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1
Presented by:
Pranali.M.Palandurkar
M.Pharm 1st sem
University Department of
Pharmaceutical Sciences R.T.M.N.U
Nagpur
 3D printing is one of the most revolutionary & powerful tool
serving as technology of precise manufacturing of
individually developed dosage form.
 3D printing can play a significant role in multiple active
ingredient dosage forms, where the formulation can be as a
single blend or multi layer printed tablets with sustained
release properties
 It allows the rapid conversion of information from digital 3D
mode into a physical object.
 It is a process of creating an object using a machine that
puts down the material layer by layer in three dimensions
until the desired object is formed.
2
 The term three dimensional printing was defined by
ISO(international standard organization) as " fabrication of
object through the deposition of a material using a print
head, nozzle or another printer technology.
 3D printing technology has high potential in individualized
dosage form concept called the polypill concept
 Three dimensional printing technology is a novel rapid
prototyping technique in which solid objects are
constructed by depositing several layers in sequence.
 It is also called as additive manufacturing.
3
 3D printing drug is to design and develop medicine that are
suited to an individual's need.
 In this we can easily adjust size, shape, appearance and rate
of delivery of a wide range of medicine.
 3D printing methods gain an importance in the field of
pharmaceutical sciences because of the possibility of rapid
preparation of tailor-made object which can be personalized
therapy .
 Its aims is to development of patient centered dosage form
based on structure design.
4
 Pharmaceutical product is designed in three dimension with
computer aided design .
 Design is converted to a machine readable format which
describes the external surface of the 3D dosage form.
 The computer program then slices this surface into several
distinct printable layers and transfers that layer by-layer to
the machine.
5
 Main methods are based on
 Powder solidification
 Liquid solidification
 Extrusion
6
7
 It is similar to desktop inkjet printer .
 It is also called as powder bed jetting.
Droplet of solution containing drug sprayed from print head bind the
layer of free powder bed
While unbound powder particles act as support material
Which prevent collapsing of porous structure
Formed object is lowered and a layer of free powder is applied by
roller or powder jetting system
8
 Active pharmaceutical ingredient as well as
modifying agent can be dissolved or dispersed
in ink or distributed in powder bed.
9
 It is similar to drop on solid method.
 Here the powder can be solidified by applying the beam of high
energy.
Powder bed is transformed from one compartment to another
Leveling and layering are formed by sintering or melting the
polymeric powder bed by laser beam
10
11
 Also called as polyjet technology
Droplet of solution containing drug sprayed from the nozzle
Deposit on thin layer
Cured by cooling air or in presence of high energy
Print head moves along X&Y axes during printing
Print platform bed is lowered along Z axis by the height of the layer
after the deposition of each layer of the material
12
13
14
 Photosensitive liquid polymer are used.
 The object is built by solidification of subsequent layers
of resin in the presence of high energy light.
 Laser beam guided by scanner mirrors precisely draws
layers of the object on build platform by cross linking of
the photopolymer.
 Source of light is situated under transparent bottom of a
resin tank which is coated with a non-sticking material.
15
Two modes of printing method
Extrusion of semisolid Extrusion of thermoplastic
rod-shaped material
 In both modes material is extruded from the nozzle and spread in
subsequent layers on the surface of build platform.
 Defined dimension of printed path is created by the distance of print
head to the build plate and influenced the nozzle orifice diameter.
16
 Stages of preparation of 3D-printed object .
Design 3D object with CAD software &optimize the geometry
Export of 3D model to a printer recognizable file format
Ex- STL
Import of the file to the software and generation of layer which will be
printed
Fabrication of the object by subsequent application of material layer
17
18
 Polypill refers to a single tablet that includes the combination of
several drugs.
 This concept is highly beneficial for geriatric population, as
patients of this age category are prone to multiple disorders and
hence multiple therapy.
 The drugs were physically separated by a permeable membrane.
 Three-dimensional (3D) extrusion-based printing was used to
manufacture the 'polypill' to demonstrate that complex
medication regimes can be combined in a single tablet .
19
 High drug loading ability when compared to conventional dosage
forms
 Accurate and precise dosing of potent drugs which are administered
at small doses
 In case of multi drug therapy with multiple dosing regimen,
treatment can be customized to improve patient adherence.
 As immediate and controlled release layers can be incorporated due
to the flexible design and manufacture of this dosage form, it helps in
choosing the best therapeutic regime for an individual
 3D printers occupy minimal space and are affordable.
 Reduces cost of production due to lesser material wastage
20
 Manufacturing of drug delivery system with sophisticated
structure.
 Personalized medicine can be made.
 Available in different shapes.
 Multifunctional drug delivery system with accelerated release
characteristics
21
 First 3D printed drug.
 It treats epilepsy .
 In 2015 Apercia pharmaceutical developed zipdose patented
technology for3D –printing drugs.
 It enable to make high dose medication in a rapid
disintegration form.
