SlideShare a Scribd company logo
Presented by:
Pranali .M Palandurkar
University department of
pharmaceutical Sciences
R.T.M.N.U Nagpur
Contents
Introduction
Classification
Properties
Advantages
Applications
• “Polymer are long chain organic molecules assembled form many smaller
molecules called as monomer connected by covalent bonds or chemical bonds”
• Polymers are macromolecules having very large chains contain a variety of
functional groups, can be blended with other low and high molecular weight
material
• A polymer with two different monomers is known as a copolymer or
homopolymer
• Their use for biomedical and pharmaceutical applications has gained an
enormous impact during the past decades.
• The pharmaceutical applications of polymers range from their use as binders in
tablets to viscosity and flow controlling agents in liquids, suspensions, and
emulsion. Polymers can be used as film coatings to disguise the unpleasant taste
of a drug, to enhance drug stability, and to modify drug release characteristics.
• The reaction involving combination of
two or more monomer units to form a
long chain polymer is termed as
polymerization
• By changing the molecular weight, the
physical and mechanical properties of
the polymer can be tailor-made. This
can be achieved by changing the
structure of the monomer building
blocks or by blending them with other
polymers.
Natural polymer
• Natural polymers are the
substances which are
obtained by natural
sources like plant and
animal sources.
• The specific application of
plant derived polymer in
pharmaceutical
formulations include their
use in the manufacture of
solid monolithic matrix
systems, implants, etc
• Examples-Proteins-
collagen, keratin, albumin.
Synthetic polymer
• Synthetic polymers are
industrially produced
chemical substances
consisting of a number of
molecules linked together
with covalent bond.
• A wide variety of synthetic
polymers are available with
variation in main chain as
well as side chain.
• Exanple- polyester,
polyanhydrides, polyamides,
polyglycolic acid
A) Based on origin
Semi Synthetic
• Synthetic polymers are
polymers obtained by
making modification in
natural polymers artificially
in a lab.
• These polymers formed by
chemical reaction and are of
commercial importance
• Example-cellulose derivative
(rayon)
B) Based on Bio-stability
Bio-
degradable
Polymers
• A Bio-degradable polymer is a polymer in
which the degradation results from the action
of naturally occurring microorganisms such
as bacteria, fungi.
• Examples-Albumin, Collagen, Gelatin, Starch
etc.
Non-
biodegradable
polymer
• The polymers which are not decomposed by
the action of microorganisms and are referred
to as non-biodegradable polymers.
• Example -polyethene, polystyrene
C) Based on structure
Linear polymer
• The smallest
repeating
unit arrange
in straight
line path
• Example –
polyvinyl
chloride
Branched
chain polymer
• Contain
linear chain
having some
branches
• Example-
Low density
polymer
Cross linked
chain polymer
• Formed from
bi-functional
and
trifunctional
monomer and
contain strong
covalent
bonds
• Example-
Bakelite
,melamine
a) Elastomers: Elastomers are rubber-like solid polymers, that are elastic in nature i.e
stretched by applying a little force. Example -Neoprene rubber, buna-s and buna-n
b) Thermoplastic polymers :Polymers which contain intermolecular forces higher
than Elastomers but less than Fibers. They are usually linear chain polymers and
can be remolded again. Examples: Polythene, Polyvinyl Chlorides, etc.
c) Thermosetting plastics : Polymer which are having highly branched chain
molecules with extensive cross linking and if heated becomes infusible and cannot
be reused. Example: melamine, Bakelite etc.
d) Fibres:Polymers which are a thread like in nature, and can easily be woven. They
have strong inter-molecules forces between the chains giving them less elasticity
and high tensile strength. The intermolecular forces may be hydrogen bonds or
dipole-dipole interaction. Fibres have sharp and high melting points. Example:
Nylon-66.
D)Based on Molecular Force
• These type of polymers are formed by the repeated addition of monomer
molecules with double or triple bonds.
• Addition polymers always have their empirical formulas same as their
monomers. Example: ethene n(CH2=CH2) to polyethene -(CH2-CH2)n-
Addition polymers:
• These polymers are formed by the combination of monomers, with the elimination
of small molecules like water, alcohol etc..
• The monomers in these types of condensation reactions are bi-functional or tri-
functional in nature.
• A common example is the polymerization of Hexamethylenediamine and adipic
acid. to give Nylon – 66, where molecules of water are eliminated in the process
Condensation polymers:
E)Based on Mode of Polymerization
A) Crystalline and amorphous polymers:
• Amorphous or glassy polymers do not generally display a sharp melting
point; instead, they soften over a wide temperature range.
• Polymer strength and stiffness increases with crystallinity as a result of
increased intermolecular interactions.
• From a pharmaceutical prospective, good barrier properties are needed
when polymers are used as a packaging material or as a coating.
Crystallinity increases the barrier properties of the polymer.
• On the other hand, a less crystalline, or an amorphous polymer is preferred
