections.
This document provides an overview of typhoid fever and salmonella species across 13 chapters. It discusses the history, symptoms, transmission, diagnosis and treatment of typhoid fever. It also covers salmonella nomenclature, structure, habitats and identification. Typhoid fever remains an important cause of illness in developing countries, where it is transmitted through ingestion of food or water contaminated by infected feces. Common symptoms include sustained high fever, abdominal pain, and possible complications like intestinal bleeding or perforation. Proper sanitation and antibiotic treatment have reduced typhoid prevalence in developed nations.
Treponema pallidum is a spirochete bacterium that causes syphilis. It is thin and motile, seen under darkfield microscopy. Syphilis is transmitted sexually or from mother to fetus. It has three stages - primary, secondary, and tertiary - with characteristic lesions developing at each stage like chancres. Diagnosis involves serological tests detecting antibodies like VDRL and RPR. Penicillin is the treatment of choice.
This document defines syphilis as a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. It describes the epidemiology, clinical features, laboratory diagnosis, complications, treatment, and prevention of syphilis. Syphilis presents initially as a chancre sore and progresses through primary, secondary, latent, and tertiary stages if left untreated. Penicillin is the most common treatment, though antibiotics like doxycycline may be used for those allergic to penicillin. Safe sex practices and regular STI screening are important for prevention.
Malaria is a mosquito-borne disease caused by Plasmodium parasites. In 2018, 228 million people were infected globally resulting in over 400,000 deaths. India accounts for 3% of global malaria cases and deaths, with most cases concentrated in 7 states. Malaria is transmitted via the bites of infected female Anopheles mosquitoes. Symptoms include fever, chills, and flu-like illness, with P. falciparum infections potentially causing severe complications like cerebral malaria, severe anemia, or respiratory distress. Proper diagnosis and treatment are needed to prevent mortality from this widespread and potentially deadly disease.
This document discusses Varicella Zoster Virus (VZV) which causes chickenpox (varicella) and shingles (herpes zoster). VZV establishes latency in dorsal root ganglia after primary infection of chickenpox which can later reactivate and cause shingles. Both diseases present with characteristic vesicular rashes but shingles lesions are limited to a single dermatome. Complications of shingles include postherpetic neuralgia. VZV is diagnosed through virus isolation, serology, PCR or antigen detection and treated with antiviral drugs like acyclovir. Vaccination provides effective protection against chickenpox.
Treponema pallidum is a spirochete bacterium that causes syphilis and other diseases. It has a thin, helical shape with periplasmic flagella and tightly coiled cells. Syphilis infection progresses through primary, secondary, latent, and tertiary stages and can involve multiple organ systems if left untreated. Diagnosis involves darkfield microscopy, serological tests like VDRL and RPR, and specific treponemal tests since the bacterium cannot be cultured.
This document summarizes clinical manifestations of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. It describes how dengue is caused by a virus transmitted by Aedes mosquitos. It outlines the disease progression from primary to secondary infection and discusses disease definitions. Key points include four clinical syndromes, hemorrhagic manifestations, thrombocytopenia, and signs of circulatory failure in dengue shock syndrome.
This document summarizes several types of Borrelia bacteria, including B. recurrentis, B. burgdorferi, and B. vincenti. B. recurrentis causes relapsing fever characterized by fever, chills, and relapses every 4-10 days. It is transmitted by body lice. B. burgdorferi causes Lyme disease and is transmitted through the bite of infected ticks. It can cause skin, neurological, and joint symptoms. B. vincenti is normally a mouth commensal but can cause Vincent angina in conditions of malnutrition or viral infection when associated with Fusobacterium fusiforme. Diagnosis of Borrelia infections involves microscopy, culture, serology and
Rickettsial diseases are difficult to diagnose clinically and often go unrecognized, leading to significant morbidity and mortality. They are caused by intracellular bacteria from the Rickettsia genus that are typically spread by arthropod vectors like ticks, fleas and mites. Some of the most common rickettsial diseases found in India include scrub typhus, murine typhus, Indian tick typhus and Q fever. Diagnosis relies on clinical suspicion combined with serology. Treatment involves doxycycline. Prevention focuses on vector control and improving hygiene.
Syphilis is a sexually transmitted
bacterial infection that causes genital ulcers (sores) in its early stages. If
untreated, these ulcers can then lead to more serious symptoms of
infection.
An ancient disease, syphilis is still of
major importance today. In 2008, 13,500 cases of syphilis were reported in the
united States, mostly in people 20 to 29 years of age. Of these reported cases,
63 percent were among men who have sex with men. Syphilis rates have increased
in males each year between 2000 and 2008 and in females each year between 2004
and 2008.
HIV infection and syphilis are linked.
Syphilis increases the risk of transmitting as well as getting infected with
HIV.
Among the major rickettsial diseases reported in India are scrub typhus, murine or flea-borne typhus, and Indian tick typhus. Scrub typhus is caused by Rickettsia tsutsugamushi and transmitted through the bite of trombiculid mites. It is considered an important cause of fever in India due to its prevalence and potential for serious complications if not treated promptly. Common symptoms include fever, headache, and an eschar at the site of mite bite in approximately 50% of cases. Diagnosis relies on PCR, serological tests like IFA, and the Weil-Felix test.
This document summarizes a seminar on rabies that was presented on July 20, 2013. It discusses that rabies virus causes fatal encephalitis in warm-blooded animals and is found in wild and domestic animals like dogs, cats, cattle, and some bats. An estimated 26,000 to 61,000 human deaths from rabies occur annually worldwide, with 85% in rural areas. In India, around 17,137 human rabies deaths are estimated annually. Children under 15 are particularly at risk, accounting for 50-60% of rabies deaths in India due to shorter stature and virus reaching the brain faster. The document outlines symptoms, diagnosis, exposure categories, wound management, vaccination schedules, and special considerations
Enteroviruses are a genus of picornaviruses that mainly replicate in the gut. There are at least 71 serotypes divided into 5 groups: polioviruses, coxsackie A viruses, coxsackie B viruses, echoviruses, and newly identified enteroviruses. Enterovirus infections can range from subclinical to abortive infections with minor illness to major illness with paralysis. Prevention is focused on vaccination with oral or intramuscular poliovirus vaccines. While poliovirus has been largely eradicated, surveillance continues to monitor outbreaks and achieve global eradication.
