This review summarizes the structure of ligaments and tendons, the roles of their constituent components for load transfer across the hierarchy of structure, and the current understanding of how damage occurs in these tissues.
Musculoskeletal Biomechanics. Biomechanics in its broadest sense is mechanics (that is the study of loads, motion, stress, and strain of solids and fluids) applied to biological systems. Musculoskeletal Biomechanics is a branch of biomechanics specifically focussing on the musculoskeletal system.
Prior to attending hands on clinical training, Diploma in Osteopathic Manual Practice (DOMP) students are supported by LCO faculty in preparing a thesis dissertation based on a case study or literature review. As part of our ongoing effort to disseminate osteopathic research, we are proud to highlight selected student works.
In her dissertation, Restoration of Bone's Elastic Response Using Osteopathic Techniques”, Canadian based therapist, Vickie Keam, examines how osteopathic treatment approach can be directly guided by the anatomical structure and biomechanical properties of bone tissue.
Human brain tissue is a porous, fluid-saturated, nonlinear solid with very small volumetric drained compressibility and negatively charged molecules, capable of permanent deformations.
It is a multi-component material with viscous contributions to its solid phase deformation.
This article discusses about the relationship between stapling mechanics and mastication biomechanics at molar region. Also it discusses that these two mechanics may belong to an unindentified lever system and the same can be classifed as fourth class lever.
Biomechanics of Tendon, Ligament, Cartilage,, Bone
Wolf's Law
Mechnical Behavior
stress strain curve (Young's Moudulas)
viscoelasticity
time depended and rate depended properties
creep stress relaxation, hyteresis,
Thank You
what biomechanics is and why it's important in understanding ligaments and tendons. structure and composition of ligaments and tendons. the roles of ligaments and tendons in the body and how they contribute to movement and stability. mechanical properties of ligaments and tendons, including strength, elasticity, and viscoelasticity.
Musculoskeletal Biomechanics. Biomechanics in its broadest sense is mechanics (that is the study of loads, motion, stress, and strain of solids and fluids) applied to biological systems. Musculoskeletal Biomechanics is a branch of biomechanics specifically focussing on the musculoskeletal system.
Prior to attending hands on clinical training, Diploma in Osteopathic Manual Practice (DOMP) students are supported by LCO faculty in preparing a thesis dissertation based on a case study or literature review. As part of our ongoing effort to disseminate osteopathic research, we are proud to highlight selected student works.
In her dissertation, Restoration of Bone's Elastic Response Using Osteopathic Techniques”, Canadian based therapist, Vickie Keam, examines how osteopathic treatment approach can be directly guided by the anatomical structure and biomechanical properties of bone tissue.
Human brain tissue is a porous, fluid-saturated, nonlinear solid with very small volumetric drained compressibility and negatively charged molecules, capable of permanent deformations.
It is a multi-component material with viscous contributions to its solid phase deformation.
This article discusses about the relationship between stapling mechanics and mastication biomechanics at molar region. Also it discusses that these two mechanics may belong to an unindentified lever system and the same can be classifed as fourth class lever.
Biomechanics of Tendon, Ligament, Cartilage,, Bone
Wolf's Law
Mechnical Behavior
stress strain curve (Young's Moudulas)
viscoelasticity
time depended and rate depended properties
creep stress relaxation, hyteresis,
Thank You
what biomechanics is and why it's important in understanding ligaments and tendons. structure and composition of ligaments and tendons. the roles of ligaments and tendons in the body and how they contribute to movement and stability. mechanical properties of ligaments and tendons, including strength, elasticity, and viscoelasticity.
CHAPTER 13
WORK-RELATED MUSCULOSKELETAL DISORDERS
LEARNING OBJECTIVE
At the end of the module, the students will have a basic understanding of various musculoskeletal disorders that are caused by occupational exposure to physical workplace risk factors. Anatomy of the muscular and skeletal systems is covered as well as injury and disorder prevention techniques.
INTRODUCTION
Musculoskeletal disorders are a broad class of disorders involving damage to muscles, tendons, ligaments, peripheral nerves, joints, cartilage, vertebral discs, bones, and/or supporting blood vessels. Work-related musculoskeletal disorder (WMSD) is a subcategory; these are injuries and illnesses that are caused or aggravated by working conditions. MSDs are not typically caused by acute events but occur slowly over time due to repeated wear and tear or microtraumas.
WMSDs are also known as cumulative trauma disorders (CTDs), repetitive strain injuries (RSIs), repetitive motion trauma (RMT), or occupational overuse syndrome. Examples of WMSDs include herniated disc, epicondylitis (tennis elbow), tendinitis, de Quervain's disease (tenosynovitis of the thumb), trigger finger, and Reynaud's syndrome (vibration white finger).