when the release of a drug or an active material is intended.
B) Thermal transitions
• Thermal transitions in polymers can occur in different orders.
• That is, the volume of a polymer can change with temperature as a first-or
second-order transition. When a crystal melts , the polymer volume
increases significantly as the solid turns to a liquid. The melting temperature
(Tm) represents a first-order thermal transition in polymers. On the other
hand, the volume of an amorphous polymer gradually changes over a wide
temperature range or so-called glass transition temperature. This behaviour
represents a second-order thermal transition in polymers .
C) Plasticized polymer
• A plasticizer is added to a polymer formulation to enhance its flexibility and to help its
processing. It facilitates relative movement of polymer chains against each other. This
results in a reduction in the glass transition temperature of the mixture.
• Since plasticizers increase molecular motion, drug molecules can diffuse through the
plasticized polymer matrix at a higher rate depending on the plasticizer concentration
D) Molecular weight
• There are different ways that molecular weights of a polymer can be expressed:
• by the number of the chains,
• by the weight of the chains (the chain size),
• or by viscosity.
• However, the two most common ways are number (Mn) and weight (Mw) average
calculations.
• Based on that polymers can be termed as polydispered and monodispersed.
E) Mechanical properties
• Depending on their structure, molecular weight, and intermolecular forces,
polymers resist differently when they are stressed.
• They can resist against stretching,compression, bending and dynamic loading.
With increasing molecular weight the level of intermolecular forces, polymers
display superior properties under an applied stress
F) Viscoelastic Properties
• Materials that exhibit both viscous and elastic characteristics when deformed
under stress are known to be viscoelastic.
• Polymers are neither a pure elastic nor a pure fluid material. They have the
ability to store energy (display elastic behaviour ) and to dissipate it (display
viscous behaviour ). For this reason, most polymers are viscoelastic materials.
• The polymer enhances the pharmacodynamic and pharmacokinetic properties of
biopharmaceuticals though several sources, such as, increases the plasma ½ life,
decreases the immunogenicity, boost stability of biopharmaceuticals,
• Polymer can also improves solubility of low molecular weight drugs, and has
potential for targeted drug delivery
• Sustained delivery of drug can be achieved by polymers hence decrease in dosing
frequency.
• Polymer can be use for taste masking of bitter drug which increases the patient
compliance .
• Localised delivery of drug-The product can be implanted directly at the site where
drug action is needed
• Due to biodegradable polymers their degradability reduces the need for subsequent
surgical removal, saving time and money
• The polymer can protect the drug from the physiological environment and hence
improve its stability in vivo
Controlled drug delivery occurs when a polymer ,whether natural or
synthetic, is judiciously combined with a drug or other active agents such
away that the active agent is released from the material in a predesigned
manner .
1.Extended release dosage forms: Extended and sustained release dosage forms
prolong the time that’ systemic drug levels are within the therapeutic range and
thus reduce the number of doses the patient must take to maintain a therapeutic
effect there by increasing compliance. The most commonly used water insoluble
polymers for extended release applications are the ammonium ethacrylate
copolymers cellulose derivatives ethyl cellulose and cellulose acetate, and
polyvinyl derivative, polyvinyl acetate
2.Gastro retentive Dosage forms: To achieve gastro retention mucoadhesive
and low density, polymers have been evaluated, with little success so far their
ability to extend gastric residence time by bonding to the mucus lining of the
stomach and floating on top of the gastric contents respectively.
3.Ocular drug delivery system –It allows prolonged contact with corneal
surface of eye .
Example –Pillocarpine in the treatment of glaucoma –In this mucoadhesive
polymers (Polyacrylic acid or copolymer of acetate vinyl &ethyl) are used as
barrier to control the drug release.
The efficiency of ocular drug delivery is improved through the use of
polymeric implants i.e Occusert that are implanted under the cul-de-sac of the
eye.
4.Trandermal drug delivery –It involves the diffusion of the drug through the
skin and ultimately absorption into the systemic circulation.
The drug delivery system is composed of several layers, namely a metallic
backing layer ,which is impermeable to drug diffusion ,the drug containing
reservoir, a rate controlling membrane and an adhesive layer.
In the matrix drug is dissolved or dispersed with solid polymer(acrylate co –
polymer)
5.Polymers in nanoparticles Nanoparticles have size range of 10-1000nm. In
nanoparticle drug delivary system drug is attached, entrapped and dissolve to
polymeric matrix. Example of synthetic biodegradable polymers are poly
lactide, poly(lactide-co-glyolide), poly-ɛ-caprolactone and polyanhydrides.
Polymers