Dengue fever is a disease caused by viruses transmitted by mosquitoes. Symptoms include headache, fever, joint pain, and rash. It can range from mild to life-threatening hemorrhagic fever. While prevalent in tropical areas, local transmission has occurred in Florida. There is no vaccine or specific treatment, so prevention depends on controlling the mosquito population.
Syphilis is a sexually transmitted disease caused by the bacterium Treponema pallidum. It has four stages - primary, secondary, latent, and tertiary. The document provides an overview of the history, morphology, culture characteristics, epidemiology, pathogenesis, signs and symptoms, diagnostic tests, prophylaxis, and treatment for each stage of syphilis. Laboratory diagnosis involves darkfield microscopy, serological tests like VDRL and TPPA. Penicillin is usually used for treatment, while prevention involves condom use and testing of pregnant women.
Here's a little information about a very common pathogen in human diseases Streptococcus pyogenes. This presentation consists of the history of the organism, its introduction, its morphology, the cell antigens and proteins, the diseases caused by this organism its diagnosis and treatment. I hope it is helpful for the people studying medical microbiology.
This document provides an overview of malaria, including its epidemiology, life cycle, symptoms, diagnosis and treatment. Some key points:
- Malaria is caused by Plasmodium parasites and transmitted via the bites of infected Anopheles mosquitoes. P. falciparum causes the most severe form of the disease.
- It is widespread in tropical and subtropical regions, especially sub-Saharan Africa. An estimated 1-3 million people die from malaria each year.
- Symptoms include fever, chills, fatigue and headaches. Severe malaria can lead to coma, organ failure or death if not promptly treated. Diagnosis involves blood smear examination and rapid tests.
-
Malaria is a vector-borne infectious disease caused by protozoan parasites that is transmitted through the bites of infected Anopheles mosquitoes. It is widespread in tropical and subtropical regions and affects around 40% of the world's population. The most common and deadly type is Plasmodium falciparum malaria, which can lead to complications like cerebral malaria. Signs and symptoms include periodic fevers, headaches, chills, and anemia. Diagnosis involves examining blood smears under a microscope to look for the parasites. Treatment involves antimalarial drugs like chloroquine, primaquine, and artemisinin combination therapies.
Structure of Virus, modes of transmission, pathogenesis, clinical features, biochemical basis of clinical symptoms, laboratory diagnosis, treatment and prevention.
Cytomegalovirus is a herpesvirus that commonly infects humans. It can cause enlarged cells (cytomegalic inclusion disease) and poses a risk for severe infections in infants during pregnancy or birth as well as immunosuppressed individuals. The virus replicates slowly in human fibroblasts and establishes lifelong latent infections. Primary infection is usually asymptomatic but can resemble mononucleosis. Congenital infection may cause death, growth problems, or long-term neurological and vision issues in infants. Polymerase chain reaction testing and antigen detection are now used to diagnose active cytomegalovirus infections.
Poliomyelitis is an acute viral infectious disease caused by the poliovirus. It has affected humans for thousands of years. While effective vaccines were developed by the mid-20th century, polio outbreaks were still common worldwide. The presentation provides an overview of the history, epidemiology, pathogenesis, clinical features, diagnosis, treatment, prognosis, and prevention of poliomyelitis. It also describes rehabilitation programs and case studies of polio survivors.
Enteroviruses are a genus of picornaviruses that replicate in the gut. There are at least 71 serotypes including polioviruses, coxsackie A and B viruses, echoviruses, and newer enteroviruses. They are single stranded RNA viruses with icosahedral symmetry that are stable in acid pH. Poliovirus was first identified in 1909 and causes the disease poliomyelitis, which can result in paralysis. The Sabin oral polio vaccine uses live attenuated poliovirus grown in monkey kidney cells to induce long lasting immunity after multiple doses.
Arboviruses are viruses transmitted by arthropods like mosquitoes and ticks. They cause diseases in both animals and humans. There are two main transmission cycles - man-arthropod-man and animal-arthropod-man. Some major arboviruses include dengue, yellow fever, Japanese encephalitis, West Nile virus and chikungunya. They can cause febrile illnesses, encephalitis or hemorrhagic fevers. Diagnosis involves virus isolation or serological tests. There are vaccines available for only a few arboviruses like yellow fever and Japanese encephalitis. Treatment is generally supportive care.
Malaria is a life-threatening disease caused by Plasmodium parasites transmitted via mosquito bites. It is most prevalent in developing countries, especially sub-Saharan Africa. The most severe form is caused by P. falciparum. Symptoms include fever, chills, and flu-like illness. Diagnosis involves microscopy of blood smears or rapid diagnostic tests to detect parasites. Treatment depends on the Plasmodium species and disease severity, ranging from chloroquine for non-severe P. vivax to artemisinin-based combination therapy for P. falciparum. Prevention involves mosquito control and antimalarial drugs. Malaria poses a major global health challenge but can be controlled through
The document provides information on scrotal swelling and its underlying causes. It begins with an anatomy section describing the structures of the scrotum. It then discusses various conditions that can cause scrotal swelling including varicocele, hydrocele, haematocele, skin problems, infections, testicular inflammation and tumors, and scrotal hernias. For each condition, it provides details on anatomy, risk factors, clinical features, complications, and management approaches.
This document summarizes several types of Borrelia bacteria, including B. recurrentis, B. burgdorferi, and B. vincenti. B. recurrentis causes relapsing fever characterized by fever, chills, and relapses every 4-10 days. It is transmitted by body lice. B. burgdorferi causes Lyme disease and is transmitted through the bite of infected ticks. It can cause skin, neurological, and joint symptoms. B. vincenti is normally a mouth commensal but can cause Vincent angina in conditions of malnutrition or viral infection when associated with Fusobacterium fusiforme. Diagnosis of Borrelia infections involves microscopy, culture, serology and
Rickettsial diseases are difficult to diagnose clinically and often go unrecognized, leading to significant morbidity and mortality. They are caused by intracellular bacteria from the Rickettsia genus that are typically spread by arthropod vectors like ticks, fleas and mites. Some of the most common rickettsial diseases found in India include scrub typhus, murine typhus, Indian tick typhus and Q fever. Diagnosis relies on clinical suspicion combined with serology. Treatment involves doxycycline. Prevention focuses on vector control and improving hygiene.
