Allergic disorders are common in children, affecting 15-30% globally. Allergies are caused by an inappropriate immune response to substances called allergens. Common allergic disorders in children include allergic rhinitis, atopic dermatitis, urticaria, insect bites, food allergy, and anaphylaxis. Allergic reactions involve the release of mediators like histamine from immune cells. Treatment focuses on avoidance of triggers, antihistamines, and management of symptoms.
2. Allergy
It represents the clinical expression of
IgE-mediated allergic diseases that have a
familial predisposition and that manifest as hyper-
responsiveness in the target organs.
Atopy
It refers to the genetic tendency to develop allergic
diseases
3. Why Allergy Is Important?
Allergy affects approximately 15-30% of the
general population around the world, most of
which are children.
Most allergies interfere with sleep, intellectual
functioning and recreational activities, whereas
food allergy leads to considerable anxieties and
fear of accidentally ingesting some notorious
allergen.
• Allergies are chronic conditions and fighting them
may need a
change of lifestyle, or even profession, adhering
to a diet and to maintain allergen avoidance.
4. Types of Allergen
• There are 2 types of Allergens
(a) Allergens from the natural environment:
- high molecular weight compounds(> 10 kDa).
- most of these allergens have an enzymatic function
examples are: pollen, fungi , spores, house dust mites,
epidermis of house pets, insect venom, some food
proteins, etc.
(b) Allergens from a chemically contaminated
environment:
- usually low-molecular chemical compounds(<10kDa).
- need to bind to a carbohydrate to attach to IgE.
examples are: metals, drugs, additives to food products,
latex.
5. Cells Involved In Allergic
Reactions
• CD4+ T cells play the central role in allergic inflammation.
• Types of CD4+:
T helper 1 (TH1)
- Secretes IL-2, TNF-b, and interferon-g (IFN-g).
- Antagonize the allergic response.
T helper 2 (TH2):
- Produces IL-4, IL-5, IL-6,IL-9,IL-10, and IL-13. IL-4 and IL-13
play the
main role in allergic response.
T-regulatory (Treg) cells
- critical role in expression of allergic and autoimmune diseases.
- These cells have the ability to suppress effector T cells of
either the Th1 or
Th2 phenotypes
6. Mechanism of action of allergens
• Generally allergic reactions takes place in
following steps:
1) Primary Exposure
2) Secondary Exposure & Release of mediators
9. Allergies to be covered....
Allergic rhinitis
Atopic dermatitis
Urticaria and Angioedema
Insect bites
Food allergy
Anaphylaxis
10. Allergic Rhinitis
Inflammatory disorder of the nasal mucosa
marked by nasal congestion, rhinorrhea, and
itching, often accompanied by sneezing and
conjunctival inflammation.
16. Classification Of Allergic Rhinitis
•Intermittent allergic rhinitis :
Symptoms present for less than 4 days a week , or
for less than
4 consecutive weeks.
• Persistent allergic rhinitis :
Symptoms present for more than 4 days a week
and for more
than 4 consecutive weeks
18. Allergic Rhinitis And Quality Of Life
• Sleep loss or disturbance
• Increased daytime sleepiness
• Learning problems
• Reduction in work productivity
19. Diagnosis
The 3 most common tests used to confirm
the diagnosis
1)Skin testing
2)Nasal smear
3) In vitro testing for serum levels of specific IgE
antibodies.
20. Prevention : Avoidance Of Allergens
• Removing a pet from the house
• Covering pillows and mattresses
• Washing bedding with hot water
• Vacuuming mattresses and pillows.
No dry dusting
21. Pharmacotherapy
Drug type Itch /
sneezing
Discharge Blockag
e
Impaire
d smell Preparation
Antihistamin
es
+++ ++ + - Fexofenadin
e
Cetrizine
Anticholinergic
s
- +++ - - Ipratropium
Decongesta
nts
- +++ ++ - Xylometazoli
ne
Oxymetazoli
ne
Mast Cell
Stabilizers
+ + - - Sodium
cromoglycat
e
22. Atopic Dermatitis
Chronic Relapsing Skin Disease
Most commonly during early infancy and
childhood
AD remains a clinical diagnosis
Pruritus is a consistent feature
Family history of atopic disease (asthma, allergic
rhinitis, atopic dermatitis)
23. Etiology
Complex integration of environmental and genetic
factors
Wool, harsh detergents are particularly irritating
Emotional stress can lead to flares
Exclusive breast feeding for first 3 months of life
is associated with lower incidence rates of atopic
dermatitis during childhood in children with a
family history of atopy
24. In healthy people, the skin acts as a protective
barrier against external irritants, moisture loss, and
infection.