More Related Content

What's hot

Polymers in pharmaceuticals
Polymers in pharmaceuticalsPolymers in pharmaceuticals
Polymers in pharmaceuticals
Chayan Dhar Clinton
 
Bioadhesive drug delivery system
Bioadhesive drug delivery systemBioadhesive drug delivery system
Bioadhesive drug delivery system
Dr. Shreeraj Shah
 
Factors affecting design of Controlled Release Drug Delivery Systems (write-up)
Factors affecting design of Controlled Release Drug Delivery Systems (write-up)Factors affecting design of Controlled Release Drug Delivery Systems (write-up)
Factors affecting design of Controlled Release Drug Delivery Systems (write-up)
Suraj Choudhary
 
Microencapsulation
MicroencapsulationMicroencapsulation
Controlled release drug delivery system2
Controlled release drug delivery system2Controlled release drug delivery system2
Controlled release drug delivery system2
Bansari Patel
 
Controlled Release Oral Drug Delivery System
Controlled Release Oral Drug Delivery SystemControlled Release Oral Drug Delivery System
Controlled Release Oral Drug Delivery System
Ravishankar University, Raipur
 
Physics of tablet compression
Physics of tablet compressionPhysics of tablet compression
Physics of tablet compression
Mahadev Birajdar
 
Implantable Drug Delivery System
Implantable Drug Delivery SystemImplantable Drug Delivery System
Implantable Drug Delivery System
paresh bharodiya
 
Bio Adhesive Drug Delivery System
Bio Adhesive Drug Delivery SystemBio Adhesive Drug Delivery System
Bio Adhesive Drug Delivery System
optimpharma
 
Polymers of Controlled Drug Delivery System
Polymers of Controlled Drug Delivery SystemPolymers of Controlled Drug Delivery System
Polymers of Controlled Drug Delivery System
Nabeela Moosakutty
 
Osmotic drug delivery system
Osmotic drug delivery systemOsmotic drug delivery system
Osmotic drug delivery system
Dr. Shreeraj Shah
 
Floating drug delivery system ppt
Floating drug delivery system ppt Floating drug delivery system ppt
Floating drug delivery system ppt
Shireen Zeba
 
Buccal Drug Delivery System
Buccal Drug Delivery SystemBuccal Drug Delivery System
Buccal Drug Delivery System
MOHAMMAD ASIM
 
Polymers in controlled release Drug Delivery System
Polymers in controlled release Drug Delivery SystemPolymers in controlled release Drug Delivery System
Polymers in controlled release Drug Delivery System
Dr. Prashant L. Pingale GES's Sir Dr. M. S. Gosavi College of Pharmacy, Nashik
 
Buccal drug delivery system
Buccal drug delivery systemBuccal drug delivery system
Buccal drug delivery system
shivamthakore
 
Polymers - Mucoadhesive Drug Delivery
Polymers - Mucoadhesive Drug DeliveryPolymers - Mucoadhesive Drug Delivery
Polymers - Mucoadhesive Drug Delivery
Suraj Choudhary
 
POLYMERS IN SOLID STATE, PHARMACEUTICAL APPLICATIONS OF POLYMERS AND RECENT A...
POLYMERS IN SOLID STATE, PHARMACEUTICAL APPLICATIONS OF POLYMERS AND RECENT A...POLYMERS IN SOLID STATE, PHARMACEUTICAL APPLICATIONS OF POLYMERS AND RECENT A...
POLYMERS IN SOLID STATE, PHARMACEUTICAL APPLICATIONS OF POLYMERS AND RECENT A...
Priyanka Modugu
 
Controlled Release Drug Delivery Systems - Types, Methods and Applications
Controlled Release Drug Delivery Systems - Types, Methods and ApplicationsControlled Release Drug Delivery Systems - Types, Methods and Applications
Controlled Release Drug Delivery Systems - Types, Methods and Applications
Suraj Choudhary
 
EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMS
EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMSEVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMS
EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMS
SANI SINGH
 
Techniques for enhancement of dissolution rate
Techniques for enhancement of dissolution rateTechniques for enhancement of dissolution rate
Techniques for enhancement of dissolution rate
Sagar Savale
 

What's hot (20)

Polymers in pharmaceuticals
Polymers in pharmaceuticalsPolymers in pharmaceuticals
Polymers in pharmaceuticals
 
Bioadhesive drug delivery system
Bioadhesive drug delivery systemBioadhesive drug delivery system
Bioadhesive drug delivery system
 
Factors affecting design of Controlled Release Drug Delivery Systems (write-up)
Factors affecting design of Controlled Release Drug Delivery Systems (write-up)Factors affecting design of Controlled Release Drug Delivery Systems (write-up)
Factors affecting design of Controlled Release Drug Delivery Systems (write-up)
 
Microencapsulation
MicroencapsulationMicroencapsulation
Microencapsulation
 
Controlled release drug delivery system2
Controlled release drug delivery system2Controlled release drug delivery system2
Controlled release drug delivery system2
 
Controlled Release Oral Drug Delivery System
Controlled Release Oral Drug Delivery SystemControlled Release Oral Drug Delivery System
Controlled Release Oral Drug Delivery System
 
Physics of tablet compression
Physics of tablet compressionPhysics of tablet compression
Physics of tablet compression
 
Implantable Drug Delivery System
Implantable Drug Delivery SystemImplantable Drug Delivery System
Implantable Drug Delivery System
 
Bio Adhesive Drug Delivery System
Bio Adhesive Drug Delivery SystemBio Adhesive Drug Delivery System
Bio Adhesive Drug Delivery System
 
Polymers of Controlled Drug Delivery System
Polymers of Controlled Drug Delivery SystemPolymers of Controlled Drug Delivery System
Polymers of Controlled Drug Delivery System
 
Osmotic drug delivery system
Osmotic drug delivery systemOsmotic drug delivery system
Osmotic drug delivery system
 
Floating drug delivery system ppt
Floating drug delivery system ppt Floating drug delivery system ppt
Floating drug delivery system ppt
 
Buccal Drug Delivery System
Buccal Drug Delivery SystemBuccal Drug Delivery System
Buccal Drug Delivery System
 