Syphilis is a sexually transmitted
bacterial infection that causes genital ulcers (sores) in its early stages. If
untreated, these ulcers can then lead to more serious symptoms of
infection.
An ancient disease, syphilis is still of
major importance today. In 2008, 13,500 cases of syphilis were reported in the
united States, mostly in people 20 to 29 years of age. Of these reported cases,
63 percent were among men who have sex with men. Syphilis rates have increased
in males each year between 2000 and 2008 and in females each year between 2004
and 2008.
HIV infection and syphilis are linked.
Syphilis increases the risk of transmitting as well as getting infected with
HIV.
Among the major rickettsial diseases reported in India are scrub typhus, murine or flea-borne typhus, and Indian tick typhus. Scrub typhus is caused by Rickettsia tsutsugamushi and transmitted through the bite of trombiculid mites. It is considered an important cause of fever in India due to its prevalence and potential for serious complications if not treated promptly. Common symptoms include fever, headache, and an eschar at the site of mite bite in approximately 50% of cases. Diagnosis relies on PCR, serological tests like IFA, and the Weil-Felix test.
This document summarizes a seminar on rabies that was presented on July 20, 2013. It discusses that rabies virus causes fatal encephalitis in warm-blooded animals and is found in wild and domestic animals like dogs, cats, cattle, and some bats. An estimated 26,000 to 61,000 human deaths from rabies occur annually worldwide, with 85% in rural areas. In India, around 17,137 human rabies deaths are estimated annually. Children under 15 are particularly at risk, accounting for 50-60% of rabies deaths in India due to shorter stature and virus reaching the brain faster. The document outlines symptoms, diagnosis, exposure categories, wound management, vaccination schedules, and special considerations
Enteroviruses are a genus of picornaviruses that mainly replicate in the gut. There are at least 71 serotypes divided into 5 groups: polioviruses, coxsackie A viruses, coxsackie B viruses, echoviruses, and newly identified enteroviruses. Enterovirus infections can range from subclinical to abortive infections with minor illness to major illness with paralysis. Prevention is focused on vaccination with oral or intramuscular poliovirus vaccines. While poliovirus has been largely eradicated, surveillance continues to monitor outbreaks and achieve global eradication.
Dengue fever is a disease caused by viruses transmitted by mosquitoes. Symptoms include headache, fever, joint pain, and rash. It can range from mild to life-threatening hemorrhagic fever. While prevalent in tropical areas, local transmission has occurred in Florida. There is no vaccine or specific treatment, so prevention depends on controlling the mosquito population.
Syphilis is a sexually transmitted disease caused by the bacterium Treponema pallidum. It has four stages - primary, secondary, latent, and tertiary. The document provides an overview of the history, morphology, culture characteristics, epidemiology, pathogenesis, signs and symptoms, diagnostic tests, prophylaxis, and treatment for each stage of syphilis. Laboratory diagnosis involves darkfield microscopy, serological tests like VDRL and TPPA. Penicillin is usually used for treatment, while prevention involves condom use and testing of pregnant women.
Here's a little information about a very common pathogen in human diseases Streptococcus pyogenes. This presentation consists of the history of the organism, its introduction, its morphology, the cell antigens and proteins, the diseases caused by this organism its diagnosis and treatment. I hope it is helpful for the people studying medical microbiology.
This document provides an overview of malaria, including its epidemiology, life cycle, symptoms, diagnosis and treatment. Some key points:
- Malaria is caused by Plasmodium parasites and transmitted via the bites of infected Anopheles mosquitoes. P. falciparum causes the most severe form of the disease.
- It is widespread in tropical and subtropical regions, especially sub-Saharan Africa. An estimated 1-3 million people die from malaria each year.
- Symptoms include fever, chills, fatigue and headaches. Severe malaria can lead to coma, organ failure or death if not promptly treated. Diagnosis involves blood smear examination and rapid tests.
-
Malaria is a vector-borne infectious disease caused by protozoan parasites that is transmitted through the bites of infected Anopheles mosquitoes. It is widespread in tropical and subtropical regions and affects around 40% of the world's population. The most common and deadly type is Plasmodium falciparum malaria, which can lead to complications like cerebral malaria. Signs and symptoms include periodic fevers, headaches, chills, and anemia. Diagnosis involves examining blood smears under a microscope to look for the parasites. Treatment involves antimalarial drugs like chloroquine, primaquine, and artemisinin combination therapies.
Structure of Virus, modes of transmission, pathogenesis, clinical features, biochemical basis of clinical symptoms, laboratory diagnosis, treatment and prevention.
Cytomegalovirus is a herpesvirus that commonly infects humans. It can cause enlarged cells (cytomegalic inclusion disease) and poses a risk for severe infections in infants during pregnancy or birth as well as immunosuppressed individuals. The virus replicates slowly in human fibroblasts and establishes lifelong latent infections. Primary infection is usually asymptomatic but can resemble mononucleosis. Congenital infection may cause death, growth problems, or long-term neurological and vision issues in infants. Polymerase chain reaction testing and antigen detection are now used to diagnose active cytomegalovirus infections.
Poliomyelitis is an acute viral infectious disease caused by the poliovirus. It has affected humans for thousands of years. While effective vaccines were developed by the mid-20th century, polio outbreaks were still common worldwide. The presentation provides an overview of the history, epidemiology, pathogenesis, clinical features, diagnosis, treatment, prognosis, and prevention of poliomyelitis. It also describes rehabilitation programs and case studies of polio survivors.
Enteroviruses are a genus of picornaviruses that replicate in the gut. There are at least 71 serotypes including polioviruses, coxsackie A and B viruses, echoviruses, and newer enteroviruses. They are single stranded RNA viruses with icosahedral symmetry that are stable in acid pH. Poliovirus was first identified in 1909 and causes the disease poliomyelitis, which can result in paralysis. The Sabin oral polio vaccine uses live attenuated poliovirus grown in monkey kidney cells to induce long lasting immunity after multiple doses.
