The document discusses electrodiagnostic studies, which use electrical impulses and electrodes to evaluate the nervous system and determine if there are any problems, and if so, where they are located. It focuses on nerve conduction studies (NCS), which test motor and sensory nerves. NCS examine how fast nerves conduct impulses and the shape of the nerve response. The document also discusses H-reflex and F-wave testing, which electrically assess spinal reflexes and motor neurons. Key differences between H-reflexes and F-waves are outlined. The goal of electrodiagnostic studies is to correctly diagnose nervous system issues.
Late response are the most helpful findings in some of the diseases affecting the peripheral nerves, (e.g GBS, Radiculopathies, ). How to assess these responses while performing Nerve Conduction Studies, is the most technical and theoretical consideration.... Here we go with the same things in the stated slides
Late response are the most helpful findings in some of the diseases affecting the peripheral nerves, (e.g GBS, Radiculopathies, ). How to assess these responses while performing Nerve Conduction Studies, is the most technical and theoretical consideration.... Here we go with the same things in the stated slides
what is RNS and what the techniques to perform this test in the lab. Its significance in the evaluation and diagnosis of NMJ disorders like MG, LEMBS etc..
This presentation is an introduction to the principles of Nerve Conduction Study and is entirely sourced from the book by David C Preston and Barbara E Shapiro: Electromyography and Neuromuscular disorders, 3rd Edition
Electrotherapy: a subject of physiotherapy usually dealt in second or sometimes first year bachelor of physiotherapy students. the subject deals with; various recent machines which are used to treat patients with pain and discomfort.
Therapeutic Ultrasound for Physiotherapy studentsSaurab Sharma
This lecture intends to provide general outline about the uses, parameters, precautions and contraindications of therapeutic ultrasound for undergraduate physiotherapy students at Kathmandu University School of Medical Sciences, Nepal. After the lecture, students will explore the evidences about current practices of therapeutic ultrasound in various musculoskeletal pain conditions, critically appraise them and present the evidences to the class.
There are few diagnostic tests that a Physiotherapist performs in routine. These tests provide insights to a diagnosis. Faradic galvanic test, Reaction of Degeneration test, F wave and H reflex are mentioned over here. This helps a student to peak into the fantastic tools that a good physio uses to get maximum benefits in developing diagnostic skills,.
what is RNS and what the techniques to perform this test in the lab. Its significance in the evaluation and diagnosis of NMJ disorders like MG, LEMBS etc..
This presentation is an introduction to the principles of Nerve Conduction Study and is entirely sourced from the book by David C Preston and Barbara E Shapiro: Electromyography and Neuromuscular disorders, 3rd Edition
Electrotherapy: a subject of physiotherapy usually dealt in second or sometimes first year bachelor of physiotherapy students. the subject deals with; various recent machines which are used to treat patients with pain and discomfort.
Therapeutic Ultrasound for Physiotherapy studentsSaurab Sharma
This lecture intends to provide general outline about the uses, parameters, precautions and contraindications of therapeutic ultrasound for undergraduate physiotherapy students at Kathmandu University School of Medical Sciences, Nepal. After the lecture, students will explore the evidences about current practices of therapeutic ultrasound in various musculoskeletal pain conditions, critically appraise them and present the evidences to the class.
There are few diagnostic tests that a Physiotherapist performs in routine. These tests provide insights to a diagnosis. Faradic galvanic test, Reaction of Degeneration test, F wave and H reflex are mentioned over here. This helps a student to peak into the fantastic tools that a good physio uses to get maximum benefits in developing diagnostic skills,.
Entrapment Neuropathies in Upper Limb.pptxNeurologyKota
This presentation is about the entrapment syndrome of upper limb giving an insight regarding diagnosis clinically as well as electrophysiologically and
its management.
A person suffering from pain in teres major or teres minor pain can feel symptoms of pain at the back of the upper arm when they stretch their arm forward to reach up something. Teres major and minor pain or injuries can be treated with various types of exercise, gels, therapy wraps, and workouts.
"Knee locking" is quite literally when your knee locks up momentarily, inhibiting your ability to move in any direction. This can also be described as "catching" where it feels as if your knee gets caught during extension or flexion, the knee
"giving out," or as a popping sensation with knee movement. Unfortunately, there is no "key" or secret trick to unlock your knee joint, though various treatments exist to help with knee locking symptoms.
