This was a lecture in the course "Significant Medical Conditions in Seniors" presented at Peer Learning in Chapel Hill, NC, USA in 2016 by Michael C. Joseph, MD, MPH.
Our second speaker was Dr. Madhukar Kaloji, a local board certified pulmonologist and sleep medicine specialist and owner of Pulmonary & Sleep Medicine Consultants, PC. Dr. Kaloji spoke on health -related consequences of Insomnia & sleep deprivation tying specifically into employee health. Insomnia is the inability to sleep, there is acute or short term insomnia as well as chronic or long term insomnia. Employees who have shift changes, or night shifts are more prone to the insomnia. Below we have included a few of his slides from presentation for you to review. Dr. Kaloji encouraged employers to take sleep deprivation seriously because there is a direct correlation between fatigue and accidents. Educate your employees on the right amount of sleep to thrive during their workday. If you have employees who show signs of fatigue you as an employer can recommend or require a sleep studies. If you have further questions about sleep studies and or proper sleep for your employees please contact Pulmonary & Sleep Medicine Consultants, PC at 757-460-6081.
Our second speaker was Dr. Madhukar Kaloji, a local board certified pulmonologist and sleep medicine specialist and owner of Pulmonary & Sleep Medicine Consultants, PC. Dr. Kaloji spoke on health -related consequences of Insomnia & sleep deprivation tying specifically into employee health. Insomnia is the inability to sleep, there is acute or short term insomnia as well as chronic or long term insomnia. Employees who have shift changes, or night shifts are more prone to the insomnia. Below we have included a few of his slides from presentation for you to review. Dr. Kaloji encouraged employers to take sleep deprivation seriously because there is a direct correlation between fatigue and accidents. Educate your employees on the right amount of sleep to thrive during their workday. If you have employees who show signs of fatigue you as an employer can recommend or require a sleep studies. If you have further questions about sleep studies and or proper sleep for your employees please contact Pulmonary & Sleep Medicine Consultants, PC at 757-460-6081.
Parkinson’s: What Do We Know About the Disease and What Can Be Done About It?asclepiuspdfs
ABSTRACT
In this article, I aim to answer important questions regarding Parkinson’s disease and the associated dementia. While the
disease was identified and described over a century ago, we still have not as yet been able to ferret out its root cause,
notwithstanding the tremendous progress made in recent years. Like for many other diseases, it is believed to involve three
main causal components (inherited genetics, environmental influences, and, to a much lesser extent, lifestyle choices),
which collectively determine if someone will develop the disease. I will survey its signs, symptoms (motor and non-motor),
risks, and stages, distinguishing between the disease’s early- and late-onset. While discriminating between the disease and
its associated dementia, I will localize the latter within the broad spectrum of dementias. I will also describe what happens
to the brain as the disease takes hold and evolves. A number of medical conditions called Parkinsonisms may have one or
more of their signs and symptoms mimicking Parkinson’s. I will discuss them in some detail, including their five proposed
mechanisms (protein aggregation in Lewy bodies, disruption of autophagy, mitophagy, neuroinflammation, and breakdown
of the blood–brain barrier). I will further describe the approach to diagnosis, prediction, prevention, and prognosis. While
there is no cure and treatment for each affected person, motor symptoms are managed with several medications (Levodopa
always combined with a dopa decarboxylase inhibitor and sometimes also with a catechol-O-methyltransferase [COMT]
inhibitor, dopamine agonists, and monoamine oxidase-B [MAOB]-inhibitors) and eventually surgical therapy. Numerous
pharmaceutical agents are also available for individual non-motor symptoms (L-Dopa emulsions, non-ergot dopamine
agonists, cholinesterase inhibitors for dementia, modafinil for daytime sleepiness, and quetiapine for psychosis). Fortunately,
we can track the drug effectiveness with exosomes. Keeping in mind patients and their caregivers/partners, I will outline
available complementary therapies, palliative care, and rehabilitation, measures they can take beyond seeking standard
treatments, and supporting and advocating organizations at their disposal. Finally, I will survey promising new research
vistas in the field.