Proper function of the skin depends on adequate
moisture and lipid content, functional immune
responses, and structural integrity.
Severely dry skin is a hallmark of AD.
This results from compromise of the epidermal
barrier, which leads to excess transepidermal water
loss, allergen penetration, and microbial
colonization.
25. Filaggrin
Structural protein in the epidermis
It is critical to skin barrier function.
Genetic mutations in the filaggrin gene family have
been identified in up to 50% of patients with severe
AD.
26. Clinical features
Vary with the age
Infancy:
Ill-defined scaling,
erythematous patches
and confluent,
edematous papules and
vesicles are typical.
Scalp and face are
most often involved
When crawling :
extensor surfaces
especially knees are
involved
27. Childhood
Lesions are drier, less
eczematous, involve
flexural areas & neck
Scaling, fissured &
crusted hands
become troublesome
Infraorbital folds
(Morgan lines)
28. Chronic or chronically relapsing
Pruritic, erythematous papulovesicular eruptions that
progress to scaling lichenified dermatitis is common.
29. Diagnosis
Radioallergosorbent tests (RASTs) or skin tests
may suggest dust mite allergy.
Eosinophilia and increased serum IgE levels may
be present but are nonspecific.
30. Treatment
Reduction of trigger factors
Bland emollients, mild non alkali soaps
Scented soaps and oil can be irritating
Cotton clothing is preferable to wool and synthetics
Topical steroids
Systemic steroids for severe, acute flares
Calcineurin inhibitors: tacrolimus, pimecrolimus: no
skin atrophy, therefore, useful on face and neck
Antihistamines helpful in breaking itch-scratch cycle
31. Urticaria and Angioedema
Urticaria (hives) is a vascular reaction of the skin
characterized by wheals surrounded by a red
halo or erythema.
Cardinal symptom is PRURITUS
Caused by swelling of the upper dermis
Up to 20% of the population experience urticaria
at some point in their lives
33. Angioedema can be caused by the same pathogenic
mechanisms as urticaria, but the pathology is in the
deep dermis and subcutaneous tissue.
Swelling is the major manifestation
Commonly affects the face or a portion of an
extremity
May be painful or burning, but not pruritic
May last several days
35. COMMON CAUSES OF ACUTE
URTICARIA
Idiopathic
Upper respiratory streptococcal infections, helminthes
Food reactions
Shellfish, nuts etc.
Drug reactions
IV administration Blood products, contrast agents
36. ETIOLOGY OF CHRONIC
URTICARIA
Idiopathic: over 50% of chronic urticaria
Physical urticarias: many patients with chronic
urticaria have physical factors that contribute to their
urticaria
These factors include pressure, cold, heat, water
(aquagenic), sunlight (solar), vibration, and
exercise
Cholinergic urticaria is triggered by heat and
emotion
37. DERMATOGRAPHISM
Most common form of
physical urticaria
Sharply localized
edema or wheal within
seconds to minutes
after the skin has
been rubbed
Affects 2-5% of the
population
38. PATHOPHYSIOLOGY
The mast cell is the major effector cell in urticaria
Immunologic Urticaria: antigen binds to IgE on
the mast cell surface causing degranulation,
which results in release of histamine
Histamine binds to H1 and H2 receptors to cause
arteriolar dilatation, venous constriction and
increased capillary permeability.
39. Non-Immunologic Urticaria: not dependent on the
binding of IgE receptors
For example, aspirin may induce histamine
release through a pharmacologic mechanism
where its effect on arachidonic acid metabolism
causes a release of histamine from mast cells.
• Physical stimuli may induce histamine release
through direct mast cell degranulation
40. CLINICAL FINDINGS
Lesions typically appear over the course of minutes,
enlarge, and then disappear within hours
Individual wheals rarely last >12hrs
Erythema blanches with pressure
Urticaria may be acute or chronic
Acute = new onset urticaria < 6 weeks
Chronic = recurrent urticaria (most days) > 6
weeks
Most urticaria is acute and resolves
41. Diagnosis
Urticaria is a clinical diagnosis
A detailed history and physical examination
If a physical urticaria is suspected, a challenge test with
the respective trigger may be performed
IgE-mediated food allergy is far more likely to present
with acute urticaria
A detailed food diary or dietary modification may reveal
foods (or additives) that cause fluctuations in symptoms
of chronic urticaria
Allergy testing is not routinely performed in patients with
42. Treatment
The following are examples of H1 antihistamines:
• 1st Generation
- Diphenhydramine
- Hydroxyzine
- Chlorpheniramine
• 2nd Generation
- Cetirizine
- Loratadine
- Fexofenadine
43. Epinephrine 1 : 1,000, 0.01 mL/kg intramuscularly
– rarely needed
Cyclosporine 4-6 mg/kg/day has been effective in
some adults with chronic urticaria but its use is
limited by hypertension and/or nephrotoxicity .