Researchers have identified specific physical workplace risk factors for the development of WMSDs: force, posture, compression, repetition, duration, vibration, and temperature. Exposure to these risk factors can result in decreased blood flow, elongation, compression, tears or strains to muscles, tendons, ligaments and nerves as well as disc or joint damage. When present for sufficient duration, frequency, or magnitude, physical workplace risk factors may cause WMSDs. In addition, personal risk factors, such as physical conditioning, existing health problems, gender, age, work technique, hobbies and organizational factors (e.g., job autonomy, quotas, deadlines) contribute to, but do not cause, the development of WMSDs.
Applying ergonomics principles to reduce a worker's exposure to the physical workplace risk factors decreases the chance of injury.
This unit is not designed to impart skills in the diagnoses of WMSDs, only occupational healthcare providers do so. This unit is a background in some of the more common WMSDs and explores anatomic features that are affected by WMSDs. It is written from the view point of an ergonomist and not a healthcare provider. For convenience, this chapter is divided into four sections:
· The musculoskeletal system
· Disorders of the
· spine
· upper extremities
· lower extremities.
THE MUSCULOSKELETAL SYSTEM
The musculoskeletal system's primary functions include supporting the body, allowing motion, and protecting vital organs. The musculoskeletal system is an organ system that gives humans the ability to move using their muscular + skeletal systems (musculoskeletal). The musculoskeletal system provides form, support, stability, and movement to the body. It is made up of the bones of the skeleton, cartilage (framework), musc.
CHAPTER 13
WORK-RELATED MUSCULOSKELETAL DISORDERS
LEARNING OBJECTIVE
At the end of the module, the students will have a basic understanding of various musculoskeletal disorders that are caused by occupational exposure to physical workplace risk factors. Anatomy of the muscular and skeletal systems is covered as well as injury and disorder prevention techniques.
INTRODUCTION
Musculoskeletal disorders are a broad class of disorders involving damage to muscles, tendons, ligaments, peripheral nerves, joints, cartilage, vertebral discs, bones, and/or supporting blood vessels. Work-related musculoskeletal disorder (WMSD) is a subcategory; these are injuries and illnesses that are caused or aggravated by working conditions. MSDs are not typically caused by acute events but occur slowly over time due to repeated wear and tear or microtraumas.
WMSDs are also known as cumulative trauma disorders (CTDs), repetitive strain injuries (RSIs), repetitive motion trauma (RMT), or occupational overuse syndrome. Examples of WMSDs include herniated disc, epicondylitis (tennis elbow), tendinitis, de Quervain's disease (tenosynovitis of the thumb), trigger finger, and Reynaud's syndrome (vibration white finger).
Researchers have identified specific physical workplace risk factors for the development of WMSDs: force, posture, compression, repetition, duration, vibration, and temperature. Exposure to these risk factors can result in decreased blood flow, elongation, compression, tears or strains to muscles, tendons, ligaments and nerves as well as disc or joint damage. When present for sufficient duration, frequency, or magnitude, physical workplace risk factors may cause WMSDs. In addition, personal risk factors, such as physical conditioning, existing health problems, gender, age, work technique, hobbies and organizational factors (e.g., job autonomy, quotas, deadlines) contribute to, but do not cause, the development of WMSDs.
Applying ergonomics principles to reduce a worker's exposure to the physical workplace risk factors decreases the chance of injury.
This unit is not designed to impart skills in the diagnoses of WMSDs, only occupational healthcare providers do so. This unit is a background in some of the more common WMSDs and explores anatomic features that are affected by WMSDs. It is written from the view point of an ergonomist and not a healthcare provider. For convenience, this chapter is divided into four sections:
· The musculoskeletal system
· Disorders of the
· spine
· upper extremities
· lower extremities.
THE MUSCULOSKELETAL SYSTEM
The musculoskeletal system's primary functions include supporting the body, allowing motion, and protecting vital organs. The musculoskeletal system is an organ system that gives humans the ability to move using their muscular + skeletal systems (musculoskeletal). The musculoskeletal system provides form, support, stability, and movement to the body. It is made up of the bones of the skeleton, cartilage (framework), musc.
Homework V - Biomaterials Science
Cells are the most fundamental structures and functional units in a living body. Depending on their biological characteristics, they can be linked to 5 different kingdoms: Animalia, Plantae, Fungi, Protista and Monera. Eukaryote cells present in the Animalia, Plantae and Fungi are the most complex and the ones that are more often seen grouped in multicellular organisms. Some million years ago, cells started to organize themselves in tissues and later in organs, each one playing a different role in a living system.
IST - 4th Year - 2nd Semester - Biomedical Engineering.
Histological changes in dentofacial orthopaedics1 /certified fixed orthodont...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
A person suffering from pain in teres major or teres minor pain can feel symptoms of pain at the back of the upper arm when they stretch their arm forward to reach up something. Teres major and minor pain or injuries can be treated with various types of exercise, gels, therapy wraps, and workouts.
"Knee locking" is quite literally when your knee locks up momentarily, inhibiting your ability to move in any direction. This can also be described as "catching" where it feels as if your knee gets caught during extension or flexion, the knee
"giving out," or as a popping sensation with knee movement. Unfortunately, there is no "key" or secret trick to unlock your knee joint, though various treatments exist to help with knee locking symptoms.