Arboviruses are viruses transmitted by arthropods like mosquitoes and ticks. They cause diseases in both animals and humans. There are two main transmission cycles - man-arthropod-man and animal-arthropod-man. Some major arboviruses include dengue, yellow fever, Japanese encephalitis, West Nile virus and chikungunya. They can cause febrile illnesses, encephalitis or hemorrhagic fevers. Diagnosis involves virus isolation or serological tests. There are vaccines available for only a few arboviruses like yellow fever and Japanese encephalitis. Treatment is generally supportive care.
Malaria is a life-threatening disease caused by Plasmodium parasites transmitted via mosquito bites. It is most prevalent in developing countries, especially sub-Saharan Africa. The most severe form is caused by P. falciparum. Symptoms include fever, chills, and flu-like illness. Diagnosis involves microscopy of blood smears or rapid diagnostic tests to detect parasites. Treatment depends on the Plasmodium species and disease severity, ranging from chloroquine for non-severe P. vivax to artemisinin-based combination therapy for P. falciparum. Prevention involves mosquito control and antimalarial drugs. Malaria poses a major global health challenge but can be controlled through
The document provides information on scrotal swelling and its underlying causes. It begins with an anatomy section describing the structures of the scrotum. It then discusses various conditions that can cause scrotal swelling including varicocele, hydrocele, haematocele, skin problems, infections, testicular inflammation and tumors, and scrotal hernias. For each condition, it provides details on anatomy, risk factors, clinical features, complications, and management approaches.
Syphilis is a contagious bacterial infection caused by Treponema pallidum that is transmitted through direct contact with a chancre sore, usually during sexual contact. It progresses through primary, secondary, latent, and tertiary stages if left untreated. Symptoms vary by stage but may include sores, rashes, and damage to internal organs over time. Diagnosis involves tests of fluids from sores, blood tests, and spinal taps. Treatment is with antibiotics but damage cannot be reversed. Prevention involves safe sex practices and regular testing to catch the infection early.
This document provides information about syphilis, including its historical background, stages, tests, and management. It discusses the primary, secondary, latent, and tertiary stages of syphilis and their associated signs and symptoms. Congenital syphilis and syphilis in pregnancy are also covered. The modes of transmission are described. Both nontreponemal and treponemal tests for detecting syphilis are outlined. Treatment options are provided for each stage of syphilis.
This document provides information on various dermatological conditions including:
- Pityriasis versicolor, describing presentation, diagnosis via KOH mount, and treatment with selenium sulfide or ketoconazole.
- Acne vulgaris, outlining exacerbating factors to avoid and medical management approaches for moderate and severe cases including topical and oral medications. Details are given on isotretinoin use and monitoring.
- Rosacea, defining diagnostic criteria and stages, differential diagnosis, and treatment approaches including lifestyle modifications and topical or oral antibiotics.
- Vitiligo, alopecia areata, scabies, lichen planus, and psoriasis, briefly covering presentation, diagnosis
Syphilis is a sexually transmitted disease caused by the bacterium Treponema pallidum. It has various stages including primary, secondary, latent, and tertiary syphilis. Primary syphilis involves a painless sore or ulcer called a chancre, usually in the genital area. Secondary syphilis causes a rash on the body and mucous membranes. Latent syphilis has no symptoms but can be detected through blood tests. Tertiary syphilis can damage internal organs if left untreated.
Spirochetes are long, helical, motile bacteria that include the genera Treponema, Borrelia, and Leptospira. Treponema pallidum causes syphilis, presenting initially with a chancre then secondary and latent stages before potential progression to tertiary disease. Borrelia burgdorferi causes Lyme disease transmitted by ticks, presenting with a skin lesion and flu-like symptoms. These spirochetes are diagnosed via microscopy, culture, and serology. Penicillin is the treatment of choice for diseases caused by Treponema and Borrelia.
Spirochetes are long, helical, motile bacteria that include the genera Treponema, Borrelia, and Leptospira. Treponema pallidum causes syphilis, presenting initially with a chancre then secondary and latent stages before potential progression to tertiary disease. Borrelia burgdorferi causes Lyme disease transmitted by ticks, presenting with a skin lesion and flu-like symptoms. These spirochetes are diagnosed via microscopy, culture, and serology. Penicillin is the treatment of choice for diseases caused by Treponema and Borrelia.
1. Spirochetes are spiral-shaped, motile bacteria that include pathogens causing syphilis, Lyme disease, and leptospirosis.
2. Treponema pallidum causes syphilis, which has primary, secondary, and tertiary stages and can be transmitted congenitally. Darkfield microscopy and serological tests are used for diagnosis.
3. Other human pathogenic spirochetes include Borrelia burgdorferi, which causes Lyme disease transmitted through tick bites, and Leptospira interrogans, which causes leptospirosis transmitted through contact with infected animal urine.
Syphilis is a sexually transmitted disease caused by the spirochete Treponema pallidum. It has four stages - primary, secondary, latent, and tertiary - and can cause lesions, rashes, and long-term damage if untreated. It is diagnosed through direct visualization of spirochetes or serological tests. Treatment involves penicillin, doxycycline, or tetracycline depending on the stage of disease. Syphilis can also be transmitted from mother to child during pregnancy or childbirth, potentially causing fetal death or lifelong infections.
Syphilis introduction and primary syphilismadhu sunkara
Treponema pallidum, the spirochete bacterium that causes syphilis, was discovered in 1905. Syphilis presents as a primary chancre sore at the site of infection, usually the genitals, which heals on its own within 3-6 weeks if left untreated. The chancre is characterized by being painless, indurated, and having a clean ulcer base. Lymph nodes also swell within 1-2 weeks. Without treatment, the infection enters subsequent secondary and tertiary stages affecting multiple organ systems.
This document discusses several non-conventional pathogens including mycoplasmas, chlamydia, spirochetes, and legionella. It provides detailed information on mycoplasmas including their morphology, biological features, culture characteristics, and associated diseases. Chlamydia traits and the diseases it causes like nongonococcal urethritis are described. Finally, it examines spirochetes that cause diseases like syphilis, relapsing fever, and Lyme disease providing information on their transmission, clinical manifestations, diagnosis and treatment.
SYPHILIS.pptx bachelors degree in medicineJosphatSiele
Syphilis is caused by the bacterium Treponema pallidum. It is usually transmitted sexually but can also be transmitted congenitally from mother to fetus. There are four stages of syphilis: primary, secondary, latent, and tertiary. Left untreated, syphilis can cause serious long term complications affecting the heart, brain, and other organs. Penicillin remains the treatment of choice and can cure syphilis if administered properly in the early stages of infection. Complications from treatment may include anaphylaxis or Jarisch-Herxheimer reaction.
