The document discusses atopic and non-atopic asthma. It notes that Frances M. Rackemann first classified asthma into these categories in 1947 based on skin prick tests. However, more recent research shows that atopic and non-atopic asthma share more similarities than differences in their clinical manifestations and pathobiology. Non-atopic asthma tends to have a later onset, affect females more, and be more severe requiring higher steroid doses. Several immunopathological mechanisms are proposed for non-atopic asthma including autoimmunity, superantigens, and monomeric IgE acting as an independent sensitizer. Further research is still needed to better understand the phenotypes and endotypes of non-atopic asthma.
Bronchial Asthma: Definition,Pathophysiology and ManagementMarko Makram
Definition and Pathophysiology of Asthma in addition to classification and recent updates in the management of asthma based on GINA-2019 Guidelines, by Dr. Marco Makram.
A description of Work related asthma, Occupational Asthma and Work exacerbated asthma
References: Murray and Nadel's Textbook of Respiratory Medicine
American College of Chest Physicians 2008 Consensus Statement
Hope you find it useful.
Bronchial Asthma: Definition,Pathophysiology and ManagementMarko Makram
Definition and Pathophysiology of Asthma in addition to classification and recent updates in the management of asthma based on GINA-2019 Guidelines, by Dr. Marco Makram.
A description of Work related asthma, Occupational Asthma and Work exacerbated asthma
References: Murray and Nadel's Textbook of Respiratory Medicine
American College of Chest Physicians 2008 Consensus Statement
Hope you find it useful.
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NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
2. Frances M. Rackemann 1887-1973:
In 1947,he classified asthma into
atopic or nonatopic
based on the presence or absence
of clinical symptoms precipitated by
one or more common aeroallergens,
supported by skin prick test
F. M. Rackemann, The American Journal
of Medicine, vol. 3, no. 5, pp. 601–606,
3. Recent results led to the conclusion that both
kinds of asthma share more similarities than
differences .
•R. Pawankar et al. ,Allergy Frontiers: Clinical Manifestations, 321,2009
4. further studies has promoted the concept that asthma
consists of multiple phenotypes, each of which is defined
by distinct clinical, functional and pathobiological patterns.
Mouthuy J, et al. Am J Respir Crit
Care Med. 2011 .
5. NON-ATOPIC ASTHMA
there have been major advances in our
understanding of the molecular mechanisms of
atopic asthma, but relatively little progress in
understanding of non-atopic asthma.
Recently, scientific evidence has challenged the
dualistic concept of extrinsic and intrinsic asthma
Siroux, V. et al. Eur. Respir. J. 38, 310–317 (2011).
6. NON ATOPIC ASTHMA IS
TYPICALLY:
late-onset .
More common in females
Tends to be more severe .
Requiring higher doses of corticosteroids .
Often starts following respiratory tract infection.
Less familial association
http://thorax.bmj.com/ on April 6, 2016
8. COMMON TRIGGERS IN BOTH ATOPIC & NON
ATOPIC ASTHMA,
Barnes PJ,Exp Allergy. 2009 Aug;39(8):1145–51.
9. Mouthuy J, et al. Am J Respir
Crit Care Med. 2011 .
Immunopathological mechanisms in non-
atopic asthma.
10. CHALLENGES TO THE DUALISTIC CONCEPT
OF ATOPIC AND NON ATOPIC ASTHMA.
Inflammatory cytokines IL-4, IL-5, and IL-13 in bronchial
biopsies were similar both in allergic and in intrinsic
asthmatics.
enhanced expression of high-affinity IgE receptor (Fc RI)ɛ
in bronchial biopsies obtained from non-atopic
asthmatics is probably due to IgE synthesis occurring at
least locally in the airways of these patients, despite
their having negative skin prick tests and low serum IgE.
Pillai P, et al. ISRN Allergy. 2011
13. PROBABLE IMMUNOPATHOGENESIS:
• Autoimmunity theory:
IgE could express a humoral autoimmunity, against
human proteins with structural similarity to allergens .
in accordance with the late-onset occurrence of intrinsic
asthma, seen mainly in females. Anti-nuclear antibodies
are more common in patients with asthma than non-
asthmatics,
Autoantibodies to cytokeratin-18 have been described in
patients with non atopic asthma
14. SUPERANTIGEN THEORY
invasion of airway epithelial cells by S. aureus causes
the release of staphylococcal superantigens which act
on airway B lymphocytes to cause local production of
polyclonal IgE, together with IgE directed against
staphylococcal antigens .
This leads to sensitization of mast cells, which can be
activated by the usual asthma triggers ,
also stimulate clonal expansion of T-cells, resulting in
increased Th2 cells and CD8+
cells while suppressing
regulatory T cells
Jing L.etal.,Allergy Asthma Immunol Res. 2014 May; 6(3): 263–266.
15. • The monomeric IgE theory
• Is IgE an independent sensitizer of effector
cells (mast cells and basophils) triggering
bronchial hyperresponsiveness even in the
absence of specific sensitizations in non-
allergic patients.
• Several in vitro studies have supported
this idea showing that bronchial
hyperresponsiveness in tracheal segments
may occur after incubation with sera of
patients with high IgE levels .
Kashiwakura J .Adv Exp Med Biol. 2011;716:29-46.
16. IN CONCLUSION:
Atopic and non atopic asthma share more similarities
than differences .
Local IgE, cytokine production and bronchial
epithelial components ,more or less the same
family history is strongly associated with non atopic
asthma as well.
Despite the absence of circulating peripheral IgE in
non-atopic asthmatics there is activation of the
cellular machinery of atopy at least locally in the
bronchial mucosa
17. Omalizumab may be tried in non-allergic asthmatics
As superantigens may be involved in the pathogenesis of
non atopic asthma,so measures to eradicate
microorganisms might be effective.
Intravenous immunoglobulin (IVIG), which has been used in
the treatment of toxic shock syndrome associated with
staphylococcal toxins ,may be beneficial in treating asthma.
Since autoantibodies to epithelial proteins have been
reported, the use of immunosuppressants may be indicated
More studies are needed to clarify further phenotypes and
endotypes of non atopic asthma