During my 1st &2nd year of residency period , i used to teach Anatomy and Orthopaedics for foreign undergraduate medical students. At last year i taught Neurology for one batch. so i posted some of my collections for competely educational purpose coz i believe in knowledge ...inseted of deleting these ppts , they may me useful for others so i shared it ....
This was a lecture in the course "Significant Medical Conditions in Seniors" presented at Peer Learning in Chapel Hill, NC, USA in 2016 by Michael C. Joseph, MD, MPH.
This was a lecture in the course "Significant Medical Conditions in Seniors" presented at Peer Learning in Chapel Hill, NC, USA in 2016 by Michael C. Joseph, MD, MPH.
This was a lecture in the course "Significant Medical Conditions in Seniors" presented at Peer Learning in Chapel Hill, NC, USA in 2016 by Michael C. Joseph, MD, MPH.
This was a lecture in the course "Significant Medical Conditions in Seniors" presented at Peer Learning in Chapel Hill, NC, USA in 2016 by Michael C. Joseph, MD, MPH.
This was a lecture in the course "Significant Medical Conditions in Seniors" presented at Peer Learning in Chapel Hill, NC, USA in 2016 by Michael C. Joseph, MD, MPH.
This was a lecture in the course "Significant Medical Conditions in Seniors" presented at Peer Learning in Chapel Hill, NC, USA in 2016 by Michael C. Joseph, MD, MPH.
This was a lecture in the course "Significant Medical Conditions in Seniors" presented at Peer Learning in Chapel Hill, NC, USA in 2016 by Michael C. Joseph, MD, MPH.
This was a lecture in the course "Significant Medical Conditions in Seniors" presented at Peer Learning in Chapel Hill, NC, USA in 2016 by Michael C. Joseph, MD, MPH.
This was a lecture in the course "Significant Medical Conditions in Seniors" presented at Peer Learning in Chapel Hill, NC, USA in 2016 by Michael C. Joseph, MD, MPH.
This is the initial lecture in the course "Significant Medical Conditions in Seniors" presented at Peer Learning in Chapel Hill, NC, USA in 2016 by Michael C. Joseph, MD, MPH.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
3. Historical Perspective
First described by British doctor James Parkinson in An
Essay on the Shaking Palsy (1817).
Research progressed slowly until the 1960’s.
In the 1960’s the disease was linked to the loss of
dopamine-producing cells in the brain.
Public Awareness campaigns include Parkinson Disease
Day (on the birthday of Dr. James Parkinson, April 11), and
the use of a red tulip as a symbol of the disease.
4. Epidemiology
Affects 1 in 100 persons over age 60 in the U.S.
Average age of onset is 60 years
5-10 % of patients experience symptoms before age 40
60,000 new cases diagnosed each year in the U.S.
Numbers are higher because of dismissal of symptoms or misdiagnosis
More than 1 Million cases currently in the U.S.
More than 5 Million cases currently in the World
NOT Gender-Specific
5. Famous Patients
American:
−Michael J. Fox
−Muhammad Ali
−Janet Reno
−Johnny Cash
−Billy Graham
−Howard Clement
−Foreign:
Mao Zedong (?)
Deborah Kerr
Bob Hoskins
7. PD Subtypes
Primary or Idiopathic (unknown cause);
Secondary or Acquired (e.g. pesticides);
Hereditary Parkinsonism (1 in 5 PD
patients has a 1st-degree relative with the
disease);
“Parkinson Plus” syndromes or “Multiple
System Degeneration” (MSD).
8. Brain Pathology
The neurotransmitter dopamine is
responsible for smooth coordination of
muscle movements, motivation, and
mood
60% of these cells die before the first
symptoms appear
The typical PD patient has lost 85 % of
these cells
9. Movement Disorders
(External Signs)
Hand tremors:
−Typically involves a rhythmic back-and-forth motion
of the thumb at 3 bpm;
−Most evident when the limb is at rest or the patient
is under stress.
