This document discusses strategies for setting positive end-expiratory pressure (PEEP) in mechanical ventilation of pediatric and neonatal patients. It recommends starting with a PEEP of 5-6 cm H2O and gradually increasing up to 8 cm H2O if needed to improve oxygenation. Higher PEEPs may be needed for conditions like respiratory distress syndrome while medium PEEPs of 5-8 cm H2O are suitable for other conditions. The document describes several methods for determining the optimal level of PEEP based on oxygenation, compliance, or esophageal pressure measurements and emphasizes selecting PEEP levels that balance oxygenation with lung protection.