This document discusses fractures of the axis vertebra (C2). It begins by describing the embryology and anatomy of C2. It then covers the different types of C2 fractures including odontoid fractures (Type I-III), Hangman's fractures (Levine classification Type I-III), and miscellaneous C2 fractures (Benzel classification). For each type of fracture, the mechanisms of injury, evaluation, management options (surgical vs nonsurgical), specific treatment approaches, complications, and considerations in elderly patients are described in detail.
A fractured neck of femur (NOF) is a serious injury, especially in older people. It is likely to be life changing and for some people life threatening.
Neck of femur fractures (NOF) are common injuries sustained by older patients who are both more likely to have unsteadiness of gait and reduced bone mineral density, predisposing to fracture. Elderly osteoporotic women are at greatest risk.
Hoffa's Fracture: Diagnosis, management & New Classification System by BAGARI...Vaibhav Bagaria
Hoffa's Fracture - coronal split fracture of distal femur, its diagnosis, management strategy, a new classification and tips and tricks of management. First described Hoffa, a new classification system by Bagaria et al helps plan the surgery for these tricky fracture. The most crucial step is not to miss these fractures in ER.
A fractured neck of femur (NOF) is a serious injury, especially in older people. It is likely to be life changing and for some people life threatening.
Neck of femur fractures (NOF) are common injuries sustained by older patients who are both more likely to have unsteadiness of gait and reduced bone mineral density, predisposing to fracture. Elderly osteoporotic women are at greatest risk.
Hoffa's Fracture: Diagnosis, management & New Classification System by BAGARI...Vaibhav Bagaria
Hoffa's Fracture - coronal split fracture of distal femur, its diagnosis, management strategy, a new classification and tips and tricks of management. First described Hoffa, a new classification system by Bagaria et al helps plan the surgery for these tricky fracture. The most crucial step is not to miss these fractures in ER.
Monteggia fractures and neglected cases
A simple presentation to understand the fracture and its classifications and answer some coomonly asked questions regarding the neglected cases managment
Dear Readers,
this is my ppt was made from a book of BAGHERI ( Current therapy in oral and maxillofacial surgery)- 2012 PLUS other sources.. hope you find it beneficial.
have a nice day,
hanan
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
2. Embryology
• Gastrulation begins in 3rd week
• The mesoderm thickens bilaterally and segments
into paired cuboidal structures called somites at
around 20 days’ gestation.
• They form along a rostrocaudal axis. A total of 42
to 44 pairs of somites form, 4 occipital, 8 cervical,
12 thoracic, 5 lumbar, 5 sacral and 8 to 10
coccygeal.
• regression of the first occipital somite and the
last five to seven coccygeal somites, leaving a
total of 38.
3. • The ventral portions of the somites are the
sclerotomes that eventually become the
skeletal system, including the vertebral bodies,
the cartilaginous tissue, the disks, and the
cells of the spinal meninges.
4.
5.
6. Anatomy of axis vertebra
Features :
• Odontoid process: 1-1.5 cm long and 1 cm
wide
• Articulating facets : The superior facets do not
form an articular pillar with the inferior facets,
but are anterior to the latter
• Thick lamina, stout pedicle and large spinous
process
16. Prof Goel`s additional parameter
• Type A: vertical or compression
fracture
• Type B : facets of atlas and axis are
malaligned
• Type C : fracture line traverses
through facet of axis
17. Type I odontoid fracture
• MOI : avulsion of alar ligament
• Evaluation : thin CT / MRI
• Management : NONSURGICAL Vs
surgical
• Collar vs halo vest
18.
19. Problems with halo vest
• Pressure sore
• Pin site infection
• Pin loosening
• Breathing issues
• Pneumonia
20. Type II odontoid fracture
• Due to lateral bending and extension
forces
• Considered unstable
• Surgery vs nonsurgical
• Collar (53-57%)
• Halo vest (70-73%)
21. Nonsurgical usually fails
• Watershed zone with poor blood supply
(apex by ICA branches- cleft perforating
vs , Base by VA branches- ant and post vs)
• Neck is area of enormous load
transmission
22.
23. Type III odontoid #
• Due to pure extension
• Conservative
• 87-100% healing rate on conservative
management
• Shallow type III = Type II >>> surgical mx
28. Surgical
Anterior
• less morbidity
• Less loss of motion compared to post fixation
• Fracture < 6 months
• Intact transverse ligament
• One screw = two screw (biomechanically)
• c/I : severe osteopenia, ant oblique sloping
fracture
• Complication : screw fall out / pullout
29. Anterior odontoid screw fixation
• If unstable fibre optic intubation
• Supine with shoulder roll
• Tong traction
• Fluoroscopy for proper reduction and alignment
• Skin incision at C5-6 disc space
• Left side prefered
• Trachea and esophagus medially and carotid
laterally
30. • Soft tissue opened cephalad to C2 region
• Two tech
• Cannulated screw tech
• Lag screw tech
31.
