Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) that should only be prescribed as a second line treatment to reduce acute pain and treat conditions like degenerative joint disease and dysmenorrhoea. While it has superior gastrointestinal safety compared to other NSAIDs and helps treat various pains and symptoms, it should only be used for the shortest necessary period based on an assessment of individual patient risk. Nimesulide has a complex mode of action and is available as a gel, powder, or under various brand names in over 50 countries as a pain killer with quick analgesic effects.