Syphilis is a chronic bacterial infection caused by the bacteria Treponema pallidum that is primarily transmitted through sexual contact. It progresses through three stages - primary, secondary, and tertiary - if left untreated. Primary syphilis involves skin sores, secondary syphilis involves rashes and mouth sores, and tertiary syphilis can damage internal organs. Syphilis is diagnosed through tests that detect antibodies produced in response to the infection. While antibiotics can cure it in its early stages, later stages may cause permanent damage without treatment.
Syphilis is caused by the bacterium Treponema pallidum. It has various stages including primary, secondary, latent, and tertiary syphilis. Primary syphilis involves a painless sore called a chancre, secondary syphilis presents with a rash and other symptoms affecting multiple organ systems, and latent and tertiary syphilis can cause long term damage if left untreated. Penicillin is the treatment of choice and works against all stages of syphilis.
This document summarizes information about Treponema pallidum, the causative agent of syphilis. It describes key details such as:
1. T. pallidum was discovered in 1905 by Schaudinn and Hoffmann in samples from syphilitic patients.
2. It is a thin, helically coiled bacterium that is difficult to view with conventional microscopy but can be seen with specialized staining techniques or darkfield microscopy.
3. Syphilis is diagnosed through direct visualization of T. pallidum, nontreponemal tests that detect antibodies to cardiolipins and treponemal tests that detect antibodies to T. pallidum antigens.
Spirochetes ppt microbiology and immunologyNellyPhiri5
Treponema pallidum is a spirochete bacterium that causes syphilis. It is transmitted through direct contact with syphilitic sores during sexual activity or from mother to child in utero. Syphilis progresses through primary, secondary, latent, and tertiary stages if left untreated. Primary syphilis causes a painless sore called a chancre, while secondary syphilis features a rash and mucous membrane lesions. Late syphilis can result in damage to the nervous system, heart, or other organs. Syphilis is effectively treated with penicillin.
This document provides information about syphilis, including:
1. Syphilis is a chronic infection caused by the bacterium Treponema pallidum that is transmitted sexually or congenitally.
2. Primary syphilis presents as a chancre on the genitals or mouth. Secondary syphilis causes a rash and mucous membrane lesions. Tertiary syphilis can damage internal organs if left untreated.
3. Diagnosis involves darkfield microscopy of lesions, serological tests like RPR and FTA-Abs, and PCR. Treatment is with penicillin. Counseling involves educating patients about transmission risks and screening of partners.
Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. It has four stages - primary, secondary, latent, and tertiary. It is most commonly spread through sexual activity but can also be transmitted from mother to baby. Diagnosis involves blood tests and microscopy. While treatable with antibiotics, syphilis remains a global health problem.
Yaws is a chronic infectious disease caused by the bacterium Treponema pertenue that affects the skin, bones, and joints. It is transmitted through direct skin contact with infected individuals. The disease primarily affects children in tropical parts of Africa, Asia, South America, and the Pacific Islands. Yaws progresses through primary, secondary, latent, and tertiary stages, and can cause disfigurement if left untreated. It is diagnosed clinically or through blood tests and dark-field microscopy. Treatment involves antibiotics like benzathine penicillin or azithromycin, which can cure yaws in the early stages. Public health efforts aim to eradicate the disease by 2020 through early detection and treatment.
This document provides information on spirochetes, including their morphology, classification, pathogenic species, and details on specific diseases caused by them. It discusses the characteristics of Treponema pallidum and Borrelia burgdorferi, which cause syphilis and Lyme disease respectively. It also provides clinical manifestations, laboratory diagnosis, treatment and other relevant details about these diseases. Leptospira interrogans is described as the causative agent of Weil's disease or leptospirosis. The document contains detailed diagrams and explanations.
Toxoplasmosis during pregnancy can threaten the health of the unborn child if the mother becomes infected during pregnancy. While toxoplasmosis infection usually causes no symptoms, primary infection during pregnancy can lead to congenital toxoplasmosis in the baby. However, after primary infection, immunity develops that usually protects against reactivation and prevents transmission during subsequent pregnancies. Many doctors mistakenly believe all pregnant women need treatment, when in fact treatment is only necessary for those with primary active infections during pregnancy.
Syphilis is a bacterial infection caused by Treponema pallidum that is primarily transmitted through sexual contact. It develops in stages, beginning with a chancre sore and progressing to rashes, fever, and lymph node swelling if left untreated. Without treatment, syphilis can spread to the heart, brain and other organs. It is diagnosed through blood tests and treated with antibiotics like penicillin. Untreated syphilis can cause serious long term complications or death.
Mycoplasmas are the smallest free-living organisms that can cause diseases in humans. They lack cell walls and have minimal genetic material. Several Mycoplasma species can cause respiratory illnesses like pneumonia from M. pneumoniae or urogenital infections from M. hominis, U. urealyticum, and M. genitalium. They are difficult to culture but can be identified using PCR or serological tests. Mycoplasma pneumonia is most common in children aged 5-15 years old and is typically treated with tetracyclines or macrolides.
The document discusses body fluids, cerebrospinal fluid (CSF), and distinguishing between transudates and exudates. Key points include:
- CSF is produced by the choroid plexus at a rate of 500 ml per day and acts as a cushion and lubricant for the brain. Analysis of CSF provides information about infections and CNS disorders.
- Transudates have a low protein content and occur due to decreased plasma proteins or increased venous pressure. Exudates have a high protein content and occur due to inflammation or tissue damage.
- CSF analysis involves examination of appearance, chemical properties like glucose and protein levels, cell counts, and microbiological tests to identify infections. Abnormal results can indicate conditions
Enzymes are protein catalysts found in cells and tissues. They are responsible for chemical reactions in the body and can be detected in serum to diagnose diseases. Increased enzyme levels in serum may indicate tissue damage or certain disease states. Common enzymes measured include alkaline phosphatase, acid phosphatase, amylase, lipase, SGPT and SGOT which can help diagnose diseases of the bones, prostate, pancreas and liver. Enzymes function as biological catalysts by lowering the activation energy of reactions and increasing their rates without being consumed in the process. They are highly specific and their activity can be affected by factors like pH, temperature, substrate and inhibitor concentrations.
