The document discusses the glomerular filtration rate (GFR) as a standard measure of renal function, detailing its calculation through plasma clearance and indications for its use, including assessing kidney function before chemotherapy. It outlines patient preparation, procedures for measuring GFR, and provides case studies illustrating normal and abnormal results. The conclusion emphasizes GFR's importance in detecting renal failure and evaluating donor suitability for kidney transplantation.

1. Glomerular Filtration Rate
(GFR)
Done By
Budour Alzahrani - Reem Alattas
Under supervise
Amal AlQahtani - Amer Amro

2. Case Study
Outlines

3. Nuclear
Medicine
Procedures
Imaging
Procedures
Non-Imaging
Procedures

4. Imaging procedures
Myocardial perfusion imaging
Thyroid scan
Renogram
Bone scan
Non-Imaging procedures
GFR (in-vitro)
RBC’s (Red Cell Mass)
Schilling Test
MostCommon…

5. Glomerular Filtration

6. Glomerular filtration rate (GFR) is a commonly accepted
standard measure of renal function.
GFR is calculated from the area under the plasma clearance
curve, which required multiple blood samples to be taken
over a period of several hours.
Glomerular Filtration Rate

7. Indications
Calculation of dose
in chemotherapy
Detection of renal
failure
Assessment of
donors for
transplantation
evaluation of single
kidney function

8. Contraindication
Patients with ascites.
Edema or other expanded body space.

9. Patient’s Preparation
• Excessive intake of drinks containing caffeine including tea, coffee
and Coke should be avoided after 10 pm the night before the
test because of their diuretic effect
• recommended to avoid high protein meals before the study
• Some drugs can reduce renal function, should be stopped e.g.
diuretics.
• Note patient’s height and weight

10. Radiopharmaceuticals
• Cr-51 EDTA
Half Life : 27.7 days
Dose : 2.0 MBq I.V
• Tc-99m DTPA is also used.

11. Procedure
Explain the procedure .
Inject the Cr-51 EDTA .
Ask the patient to come back after 2,3 and 4
hours from the injection time for blood sample .
01
02
03

12. Procedure
04
05
06
Centrifuge the blood samples.
Dispense 2 ml of plasma.
Count sample tube on Gamma counter.

13. Case studyCase1
Case2
Age: 66y.
Gender: female.
Clinical history: Brest cancer.
Reason of study: assess kidney
function before chemotherapy.
Age: 65y.
Gender: male.
Clinical history: DM , HTN .
Reason of study: diabetic
nephropathy.

14. Normal Case Result Abnormal Case ResultCase 1 Case 2

15. This sheet is used for calculation of Adult GFR

16. Conclusion
• GFR is the best test to measure kidney function , and to determine
the kidneys filtration rate.
• GFR used to detect renal failure and to assess donors for kidney
transplantation, also help to assess patient kidney function before
chemotherapy.

17. References
• PSMMC Protocol.
• (2016). Bnms.org.uk. Retrieved 11 May 2016, from
http://www.bnms.org.uk/~bnms/images/stories/downloads/documents/gfrguidelin
esv5.2.pdf
• http://www.nuclearmedicine.org.uk/gfr/GFR_autumn2003_web.pdf

18. Thank You