This document provides an overview and reference manual for the Nexys4 DDR FPGA board. It describes the board's features such as the Artix-7 FPGA, memory resources, ports, and peripherals. It also provides details on power supplies, FPGA configuration options, and migrating designs from the original Nexys4 board. The manual is intended to help users understand and utilize the capabilities of the Nexys4 DDR board.