The European Medicines Agency has finished an review of the security and viability of solutions containing Nimesulide (capsules, tablets, suppositories and powder or granules for oral suspension).
Non-steroidal anti-inflammatory drug – Nimesulidesonucro
Nimesulide medication is a non-steroidal anti-inflammatory drug with analgesic and antyperetic properties, prescribed for painful inflammatory conditions, back pain, dysmenorrhea and etc.
Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which means it provides analgesic (pain-killing) and antipyretic(fever-reducing) effects. Nimesulide is mostly used for treatment of short-term pain(Acute), joint pain (osteoarthritis), period pains (Primary dysmennorhea), Chronic pains and many.
Non-steroidal anti-inflammatory drug – Nimesulidesonucro
Nimesulide medication is a non-steroidal anti-inflammatory drug with analgesic and antyperetic properties, prescribed for painful inflammatory conditions, back pain, dysmenorrhea and etc.
Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which means it provides analgesic (pain-killing) and antipyretic(fever-reducing) effects. Nimesulide is mostly used for treatment of short-term pain(Acute), joint pain (osteoarthritis), period pains (Primary dysmennorhea), Chronic pains and many.
Nigerian growers beat high temperatures with new dry-season groundnut varieti...ICRISAT
Not only are farmers, who have previously concentrated on vegetables, green maize and wheat, able to get worthwhile groundnut yields, they can also supply the market for maximum returns at a time of peak demand. The practice of dry season irrigation provides an important source of food, income and employment, and has expanded significantly over the last few years because of increasing demand for food and animal feed due to increasing population and pressure on land.
Какой бы ни была система, микросистема или макросистема, наборы правил, определяющих существование в ней подсистем и органов, определяют способы и правила взаимодействия этих подсистем и организмов друг с другом.
Что же такое ЕДИНОМЫСЛИЕ, по отношению к одним и тем же исходным объектам, и субъектам и способам их взаимодействия?
Принципы и основные направления применения систем управления бизнесом и взаимодействием с внешним миром Асис Софт, г. Зеленоград www.asys.ru
Объекты и субъекты связаны информационными и коммуникационными технологиями
World Journal of Engineering and Technology, 2014, 2, 55-67
Published Online May 2014 in SciRes. http://www.scirp.org/journal/wjet
http://dx.doi.org/10.4236/wjet.2014.22006
Nimesulide also improves the skin tone and to increase in energy levels. Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics.
Its binding conformation and interaction mode were studied with molecular docking experiments. Compound 20f could become a lead compound for further development for potential anti-inflammatory drugs.
Nimesulide also improves the skin tone and to increase in energy levels. Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics.
Unlike, other NSAIDs, the chemical structure of nimesulide does not contain a carboxylic group but a sulfonanilide moiety as the acidic group.
Nigerian growers beat high temperatures with new dry-season groundnut varieti...ICRISAT
Not only are farmers, who have previously concentrated on vegetables, green maize and wheat, able to get worthwhile groundnut yields, they can also supply the market for maximum returns at a time of peak demand. The practice of dry season irrigation provides an important source of food, income and employment, and has expanded significantly over the last few years because of increasing demand for food and animal feed due to increasing population and pressure on land.
Какой бы ни была система, микросистема или макросистема, наборы правил, определяющих существование в ней подсистем и органов, определяют способы и правила взаимодействия этих подсистем и организмов друг с другом.
Что же такое ЕДИНОМЫСЛИЕ, по отношению к одним и тем же исходным объектам, и субъектам и способам их взаимодействия?
Принципы и основные направления применения систем управления бизнесом и взаимодействием с внешним миром Асис Софт, г. Зеленоград www.asys.ru
Объекты и субъекты связаны информационными и коммуникационными технологиями
World Journal of Engineering and Technology, 2014, 2, 55-67
Published Online May 2014 in SciRes. http://www.scirp.org/journal/wjet
http://dx.doi.org/10.4236/wjet.2014.22006
Nimesulide also improves the skin tone and to increase in energy levels. Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics.
Its binding conformation and interaction mode were studied with molecular docking experiments. Compound 20f could become a lead compound for further development for potential anti-inflammatory drugs.
Nimesulide also improves the skin tone and to increase in energy levels. Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics.
Unlike, other NSAIDs, the chemical structure of nimesulide does not contain a carboxylic group but a sulfonanilide moiety as the acidic group.
Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a selective Cox-2 anti-inflammatory drug. This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatory drug.
