Parkinson's disease is a progressive brain disorder that causes a gradual loss of muscle control. Its symptoms include tremors, stiffness, slowed movements, and poor balance. Early signs may include slight shaking, difficulty walking or writing, and stooped posture. Treatments include medications like dopamine agonists and surgeries like deep brain stimulation. Physical therapy focuses on exercises to improve mobility, balance, posture, and prevent contractures. Symptoms fluctuate between "on" and "off" periods depending on dopamine levels, affecting the appropriate exercises.
Dystonia – are you aware of this movement disorder - diseases and treatmentsSehat.com
What is Dystonia? Are you aware of its causes, symptoms and treatment. Dystonia is often described as a movement disorder. It is a state of abnormal muscle tone resulting in muscular spasm and abnormal posture, typically due to neurological disease or due to the side effect of drug therapy.
Dystonia
Dystonia is a movement disorder in which your muscles contract involuntarily, causing repetitive or twisting movements.
The condition can affect one part of your body (focal dystonia), two or more adjacent parts (segmental dystonia) or all parts of your body (general dystonia). The muscle spasms can range from mild to severe. They may be painful, and they can interfere with your performance of day-to-day tasks.
Dystonia: Causes, Types, Symptoms, and Treatments
Dystonia – are you aware of this movement disorder - diseases and treatmentsSehat.com
What is Dystonia? Are you aware of its causes, symptoms and treatment. Dystonia is often described as a movement disorder. It is a state of abnormal muscle tone resulting in muscular spasm and abnormal posture, typically due to neurological disease or due to the side effect of drug therapy.
Dystonia
Dystonia is a movement disorder in which your muscles contract involuntarily, causing repetitive or twisting movements.
The condition can affect one part of your body (focal dystonia), two or more adjacent parts (segmental dystonia) or all parts of your body (general dystonia). The muscle spasms can range from mild to severe. They may be painful, and they can interfere with your performance of day-to-day tasks.
Dystonia: Causes, Types, Symptoms, and Treatments
This was a lecture in the course "Significant Medical Conditions in Seniors" presented at Peer Learning in Chapel Hill, NC, USA in 2016 by Michael C. Joseph, MD, MPH.
Sleep is a subject dear to all our hearts, so here is my current assignment.
Please do not use this information as medical advice. It is only a brief summary of other people's research. Consult your doctor or psychologist if you have insomnia
Alan T. Rasof explains the four major types of Cerebral Palsy and why it is important that we, as a society, understand the differences and affects of each.
Evaluation of an infant with hypotonia is described including history, examination and investigations. Clinical algorithm for such evaluation is presented.
This was a lecture in the course "Significant Medical Conditions in Seniors" presented at Peer Learning in Chapel Hill, NC, USA in 2016 by Michael C. Joseph, MD, MPH.
Sleep is a subject dear to all our hearts, so here is my current assignment.
Please do not use this information as medical advice. It is only a brief summary of other people's research. Consult your doctor or psychologist if you have insomnia
Alan T. Rasof explains the four major types of Cerebral Palsy and why it is important that we, as a society, understand the differences and affects of each.
Evaluation of an infant with hypotonia is described including history, examination and investigations. Clinical algorithm for such evaluation is presented.
Parkinson’s disease is known primarily as a disorder that impairs movement. Coping with dementia, including difficulties with memory and slowed thinking or communication.
Parkinson's Disease Things You Need to KnowNHS Neurocare
Parkinson's disease is characterised by a progressive disorder that affects our nervous system and interfere in their functions. This condition affects body part’s movement controlled by those nerves. The most difficult thing with this condition is it starts to show symptoms very slowly.
this is useful for all the students of bachelors degree in nursing , mostly fresh students . this will be useful during their exam preparation, material for future as a tutor/lecturer/teacher/associate professors for nursing college. this can be useful for non nursing and non teaching faculty who needs health education regarding sleep and rest.
-Detailed Introduction, Patho-physiology, Evaluation & Physiotherapy Management of Parkinsonism.
-Clinical classification is discussed.
-Various measures of evaluation and physical therapy is discussed in this.
Parkinson's Disease, SYMPTOMS OF PARKINSONISM, STAGES OF PARKINSONISM, ETIOLOGY OF PARKINSONISM, PATHOPHYSIOLOGY OF PARKINSONISM, TREATMENT OF PARKINSONISM.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
2. What Is Parkinson's Disease?
Parkinson's disease is a brain disorder that
causes a gradual loss of muscle control. The
symptoms of Parkinson's tend to be mild at
first and can sometimes be overlooked.
Distinctive signs of the disease
include:tremors, stiffness, slowed body
movements, and poor balance.
3. Early Signs of Parkinson's
The early signs of Parkinson's may be subtle and
can be confused with other conditions. They
include:
• Slight shaking of a finger, hand, leg, or lip
• Stiffness or difficulty walking
• Difficulty getting out of a chair
• Small, crowded handwriting
• Stooped posture
• A 'masked' face, frozen in a serious expression
4. SYMPTOMS
Tremor
Tremor is an early symptom for about 70% of
people with Parkinson's. It usually occurs in a finger
or hand when the hand is at rest but not when the
hand is in use. It will shake rhythmically, usually four
to six beats per second, or in a "pill-rolling" manner,
as if rolling a pill between the thumb and index
finger. Tremor also can be a symptom of other
conditions, so by itself it does not indicate Parkinson
disease.
Bradykinesia (slowness of movements)
5. POSTURAL INSTABILITY
People with Parkinson's
tend to develop a stooped
posture, with drooping
shoulders and their head
jutted forward. Along with
their other movement
issues, they may have a
problem with balance. This
increases the risk of falling.
