For Undergraduates Revise – anatomy and histology Developmental lesion Inflammatory lesions Fibrocystic disease

1. NON-NEOPLASTIC BREAST
LESIONS

2. SLOs
• Revise – anatomy and histology
• Developmental lesion
• Inflammatory lesions
• Fibrocystic disease

5. Life cycle changes

6. Changes with menstrual periods
• Post ovulation - Estrogen and rising
progesterone
– Proliferation of the acini
– Intralobular stromal edema

7. Developmental disorders

8. Milk line remnants

9. Accessary breast tissue

10. Congenital inverted nipple

11. Presentation

12. Inflammatory lesions

13. Acute Mastitis
• 1st mth of breastfeeding
• Vulnerable - cracks and fissures
• Staphylococcus aureus, Streptococci
• Acute inflammation – Abscess
• Antibiotics, milk expression, drainage

14. Periductal Mastitis
• Smoking, Vitamin A deficiency
• Squamous metaplasia

15. Duct ectasia
• Not related to
– Lactation
– Smoking
• Duct dilation
• Chronic
Inflammatory
response
• Nipple discharge /
retraction / mass

16. Fat necrosis

17. Lymphocytic mastopathy
• Type 1 Diabetes or thyroiditis
• Autoimmune association

18. Granulomatous mastitis
• Infective
• Hypersensitivity to lobular antigens

19. Fibrocystic disease
• Lumpiness
• Dense breast with cysts
• Benign histopathology

20. • Cysts, Fibrosis and Adenosis

21. Summarise