The Anterior Chest Wall Release was originally called the Thoracic Inlet Release, which is semantically misleading and anatomically incorrect. The fascia throughout the anterior and posterior chest wall is the only known physical structure that can be affected during this release.
Tender points are areas of the body that experience different types of pain when pressure is applied to them.
A Trigger Point (TrP) is a hyperirritable spot, a palpable nodule in the taut bands of the skeletal muscles' fascia.
This review summarizes the structure of ligaments and tendons, the roles of their constituent components for load transfer across the hierarchy of structure, and the current understanding of how damage occurs in these tissues.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
1. The entire purpose of electro diagnostic studies is to help you figure out whether there is a problem
in the nervous system and if so, where the problem is occurring.
NCS are done by placing electrodes on the skin and stimulating the nerves through electrical
impulses. To study motor nerves, electrodes are placed over a muscle that receives its innervation
from the nerve you want to test (stimulate). The electrical response of the muscle is then recorded
and you can determine both how fast and how well the nerve responded. This is very valuable
information and can help you to determine whether the patient’s condition is stemming from a
problem with the nerve or the muscle.
The electrodiagnostic process:
1. Evaluate the patient by doing a history and physical examination with the goal of developing
a differential diagnoses list.
2. Select the appropriate electrodiagnostic tests you want to perform in order to rule in or out
diagnoses on your list.
3. Explain to the patient what the test will feel like and why it is being done.
4. Perform the study in a technically competent fashion, usually starting with the nerve
conduction studies and then proceeding with the EMG.
5. Interpret the results in order to arrive at the correct diagnosis or to narrow your list of
differential diagnoses.
6. Communicate the test results to the referring physician in a timely and meaningful manner.
NCS are broken down into two categories: motor and sensory nerve conduction testing. The
autonomic nervous system can be tested, but rarely has clinical applications and is beyond the scope
of this text. NCS can be performed on any accessible nerve including peripheral nerves and cranial
nerves. The basic findings are generally twofold: 1. how fast is the impulse traveling? (e.g., how well
is the electrical impulse conducting?); and, 2. what does the electrical representation of the nerve
stimulation (action potential morphology) look like on the screen? (e.g., does there appear to be a
problem with the shape or height that might suggest an injury to some portion of the nerve such as
the axons or the myelin?)
2. The H-reflex is a monosynaptic or oligosynaptic spinal reflex involving both motor and sensory fibers.
It electrically tests some of the same fibers as are tested in the ankle jerk reflexes. In fact it is rare to
be unable to obtain an H-reflex in the presence of an ankle jerk reflex. If this occurs, technical factors
should be considered. In theory it is a sensitive measure in assessing radiculopathy because 1. it
helps to assess proximal lesions, 2. it becomes abnormal relatively early in the development of
radiculopathy, and 3. it incorporates sensory fiber function proximal to the dorsal root ganglion. The
H reflex primarily assesses afferent and efferent S1 fibers. Clinically, L5 and S1 radiculopathies may
appear similar on EMG due to the overlap of myotomes. H-reflexes are probably of greatest value in
distinguishing S1 from L5 radiculopathies. When assessing for S1 radiculopathy, the H-reflex latency
is recorded from the gastrocnemius-soleus muscle group upon stimulating the tibial nerve in the
popliteal fossa. The H-reflex is elicited with a submaximal stimulation with the cathode proximal to
the anode. As the intensity of the stimulation is gradually increased from peak H-amplitude, we
generally see a diminishment of the H-amplitude with a concurrent increase in the M wave
amplitude. With supra maximal stimulation, the H-reflex is usually absent. The H-reflex can also be
used in C6/C7 radiculopathy by recording over the flexor carpi radialis muscle and stimulating the
median nerve at the elbow. The median H-reflex is less commonly performed and clinically is less
likely to be helpful for radiculopathy than a lower extremity H-reflex. Generally, gastrocnemius-
soleus H-reflex latency side-toside differences of greater than 1.5 ms are suggestive of S1
radiculopathy. Although the H-reflex is sensitive, it has certain limitations: 1. patients with S1
radiculopathy can have a normal H-reflex; 2. an abnormal H-reflex is only suggestive, but not
definitive for radiculopathy because the abnormality may originate in other components of the long
pathway involved, such as the peripheral nerves, plexuses, or spinal cord; 3. once the H-reflex
becomes abnormal, it usually does not return to normal, even over time; and finally the H-reflex is
often absent in otherwise normal individuals over the age of 60 years. The reflexes therefore can be
considered a sensitive, but not specific indicator of pathology. Latency of the H-reflex is dependent
on the age and leg length of the patient. A side-to-side amplitude difference of 60% or more may
also indicate pathology. F-waves are low amplitude late responses thought to be due to antidromic
activation of motor neurons (anterior horn cells) following peripheral nerve stimulation, which then
cause orthodromic impulses to pass back along the involved motor axons. Some electromyographers
have called this a ‘backfiring’ of axons. It is called the F-wave because it was first noted in intrinsic
foot muscles. The F-wave has small amplitude, a variable configuration, and a variable latency.