NCS are done by placing electrodes on the skin and stimulating the nerves through electrical impulses. To study motor nerves, electrodes are placed over a muscle that receives its innervation from the nerve you want to test (stimulate).
The Anterior Chest Wall Release was originally called the Thoracic Inlet Release, which is semantically misleading and anatomically incorrect. The fascia throughout the anterior and posterior chest wall is the only known physical structure that can be affected during this release.
Tender points are areas of the body that experience different types of pain when pressure is applied to them.
A Trigger Point (TrP) is a hyperirritable spot, a palpable nodule in the taut bands of the skeletal muscles' fascia.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
1. Behaviour of tendons and ligaments
towards Load.
Understanding anatomy
The skeleton is first and foremost a mechanical organ. Its primary functions are to
transmit forces from one part of the body to another and to protect certain other
organs (e.g., the brain) from mechanical forces that could damage them. Therefore,
the principal biologic role of skeletal tissues is to bear loads with limited amounts
of deformation.
These forces result from loads being passed from the part of the body in contact
with a more or less rigid environmental surface (e.g., the heel on the ground when
walking) through one or more bones to the applied or supported load (e.g., the
torso). In addition to the forces transmitted in bone to-bone contact, muscle and
ligament forces act on the bones, and these forces (especially the muscle forces)
are large and important.
Most muscle, ligament, and bone-to-bone forces act in or near the body’s major
diarthrodial joints.
Ligaments and tendons, the flexible structures that bind together the
musculoskeletal system, are extraordinarily strong in resisting tensile loads. For
example, the digital flexor tendon from the foreleg of a horse can bear the weight
of two large automobiles without failure. The Anglo-Saxon word for tendon is
“sinew,” which also means “strong” or “tough.” As Aristotle realized, without
ligaments and tendons to stabilize and animate our skeletons, they would be
mechanically useless.
Tendons and ligaments differ in morphology and function. Ligaments bind one
bone to another to restrict their relative motions. Tendons provide the connecting
link from a muscle to a bone. Many ligaments represent thickenings or
specializations within a joint capsule, and their margins may be blurred and
indistinct.
Tendons and ligaments, along with other non-calcified, non-cartilaginous load
bearing structures of the musculoskeletal system (e.g. synovial joint capsules,
aponeuroses, and retinacula), are all composed of dense connective tissue. These
structures are characterized by an abundance of tightly packed collagen fibers
which give the tissue superior tensile strength. In tendons and ligaments the
2. collagen is packaged into bundles of parallel fibers aligned with the predominant
force direction. The vast majority of the collagen is type I with trace amounts of
types II, III, V, VI, IX, XII, and XIV present at some locations. Ligaments and to a lesser
extent tendons, also contain highly extensible elastic fibers constructed from
another fibrillar protein called elastin. Small amounts of the proteoglycan
molecules biglycan, decorin, fibromodulin, lumican and versican are also present in
the extracellular matrix of tendon and ligament, many of which modulate collagen
fibril formation and size. Aggrecan, the large hydrophilic molecule found in articular
cartilage, is present in regions of the tissue that wrap around bony structures (e.g.,
tendon of posterior tibialis at the medial malleolus of the ankle; annular ligament
that retains the head of the radius) and are routinely subjected to compressive
force.
Structure and Composition
Ligament
In its natural state, ligament is 55–65 % water. Collagen comprises approximately
70–80 % of the dry weight and elastin usually comprises another 10–15 %, more in
some specialized ligaments (e.g. nuchal (neck) ligaments). In most cases
proteoglycans comprise a very small percentage of the extracellular matrix in
ligaments and tendons. It should be kept in mind that these proportions are general
approximations; exact percentages vary according to ligament location and
function.
Fig 1. Structure of a collagen
fiber in ligament.
Tendon
The composition of tendon is similar to that of ligament. Collagen comprises as
much as 85 % of tendon dry weight; of this, 95 % is type I and 5 % type III and/or
type V (Cetta et al. 1982). Unlike ligament, elastin constitutes less than 3 % of
tendon dry weight. In most locations, the proteoglycan concentration is usually less
3. than 2 %; however, tendons that curve around bony surfaces experience
compressive forces, and the cells within them respond by producing more
proteoglycans. Increasing proteoglycan concentrations give the tendon a more
cartilaginous quality that decreases friction and enhances motion. The structural
hierarchy of tendon resembles that of ligament except that collagen fibers are
arranged into discrete packets, which in turn are bundled together within fascicles.
Fig 2. The structure of tendon, at different
length scales.
Mechanical Properties of Ligament and Tendon
Quasi-static Tensile Properties
When loaded in the laboratory, ligaments and tendons produce characteristic load-
deformation patterns that reflect their structural architecture. Materials such as
steel and aluminum display linear stress-strain characteristics because of their
crystalline nature.