NSAIDs- Nimesulide, is the first line pharmacological approaches to postoperative headache.
It is also used for the treatment of acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders, acute pain, osteoarthritis, primarydysmenorrhoea.
Dosage & When it is to be taken :
The usual dose is 100mg twice a day.
Children: 5mg/kg of body weight in 2 or 3 divided doses.
Nimesulide gives rapid onset of pharmacological action, good pain relief and stable effect for many hours is an ideal drug for postoperative headache with no contraindications.
Nimesulide Granules is non-steroidal anti-inflammatory drugs, indicated for the treatment of juvenile chronic arthritis, postoperative pain, acute pain after trauma and primary dysmenorrhea.
Nimesulide is available in the market in various forms including tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).
Nimesulide Gel should be applied to the affected area, for 2 to 4 times every day.
Gel is used for the treatment of chronic and acute musculoskeletal disorders including discomfort in the muscles, tendonitis (cord), back pain/ache, arthritis, tenosynovitis(swelling in tendon) sprains, or strains.
Some patients were analysed for assessing the efficacy and safety of this gel. This studies results in better relief from pain and inflammation(redness/ swelling in a part of a body) parameters in more number of patients with nimesulide Gel.
Nimesulide exhibited better efficacy, and demonstrated faster onset of action. Nimesulide provides significant analgesic (painrelief) activity when applied topically. Peak analgesic effect was observed at 120 min from treatment.
It functions by inhibiting particular nerve impulses sent from the periphery to your central system, leading to a decrease of sensitivity from the kinds of symptoms associated with the conditions above.
The main purpose of Nimesulide tablets is for the treatment of painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.
Nimesulide belongs to a class of medications called non-steroidal anti-inflammatory drugs (NSAIDs) which works by blocking the production of prostaglandins (a chemical associated with pain) thereby relieving pain and inflammation
Apart for the treatment of acute pain, osteoarthritis and primary dysmenorrhoea. Nimesulide is also being widely used for anticancer and antiviral agents.
It has superior gastrointestinal safety as compared to other NSAIDs. It is an analgesic and antipyretic in action, other than its anti inflammatory action.
The safety of Nimesulide has been reported before as well. In conclusion, Nimesulide has better antipyretic effect in children in the doses used in the study and appears to be safe for use in them.
Clinical studies have been carried out in a wide variety of acute inflammatory and painful conditions with the aim of evaluating the analgesic activity of nimesulide in comparison to placebo and to some of the most common NSAIDs.
Nimesulide is a recently developed analgesic, antipyretic and anti-inflammatory agent that differs from conventional nonsteroidal anti-inflammatory drugs both in structure and pharmacological profile.
Nimesulide is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, Nimesulide should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. Nimesulide has a solubility of approximately
<200 μg/ml in a 10% DMSO in PBS (pH 7.2) solution using this method.
NSAID drug NImesulide has proven benefits in the treatment of Acute (short term) pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea (Period Pains).
Nimesulide is available in various forms like Nimesulide Tablets, Nimesulide Powder, Nimesulide Gell, suppositories etc.
Nimesulide is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).
It is recommended to use the dosage of 20mg. Over dosage may cause certain side effects like headaches, insomnia, diarrhoea, nausea and abdominal pain.
Omez is used for short-term treatment of Pet Dukhna, ulcers of the stomach or small intestines, Hyperacidity, Epigastric pain, Stomach upset, Gas, Indigestion, Gastric, Jalan, Badhazmi, Pet Dukhna, Bloating, Belching, Reflux and Gastritis problem.
The abilities of NSAID’s drug Nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety with highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.
Nimesulide is generally utilized as a part of the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
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As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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1. Nimesulide medicine uses
Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a
cyclooxygenase- 2 inhibitor. It has become a leading NSAID in over 50 countries
worldwide.
Nimesulide tablet is used for the treatment of osteoarthritis, postoperative trauma, sports
injuries, acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains,
strains and low back pain, ear, nose and throat disorders
Nimesulide a specific Cox-2 anti-inflammatory medication which have been turned out to
be fundamentally more suitable in giving symptomatic alleviation for intense agony,
symptomatic treatment of horrifying degenerative joint sickness and first dysmenorrhoea.
Usage of Nimesulide 100mg- Tablet:
Nimesulide has less gastrointestinal adverse effects than other NSAIDs
It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to
placebo.
Its multifactorial mode of action gives it a unique and broad action on inflammatory.
Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in
relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media
with concomitant antibiotic treatment.