Generally F-wave amplitudes are up to 5% of the orthodromically generated motor response (M-
response). The most widely used parameter is the latency of the shortest reproducible response. The
F-wave can be found in many muscles of the upper and lower extremities. Unfortunately F-waves
have not turned out to be as sensitive a test as initially hoped. The reasons for this are: 1. the
pathways involve only the motor fibers, 2. as with the H-reflex, it involves a long neuronal pathway
so that if there is a focal lesion it might be obscured, 3. if an abnormality is present, the F-wave will
not pinpoint the exact location because any lesion, from the anterior horn cell to the muscle being
tested, can affect the Fwave similarly, 4. since muscles have multiple root innervations, the shortest
latency may reflect the healthy fibers in the non-affected root, and 5. the latency and amplitude of
an F-wave is variable so that multiple stimulations must be performed to find the shortest latency. If
not enough stimulations are done (usually more than 10), the shortest latency may not be apparent.
Thus, use of Fwaves in evaluating for radiculopathy are extremely limited and should not be the sole
basis upon which the diagnosis is made.
F-wave Ratio Because errors can occur when measuring distances for F-wave conduction velocities,
an alternative F-wave technique was developed which did not require distance measurements. The
ratio is as follows:
3. (M = CMAP latency; this ratio may be rewritten as (F – M – 1)/2 M). The ratio assumes that the
distance from the elbow (or knee) to the hand (or foot) is approximately equal to the distance from
the elbow (or knee) to the spinal cord. Therefore, stimulation must be performed at the elbow or
knee. The normal F-wave ratio in the upper limb is approximately 1 ± 0.3 and in the lower limb the
normal F-ratio is 1.1 ± 0.3. A ratio higher than 1.3 indicates a proximal lesion, since the numerator of
the equation includes the proximal stimulation from the F-wave. A ratio below 0.7 indicates a distal
lesion, since a larger CMAP latency will decrease the numerator and increase the denominator.
Therefore, an F-ratio is not necessarily more sensitive than F-latency, but it does allow one to assess
whether the slowing is in the proximal or distal segment of the nerve. It should be noted that F-
waves are non-specific. Therefore, interpreting NCS results using F-waves must be done in
conjunction with other information.
Comparison of H-reflex and F-wave
Parameter H-reflex F-wave
Derivation of name Originally described Originally obtained in
by Hoffman foot muscles
Type of synapse Monosynaptic or oligosynaptic Polysynaptic
Pathway Sensory orthodromic Motor antidromic
Motor antidromic Motor orthodromic
Stimulus required Submaximal (stronger stimulation
produces inhibition secondary to
collision of orthodromic impulses by
antidromic conduction in motor
axons)
Supramaximal
Where they can be Soleus Most muscles (distal preferred)
elicited? (Normals) Flexor carpi radialis
Stimulation site Posterior tibial nerve in popliteal
fossa
Along peripheral nerve
Stimulus cathode Proximal Proximal
Size of response Amplification of motor Small (motor neurons are
(compared to M) response centrally activated infrequently with
(due to reflex activation of motor
neurons)
antidromic stimulation)
Facilitation Enhanced by maneuvers that increase
motor-neuron pool excitability
(contraction or
CNS lesion)
N/A
Uses S Radiculopathy
1
Demyelinating polyneuropathies
(sensitive but not Guillain–Barré
specific) Proximal nerve or root injury
Guillain–Barré syndrome (not test of choice – non-specific)
Latency, amplitude Reproducible latency Variable in amplitude, latency
4. and configuration and configuration (amplitude
dependent on stimulation)
and configuration
Side-to-side > 1.5 msec >2 msec from hand
difference >3 msec from calf
>4 msec from foot
Ratio N/A ––––––––– F – M – 1
2 M