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PEMPHIGUS VULGARIS AND EFFECTS
ON PERIDONATAL HEALTH
REGISTRATION NUMBER 825
INTRODUCTION
• Pemphigus vulgaris (PV) is an autoimmune mucocutaneous disease
characterized by epithelial blistering affecting the mucosal/cutaneous
surfaces. This case report demonstrates the oral manifestations of PV
in the uncommon locations such as the attached, marginal, interdental
gingiva and palate with no involvement of oral mucosa, tongue, or
buccal mucosa.
• It not only affects the oral mucosa and the skin but also affects the
mucosa of the conjunctivae, nose, pharynx, larynx, genitals, and
esophagus.
• It affects both sexes equally and is more common in middle-aged and
elderly patients
• The oral mucous membrane is frequently affected in PV patients; most
of patients present with oral lesions as the first sign of PV.
• Lesions may occur anywhere on the oral mucosa, but the buccal
mucosa is the most commonly affected site, followed by involvement
of the palatal, lingual, and labial mucosa; the gingiva is the least
commonly affected site and erosive or desquamative gingivitis is a
common manifestation of the disease
CASE PRESENTATION
• A 32-year-old male engineer reported to the department of
periodontology with a chief complaint of bleeding from gums while
brushing and eating, and painful gingival erosion and desquamation
for the past 8 months. The patient was not able to eat or drink
adequately.
• Patient has history of smoking 8-10 cigrettes/day before 10years back.
INTRAORAL EXAMINATION
• On intraoral examination, there were denuded, spontaneously bleeding
gingival zones. Nikolsky's sign showed a positive reaction, and the
epithelium could be peeled away easily by slightly scratching the surface of
the gingiva. There was presence of white patches and ulcerative and
erythematous area on the on the gingival surface. Periodontal examination
revealed calculus and plaque formation. There was loss of attachment and
bone loss present.
• Gingiva was reddish blue, soft, and edematous and showed bleeding on
probing.
• The site most severely affected was her gingival surface (attached marginal
and interdental gingival) with involvement of oral mucosa and palate.
• On extraoral examination, no skin lesions were present. A
dermatologist confirmed the absence of any cutaneous lesions.
• An incisional biopsy was drawn from perilesional site of the involved
gingival surface. Histopathological examination revealed suprabasal
separation with the formation of tombstone appearance. Tzanck
(acantholytic) cells with a high nuclear–cytoplasmic ratio with
hyperchromatic nuclei and a very smooth nuclear outline.
Suprabasilar split
Inflammatory cells
Tzank cells
Suprabasilar split
• Differential diagnosis of PV included aphthous stomatitis,
gingivostomatitis, erythema multiforme, erosive lichen planus, or oral
candidiasis
TREATMENT
• The mainstay of treatment is systemic corticosteroids though the oral
lesions may respond partially to topical corticosteroids.
• The initial dose of Tab omnacort 10mg /kg/day for 30days
• Kenacort gel is also given.
• The periodontal care consists of frequent professional oral
prophylaxis, 0.2% chlorhexidine mouth rinse, the powered tooth
brushes for home care, and removing local irritating factors .
• Being a serious disease, it becomes very important to diagnose PV at
an early stage when it is limited to oral cavity and a close follow-up is
essential.
• Persistent oral lesions of pemphigus vulgaris prevent
effective brushing, leading to an increase in the dental
biofilm and consequently worsening of the
dermatological disease.
• These oral manifestations cause local discomfort
directly affecting physical and psychic aspects and
quality of life of the patients
CONCLUSION
• After intraoral scaling and root planing and the administration of local
and systemic medications. patient counselling and with patient's
improved oral hygiene maintainance lesions like mucosal blisters and
desquamations of gingiva and gingival inflammation showed good
healing response.
pemphigus_paper_Autosaved.pptx

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pemphigus_paper_Autosaved.pptx

  • 1. PEMPHIGUS VULGARIS AND EFFECTS ON PERIDONATAL HEALTH REGISTRATION NUMBER 825
  • 2. INTRODUCTION • Pemphigus vulgaris (PV) is an autoimmune mucocutaneous disease characterized by epithelial blistering affecting the mucosal/cutaneous surfaces. This case report demonstrates the oral manifestations of PV in the uncommon locations such as the attached, marginal, interdental gingiva and palate with no involvement of oral mucosa, tongue, or buccal mucosa. • It not only affects the oral mucosa and the skin but also affects the mucosa of the conjunctivae, nose, pharynx, larynx, genitals, and esophagus. • It affects both sexes equally and is more common in middle-aged and elderly patients
  • 3. • The oral mucous membrane is frequently affected in PV patients; most of patients present with oral lesions as the first sign of PV. • Lesions may occur anywhere on the oral mucosa, but the buccal mucosa is the most commonly affected site, followed by involvement of the palatal, lingual, and labial mucosa; the gingiva is the least commonly affected site and erosive or desquamative gingivitis is a common manifestation of the disease
  • 4. CASE PRESENTATION • A 32-year-old male engineer reported to the department of periodontology with a chief complaint of bleeding from gums while brushing and eating, and painful gingival erosion and desquamation for the past 8 months. The patient was not able to eat or drink adequately. • Patient has history of smoking 8-10 cigrettes/day before 10years back.
  • 5. INTRAORAL EXAMINATION • On intraoral examination, there were denuded, spontaneously bleeding gingival zones. Nikolsky's sign showed a positive reaction, and the epithelium could be peeled away easily by slightly scratching the surface of the gingiva. There was presence of white patches and ulcerative and erythematous area on the on the gingival surface. Periodontal examination revealed calculus and plaque formation. There was loss of attachment and bone loss present. • Gingiva was reddish blue, soft, and edematous and showed bleeding on probing. • The site most severely affected was her gingival surface (attached marginal and interdental gingival) with involvement of oral mucosa and palate.
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  • 8. • On extraoral examination, no skin lesions were present. A dermatologist confirmed the absence of any cutaneous lesions. • An incisional biopsy was drawn from perilesional site of the involved gingival surface. Histopathological examination revealed suprabasal separation with the formation of tombstone appearance. Tzanck (acantholytic) cells with a high nuclear–cytoplasmic ratio with hyperchromatic nuclei and a very smooth nuclear outline.
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  • 13. • Differential diagnosis of PV included aphthous stomatitis, gingivostomatitis, erythema multiforme, erosive lichen planus, or oral candidiasis
  • 14. TREATMENT • The mainstay of treatment is systemic corticosteroids though the oral lesions may respond partially to topical corticosteroids. • The initial dose of Tab omnacort 10mg /kg/day for 30days • Kenacort gel is also given. • The periodontal care consists of frequent professional oral prophylaxis, 0.2% chlorhexidine mouth rinse, the powered tooth brushes for home care, and removing local irritating factors . • Being a serious disease, it becomes very important to diagnose PV at an early stage when it is limited to oral cavity and a close follow-up is essential.
  • 15. • Persistent oral lesions of pemphigus vulgaris prevent effective brushing, leading to an increase in the dental biofilm and consequently worsening of the dermatological disease. • These oral manifestations cause local discomfort directly affecting physical and psychic aspects and quality of life of the patients
  • 16. CONCLUSION • After intraoral scaling and root planing and the administration of local and systemic medications. patient counselling and with patient's improved oral hygiene maintainance lesions like mucosal blisters and desquamations of gingiva and gingival inflammation showed good healing response.