The document discusses the basic structures and properties of amino acids and proteins. It provides details on the 20 standard amino acids, including their abbreviations and the characteristics of their R-groups. The amino acids are classified as neutral, acidic, basic, or polar based on the properties of their side chains. Essential amino acids cannot be synthesized by the human body and must be obtained through diet.
The document discusses abnormalities of white blood cells, including quantitative abnormalities like leukocytosis and leukopenia as well as qualitative abnormalities involving the nucleus or cytoplasm of white blood cells. Some examples of qualitative abnormalities discussed include Pelger-Huet anomaly, Chediak-Steinbrinck-Higashi syndrome, and Auer rods. The types of white blood cells are described along with causes of conditions like neutrophilia, eosinophilia, lymphocytosis, and monocytosis. Inherited and acquired morphological and functional abnormalities of white blood cells are also summarized.
This document summarizes the three main stages of cellular respiration: glycolysis, the Krebs cycle, and the electron transport chain.
[1] Glycolysis occurs in the cytoplasm and breaks down glucose into pyruvate, while the Krebs cycle in the mitochondrial matrix further breaks down pyruvate into carbon dioxide. [2] Several steps in glycolysis and the Krebs cycle pass electrons to NAD+, which is then used by the electron transport chain in the mitochondria. [3] The electron transport chain uses a series of electron carriers and pumps hydrogen ions across the inner mitochondrial membrane. This proton gradient is then used by ATP synthase to produce ATP through oxidative phosphorylation.
This document provides information on methods for performing a complete blood count (CBC), including white blood cell (WBC) count, corrected WBC count, and differential leukocyte count (DLC). The WBC count involves using a counting chamber, pipettes, and diluting fluids to count WBCs under a microscope. The DLC involves making a blood smear, staining it, counting different types of WBCs, and reporting results as relative or absolute counts. Normal ranges are provided for WBC subtype percentages and counts.
The document discusses various methodologies for analyzing red blood cells (RBCs). It describes the erythrocyte sedimentation rate (ESR) test, which measures how quickly RBCs settle in plasma, and lists several methods for performing the test including the Wintrobe and Westergren methods. It also covers the osmotic fragility test, which examines RBC stability in hypotonic solutions, and erythrocyte indices, which provide information about average RBC size, hemoglobin content, and concentration by calculating mean corpuscular volume, hemoglobin, and hemoglobin concentration.
The MHC encodes antigen presenting molecules that display peptide fragments to T cells to initiate immune responses. It contains three regions - Class I MHC presents intracellular peptides to CD8+ T cells, Class II MHC presents extracellular peptides to CD4+ T cells, and Class III MHC encodes complement proteins. MHC molecules are highly polymorphic and individuals inherit multiple alleles from each parent. This polymorphism allows presentation of a wide range of peptides and enhances immune responses against pathogens. MHC matching is important for transplantation, as mismatch can lead to graft rejection through T cell recognition of foreign MHC.
Brucella species are small, gram-negative bacteria that can cause brucellosis in humans and animals. They infect a variety of animal hosts and are transmitted to humans through contact with infected animals or consumption of unpasteurized dairy. In humans, Brucella bacteria localize in tissues like lymph nodes, liver, and bone, causing non-specific symptoms like fever, sweats, and joint pain. Diagnosis involves culture of the bacteria from blood or tissues or detection of antibodies in serum. Treatment requires a combination of antibiotics for an extended duration.
This document describes various abnormalities that can be seen in red blood cells during a blood smear examination. It defines different types of anisocytosis (variation in red blood cell size), anisochromia (variation in hemoglobin concentration), and abnormal red blood cell shapes that may indicate underlying hematological disorders. Various intracellular inclusions and remnants such as Howell-Jolly bodies, Heinz bodies, and Pappenheimer bodies are also described.
Chapter wise All Notes of First year Basic Civil Engineering.pptxDenish Jangid
Chapter wise All Notes of First year Basic Civil Engineering
Syllabus
Chapter-1
Introduction to objective, scope and outcome the subject
Chapter 2
Introduction: Scope and Specialization of Civil Engineering, Role of civil Engineer in Society, Impact of infrastructural development on economy of country.
Chapter 3
Surveying: Object Principles & Types of Surveying; Site Plans, Plans & Maps; Scales & Unit of different Measurements.
Linear Measurements: Instruments used. Linear Measurement by Tape, Ranging out Survey Lines and overcoming Obstructions; Measurements on sloping ground; Tape corrections, conventional symbols. Angular Measurements: Instruments used; Introduction to Compass Surveying, Bearings and Longitude & Latitude of a Line, Introduction to total station.
Levelling: Instrument used Object of levelling, Methods of levelling in brief, and Contour maps.
Chapter 4
Buildings: Selection of site for Buildings, Layout of Building Plan, Types of buildings, Plinth area, carpet area, floor space index, Introduction to building byelaws, concept of sun light & ventilation. Components of Buildings & their functions, Basic concept of R.C.C., Introduction to types of foundation
Chapter 5
Transportation: Introduction to Transportation Engineering; Traffic and Road Safety: Types and Characteristics of Various Modes of Transportation; Various Road Traffic Signs, Causes of Accidents and Road Safety Measures.
Chapter 6
Environmental Engineering: Environmental Pollution, Environmental Acts and Regulations, Functional Concepts of Ecology, Basics of Species, Biodiversity, Ecosystem, Hydrological Cycle; Chemical Cycles: Carbon, Nitrogen & Phosphorus; Energy Flow in Ecosystems.
Water Pollution: Water Quality standards, Introduction to Treatment & Disposal of Waste Water. Reuse and Saving of Water, Rain Water Harvesting. Solid Waste Management: Classification of Solid Waste, Collection, Transportation and Disposal of Solid. Recycling of Solid Waste: Energy Recovery, Sanitary Landfill, On-Site Sanitation. Air & Noise Pollution: Primary and Secondary air pollutants, Harmful effects of Air Pollution, Control of Air Pollution. . Noise Pollution Harmful Effects of noise pollution, control of noise pollution, Global warming & Climate Change, Ozone depletion, Greenhouse effect
Text Books:
1. Palancharmy, Basic Civil Engineering, McGraw Hill publishers.
2. Satheesh Gopi, Basic Civil Engineering, Pearson Publishers.
3. Ketki Rangwala Dalal, Essentials of Civil Engineering, Charotar Publishing House.
4. BCP, Surveying volume 1
This presentation includes basic of PCOS their pathology and treatment and also Ayurveda correlation of PCOS and Ayurvedic line of treatment mentioned in classics.