In these materials, the modulus of elasticity is constant throughout the elastic
region and is representative of the atomic forces at work within their crystalline
architecture. If the elastic limit is exceeded, crystalline materials will yield and
eventually fail. In contrast, noncrystalline materials display what is termed rubbery
elasticity. Tensile tests of these materials produce continuous upwardly concave
load displacement and stress-strain curves. In the noncrystalline materials, the
elastic modulus is dependent on load magnitude because of intra- and
intermolecular forces and molecular cross-linking. Failure of these materials is
often abrupt and can occur without a well-defined yield point. Tensile tests of
tendon and ligament produce curves that display both crystalline and rubbery
4. characteristics, reflecting their complex structural hierarchy and molecular
interactions.
A typical load-deformation (or stress-strain) curve for tendon or ligament (Fig. 3)
can be divided into three regions. In the toe region, collagen crimps are removed
by elongation. Initially minimal force is required for this elongation, but as the
collagen fibers straighten, more and more force is required and the curve swings
upward. The toe region
typically ends at about
1.5– 3.0 % strain.
Fig 3. Typical load-deformation
curve from a tendon or ligament
showing the toe, linear and yield
and failure regions.
Viscoelastic Properties
The mechanical behavior of ligament and tendon is viscoelastic; thus, their load-
displacement and stress-strain relationships are rate and history dependent.
Tendon and ligament display hysteresis, another behavior caused, at least in part,
by viscoelasticity. Hysteresis refers to loss of energy during a load deformation
cycle. If a purely elastic material is loaded in its elastic range and then immediately
unloaded, the load-deformation curve for the loading phase is identical to the load-
deformation curve for the unloading phase. The energy absorbed during loading
and returned to the system during unloading will be the same, and the system will
be 100 % efficient. The loading-unloading profiles of ligaments and tendons are not
identical, however. The area under the loading curve is greater than the area under
the unloading curve, and the difference between the two represents the energy
lost during the load cycle, which is referred to as hysteresis. The amount of
hysteresis observed depends on the particular ligament or tendon and on the
testing conditions. Tendons involved in gait tend to be efficient stores of elastic
energy (i.e., have minimal hysteresis). For example, the digital flexor tendons of
horses studied by Gillis et al. (1995) lost only about 5 % of their strain energy during
a loading-unloading cycle.
5. Where the lost energy goes is difficult to determine. Frictional forces at work within
the sample cause some energy to be converted to heat, some of which flows to the
surroundings while the remainder remains within the sample, raising its
temperature and altering its mechanical properties. When the load is removed, the
accumulated thermal energy slowly dissipates and the tendon or ligament may
shorten further with time. However, residual strain may remain in the tissue for
some time or indefinitely. Some of the lost strain energy has probably been used
to break molecular cross-links or otherwise disrupt the molecular structure of the
tissue.
Fig 4.
(a) When a constant load is applied to a tendon or
ligament, its deformation gradually "creeps" to a
stable value.
(b) When a constant deformation is applied, the
load “relaxes” to a stable value. The times required
for these processes are of the order of minutes or
hours.
Mechanobiology of tendons and ligaments.
Tendons and ligaments change their composition and structure as a response to
mechanical forces (Wang, 2006). Tenocytes and tendon fibroblasts (tenoblasts) are
primarily involved in this mechanical adaptation. They react towards force
application by biochemical signals ending up in physiological and also pathological
changes, which include mechanisms on the tendon tissue level as well as on the cell
and molecular level (Wang and Thampatty, 2006). Discussion of mechanobiology
of tendons and ligaments therefore covers a diverse set of effects of mechanical
Forces during development, homeostasis as well as healing of the tendon and
ligament tissue.
In the musculoskeletal system, tendons allow transmitting force from muscles to
bones. They provide stability as well as efficient motion. This transmittance of force
6. acts as a mechanical stimulus on tenocytes. Roughly, they “receive” this stimulus
via the tendon tissue, in other words via various matrix components including
collagen type I, elastin, glycoproteins, proteoglycans, glycolipids and water among
others. As such, the tendon cell experiences force on its surface, and from the
exterior the force is transmitted to the interior of the cell by a series of biochemical
pathways including transmembrane structures.
Based on their structure and cellular organization, whole tendons behave in a
nonlinear viscoelastic manner when load is applied. Mainly, the predominant
component collagen I is responsible for the typical stress-strain curves found in
tendon tensile stretching experiments, with a primary toe region where the crimps
of the collagen fibers are stretched, followed by a linear region provided by the
high strength of covalent bonds between collagen molecules (intermolecular
collagen-crosslinking), being also responsible for the sliding between fibers (Fessel
et al., 2014). Also water ads up to the visco-elasticity found for typical tendon
tissue. Under physical load, water is transferred from the central to the periphery
of the tendon and thereby changes its biomechanical behavior.
Within the tendon tissue, the tenocytes are arranged in parallel linear arrays. When
load is applied, the extracellular matrix of the cells is deformed and a combination
of compressive and tensile forces as well as shear and strain stresses act on the
cells. Thereby noteworthy to mention is the fact, that local tissue strains are only
25–30% of grip-to-grip strains (Butler et al., 1984) and that the applied load is
always smaller than the received one (Screen et al., 2003), which can be made
visible by the deformation of the localized cells in response to a given deformation
of the whole tendon.