6. RIGIDITY
Stiffness or rigidity of the muscles, resulting in
decreased ability to move. When a joint of a
Parkinson's patient is moved, there is
resistance to the movement. "Lead
pipe" rigidity is a form of increased tone that is
particularly prominent in Parkinson's and can
result in muscle stiffness, fatigue, and
weakness. "Cogwheel" rigidity occurs when
there is also a tremor and is characterized by a
"stop and go" effect during a range of motion
maneuver.
7. OTHER SYMTOMS :
Weakness of face and throat muscles
It may get harder to talk and swallow. Speech
becomes softer and monotonous. Loss of
movement in the muscles in the face can
cause a fixed, vacant facial expression, often
called the "Parkinson's mask.“
Constipation
Sleep problems
Depression
8. Who Gets PD?
The average age of
onset is 62, but people
over 60 still have only a
2% to 4% likelihood of
developing the disease.
Having a family
member with PD
slightly increases the
risk. Men are one-and-
a-half times more likely
to have Parkinson's
than women.
9. Surgeries used:
Deep Brain Stimulation
Electrodes can be implanted
into one of three areas of the
brain(VIN of the talamus)A
pulse generator(pacemaker)
goes in the chest near the
collarbone. Electric pulses
stimulate the brain to help
reduce a patient's rigidity,
tremors, and bradykinesia. It
doesn’t stop the progression of
PD or affect other symptoms.
Not everyone is a good
candidate for this surgery.
Phlebotomy and
Thalamotomy
• These surgical procedures use
radio-frequency to destroy a
pea –sized area in the globus
pallidus of the tallamus
10. Treatment (drugs)
Dopamine Agonists
Drugs that mimic dopamine,
called dopamine agonists,
may be used to delay the
movement-related
symptoms of Parkinson's.
They include Levadopa,
Apokyn, Mirapex, Parlodel.
Side effects may include
nausea and vomiting,
drowsiness, fluid retention,
and psychosis.
11. Parkinson's and Exercise
Exercise may actually have a protective effect by
enabling the brain to use dopamine more effectively.
It also helps improve motor coordination, balance,
gait, and tremor. For the best effect exercises
should be done consistently and as
intensely.Preferably three to four times a week.
Working out on a treadmill or biking have been
shown to have a benefit.
12. Most PD patients face mobility deficits
Difficulties with transfers
Posture
Balance
Walking
Fear of falls
Loss of independence
Inactivity
14. Şükriye Arslan is a 68-years-old
woman,1,57 hight and 68kg weight.She
was a cook for the last 12 years and she
finished just primiry school.She came to
the PAU hospital for consult and she
obteined schedule for deep brain
stimulation surgery and she was
operated on 13.03.2014
15. Pre-operation PT assesment wasn’t made.
Post-operation PT assesment was porformed
with couple of tests and meassurments.
21. SENSATION :
Is intanct for light touch,pain,temperature,
deep pressure ,and kinesthesia.
22. BED MOBILITY AND TRANSFER
Independent rolling on bed with low axial
rotation,difficult independent sitting from
supine position.
Sit transfer :
sit – stand = independent
bed –chair =independent
23. GAIT AND POSTURE
At this time patient is walking without any
assistive device ,without freezing,with
minimal forward flexed posture.While walking
there is swinging of her arms with no
cerebellar signs.
Balance test is positiv in static and dinamic
position,without retropulsion or propulsion.
24. Time up & go test (3m) = 13,81 sec.
12 metere walking = 17,45 sec.
sit – stand /14 times = 30 sec.
27. Schwab & England Activities of Daily Living
scale
• She is estimate on 90 % - completely
independent. Able to do all chores with some
slowness, difficulty, and impairment. Might
take twice as long. Beginning to be aware of
difficulty.
Hoehn – Yahr scale (stages of PD)
• Stage 1.5 -Unilateral and axial involvement
28. MUSCLE AND ROM EXAMINATION
Moderate dicrease of muscles power on neck
and trunk muscles.
PROM without dicrease .
Moderate dicrease in AROM on neck and
trunk muscles.
30. Physical Therapy Pogram
of the patient
Relaxation tehniques to dicrease rigidity
Slow lhytmic rotational movements
Gentle ROM and streching exercises to
prevent contractures,quadriceps and hip
isometric exercises.
Neck and trunk rotation exercises
Back extension exercises and pelvic tilt
Breathing exercises
31. Functional mobility training including bed
mobility,transfer training
Training in rhytmic pattern to music such as
clapping may help in alternating
movements,standing and balancing in
parallel bars(static and dynamic)with weight
shifting,ball throwing
Stationary bicycle to help train reciprocal
movements.
32. Large steps progresssive training using
blocks to lift legs,teaching proper heel –
floor strike.
Arm swing exercises
33. Motor Fluctuations
The on – off respons:
On and Off periods
occur wuthout warning
as a result of fluctuating
dopamine levels in the
brain.
34. During ON times, patients report they feel
relatively fluid, clear, and in control of their
movements. Often, symptoms of PD may be
invisible to all but professionals.
During OFF periods, patients experience
stiffness, lack of muscular coordination, pain,
difficult handwriting — the full range of classic
PD symptoms. Most patients have visible
symptoms. Typically, patients will cycle
between ON and OFF periods three to four
times every day, although everyone’s
experience is unique.
35. In the “off” period , we need to prefer
approaches that does not require the
patiant to actively participate that much,such
as respiratory therapy ,inhibation for pain
and rigidity
In the “on” period , balance,
coordonation,posture,walking exercises and
gait training should be preferred.