Leveraging Generative AI to Drive Nonprofit InnovationTechSoup
In this webinar, participants learned how to utilize Generative AI to streamline operations and elevate member engagement. Amazon Web Service experts provided a customer specific use cases and dived into low/no-code tools that are quick and easy to deploy through Amazon Web Service (AWS.)
This document provides an overview of wound healing, its functions, stages, mechanisms, factors affecting it, and complications.
A wound is a break in the integrity of the skin or tissues, which may be associated with disruption of the structure and function.
Healing is the body’s response to injury in an attempt to restore normal structure and functions.
Healing can occur in two ways: Regeneration and Repair
There are 4 phases of wound healing: hemostasis, inflammation, proliferation, and remodeling. This document also describes the mechanism of wound healing. Factors that affect healing include infection, uncontrolled diabetes, poor nutrition, age, anemia, the presence of foreign bodies, etc.
Complications of wound healing like infection, hyperpigmentation of scar, contractures, and keloid formation.
বাংলাদেশের অর্থনৈতিক সমীক্ষা ২০২৪ [Bangladesh Economic Review 2024 Bangla.pdf] কম্পিউটার , ট্যাব ও স্মার্ট ফোন ভার্সন সহ সম্পূর্ণ বাংলা ই-বুক বা pdf বই " সুচিপত্র ...বুকমার্ক মেনু 🔖 ও হাইপার লিংক মেনু 📝👆 যুক্ত ..
আমাদের সবার জন্য খুব খুব গুরুত্বপূর্ণ একটি বই ..বিসিএস, ব্যাংক, ইউনিভার্সিটি ভর্তি ও যে কোন প্রতিযোগিতা মূলক পরীক্ষার জন্য এর খুব ইম্পরট্যান্ট একটি বিষয় ...তাছাড়া বাংলাদেশের সাম্প্রতিক যে কোন ডাটা বা তথ্য এই বইতে পাবেন ...
তাই একজন নাগরিক হিসাবে এই তথ্য গুলো আপনার জানা প্রয়োজন ...।
বিসিএস ও ব্যাংক এর লিখিত পরীক্ষা ...+এছাড়া মাধ্যমিক ও উচ্চমাধ্যমিকের স্টুডেন্টদের জন্য অনেক কাজে আসবে ...
How to Setup Warehouse & Location in Odoo 17 InventoryCeline George
In this slide, we'll explore how to set up warehouses and locations in Odoo 17 Inventory. This will help us manage our stock effectively, track inventory levels, and streamline warehouse operations.
Walmart Business+ and Spark Good for Nonprofits.pdfTechSoup
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A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
2. Morphology of Treponema pallidium
Member of the order Spirachaetales family Treponemateceae genus -
Treponema
Darkfield illumination
Three genera :- Borelia, Treponema, Leptospira
Genus treponema has four principal pathogenic species
3. PATHOGENIC SPECIES
1)T. Pallidum – responsible for human syphilis.
2)T. Pertenue – Etiologic agent for Yaws and Pinta.
3)T. Carateum - same as pertenue
4)T. Cuniculi – responsible for rabbit syphilis.
4. 1) T. Pallidum
Close- colied, thin regular spiral organism
6-15 u, 8-24 coils width is seldom more than 0.25 u
Periplast or capsular structure
Multiplies by transverse fission, active phase occurs
about every 30 hrs.
5. In aqueous media, young treponemas spins vigorously in more viscous
media, they propel themselves in a tissue they show flexibility.
Cork screw motility is due to the internal periplasmic flagella.
Extremely susceptible to a variety of physical and chemical agents which
rapidly destroy them.
Viable or motile up to 15 days when kept at 35 degree celcius under
anaerobic condition containing serum albumin CHON,CO2.
6. Cannot be recovered in blood , serum or plasma stored at 4 degree celcius
more than 48 hrs.
May remain alive for 5 days in tissue specimens from diseased animals.
Suspension of treponemes frozen at (-70 degree celcius) or lower frozenin
glycerol is viable for years.
Both humoral and cell-mediated immune responses are involved.
7. Antitreponemal anticardiolipin antibodies are
product
Inflammatory response is initated (lymphocytes,
macrophages, plasma cells)
Immune complexes are formed, the organism is
walled off in lesions ,the disease has atendency or
remission stage.
8. WassermannAntigen(compliment fixn. Test, non-
treponemal
The original forth of wassermann test an extract of liver containing many
treponemes from human fetuses with congenital syphilis was used as antigen.
The ligand was isolated from carrdiac muscle and identified as a phospholipid,
diphosphatidglycerol called cardiolipin which is normal constituents of host
tissue.
Free cardiolipin is a hapten and must be bound to a suitable carrier to be
antigenic.
The microbial cell a foreign carrier and the bound cardiolipin is the
immunologic determinant.
9. Treponemal Antigens
In treponemes, two classes of Ag have been recognized
1. Those restricted to one or more species
2. Those shared by many different spirochetes.
Reiter treponeme
Reiter treponeme a spirochete reputed to be cultivable
non virulent variant of T. Pallidum can be used as Ag.
10. Stages of syphilis (correlation with test results)
Syphilis in human is ordianarily transmitted by sexual contact.
Infected males, T. Pallidum are present in lesions on the penis or discharged
from deeper genitourinary sites along with the seminal fluid.
Infected females, the lesions are commonly located in the perianal region or
the labia, vaginal wall or cervix.
In some cases the primary infection is extragenital usually in or about the
mouth.
11. 1. Primary stage (early)
T. Pallidum enter the skin through small breaks capable of passing through
intact mucous membranes which is carried by the blood stream to every
organ of the body.
Chancre develops at the site of entrance within 10- 60 days.
Chancre usually begins as a papule, breakdown to form a superficial ulcer.
Chancre in males occurs at the sulcus of penis or inside the urethra.
12. In females the chancre occurs at the labia majora or
minora, fourchette, clitoris, cervix, uterus or urethral
orifice.