32.
33. Magerl technique
• Transarticular screw placement
• Indication :
poor bone quality, such as in elderly
patients, fractures older than 6 months, and
transverse ligament injuries
34. • Prone position
• Occiput to c3 incision
• Subperiosteal dissection to expose C2 pars
upward to C1-C2 joint
• The screw entry point is 2 mm lateral from the
medial edge of the facet and 3 mm superior to
the caudal edge
• The desired trajectory goes through the C1-2
joint and enters the lateral mass of C1,
pointed at the anterior tubercle. Bicortical
purchase is desired
• Posterior wiring and bony fusion
38. Posterior lateral mass fixation
• Exposure similar to transarticular
• C1 entry point middle of lateral mass
• Trajectory : slightly medially and parallel to C1
arch
• C2 entry : The entry point is halfway between
the upper and lower articular surfaces of C2
• Trajectory : 25 degrees cephalad and 20 to 25
degrees medially.
39.
40. Complication of C2 #
• VAI
• Pseudarthrosis, wound infection, nerve root
injury, persistent numbness or neuropathic
pain, and screw breakage
41. C2 # in elderly
• >70yrs
• Common in spine trauma
• Surgery with anterior or posterior better than
immobilisation
• Collar better than halo vest for conservative
management
42.
43. Traumatic spondylolisthesis -
"Hangman's fracture"
• Fracture of pars interarticularis of C2 &
disruption of C2-C3 junction
• term "hangman's fracture" is not accurate for
the majority of cases: lacks large traction force
present in judicial hangings
• In cases in which there is neurologic injury,
:significant horizontal translation w/
accompanying damage to the posterior
longitudinal ligament w/ or w/o damage of
the C2-C3 interspace
44. mechanism of injury in adults:
• Judical lesion: hyperextension and distraction;
• Blow on the forehead forcing the neck into
extension is a classic mechanism of injury
producing fractures through the pedicles
of C2 known as traumatic spondyloslisthesis
of C2;
45.
46.
47. Levine Classification
• Type I
• < 3 mm translation, no angulation;
• bilateral pars frx, prevertebral soft tissue swelling,
w/ normal disc space & normal alignment;
• C2-3 disk and ligamentous structures remain
intact;
• type I A: minimal translation and little or no
angulation;
- CT demonstrates extension of fracture
through the foramen transversum (which may
injure the vertebral artery)
48.
49. TYPE II
• more than 3 mm of displacement of C2 on C3
with or without angulation and disruption of
the C2-3 disk and posterior longitudinal
ligament
• Type IIa fractures have angulation (can be >15
degrees) and minimal subluxation (<3 mm),
with the same associated disk and
ligamentous injury
50.
51. Type III
• fractures have type II features with
associated unilateral or bilateral
facet dislocation, along with injury to
anterior and posterior longitudinal
ligaments
• Type IIa and III fractures are rare and
are generally considered unstable
52.
53. Management
• Nonsurgical : fusion rate 93-100 % - 12-14
weeks
• Levine type I or Ia fractures can be treated
with collar immobilization for 3 months
• Type II fractures usually reduce with gentle
cervical traction. Patients with these fractures
should be placed in a halo vest for 3 months
54. • For fractures with more than 5 mm of
subluxation or at least 30 degrees of
angulation, surgical fixation should be strongly
considered
• Levine type IIa fractures should be reduced
immediately in a halo vest with extension and
compression applied. Halo vest immobilization
for 3 months results in a 95% union rate.
Traction in these fractures can accentuate the
deformity.
55. • Levine type III fractures require surgery for
stabilization and reduction
Surgery
• Posterior : can narrow the spinal canal as
angulation not addressed
• Anterior : exposure difficult
• Because most patients are neurologically
intact, it is often unnecessary to completely
resect the entire disk and the posterior
longitudinal ligament
56. MISCELLANEOUS C2 FRACTURES
• grouped into four basic types: vertebral body,
lamina, spinous process, and lateral mass
fractures
Benzel classification
• Type I fractures are vertically and coronally
oriented.
• Type II fractures are vertically and sagittally
oriented.
• Type III fractures are transverse (horizontally)
oriented
57. • Fractures through the foramen transversarium
>> CT angiography for VAI.
• Treatment of asymptomatic VAI remains
controversial because there is no level I
evidence. Studies have shown improved
outcomes in patients receiving anticoagulation
or antiplatelet agents.
• In symptomatic VAI patients, treatment is
necessary, but the choice of treatment
remains controversial>>>> Endovascular
recommended