Polymers in controlled release Drug Delivery System
Polymers in controlled release Drug Delivery SystemPolymers in controlled release Drug Delivery System
Polymers in controlled release Drug Delivery System
 
Buccal drug delivery system
Buccal drug delivery systemBuccal drug delivery system
Buccal drug delivery system
 
Polymers - Mucoadhesive Drug Delivery
Polymers - Mucoadhesive Drug DeliveryPolymers - Mucoadhesive Drug Delivery
Polymers - Mucoadhesive Drug Delivery
 
POLYMERS IN SOLID STATE, PHARMACEUTICAL APPLICATIONS OF POLYMERS AND RECENT A...
POLYMERS IN SOLID STATE, PHARMACEUTICAL APPLICATIONS OF POLYMERS AND RECENT A...POLYMERS IN SOLID STATE, PHARMACEUTICAL APPLICATIONS OF POLYMERS AND RECENT A...
POLYMERS IN SOLID STATE, PHARMACEUTICAL APPLICATIONS OF POLYMERS AND RECENT A...
 
Controlled Release Drug Delivery Systems - Types, Methods and Applications
Controlled Release Drug Delivery Systems - Types, Methods and ApplicationsControlled Release Drug Delivery Systems - Types, Methods and Applications
Controlled Release Drug Delivery Systems - Types, Methods and Applications
 
EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMS
EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMSEVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMS
EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMS
 
Techniques for enhancement of dissolution rate
Techniques for enhancement of dissolution rateTechniques for enhancement of dissolution rate
Techniques for enhancement of dissolution rate
 

Similar to Polymers

POLYMERS.pptx
POLYMERS.pptxPOLYMERS.pptx
POLYMERS.pptx
RAJESWARIALETI
 
Polymers
PolymersPolymers
Polymers
Akash Thakur
 
PPT ON POLYMERS.pptx
PPT ON POLYMERS.pptxPPT ON POLYMERS.pptx
PPT ON POLYMERS.pptx
SAURABH PUNIA
 
POLYMERS (BP704T) by juganta kr kalita.pptx
POLYMERS (BP704T) by juganta kr kalita.pptxPOLYMERS (BP704T) by juganta kr kalita.pptx
POLYMERS (BP704T) by juganta kr kalita.pptx
Juganta kumar Kalita
 
Polymer notes.pptx
Polymer notes.pptxPolymer notes.pptx
Polymer notes.pptx
vishalnew345
 
Polymers
PolymersPolymers
Polymers
AJETHGJ
 
Polymers.pptx
Polymers.pptxPolymers.pptx
Polymers.pptx
NARENDRABHAISVNIT
 
Polymers
PolymersPolymers
polymers-chapter, classifications, metho
polymers-chapter, classifications, methopolymers-chapter, classifications, metho
polymers-chapter, classifications, metho
Huma Hameed
 
Polymers Used in Pharmaceutical Sciences
Polymers Used in Pharmaceutical SciencesPolymers Used in Pharmaceutical Sciences
Polymers Used in Pharmaceutical Sciences
Oyshe Ahmed
 
(2) ppt -----polymers-final-3-161225131244.pdf
(2) ppt -----polymers-final-3-161225131244.pdf(2) ppt -----polymers-final-3-161225131244.pdf
(2) ppt -----polymers-final-3-161225131244.pdf
01003051130
 
Dilip kumar chapdi presentation on polymer from RITEE COLLEGE OF Pharmacy.pptx
Dilip kumar chapdi presentation on polymer from RITEE COLLEGE OF Pharmacy.pptxDilip kumar chapdi presentation on polymer from RITEE COLLEGE OF Pharmacy.pptx
Dilip kumar chapdi presentation on polymer from RITEE COLLEGE OF Pharmacy.pptx
AbhashSingh12
 
CARRIERS FOR DRUG DELIVERY.pptx
CARRIERS FOR DRUG DELIVERY.pptxCARRIERS FOR DRUG DELIVERY.pptx
CARRIERS FOR DRUG DELIVERY.pptx
Sachin Kumar
 
Pcu 101 polymeric systems
Pcu 101 polymeric systemsPcu 101 polymeric systems
Pcu 101 polymeric systems
Tatenda Chikwetu
 
Dental polymer part 1
Dental polymer part 1Dental polymer part 1
Dental polymer part 1
Dr.Dhananjay Singh
 
Polymer science
Polymer science Polymer science
Polymer science
Roshni Patel
 
Keshob's ppt
Keshob's pptKeshob's ppt
Keshob's ppt
keshob ghosh
 
Polymers final
Polymers finalPolymers final
Polymers final
Neeraj Shyam
 
Polymer
PolymerPolymer
Polymers.pptx
Polymers.pptxPolymers.pptx
Polymers.pptx
Dhiraj Malunjkar
 

Similar to Polymers (20)

POLYMERS.pptx
POLYMERS.pptxPOLYMERS.pptx
POLYMERS.pptx
 
Polymers
PolymersPolymers
Polymers
 
PPT ON POLYMERS.pptx
PPT ON POLYMERS.pptxPPT ON POLYMERS.pptx
PPT ON POLYMERS.pptx
 