44. Insect bites
Allergic responses to stinging :
1. Localized cutaneous reactions
2. Systemic anaphylaxis
Allergic reactions that are caused by inhalation of
airborne particles of insect origin result in:
1. Acute or 2.Chronic respiratory symptoms
seasonal or perennial:
i. Rhinitis
ii. Conjunctivitis
iii. Asthma
45. Most reactions to biting and stinging insects are
limited to a primary lesion isolated to the area of
the bite and do not represent an allergic
response.
Occasionally, insect bites or stings induce
pronounced localized reactions or systemic
reactions that may be based on:
1. Immediate or
2. Delayed hypersensitivity reactions.
46. Members of the order Hymenoptera include:
i. Apids:
* Honeybee * Bumblebee
ii. Vespids
* Yellow jacket * Wasp * Hornet
iii. Formicids
* Fire ants * Harvester ants
47. Clinical features
Insect bites are usually urticarial but may be papular
1.Simple local reactions
i. Involve limited swelling
ii. Pain
iii. Generally last <24 hr.
2.Large local reactions
i. Develop over hours and days
ii. involve swelling of extensive areas (>10 cm)
iii. May last for days
48. 3.Generalized cutaneous reactions
Typically progress within minutes and include cutaneous
symptoms of :
i. Urticaria
ii. Angioedema
iii. Pruritus
beyond the site of the sting
4.Systemic reactions
are identical to anaphylaxis from other triggers and
may includes symptoms of:
i. Generalized urticaria
ii .Laryngeal edema
iii. Bronchospasm
iv. Hypotension
49. 5. Toxic reactions
Stings from a large number of insects at once may
result
in toxic reactions of :
i. Fever ii. Malaise iii. Emesis iv. Nausea
6.Delayed/Late reactions
i. Serum sickness
ii. Nephrotic syndrome
iii. Vasculitis
iv. Neuritis
v. Encephalopathy
51. The primary reasons to pursue skin prick testing
are to confirm reactivity when:
i. Venom immunotherapy (VIT) is being
considered
ii. It is clinically necessary to confirm venom
hypersensitivity as a cause of a reaction
52. Treatment
At local site:
i. Cold compresses
ii. Topical medications to relieve itching
iii. oral antihistaminics, analgesic
Anaphylactic reactions after a sting are treated exactly
like anaphylaxis from any cause
Stingers should be removed promptly by scraping, with
caution not to squeeze the venom sac because doing so
could inject more venom
Sting sites rarely become infected, possibly owing to the
antibacterial actions of venom constituents
53. Venom Immunotherapy(VIT)
Hymenoptera VIT is highly effective (95-97%) in
decreasing the risk for severe anaphylaxis.
Immunotherapy against Hymenoptera is indicated
in those ≥17 yr of age who have specific IgE to
venom allergens and a history of generalized
urticaria or a systemic reaction
54. Prevention
Avoidance of stings and bites is essential to
reduce the risk of stings, sensitized individuals
should:
1. Avoid attractants – perfumes, bright-colored
clothing outdoors
2. Wear gloves when gardening
3. Wear long pants and shoes with socks when
walking in the grass or through fields
55. Drug allergy
Drug allergy is an abnormal response to the
medicine or metabolites through immunological
reactions are known as hypersensitivity reaction
that occurs during or after use of the drug.
56. Classification of ADR
• Type A (pharmacological 85-90%) –
PREDICTABLE
– Side effects
– Drug interactions
– Drug toxicity
• Type B (Hypersensitivity) – UNPREDICTABLE
– Hypersensitivity
– Idiosyncratic reactions
– Pseudoallergy
57. CLINICAL FEATURES
Severe skin reactions, often on the palms and soles.
Fever, sometimes as high as 104 degrees F, is
always present and usually appears before the skin
rash.
Joint pain (50%) - usually seen in the larger joints,
but occasionally the finger and toe joints may also be
involved.
Swelling of lymph nodes, particularly around the
site of the injection, is seen in 10-20% of cases.
