Mesopotamian civilizations were among the earliest human civilizations that emerged between the Tigris and Euphrates Rivers in the region known as Mesopotamia. Several independent city-states dominated Mesopotamia at different periods, including the Sumerians, Akkadians, Babylonians, and Assyrians. The Mesopotamians developed cuneiform writing using wedge-shaped marks and invented early mathematical concepts like the base-60 number system. They practiced a polytheistic religion and had social hierarchies with the king and priests holding power.