POLYMERS (BP704T) by juganta kr kalita.pptx
POLYMERS (BP704T) by juganta kr kalita.pptxPOLYMERS (BP704T) by juganta kr kalita.pptx
POLYMERS (BP704T) by juganta kr kalita.pptx
 
Polymer notes.pptx
Polymer notes.pptxPolymer notes.pptx
Polymer notes.pptx
 
Polymers
PolymersPolymers
Polymers
 
Polymers.pptx
Polymers.pptxPolymers.pptx
Polymers.pptx
 
Polymers
PolymersPolymers
Polymers
 
polymers-chapter, classifications, metho
polymers-chapter, classifications, methopolymers-chapter, classifications, metho
polymers-chapter, classifications, metho
 
Polymers Used in Pharmaceutical Sciences
Polymers Used in Pharmaceutical SciencesPolymers Used in Pharmaceutical Sciences
Polymers Used in Pharmaceutical Sciences
 
(2) ppt -----polymers-final-3-161225131244.pdf
(2) ppt -----polymers-final-3-161225131244.pdf(2) ppt -----polymers-final-3-161225131244.pdf
(2) ppt -----polymers-final-3-161225131244.pdf
 
Dilip kumar chapdi presentation on polymer from RITEE COLLEGE OF Pharmacy.pptx
Dilip kumar chapdi presentation on polymer from RITEE COLLEGE OF Pharmacy.pptxDilip kumar chapdi presentation on polymer from RITEE COLLEGE OF Pharmacy.pptx
Dilip kumar chapdi presentation on polymer from RITEE COLLEGE OF Pharmacy.pptx
 
CARRIERS FOR DRUG DELIVERY.pptx
CARRIERS FOR DRUG DELIVERY.pptxCARRIERS FOR DRUG DELIVERY.pptx
CARRIERS FOR DRUG DELIVERY.pptx
 
Pcu 101 polymeric systems
Pcu 101 polymeric systemsPcu 101 polymeric systems
Pcu 101 polymeric systems
 
Dental polymer part 1
Dental polymer part 1Dental polymer part 1
Dental polymer part 1
 
Polymer science
Polymer science Polymer science
Polymer science
 
Keshob's ppt
Keshob's pptKeshob's ppt
Keshob's ppt
 
Polymers final
Polymers finalPolymers final
Polymers final
 
Polymer
PolymerPolymer
Polymer
 
Polymers.pptx
Polymers.pptxPolymers.pptx
Polymers.pptx
 

More from Pranali Palandurkar

Gastroretentive drug delivery System
Gastroretentive drug delivery SystemGastroretentive drug delivery System
Gastroretentive drug delivery System
Pranali Palandurkar
 
Mucosal drug delivery system
Mucosal drug delivery systemMucosal drug delivery system
Mucosal drug delivery system
Pranali Palandurkar
 
Therapeutic goods adminstration
Therapeutic goods adminstration   Therapeutic goods adminstration
Therapeutic goods adminstration
Pranali Palandurkar
 
Orodispersible liquisolid compacts
Orodispersible liquisolid compactsOrodispersible liquisolid compacts
Orodispersible liquisolid compacts
Pranali Palandurkar
 
Ocular drug delivery system
Ocular drug delivery systemOcular drug delivery system
Ocular drug delivery system
Pranali Palandurkar
 
3 d printing of pharmaceuticals
3 d printing  of  pharmaceuticals 3 d printing  of  pharmaceuticals
3 d printing of pharmaceuticals
Pranali Palandurkar
 
Master formula record
Master formula recordMaster formula record
Master formula record
Pranali Palandurkar
 

More from Pranali Palandurkar (7)

Gastroretentive drug delivery System
Gastroretentive drug delivery SystemGastroretentive drug delivery System
Gastroretentive drug delivery System
 
Mucosal drug delivery system
Mucosal drug delivery systemMucosal drug delivery system
Mucosal drug delivery system
 
Therapeutic goods adminstration
Therapeutic goods adminstration   Therapeutic goods adminstration
Therapeutic goods adminstration
 
Orodispersible liquisolid compacts
Orodispersible liquisolid compactsOrodispersible liquisolid compacts
Orodispersible liquisolid compacts
 
Ocular drug delivery system
Ocular drug delivery systemOcular drug delivery system
Ocular drug delivery system
 
3 d printing of pharmaceuticals
3 d printing  of  pharmaceuticals 3 d printing  of  pharmaceuticals
3 d printing of pharmaceuticals
 
Master formula record
Master formula recordMaster formula record
Master formula record
 

Recently uploaded

ESR spectroscopy in liquid food and beverages.pptx
ESR spectroscopy in liquid food and beverages.pptxESR spectroscopy in liquid food and beverages.pptx
ESR spectroscopy in liquid food and beverages.pptx
PRIYANKA PATEL
 
快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样
快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样
快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样
hozt8xgk
 
Oedema_types_causes_pathophysiology.pptx
Oedema_types_causes_pathophysiology.pptxOedema_types_causes_pathophysiology.pptx
Oedema_types_causes_pathophysiology.pptx
muralinath2
 
SAR of Medicinal Chemistry 1st by dk.pdf
SAR of Medicinal Chemistry 1st by dk.pdfSAR of Medicinal Chemistry 1st by dk.pdf
SAR of Medicinal Chemistry 1st by dk.pdf
KrushnaDarade1
 