Urine analysis may show traces of blood and protein
in the urine.
Other symptoms may include changes in vision, and
58. Erythema multiforme and Steven Johnson
Syndrome:
Cotrimoxazole
Penicillin
Tetracyclines
NSAIDs
Anticonvulsant
61. Fixed Drug Eruption
Patients may complain of burning in the affected area
before the appearance of lesions but systemic
symptoms are usually absent.
The period required for sensitization
ranges from weeks to years and
the time between drug administration
& eruption can be anything from a
day or two to a few weeks.
It is so named because the site of
the eruption is FIXED
It occurs in exactly the same place
when the same drug is again
encountered
62. Treatment
Discontinuation of the drug.
When the drug is considered to be very important
and cannot be replaced, can continue to be
provided with the approval of the family, and by
way of desensitization.
Mild clinical manifestations – no treatment
needed.
For pruritus, urticaria or edema -antihistamines
When very severe clinical symptoms - supportive
treatment with corticosteroids and maintain fluid
and electrolyte needs, transfusion, antibiotic
63. Food allergy
Adverse reactions to foods consist of any
untoward reaction following the ingestion of a
food or food additive and are classically divided
into
food intolerances which are adverse physiologic
responses
food allergies which are adverse immunologic
responses
When allergens are encountered in the GI
system, they activate an immune response. The
allergic cascade is activated and response is
66. Clinical features
Gastrointestinal :
1) Food protein–induced enterocolitis syndrome
(FPIES) typically manifests in the first several
months of life as irritability, intermittent vomiting and
protracted diarrhoea
2) Food protein-induced proctocolitis
presents in the first few mo of life as blood-streaked
stools in otherwise healthy infants
67. 3) Food protein–induced enteropathy
often manifests in the first several months of
life as diarrhea, often with steatorrhea and
poor weight gain
4) Eosinophilic gastroenteropathies may
appear from infancy through adolescence,
more frequently in boys manifests as chronic
gastroesophageal reflux, intermittent emesis,
food refusal, abdominal pain, dysphagia,
irritability, sleep disturbance, and failure to
respond to conventional reflux medications
69. Treatment
Appropriate identification and elimination of foods
responsible for food hypersensitivity reactions are
the only validated treatments for food allergies.
70. Anaphylaxis
Anaphylaxis is defined as a serious allergic
reaction that is rapid in onset and may cause
death.
Anaphylaxis in children, particularly infants, is
underdiagnosed.
Anaphylaxis occurs when there is a sudden
release of potent biologically active mediators
from mast cells and basophils leading to
symptoms
71.
72.
73. Diagnosis of Anaphylaxis
Anaphylaxis is highly likely when any 1 of the following 3 criteria
is fulfilled:
1. Acute onset of an illness (minutes to several hours) with
involvement of the skin and/or mucosal tissue
AND AT LEAST 1 OF THE FOLLOWING:
a. Respiratory compromise
b. Reduced BP or associated symptoms of end-organ dysfunction
2. Two or more of the following that occur rapidly after exposure to
a likely allergen for that patient (minutes to several hours):
a. Involvement of the skin/mucosal tissue
b. Respiratory compromise
c. Reduced BP or associated symptoms
d. Persistent gastrointestinal symptoms
3. Reduced BP following exposure to known allergen for that
Patients with mutations in the human FOXP3 gene lack Treg cells and develop severe immune dysregulation, with
polyendocrinopathy, food allergy, and high serum IgE levels
When the body is first subjected to the allergen (antigen), the condition is referred to
as primary exposure. Because no antibodies has been formed previously, no symptoms of the allergy are produced during the primary
exposure. However during the subsequent exposure, the allergen contacts the antigen-antibody reactions.
During secondary expose the antibody become attach to the mast cells-white blood cells (basophils), and form a complex and as a result basophils burst due to antigen-antibody reaction causes a liberation of histamine, bradykinin and other mediators of allergic symptoms.
Allergic shiners : blackish discolouration and puffiness under eyes
Allergic salute : habitual upward stroking of the nose to relieve itching and wipe off secretions
Hyponasility : rhinolalia clausa
Cobblestoning of naopharynx : due to lymphoid aggregates, inflammation
Nasal smear in allergic rhinitis shows presence of eosinophils
The consequence of epidermal barrier dysfunction and an altered stratum corneum leading to increased transepidermal water loss
Erythema Multiforme
• A self-limiting cutaneous hypersensitivity reaction to infection (mostly) or drugs