Rigidity or resistance to movement:
−“en bloc” turns;
−“masked facies”.
10. Movement Disorders
(Muscle Asynchronicity)
Muscles associated with movement all have
opposing muscles
−when one is activated, the other is relaxed.
The brain’s signals in PD patients become
confused
−both sets of muscles remain engaged and
contracted.
11. Movement Disorders
(Motion)
“Bradykinesia”
−spontaneous movements can become progressively
slower, and may actually cease.
Postural Instability
−impaired balance and coordination;
−Positive “Pull Test”;
−Patients lean unnaturally backward or forward
(stooping).
12. Movement Disorders
(Gait)
Reduced arm swing.
Decreased stride length
Those who tend to lean backward have to step backward first before they
begin walking (retropulsion).
Some develop a mid-stride halting (“FOG” - freezing of gait), which creates a
risk for falls.
Short, quick steps (festinating gait). It can appear as if they are scrambling
forward to keep their balance.
VIDEO: Gait Disorders (3:45)
https://www.youtube.com/watch?v=Be2Enu65ZE8
Terminology:
Truncal Dystonia – rigid twisting of the trunk to one side.
13. Non-movement Symptoms
VIDEO
Top 10 Non-movement Symptoms (9:00)
https://www.youtube.com/watch?v=h78x80xAMEk
Terminology:
Vagus nerve – controls autonomic (self-
regulating) functions such as digestion,
heartbeat, and breathing.
14. Mild Parkinson’s
Movement symptoms may be inconvenient,
but do not affect daily activities.
Movement symptoms, often tremor, occur on
one side of the body.
Friends may notice changes in a person’s
posture, walking ability or facial expression.
Parkinson's medications suppress movement
symptoms effectively.
Regular exercise improves and maintains
mobility, flexibility, range of motion and
balance, and also reduces depression and
constipation.
15. Moderate Parkinson’s
Movement symptoms occur on both sides of the
body, and the body moves more slowly.
Trouble with balance and coordination may
develop.
“Freezing” episodes — when the feet feel stuck
to the ground — may occur.
Parkinson's medications may “wear off” between
doses or cause side effects (“dyskinesias”).
Regular exercise, with physical and occupational
therapy, are important for good mobility,
balance, and independence.
16. Advanced Parkinson’s
Great difficulty walking.
In wheelchair or bed most of the day.
Assistance needed with all daily activities.
Cognitive problems may be prominent,
including hallucinations and delusions.
Balancing the benefits of medications with
their side effects becomes more
challenging.
17. The Neurologic Exam
VIDEO:
Examining the PD patient (9:00)
https://www.youtube.com/watch?v=sJqKvajUC3k&fea
ture=em-share_video_user
Terminology:
“Glabellar reflex” – blinking when the glabella region
(between the eyes) is tapped.
“Doll’s Head” or “Doll’s Eyes” Sign – rotating of the eyes in
the opposite direction of the head movement.
18. Treatment
Medications:
L-dopa (replaces dopamine);
Dopamine agonists (act like
dopamine);
Other Central Nervous System (CNS)
agents.
Surgery:
Deep Brain Stimulation (DBS).
19. RESOURCES
(Living with Parkinson’s Disease)
VIDEO:
Parkinson’s: A Guide for
Patients and Families (25:00)
https://www.youtube.com/watch?v
=fGlmOaC5Jko&feature=youtu.be
20. CREDITS
Parkinson’s Disease.html
https://www.michaeljfox.org
http://www.pdf.org/en/progression_parkinsons
https://en.wikipedia.org/wiki/Parkinson's_disease
Examining the patient
https://www.youtube.com/watch?v=sJqKvajUC3k&feature=em-share_video_user
Parkinson’s Disease: A Guide for Patients and Families (25 min)
https://www.youtube.com/watch?v=fGlmOaC5Jko&feature=youtu.be
Gait Disorders
https://www.youtube.com/watch?v=Be2Enu65ZE8