Eukaryotic Transcription Presentation.pptx
Eukaryotic Transcription Presentation.pptxEukaryotic Transcription Presentation.pptx
Eukaryotic Transcription Presentation.pptx
RitabrataSarkar3
 
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Sharlene Leurig - Enabling Onsite Water Use with Net Zero WaterSharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Texas Alliance of Groundwater Districts
 
Equivariant neural networks and representation theory
Equivariant neural networks and representation theoryEquivariant neural networks and representation theory
Equivariant neural networks and representation theory
Daniel Tubbenhauer
 
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptxThe use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
MAGOTI ERNEST
 
Medical Orthopedic PowerPoint Templates.pptx
Medical Orthopedic PowerPoint Templates.pptxMedical Orthopedic PowerPoint Templates.pptx
Medical Orthopedic PowerPoint Templates.pptx
terusbelajar5
 
The cost of acquiring information by natural selection
The cost of acquiring information by natural selectionThe cost of acquiring information by natural selection
The cost of acquiring information by natural selection
Carl Bergstrom
 
Authoring a personal GPT for your research and practice: How we created the Q...
Authoring a personal GPT for your research and practice: How we created the Q...Authoring a personal GPT for your research and practice: How we created the Q...
Authoring a personal GPT for your research and practice: How we created the Q...
Leonel Morgado
 
GBSN - Biochemistry (Unit 6) Chemistry of Proteins
GBSN - Biochemistry (Unit 6) Chemistry of ProteinsGBSN - Biochemistry (Unit 6) Chemistry of Proteins
GBSN - Biochemistry (Unit 6) Chemistry of Proteins
Areesha Ahmad
 
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdfwaterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
LengamoLAppostilic
 
Basics of crystallography, crystal systems, classes and different forms
Basics of crystallography, crystal systems, classes and different formsBasics of crystallography, crystal systems, classes and different forms
Basics of crystallography, crystal systems, classes and different forms
MaheshaNanjegowda
 
Bob Reedy - Nitrate in Texas Groundwater.pdf
Bob Reedy - Nitrate in Texas Groundwater.pdfBob Reedy - Nitrate in Texas Groundwater.pdf
Bob Reedy - Nitrate in Texas Groundwater.pdf
Texas Alliance of Groundwater Districts
 
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...
Advanced-Concepts-Team
 
Phenomics assisted breeding in crop improvement
Phenomics assisted breeding in crop improvementPhenomics assisted breeding in crop improvement
Phenomics assisted breeding in crop improvement
IshaGoswami9
 
在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
vluwdy49
 
aziz sancar nobel prize winner: from mardin to nobel
aziz sancar nobel prize winner: from mardin to nobelaziz sancar nobel prize winner: from mardin to nobel
aziz sancar nobel prize winner: from mardin to nobel
İsa Badur
 
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...
THEMATIC  APPERCEPTION  TEST(TAT) cognitive abilities, creativity, and critic...THEMATIC  APPERCEPTION  TEST(TAT) cognitive abilities, creativity, and critic...
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...
Abdul Wali Khan University Mardan,kP,Pakistan
 

Recently uploaded (20)

ESR spectroscopy in liquid food and beverages.pptx
ESR spectroscopy in liquid food and beverages.pptxESR spectroscopy in liquid food and beverages.pptx
ESR spectroscopy in liquid food and beverages.pptx
 
快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样
快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样
快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样
 
Oedema_types_causes_pathophysiology.pptx
Oedema_types_causes_pathophysiology.pptxOedema_types_causes_pathophysiology.pptx
Oedema_types_causes_pathophysiology.pptx
 
SAR of Medicinal Chemistry 1st by dk.pdf
SAR of Medicinal Chemistry 1st by dk.pdfSAR of Medicinal Chemistry 1st by dk.pdf
SAR of Medicinal Chemistry 1st by dk.pdf
 
Eukaryotic Transcription Presentation.pptx
Eukaryotic Transcription Presentation.pptxEukaryotic Transcription Presentation.pptx
Eukaryotic Transcription Presentation.pptx
 
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Sharlene Leurig - Enabling Onsite Water Use with Net Zero WaterSharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
 
Equivariant neural networks and representation theory
Equivariant neural networks and representation theoryEquivariant neural networks and representation theory
Equivariant neural networks and representation theory
 
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptxThe use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
 
Medical Orthopedic PowerPoint Templates.pptx
Medical Orthopedic PowerPoint Templates.pptxMedical Orthopedic PowerPoint Templates.pptx
Medical Orthopedic PowerPoint Templates.pptx
 
The cost of acquiring information by natural selection
The cost of acquiring information by natural selectionThe cost of acquiring information by natural selection
The cost of acquiring information by natural selection
 
Authoring a personal GPT for your research and practice: How we created the Q...
Authoring a personal GPT for your research and practice: How we created the Q...Authoring a personal GPT for your research and practice: How we created the Q...
Authoring a personal GPT for your research and practice: How we created the Q...
 