Impact of loading on tendon cells
1. Gene expression
Tendon cells respond to shear forces as well as mechanical load. In a simple in vitro
experiment using tenocytes isolated from adult male rats in a culture plate equipped with
a rotating cone, it has been shown by complementary deoxyribonucleic acid (cDNA)
microarray and Northern blotting analysis led to an induced “antifibrotic” expression
pattern of genes. Several pro-fibrotic molecules were down regulated in different
signaling pathways (including platelet-derived growth factor, insulin-like growth factor
and fibroblast growth factor signaling pathway, respectively). Moreover, the shear forces
induced down regulation of transforming growth factor beta 2 (TGF-β2), TGF-β3 and the
receptors TGF-RI and TGF-RII, however, TGF-β1 was upregulated; this is noteworthy and
interesting because TGF-β1 has been demonstrated to be mechanosensitive (Heinemeier
et al., 2003). The TGF-β family is involved in the wound healing and in inducing collagen
production via Smads and scleraxis. While the mechanoresponsiveness of TGF-β2, TGF-
7. β3 differed from the one observed for TGF-β1, it is interesting to mention that adult scar-
mediated tendon wound healing is also characterized by a different responsiveness of
TGF-β2, TGF-β3 compared to TGF-β1; however, just in the opposite direction
(Thomopoulos et al., 2015). In the case of adult wound healing, high levels of TGF-β2 and
TGF-β3 are found and low levels of TGF-β1. Furthermore, adult tendon wound healing
differs from fetal tendon wound healing, where the expression of the mentioned growth
factors resembles the one induced by shear forces (low expression of TGF-β2 and TGF-β
3 and high expression of TGF-β1). Finally, it is noteworthy to mention that TGF-β2 plays a
pivotal role in the tendon development which can be used for example in the tissue
engineering of tendons following a paradigm called “developmental tissue engineering”
(Glass et al., 2014). With this overall down regulation of the TGF-β family induced by shear
forces, the well-known improvement of flexor tendon healing and digital motion after
early passive motion can be explained on the altered pathways, including signaling
molecules in the cascade of fibrotic tissue formation (Gupta, 2005). Going along with the
general down regulation of the TGF-β signaling molecules, also an increased expression
of matrix metalloproteinases (MMPs) as well as a decrease in tissue inhibitors of
metalloproteinases were measured (Fong et al., 2005), corroborating the overall
antifibrotic effect of shear stress on flexor tenocytes in vitro.
Fig. 5 Upon binding of
TGF-β to its receptor,
Smads are
phosphorylated and
translocated to the
nucleus, where they act
as transcription factors
to activate the
expression of scleraxis.
Scleraxis promotes the
synthesis and secretion
of collagen and other
components of the
tendon extra cellular
matrix.
2. Gap junctions
Another effect of tensile loading on tenocytes is the regulation of the gap junction
permeability (Maeda et al., 2012). Communication between tenocytes is an essential part
of mechanotransduction during shear stress and load. Maeda et al. reported experiments
with viable tenocytes in rat tail tendon fascicles that were labeled and subjected to a
fluorescent loss induced by photobleaching. As such, they were able to record the
fluorescent intensity in the neighboring tenocytes. After application of a 1 N static load
for 10 minutes, no effect was observed on the gap junction communication, however, if
the duration of load was extended to 1 hour, a significant reduction in gap junction
permeability was found. These findings were further corroborated by the fact that
connexin 43 (Cx 43) protein expression was reduced in the 1 hour-loaded samples and
8. furthermore by a significant reduction in the permeability parameters. In contrast, on the
mRNA-level, Cx 43 mRNA was upregulated. This concomitant upregulation of Cx 43 mRNA
suggests that the tenocytes respond to the reduced permeability and the disruption of
the gap junction communication by an increased connexin synthesis. Hence, tenocytes do
react towards mechanical load by two mechanisms, involving both breakdown as well as
remodeling of their gap junctions.
3. Calcium levels
In an attempt to study the mechanotransductional effect of tensile strain, fluid shear
stress or the combination of both, Maeda et al. developed a micro-grooved membrane
and a flow unit where they analyzed the calcium levels of tenocytes originating from male
bovine foot extensors (Maeda et al., 2013). As a result, tenocytes showed no increase in
calcium levels during the 5-minute fluorescence imaging period when they were not
stimulated, while under fluid flow, tensile strain or the combination of both, elevations of
calcium levels were found. Although calcium levels were significantly higher compared to
nonstimulated tenocytes, the calcium levels under combined stimulation (flow and strain)
were only tendentially higher than the calcium levels under only fluid flow or tensile
strain.
Fig 5. Fluid can be
introduced into the device
from the inlet to the outlet,
which applies fluid shear
stress to tenocytes seeded
within the microgrooves.
As the device is made from
stretchable soft material
(PDMS), both fluid shear
stress and cyclic tensile
strain can be applied to the
cells simultaneously.