22
23

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3 d printing of pharmaceuticals

  • 1. 1 Presented by: Pranali.M.Palandurkar M.Pharm 1st sem University Department of Pharmaceutical Sciences R.T.M.N.U Nagpur
  • 2.  3D printing is one of the most revolutionary & powerful tool serving as technology of precise manufacturing of individually developed dosage form.  3D printing can play a significant role in multiple active ingredient dosage forms, where the formulation can be as a single blend or multi layer printed tablets with sustained release properties  It allows the rapid conversion of information from digital 3D mode into a physical object.  It is a process of creating an object using a machine that puts down the material layer by layer in three dimensions until the desired object is formed. 2
  • 3.  The term three dimensional printing was defined by ISO(international standard organization) as " fabrication of object through the deposition of a material using a print head, nozzle or another printer technology.  3D printing technology has high potential in individualized dosage form concept called the polypill concept  Three dimensional printing technology is a novel rapid prototyping technique in which solid objects are constructed by depositing several layers in sequence.  It is also called as additive manufacturing. 3
  • 4.  3D printing drug is to design and develop medicine that are suited to an individual's need.  In this we can easily adjust size, shape, appearance and rate of delivery of a wide range of medicine.  3D printing methods gain an importance in the field of pharmaceutical sciences because of the possibility of rapid preparation of tailor-made object which can be personalized therapy .  Its aims is to development of patient centered dosage form based on structure design. 4
  • 5.  Pharmaceutical product is designed in three dimension with computer aided design .  Design is converted to a machine readable format which describes the external surface of the 3D dosage form.  The computer program then slices this surface into several distinct printable layers and transfers that layer by-layer to the machine. 5
  • 6.  Main methods are based on  Powder solidification  Liquid solidification  Extrusion 6
  • 7. 7
  • 8.  It is similar to desktop inkjet printer .  It is also called as powder bed jetting. Droplet of solution containing drug sprayed from print head bind the layer of free powder bed While unbound powder particles act as support material Which prevent collapsing of porous structure Formed object is lowered and a layer of free powder is applied by roller or powder jetting system 8
  • 9.  Active pharmaceutical ingredient as well as modifying agent can be dissolved or dispersed in ink or distributed in powder bed. 9
  • 10.  It is similar to drop on solid method.  Here the powder can be solidified by applying the beam of high energy. Powder bed is transformed from one compartment to another Leveling and layering are formed by sintering or melting the polymeric powder bed by laser beam 10
  • 11. 11
  • 12.  Also called as polyjet technology Droplet of solution containing drug sprayed from the nozzle Deposit on thin layer Cured by cooling air or in presence of high energy Print head moves along X&Y axes during printing Print platform bed is lowered along Z axis by the height of the layer after the deposition of each layer of the material 12
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  • 15.  Photosensitive liquid polymer are used.  The object is built by solidification of subsequent layers of resin in the presence of high energy light.  Laser beam guided by scanner mirrors precisely draws layers of the object on build platform by cross linking of the photopolymer.  Source of light is situated under transparent bottom of a resin tank which is coated with a non-sticking material. 15
  • 16. Two modes of printing method Extrusion of semisolid Extrusion of thermoplastic rod-shaped material  In both modes material is extruded from the nozzle and spread in subsequent layers on the surface of build platform.  Defined dimension of printed path is created by the distance of print head to the build plate and influenced the nozzle orifice diameter. 16
  • 17.  Stages of preparation of 3D-printed object . Design 3D object with CAD software &optimize the geometry Export of 3D model to a printer recognizable file format Ex- STL Import of the file to the software and generation of layer which will be printed Fabrication of the object by subsequent application of material layer 17
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  • 19.  Polypill refers to a single tablet that includes the combination of several drugs.  This concept is highly beneficial for geriatric population, as patients of this age category are prone to multiple disorders and hence multiple therapy.  The drugs were physically separated by a permeable membrane.  Three-dimensional (3D) extrusion-based printing was used to manufacture the 'polypill' to demonstrate that complex medication regimes can be combined in a single tablet . 19
  • 20.  High drug loading ability when compared to conventional dosage forms  Accurate and precise dosing of potent drugs which are administered at small doses  In case of multi drug therapy with multiple dosing regimen, treatment can be customized to improve patient adherence.  As immediate and controlled release layers can be incorporated due to the flexible design and manufacture of this dosage form, it helps in choosing the best therapeutic regime for an individual  3D printers occupy minimal space and are affordable.  Reduces cost of production due to lesser material wastage 20
  • 21.  Manufacturing of drug delivery system with sophisticated structure.  Personalized medicine can be made.  Available in different shapes.  Multifunctional drug delivery system with accelerated release characteristics 21
  • 22.  First 3D printed drug.  It treats epilepsy .  In 2015 Apercia pharmaceutical developed zipdose patented technology for3D –printing drugs.  It enable to make high dose medication in a rapid disintegration form. 22
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