GBSN - Biochemistry (Unit 6) Chemistry of Proteins
GBSN - Biochemistry (Unit 6) Chemistry of ProteinsGBSN - Biochemistry (Unit 6) Chemistry of Proteins
GBSN - Biochemistry (Unit 6) Chemistry of Proteins
 
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdfwaterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
 
Basics of crystallography, crystal systems, classes and different forms
Basics of crystallography, crystal systems, classes and different formsBasics of crystallography, crystal systems, classes and different forms
Basics of crystallography, crystal systems, classes and different forms
 
Bob Reedy - Nitrate in Texas Groundwater.pdf
Bob Reedy - Nitrate in Texas Groundwater.pdfBob Reedy - Nitrate in Texas Groundwater.pdf
Bob Reedy - Nitrate in Texas Groundwater.pdf
 
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...
 
Phenomics assisted breeding in crop improvement
Phenomics assisted breeding in crop improvementPhenomics assisted breeding in crop improvement
Phenomics assisted breeding in crop improvement
 
在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
 
aziz sancar nobel prize winner: from mardin to nobel
aziz sancar nobel prize winner: from mardin to nobelaziz sancar nobel prize winner: from mardin to nobel
aziz sancar nobel prize winner: from mardin to nobel
 
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...
THEMATIC  APPERCEPTION  TEST(TAT) cognitive abilities, creativity, and critic...THEMATIC  APPERCEPTION  TEST(TAT) cognitive abilities, creativity, and critic...
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...
 