4. Degenerative tendon tissue
So far, the effects of mechanical load or fluid shear stress on gene expression, gap
junction, and calcium levels have been discussed for healthy tendons and ligaments or
tenocytes and tendon fibroblasts isolated from healthy tissues. A study by Choi et al.
(2014) compared the gene expression of normal, healthy human tendon cells with the
one of degenerative tendon cells when cyclic strain was applied. For that purpose, tendon
tissue of three donors having a tendinopathy for more than 6 months (two ATs and one
tibialis posterior tendon) were collected. From the same three patients, also healthy
tendon tissue biopsies were received (trimmed from the distal end of the residual tendon
after debridement of degenerative tendon). Cyclic mechanical strain was applied during
15 and 60 minutes, respectively. While both, healthy and degenerative tendon cells,
responded to strain by an increased proliferation, the cell viability of the degenerative
cells was significantly lower compared the healthy cells. As for gene expression of typical
mechanotransduction genes, there was an obvious nonresponsiveness of the
degenerated tendon cells to mechanical stimulation. This pattern of gene expression
9. indicates that the cytoskeletal tensional balance is impaired in the degenerative tendon
because key cytoskeletal mediators are reduced or absent (time point 0, no mechanical
stimulation). Also the mechanotransduction is different when cyclic strain is applied;
while in healthy tendons, a 15-minute mechanical stimulation led to a significant initial
increase in gene expression, there was no such effect in the degenerative cells. At 60
minutes, healthy tendon cells still had a significantly higher gene expression, while the
degenerative cells did not show any response to the stimulation. From these findings, the
authors concluded that during tendinopathy, the most important genes of tensional
balance and recovery are suppressed or remain inactive (Choi et al., 2014).
5. Finite element model
The influence of ECM strains and fluid-induced shear stress on tenocytes was modeled
with a finite element model using a multiscale approach (Lavagnino et al., 2008). In this
model, the geometry and composition was based on the rat tail tendon, with 70–80% of
collagen I of the dry weight, an extrafibrillar matrix and water (60–80% of the wet weight).
There was an axisymmetric global poroelastic model and a nonaxisymmetric submodel
that was located in the mid-portion along the length of the global model.
Measuring tendon and ligament biomechanics
Classic tensile testing
Load–displacement and stress–strain
A common approach that is widely used to assess biomechanical properties is based on ex vivo
measurements. After extraction of the tendon or ligament of interest, it is placed in a tensile
testing machine. The two ends of the tendon or ligament are fixed with clamps which may be
based on physical force through screws (Wiig et al., 2011) (Fig. 6, left), by adding glue, wrapping
the ends in cloth (Rigozzi et al., 2009) and then also using screws (Fig. 6, right) or by cryogenic
fixation assemblies where liquid nitrogen as well as ice containers provide secure fixation (Trudel
et al., 2007). The principle of
freezing clamps was reported
to be efficient in other studies,
too (Herbort et al., 2008, 2014;
Zantop et al., 2006).
Fig 6. The testing equipment to
assess biomechanical properties
of rabbit flexor tendons. A servo-
hydraulic actuator (1), designed
for applying controlled force or
displacement is pulling the
specimen. Simultaneous force
readings are recorded by a load
aluminum frame (2) and are
10. displayed on a digital monitor (3). The tendon is fixed in a clamp (4) and the hind paw is secured to the
testing set-up by a similar construction (5). For “load-to-failure” studies, another clamp (6) is used to
prevent digit flexion.
If tendons are measured biomechanically, the end including the bone is often fixed in a different
way compared to the end facing the muscle; special devices such as that shown in Fig. 7 on the
right allow the bone to be placed at a right angle to the tendon and are themselves connected to
the base of the tensile testing machine. Basically, the tendon or ligament is then distracted with
a certain distraction rate (see below for the influence of this rate on the outcome measure) and
force–displacement curves are recorded [note that load–displacement, force–elongation, and
force–deformation are other terms for the same graph with force in newtons (N) on the y-axis
and displacement in millimeter (mm) on the x-axis]. Depending on how the tendon or ligament
tissue breaks under tension, the force–displacement curves may look different. Very often, after
a toe region and a linear region, there is an abrupt decrease in force while displacement is
increasing—many researchers define this force as the “load until gap formation” because sutured
tendons show this behavior under tensile force when the threads used for suturing eat
themselves through the tendon tissue, which leads to a gap between the tendon stumps. Other
breaking patterns include mid substance failure or interface-failures that may occur at the
interface to the bone as well as at the interface to the muscle and that often depend on the age
of the donor (Woo et al., 1991).
Fig 7. Details of testing
equipment to assess
biomechanical properties: a
cloth is wrapped around the
tendon after the addition of glue
(e.g., locktight glue,
cyanoacrylate) before it is tightly
fixed with screws on the muscle
side (left). Special devices might
be used for the fixation of the
bony part; here, a rabbit Achilles
tendon is shown where the
calcaneus is tightly fixed with 12
screws in metal cylinder (right).
