5. MILD FORM
- Diffuse, mild erythema
- Painless condition
- Prevalence- more in females
- 17-23 years of age
6. MODERATE FORM
- Patchy distribution of bright red and gray areas
- Surface is smooth, shiny and soft in consistency
- Slight pitting on pressure
- Prevalence- 30-4- years of age
- Patient presents with C/O of burning sensation and sensitivity to
thermal changes.
7. SEVERE FORM –
- Striking fiery red appearance
- Scattered irregularly shaped areas
- Most of the area is greyish blue giving an overall speckled
appearance
- Surface epithelium is shredded and friable and can be peeled off in
small patches
- Patient presents with C/O of constant dry and burning sensation
throughout the oral cavity, inability to tolerance coarse food or
temperature changes
9. The diagnostic approach for desquamative gingivitis includes hematoxylin and eosin (H&E)
and direct immunofluorescence evaluation of biopsy specimens.
10. CLINICAL HISTORY
A thorough clinical history is mandatory to begin the assessment of
desquamative gingivitis.
Data regarding the symptoms associated with this condition and its
historical aspects (e.g., lesion onset, whether it has worsened, habits
that exacerbate it) provide the foundation for a thorough
examination.
Information about previous therapy to alleviate the condition
should be documented.
11. CLINICAL EXAMINATION
The distribution pattern of the lesions (e.g., focal or multifocal,
with or without confinement to gingival tissues) provides
information that can begin to narrow the differential diagnosis.
A simple clinical maneuver such as the Nikolsky sign offers insight
into the plausibility of a vesiculobullous disorder.
12. BIOPSY
An incisional biopsy is the best strategy for beginning the
microscopic and immunologic evaluation.
An important consideration is the selection of the biopsy site.
A perilesional incisional biopsy should avoid areas of ulceration
because necrosis and epithelial denudation severely hamper the
diagnostic process.
After the tissue is excised from the oral cavity, the specimen can be
bisected and then submitted for microscopic examination
13. Buffered formalin (10%) should be used to fix the tissue for
conventional hematoxylin and eosin (H&E) evaluation.
Michel’s buffer (i.e., ammonium sulfate buffer, pH 7.0) is used as
the transport solution for immunofluorescence assessment.
MICROSCOPIC EXAMINATION
Sections of approximately 5 µm of formalin-fixed, paraffin-
embedded tissue stained with conventional H&E are obtained for
light microscopy examination.
14. IMMUNOFLUORESCENCE
For direct immunofluorescence, unfixed frozen sections are incubated
with a variety of fluorescein-labeled, antihuman serum (i.e., anti-IgG,
anti-IgA, anti-IgM, antifibrin, and anti-C3).
For indirect immunofluorescence, unfixed frozen sections of oral or
esophageal mucosa from an animal such as a monkey are first
incubated with the patient’s serum to enable attachment of serum
antibodies to the mucosal tissue. The tissue is then incubated with
fluorescein-labeled antihuman serum.
Immunofluorescence tests are positive if a fluorescent signal is
observed in the epithelium, its associated basement membrane, or the
underlying connective tissue .
15. MANAGEMENT AND TREATMENT
After the diagnosis is established, the dentist must choose the
optimal management strategy.
The choice depends on the practitioner’s experience, the systemic
impact of the disease, and the systemic complications of the
medications.
16. Oral Hygiene Evaluation
All patients with DG should have a thorough inspection of the oral
cavity.
The clinician should carefully inspect the gingiva and teeth for
accumulation of dental plaque, signs of gingival retraction,
evidence of dental root exposure, and tooth loss.
All mucosal surfaces should be inspected for the presence of
microbial colonization, including evaluation for the white plaques
of oral candidiasis, punched-out erosions of herpes simplex virus,
or honey-colored crust of impetigo.
17. Plaque control
An effective oral hygiene regimen is critical to the care of patients
with DG, and should be performed in addition to disease-targeting
therapies.
Institution of a plaque control program improved not only plaque
and gingival bleeding indices, but also pain of lesions and overall
disease activity.
Though different protocols have been used for plaque control in
studies, some general principles should be applied for all patients
with DG.
18. First, all patients should undergo a baseline tooth cleaning with a dental professional comfortable
in the management of patients with DG.
Second, patients should perform at-home dental cleaning with tooth brushing twice daily.
A soft toothbrush is recommended (either manual or electric) while active erosions are present,
using a modified Bass technique, where the bristles are placed at a 45▫ angle to the tooth surface at
the edge of the gum, and strokes are performed to the tooth edge. Rough maneuvers should be
avoided.
Plaque control should be performed either via gentle flossing or the use of a Waterpik, which is as
efficacious but gentler than flossing.
Antiseptic mouth rinse should be performed twice daily, with avoidance of alcohol-based rinses.
Periodic teeth cleaning procedures should be performed, and avoidance of local irritants, such as
ill-fitting prostheses or unsatisfactory restorations, is critical.
19. Decolonization
Reduced oral hygiene and treatment with local immunosuppressant medications can lead to
increased microbial colonization in patients with DG.
Institution of an antiseptic protocol with regular antifungal prophylaxis is recommended.
This can be performed with the twice-daily use of an antiseptic mouth rinse containing
hydrogen peroxide and daily use of antifungal troches.
An empiric treatment with a short course of an oral antifungal at the time of diagnosis, then as
needed for evidence of candidal disease can also be performed.
20. Medical therapies
Topical therapies
Topical therapies are an important component to the therapy of DG.
For some diseases, topical therapies alone can be sufficient to control disease when mild to
moderate.
For immunobullous diseases, systemic therapies are generally required, but topical modalities
represent an important adjunctive treatment.
The most commonly used first-line topical therapy is a topical corticosteroid.
• Triamcinolone acetonide 0.1%
• Fluocinonide 0.05 %
• Desonide Cream, 0.05%
21. Systemic therapies
Topical therapy alone is sometimes insufficient to control disease activity.
When patients continue to have erosions and pain despite compliance with topical
therapy, treatment with systemic therapy is indicated.
Systemic corticosteroids : Prednisolone 30-40 mg/day up to 7 days followed by 10 mg
every second day.
When steroid therapy is not successful, Tetracycline 250 mg/day for 7 days can be
helpful.
Nutritional supplements
Maintenance of proper hydration