Nimesulide is a pain reliever used for relief of acute pain, painful osteoarthritis, and period pains. It is prescribed by doctors for those over 12 years old and has superior gastrointestinal safety compared to other nonsteroidal anti-inflammatory drugs (NSAIDs). The usual oral dose is 100mg twice daily for up to 15 days to minimize risk of liver toxicity, and it can also be used as a topical gel for relief of pain from sprains and tendinitis. Studies show nimesulide is as effective as paracetamol in reducing fever and discomfort in children with upper respiratory infections. It should only be prescribed after other options are considered due to potential risks.

1. Nimesulide Drug
Nimesulide drug is also known as nice tablet. Nimesulide is use for pain relief.
nimesulide drug is best pain killer which effects and give best result. nimesulide
drug is used by above 12 year person both for male and female. nimesulide drug
should taken by physician and doctor instruction.
Nimesulide Dose
Nimesulide dose should be taken by prescription of physician and doctor which
will help to take proper dose for good result.
The usual dose is 100mg twice a day.
Children: 5mg/kg of body weight in 2 or 3 divided doses.
Nimesulide Advantages
 Nimesulide has superior gastrointestinal safety as compared to other NSAIDs.
 Its multifactorial mode of action gives it a unique and broad action on
inflammatory processes.
 It has proven benefits in the treatment of Acute (short term) pain, Painful
osteoarthritis (Swelling in the joints) and Primary dysmennorhea ( Period
Pains).
Nimesulide Usage
The prescription of a drug is appropriate when the benefit it is able to provide to a
specific patient outweigh the risks associated with its use. A careful evaluation of
individual risk factors is therefore of crucial importance.
In practice, a prescription can be considered appropriate when it is in accordance
with the approved indications of a drug in terms of demonstrated efficacy,
dosage, and treatment duration.

2. As for other NSAIDs the use of nimesulide is recommended for the shortest
duration necessary to control symptoms in patients with acute pain or primary
dysmenorrhoea.
The maximum duration and dose of a treatment course with nimesulide is 15
days, 100 mg twice a day, to minimize the risk of hepatotoxicity.
Nimesulide should only be prescribed as second line treatment. The decision to
prescribe nimesulide should be based on assessment of the individual patient’s
overall risks
Nimesulide and paracetamol
The efficacy and tolerability of nimesulide were compared with those of
paracetamol in a nonblind randomised study that recruited 110 children (64
males, 46 females; aged 3 to 6 years) with inflammation of the upper respiratory
tract and fever. Nimesulide suspension (1.5 mg/kg 3 times daily) or paracetamol
syrup (10 mg/kg 4 times daily) were administered orally until fever resolved. Body
temperature was recorded and local pain and general discomfort assessed. Three
patients treated with nimesulide and 6 patients treated with paracetamol
withdrew from the study as a result of adverse events, and 1 paracetamol-treated
patient discontinued because of a requirement for therapy with steroids.
Nimesulide was as effective as paracetamol in reducing fever, local pain, and
general discomfort. Nimesulide therefore appears to be at least as effective as
paracetamol in terms of antipyretic and anti-inflammatory activity in children
with inflammation of the upper respiratory tract and fever.
Nimesulide Gel
Nimesulide gel preparations for localized topical application are indicated for the
treatment of symptomatic relief of pain associated with sprains and acute
traumatic tendinitis.