To prevent from dehydration,
tendons are sprayed by
phosphate-buffered solution.
Load until failure
The load until failure or peak load is defined as the maximum force a tendon or ligament bears until it
breaks. As discussed above, some micro-damage may occur in the tendon tissue during loading,
accompanied by a load until gap formation; nevertheless, peak load may be higher than load until gap
formation. Therefore, researchers often define peak load by referring to the force drop after reaching a
certain peak force value. For example, Trudel et al. defined the peak load of extracted rabbit Achilles
11. tendons (AT) when a 50% drop in peak load is measured. Thus, decreases in load in the force–elongation
curves that are less than 50% are not associated with loads until failure values.
Stiffness
The stiffness in N/mm is another structural property of the tendon and ligament besides the load
until failure. It is the slope in the load–elongation curve. If not otherwise mentioned, the slope in
the linear region of the load–elongation curve is used, however, some researchers define exactly
which part of this curve they use for stiffness assessment. For example, linear regression to the
load–deformation data between 30% and 90% of the peak load was used for the calculation of
the stiffness (Trudel et al., 2007). Material properties such as maximum stress as well as the
elastic modulus (both in Pa) can also be assessed via force–elongation data; however, it has to
be taken into account that the cross-sectional area (CSA) of the specimen has to be measured,
too, because the definition of maximum stress and elastic modulus is load until failure divided by
CSA and the slope in the stress–strain curve, respectively. As the CSA varies along the
corresponding specimen, the maximum stress as well as the elastic modulus changes along the
segments of the specimen. For example, the CSA of human AT differs by more than 50% along
their lengths, with the most proximal segment being significantly smaller compared to the most
distal segment— leading to the highest stress at the interface to the calcaneus (Kongsgaard et
al., 2005; Magnusson and Kjaer, 2003). Therefore, an exact definition of WHERE the
corresponding material properties are referred to is absolutely needed. As for the determination
of the CSA, different methods are being used, for example the laser assisted measurement of the
two halves of the circumference by a linear laser scanner adapted by Vergari which is being
calculated to give the area inside (¼CSA) (Vergari et al., 2010).
Loading rate
The rate of distraction is given either in mm/s, N/s, or in %/s, the latter being the percentage of
length at the time point zero (L0) divided by time. Screening different protocols in the
biomechanical literature reveals a wide range of distraction rates. For example, rabbit digital
flexor tendons’ biomechanics were assessed with 1 mm/s (Wiig et al., 2011), rabbit ATs with 18
N/s (Trudel et al., 2007), rat patellar tendons (PT) with 0.1 mm/s (Stange et al., 2015), human,
pig, and sheep ATs with 5 mm/min (Gatt et al., 2015), bovine deep digital flexor tendons (DDFT)
with 20 mm/min (Fang et al., 2014), and human flexor digitorum profundus with 120 mm/min
(Fox et al., 2013).
In an ex vivo study by Wren et al., human ATs were subjected to tensile testing with strain rates
ranging from 1%/s to 10%/s. This increase in strain rate led to an increase in the elastic modulus
by 0.7%, while it increased the failure stress by 21% (Wren et al., 2001). Loading rates were also
varied in an in vivo study by Gerus et al., where healthy young males (n¼8) were seated on the
bench of a custom ergometer with the knee fully extended and the sole of the foot perpendicular
to the shank. Then, the subjects had to perform isometric contraction for 3 s, followed by ramp
up contractions either in 1.5 s or in minimal time (as fast as possible), having on-screen as
feedback. These motions were US-imaged with a 50 mm US probe at 10 Hz (Gerus et al., 2011).
The resulting force–strain curves were significantly different for force–strain values above 20%
of maximum forces; the contractions performed at the highest rate possible resulted in steeper
force–strain curves, implying higher values for stiffness at higher rates. As also reported by
12. Pearson et al., highly dynamic motion patterns as found for running or hopping led to
(apparently) stiffer tendons (Pearson et al., 2007). Therefore, the distraction rates, for in vivo as
well as ex vivo measurements, is of high importance, especially in terms of data comparability.
Fig 8. Typical stress–strain curve of a tendon or ligament showing three regions—the toe-in region where
the fibers get uncrimped and strain is increased to around 2%, the linear region where some micro-
damages to the fibers may occur and where usually the slope is measured to assess the elastic modulus
of the specimen (between around 2–6% of strain), and the failure region where the maximum stress is
measured and where the stress is decreased abruptly upon further straining of the specimen. This
macroscopic failure is accompanied by the tendon being completely ruptured (6%). UTS, ultimate tensile
strength.
Preconditioning
Preconditioning of the tendon or ligament specimen may include a preloading to a certain force
(N) for a defined time or a prestretching to a certain strain (% of full length), it may also be
performed by cyclic loading to specified forces or strains at a certain frequency (Hz) for a defined
time. No doubt, reconditioning has an impact on the biomechanical measurements that follow.