Persists for 1- 5 week, positive result is between the
1st and 3rd week after the appearance of chancre.
13. 2. Secondary stage
Usually occurs from 6-8 weeks after the appearance of the primary chancre.
About 1/3 of the cases it occurs before the chancre disappears.
Symptoms are generalized rash( involving the mucus membrane)
Lesions may develop in the eyes ,joints or CNS
Lesions subsides spontaneously after 2-6 weeks.
Serologic test are invariably positive.
In some cases the primary and secondary stages go unnoticed.
14. 3.The late latent stage
Occurs after the 2nd year of infection.
Disease is contagious(communicable disease) at this stage.
There are no clinical signs and symptoms positive serologic test.
May lost for many years or even for the rest of patient’s life.
For more than 4 years it is rarely communicable except between mother
and fetus.
15. 4. Tertiary stage
Lesions are usually seen from 3-10 years after the primary stage.
The lesions (gummata) usually located on the skin, mucous membranes,
subcutaneous and sub mucous tissues, joints, muscles and ligaments
Serious manifestations when lesions are present in the nervous system
(causing general paralysis) cardiovascular system(aortic aneurysm) eyes
(permanent blindness)
In about ¼ of untreated cases this stage is asymptomatic.
16. Antibodies in syphilis
Development
Individuals infected with T. Pallidum produce specific and non specific
antibodies.
Specific Abs. are directed against the pathogen T. Palladum / Treponemal
Abs.
Non-treponemal Abs./Non-specific Abs. are directed against
CHON(protein) Ag. Group common to pathogenic spirochetes.
17. Specific antibodies in early or untreated early latent syphilis are
predominantly IgM and 23% in untreated late latent stage.
IgG levels are devoted in the secondary stage.
Non-specific IgA antibodies increase significantly during the course of
untreated syphilis.
18. Production of Immunity
Resistance to reinfection increases 3 months after infection.
Termination of the disease by treatment renders the individual susceptible to
reinfection.
Protective immunity against syphilis can be induced by vaccines containing
nonviable T. Palladum but the need for high volume dosage and the
difficulties in the production of sufficient quantities of T.Palladum hampers
the use of vaccines
It is possible that there is no complete immunity to T. Palladum.
19. Treatment of syphilis(correlation with test
result)
If infected patients are treated before the appearance of the primary chancre, it
is probable that the serologic test will remain non-reactive.
If the treatment is given before the appearance of reagin the test is usually
negative.
After the appearance of reagin the test usually become negative 6 months after
treatment.
20. In the secondary stage of disease test usually become non-reactive within
12- 18 months after treatment.
After secondary stage treatment has variable effects on serologic test result
If patient is treated 10 yrs or more after the onset of disease results can be
expected to change a little.
Individuals who are allergic to penicillin and usually treated with
tetracycline.
Pregnant women are treated with erythromycin.
21. Syphilis and blood transfusion
It may be transmitted by blood transfusion when fresh blood is used.
Blood stored at 4 degree Celsius for 4 days or more is unlikely to transmit
syphilis.
STS are standard procedures for all blood donation.
22. Neurosyphilis (syphilis of CNS)
A. Asymptomatic Neurosyphilis
Reactive serologic test for syphilis.
No sign/symptoms of CNS involvement
Examination of CSF reveals as increase in cell, total CHON (protein) positive
reagin test.
B. Meningovascular Neurosyphilis
There are definite sign and symptoms of CNS damage
CSF is always abnormal increase in cell and total CHON and a positive reagin
test.
Meningeal or vascular involvement.
23. C. Parechymatous Neurosyphilis
Presents paresis (incomplete paralysis) or tabes dorsalis (degeneration) of
dorsal columns of the spinal cord and of sensory nerve trunks with wasting.
24. Conginital syphilis
Acquired fetal life from the maternal circulation through the placental
passage of T.Palladum.
More likely to occur when the mother is suffering from early syphilis.
Adequate treatment of the mother before the 18th weak of pregnancy
prevents infections of the fetus because penicillin will cross the placenta
in adequate amount.
25. Lesions of the 1st 2 year of life are infectious and resemble those of
secondary syphilis in the acquired form of the disease.
Late lesions appearing from the 3rd year onward are mostly of gummatous
type and are non-infectious.
The stigmata are the scars or deformities resulting from early or late lesions
that have healed.
26. Disease related to syphilis
1. YAWS
Caused by T. pertenue indistungishable from T.palladum the only different
in the disease is character of the lesions (more persistent).
Scar formation develops at the site of secondary infection.
Lesions are granulomatous or wart-like, tertiary stage is characherized by
modular or ulcerative necrosis
Can be treated by penicillin
Non- venereal transmission by direct contact.
27. 2. PINTA
Caused by T. carateum, nonvenereal disease endemic in central and south
america.
Usually occurs in childhood and is contracted through skin contact.
Initial lesion is commonly found in the legs, starts with a papulae soon
forms a circular scaly patch known as pintid.
Penicillin is effective in treatment
28. 3. BEJEL
Nonvenereal syphilis
No primary lesions seen
Secondary lesions contact consists of generalized popular and
papulosquamous eruptions.
Tertiary lesions may be observed in subcutaneous tissue, skin and bones.
Penicillin is effective in treatment unless cotraindication by allergy.
29. 4. RABBIT SYPHILIS
T.cuniculi is the causative agent.
A natural venereal infection of rabbits.
Producing minor lesions of the genetalia.
30. Serologic test for syphilis
PRINCIPLES
Infection of human with T. palladum provokes in the host a complex Ab
response
Based on the detection of one or more of the Abs.
* 2 known types of Antibodies
1. Non-treponemal Abs or reagin which reacts with lipid Ag (antigen)
2. Treponemal Abs which react with T. palladum and closely related strains.
31. Reagin test for syphilis
VDRL (Venereal Disease Research Laboratory ) slide test
- nonspecific antigen
- cardiolipin is used
PCT (plasmacrit)
RPR ( rapid plasma reagin test)
Unhealed serum reagin test
RPRC (rapid plasma reagin circle card)
32. Treponemal test
TPI (Treponema palladum inhibition test)
TPCF (treponema palladum complement fixation test)
RPCF (reiter CHON(protein) complement fixation test)
FTS-ABS- specific to T. palladum.