This document discusses orbital complications that can arise from acute rhinosinusitis. It begins by providing epidemiological information and noting the decreased incidence of complications due to antibiotic use. It then classifies orbital complications according to Chandler's system and describes each type in more detail. Preseptal cellulitis and orbital cellulitis are the most common and involve inflammation outside or within the orbit respectively. Abscesses such as subperiosteal or orbital abscesses involve pus collections. Cavernous sinus thrombosis is a rare but serious intracranial complication. Evaluation involves history, exam, and CT imaging. Treatment depends on severity but generally involves IV antibiotics and possibly surgical drainage or decompression.
Complications of rhinosinusitis(Dr ravindra daggupati)Ravindra Daggupati
orbital complications of rhino sinusitis,intra cranial complications of rhino sinusitis,classification of complications,diagnosis and treatment of complications
Complications of rhinosinusitis(Dr ravindra daggupati)Ravindra Daggupati
orbital complications of rhino sinusitis,intra cranial complications of rhino sinusitis,classification of complications,diagnosis and treatment of complications
CSOM may lead to different complications. Although less common in developed countries, CSOM is common in developing and underdeveloped countries.
This presentation explains the complications of CSOM in details.
CSOM may lead to different complications. Although less common in developed countries, CSOM is common in developing and underdeveloped countries.
This presentation explains the complications of CSOM in details.
Anatomy of cavernous sinus, structures passing through the caveernous sinus, spread of infections, clinical features of cavernous sinus thrombosis, investigations and management of cavernous sinus thrombosis.
Sinusitis is defined as inflammation of the mucosal lining of the sinus passages. Frequent attacks of sinusitis for over three months, also known as chronic sinusitis, result in the thickening of the mucosal membranes and an excess production of nasal and sinus secretions. These secretions are usually thick and sticky and frequently predispose the sinuses to bacterial infection.
https://www.icliniq.com/articles/ent-health/sinusitis-causes-symptoms-and-treatment
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Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Orbital complications of acute Rhinosinusitis
1. Sulaimanyia Teaching Hospital
ENT CENTER
ORBITAL COMPLICATIONS OF
ACUTE RHINOSINUSITIS
Presented by:- Dr . Sahar j .Hadi
ENT Center- Sulaimanyia Teaching Hospital- Sulaimanyia- Iraq
3. INTRODUCTION
Acute bacterial sinusitis occurs commonly,
usually as a sequel of an upper respiratory
infection. Spread of infection outside the
sinuses results in complicated sinusitis. The
incidence of complications from both acute
and chronic sinusitis has decreased four fold
due to the widespread use of antibiotics for
rhinosinusitis.
8. RISK FACTORS
Seasonal variations.
Gender: Male
Age increase admission due to complication
(3-6 yeas).
Above 7years intracranial complication.
Adult intracranial complication due to CRS,
while intracranial complications in child due to
ABRS.
Underdeveloped sinuses, highly vascular
valveless diploic system, immature posterior
table, arachnoid layer.
9. Pathogenesis
• Through the wall of sinusitisDirect
spread
• Through the subperosteal
venous plexus
Venous
spread
• Perivascular lymphatic spread
to subperiosteal plane
Lymphatic
spread
12. 1-PRESEPTAL CELLULITIS
-complication of ethmoid sinusitis .
-Far most common in pediatric age group.
-Exclude the other causes
-medical comorbidities and immune
deficiencies are risk factors for preseptal
cellulitis.
-Manifests as eyelid swelling, erythema, and
tenderness.
-There are no limitation of extra ocular muscles
movements. and no impairment of visual
acuity.
- Due to impaired venous drainage of the
ethmoidal vessels that are obstructed by
inflammation and pressure.
13. ORBITAL CELLULITIS
Orbital cellulitis is a postseptal infection .
manifests as diffuse edema of the orbital contents
without a discrete abscess .
There is eyelid edema and erythema, proptosis, and
chemosis with limited or no impairment of
extraocular movements and normal visual acuity
early in the disease process.
Visual changes and ophthalmoplegia indicating
optic neuritis and/or ischemia can occur as the
disease progresses, these are prognostically
worrisome finding.
14. SUBPERIOSTEAL ABSCESS
Collection of pus forms at the medial aspect of the
orbit between the periorbita and the lamina
papyracea .
This is the second most common orbital
complication of sinusitis .
Sever proptosis, ophthalmoplegia.
A subperiosteal abscess can displace the orbital
contents and globe downward and laterally with
normal mobility in the early stages.
An abscess may occasionally rupture the orbital
septum and present in the eyelids.
15. Orbital abscess
An orbital abscess occurs when orbital cellulitis
coalesces into a discrete collection of pus
within the orbital tissues.
This is a serious complication that can be
associated with severe exophthalmos and
chemosis, complete ophthalmoplegia and
visual impairment with a risk for progression to
irreversible blindness.
On rare occasions there is spontaneous
drainage of purulent material through the
eyelid.
16. CAVERNOUS SINUS
THROMBOSIS
can be considered an orbital as well as an
intracranial complication of sinusitis.
Venous congestion in the orbit results in
bilateral orbital pain, chemosis, proptosis, and
ophthalmoplegia. Cranial nerves III, IV; Vl, V2,
V3, and VI traverse the sinus and can all be
affected.
Extension of the phlebitis posteriorly into the
cavernous sinus results in progression of
symptoms in the opposite eye.
It can be associated with sepsis and
meningismus or frank meningitis may be
present.
17. EVALUTIONS
HISTORY(Symptoms of URTI + symptoms of ABRS).
PHYSICAL EXAMINATION.(nasal cavity , orbital EX).
RADIOLOGY.
Computed tomography (Ct) is considered the gold standard for
orbital complications of ABRS (axial + coronal view).
Aim:
1-To confirm the diagnosis.
2-Define the extent and site of disease.
3-give idea about the treatment modalities.
4-exclude other complications.