Polymers

  • 1. Presented by: Pranali .M Palandurkar University department of pharmaceutical Sciences R.T.M.N.U Nagpur
  • 3. • “Polymer are long chain organic molecules assembled form many smaller molecules called as monomer connected by covalent bonds or chemical bonds” • Polymers are macromolecules having very large chains contain a variety of functional groups, can be blended with other low and high molecular weight material • A polymer with two different monomers is known as a copolymer or homopolymer • Their use for biomedical and pharmaceutical applications has gained an enormous impact during the past decades. • The pharmaceutical applications of polymers range from their use as binders in tablets to viscosity and flow controlling agents in liquids, suspensions, and emulsion. Polymers can be used as film coatings to disguise the unpleasant taste of a drug, to enhance drug stability, and to modify drug release characteristics.
  • 4. • The reaction involving combination of two or more monomer units to form a long chain polymer is termed as polymerization • By changing the molecular weight, the physical and mechanical properties of the polymer can be tailor-made. This can be achieved by changing the structure of the monomer building blocks or by blending them with other polymers.
  • 5. Natural polymer • Natural polymers are the substances which are obtained by natural sources like plant and animal sources. • The specific application of plant derived polymer in pharmaceutical formulations include their use in the manufacture of solid monolithic matrix systems, implants, etc • Examples-Proteins- collagen, keratin, albumin. Synthetic polymer • Synthetic polymers are industrially produced chemical substances consisting of a number of molecules linked together with covalent bond. • A wide variety of synthetic polymers are available with variation in main chain as well as side chain. • Exanple- polyester, polyanhydrides, polyamides, polyglycolic acid A) Based on origin Semi Synthetic • Synthetic polymers are polymers obtained by making modification in natural polymers artificially in a lab. • These polymers formed by chemical reaction and are of commercial importance • Example-cellulose derivative (rayon)
  • 6. B) Based on Bio-stability Bio- degradable Polymers • A Bio-degradable polymer is a polymer in which the degradation results from the action of naturally occurring microorganisms such as bacteria, fungi. • Examples-Albumin, Collagen, Gelatin, Starch etc. Non- biodegradable polymer • The polymers which are not decomposed by the action of microorganisms and are referred to as non-biodegradable polymers. • Example -polyethene, polystyrene
  • 7. C) Based on structure Linear polymer • The smallest repeating unit arrange in straight line path • Example – polyvinyl chloride Branched chain polymer • Contain linear chain having some branches • Example- Low density polymer Cross linked chain polymer • Formed from bi-functional and trifunctional monomer and contain strong covalent bonds • Example- Bakelite ,melamine
  • 8. a) Elastomers: Elastomers are rubber-like solid polymers, that are elastic in nature i.e stretched by applying a little force. Example -Neoprene rubber, buna-s and buna-n b) Thermoplastic polymers :Polymers which contain intermolecular forces higher than Elastomers but less than Fibers. They are usually linear chain polymers and can be remolded again. Examples: Polythene, Polyvinyl Chlorides, etc. c) Thermosetting plastics : Polymer which are having highly branched chain molecules with extensive cross linking and if heated becomes infusible and cannot be reused. Example: melamine, Bakelite etc. d) Fibres:Polymers which are a thread like in nature, and can easily be woven. They have strong inter-molecules forces between the chains giving them less elasticity and high tensile strength. The intermolecular forces may be hydrogen bonds or dipole-dipole interaction. Fibres have sharp and high melting points. Example: Nylon-66. D)Based on Molecular Force
  • 9. • These type of polymers are formed by the repeated addition of monomer molecules with double or triple bonds. • Addition polymers always have their empirical formulas same as their monomers. Example: ethene n(CH2=CH2) to polyethene -(CH2-CH2)n- Addition polymers: • These polymers are formed by the combination of monomers, with the elimination of small molecules like water, alcohol etc.. • The monomers in these types of condensation reactions are bi-functional or tri- functional in nature. • A common example is the polymerization of Hexamethylenediamine and adipic acid. to give Nylon – 66, where molecules of water are eliminated in the process Condensation polymers: E)Based on Mode of Polymerization
  • 10. A) Crystalline and amorphous polymers: • Amorphous or glassy polymers do not generally display a sharp melting point; instead, they soften over a wide temperature range. • Polymer strength and stiffness increases with crystallinity as a result of increased intermolecular interactions. • From a pharmaceutical prospective, good barrier properties are needed when polymers are used as a packaging material or as a coating. Crystallinity increases the barrier properties of the polymer. • On the other hand, a less crystalline, or an amorphous polymer is preferred when the release of a drug or an active material is intended.
  • 11. B) Thermal transitions • Thermal transitions in polymers can occur in different orders. • That is, the volume of a polymer can change with temperature as a first-or second-order transition. When a crystal melts , the polymer volume increases significantly as the solid turns to a liquid. The melting temperature (Tm) represents a first-order thermal transition in polymers. On the other hand, the volume of an amorphous polymer gradually changes over a wide temperature range or so-called glass transition temperature. This behaviour represents a second-order thermal transition in polymers .
  • 12. C) Plasticized polymer • A plasticizer is added to a polymer formulation to enhance its flexibility and to help its processing. It facilitates relative movement of polymer chains against each other. This results in a reduction in the glass transition temperature of the mixture. • Since plasticizers increase molecular motion, drug molecules can diffuse through the plasticized polymer matrix at a higher rate depending on the plasticizer concentration D) Molecular weight • There are different ways that molecular weights of a polymer can be expressed: • by the number of the chains, • by the weight of the chains (the chain size), • or by viscosity. • However, the two most common ways are number (Mn) and weight (Mw) average calculations. • Based on that polymers can be termed as polydispered and monodispersed.
  • 13. E) Mechanical properties • Depending on their structure, molecular weight, and intermolecular forces, polymers resist differently when they are stressed. • They can resist against stretching,compression, bending and dynamic loading. With increasing molecular weight the level of intermolecular forces, polymers display superior properties under an applied stress F) Viscoelastic Properties • Materials that exhibit both viscous and elastic characteristics when deformed under stress are known to be viscoelastic. • Polymers are neither a pure elastic nor a pure fluid material. They have the ability to store energy (display elastic behaviour ) and to dissipate it (display viscous behaviour ). For this reason, most polymers are viscoelastic materials.
  • 14. • The polymer enhances the pharmacodynamic and pharmacokinetic properties of biopharmaceuticals though several sources, such as, increases the plasma ½ life, decreases the immunogenicity, boost stability of biopharmaceuticals, • Polymer can also improves solubility of low molecular weight drugs, and has potential for targeted drug delivery • Sustained delivery of drug can be achieved by polymers hence decrease in dosing frequency. • Polymer can be use for taste masking of bitter drug which increases the patient compliance . • Localised delivery of drug-The product can be implanted directly at the site where drug action is needed • Due to biodegradable polymers their degradability reduces the need for subsequent surgical removal, saving time and money • The polymer can protect the drug from the physiological environment and hence improve its stability in vivo
  • 15. Controlled drug delivery occurs when a polymer ,whether natural or synthetic, is judiciously combined with a drug or other active agents such away that the active agent is released from the material in a predesigned manner . 1.Extended release dosage forms: Extended and sustained release dosage forms prolong the time that’ systemic drug levels are within the therapeutic range and thus reduce the number of doses the patient must take to maintain a therapeutic effect there by increasing compliance. The most commonly used water insoluble polymers for extended release applications are the ammonium ethacrylate copolymers cellulose derivatives ethyl cellulose and cellulose acetate, and polyvinyl derivative, polyvinyl acetate
  • 16. 2.Gastro retentive Dosage forms: To achieve gastro retention mucoadhesive and low density, polymers have been evaluated, with little success so far their ability to extend gastric residence time by bonding to the mucus lining of the stomach and floating on top of the gastric contents respectively.
  • 17. 3.Ocular drug delivery system –It allows prolonged contact with corneal surface of eye . Example –Pillocarpine in the treatment of glaucoma –In this mucoadhesive polymers (Polyacrylic acid or copolymer of acetate vinyl &ethyl) are used as barrier to control the drug release. The efficiency of ocular drug delivery is improved through the use of polymeric implants i.e Occusert that are implanted under the cul-de-sac of the eye.
  • 18. 4.Trandermal drug delivery –It involves the diffusion of the drug through the skin and ultimately absorption into the systemic circulation. The drug delivery system is composed of several layers, namely a metallic backing layer ,which is impermeable to drug diffusion ,the drug containing reservoir, a rate controlling membrane and an adhesive layer. In the matrix drug is dissolved or dispersed with solid polymer(acrylate co – polymer)
  • 19. 5.Polymers in nanoparticles Nanoparticles have size range of 10-1000nm. In nanoparticle drug delivary system drug is attached, entrapped and dissolve to polymeric matrix. Example of synthetic biodegradable polymers are poly lactide, poly(lactide-co-glyolide), poly-ɛ-caprolactone and polyanhydrides.