For example, preconditioning of rat ATs to a strain of 2% for different times was investigated and
had an impact on the load until failure measured just right after the preconditioning. Obviously,
the load until failure was significantly higher than the control (no preconditioning) for 30, 100,
300, and 600 s (Teramoto and Luo, 2008). According to the authors, this preconditioning regimen
induced progressive collagen fiber recruitment and subsequent fatigues at the micro-level; the
latter being found in a 1000 s-preconditioning, where the failure load was smaller than at 600 s.
Moreover, as in the same study stiffness was not affected by the 2%-preconditioning, it was
concluded that failure load was more sensitive towards preconditioning than stiffness (Teramoto
and Luo, 2008). Other static preconditioning examples are to stretch sheep rotator cuffs to 40 N
13. for 2 min (Santoni et al., 2010) or human rotator cuffs to 25 N for only 10 s to remove possible
creep (van der Meijden et al., 2013).
Preconditioning can include a cyclic loading regimen between a lower and an upper border
(force) value, such as shown in a human cadaver study where the isolated medial patellofemoral
ligament was preconditioned in an uniaxial tensile testing machine with 10 cycles between 5 and
20 N at a rate of 200 mm/min. Afterwards, load until failure and stiffness were assessed with a
rate of 200 mm/min, too (Herbort et al., 2014). Also Baker et al. used a cyclic preconditioning
when testing rotator cuffs augmented and reinforced by fascia patches, however, not just 10
cycles, but 100 cycles.
Fatigue tests
Besides static tensile loading tests, dynamic tests are also in use; however, there is less literature about
structure–function relationships of tendon and ligament tissue under dynamic conditions than under
static conditions. Fatigue loading tests under high loads are not only interesting in terms of elucidating
fatigue-induced tendon or ligament injuries, but also with regard to the usually monotonic increase in
peak strains found with increasing cycles and the structural changes causing this observed behavior.
Combinations of fatigue tests with imaging methods such as polarized light imaging may help to reveal
the structural changes that lead to increasing peak strains during fatigue loading, for example as
discussed for the changes in the crimp pattern (Freedman et al., 2015). Murine PT were used and the
changes in crimp frequency and amplitude were assessed as a function of time (cycle number) and of
locality (mid-substance versus insertion site; center versus lateral) during fatigue loading and polarized
light imaging. As a result, cycle number was a significant factor for peak strain, tangent stiffness,
hysteresis, and laxity at all different localities tested. While fatigue loading, peak strain, tangent
stiffness, and laxity increased, the hysteresis decreased. As for the crimp pattern, crimp frequencies
decreased and crimp amplitudes increased with increasing cycles at 0.1 N (representing the toe region in
a typical load–displacement curve). As such, nondestructive real-time monitoring during fatigue loading
at low cost elucidated biomechanical changes in correlation to structural changes—which may be used
as a tool in diagnostics (Freedman et al., 2015).
Fig 9. Mechanical testing and image capture protocol of mouse patellar tendon (A). Tendons
were preloaded (a), preconditioned (b), imaged at three loads (0.1, 0.5, and 2.0 N) (c), and
fatigue loaded (d). After 10, 100, and 1000 cycle intervals of fatigue loading, images were
captured at these three loads to quantify tendon crimp properties in the toe, transition,
and linear regions of a representative load–displacement curve (B). This process was repeated until
tendons reached 1000 fatigue loading cycles.
14. Summary
The function of ligaments and tendons is to support and transmit loads applied to the
musculoskeletal system. These tissues are often able to perform their function for many decades;
however, connective tissue disease and injury can compromise ligament and tendon integrity. A
range of protein and non‐protein constituents, combined in a complex structural hierarchy from
the collagen molecule to the tissue and covering nanometer to centimeter length scales, govern
tissue function and impart characteristic non‐linear material behavior. This review summarizes
the structure of ligaments and tendons, the roles of their constituent components for load
transfer across the hierarchy of structure, and the current understanding of how damage occurs
in these tissues. Disease and injury can alter the constituent make‐up and structural organization
of ligaments and tendons, affecting tissue function, while also providing insight to the role and
interactions of individual constituents. The studies and techniques presented here have helped
to understand the relationship between tissue constituents and the physical mechanisms (e.g.
stretching, sliding) that govern material behavior at and between length scales. In recent years,
new techniques have been developed to probe ever smaller length scales and may help to
elucidate mechanisms of load transfer and damage and the molecular constituents involved in
the in the earliest stages of ligament and tendon damage. A detailed understanding of load
transfer and damage from the molecular to the tissue level may elucidate targets for the
treatment of connective tissue diseases and inform practice to prevent and rehabilitate ligament
and tendon injuries.
References:
1. Wang JHC, Guo Q, Li B. Tendon Biomechanics and Mechanobiology - A
Minireview of Basic Concepts and Recent Advancements. Journal of Hand
Therapy, 2012; 25(2):133–141.
2. Robi K, Jakob N, Matevz K, Matjaz V (2013). Chapter 2: The Physiology of
Sports Injuries and Repair Processes. In Hamlin M (Ed.), ISBN: 978-953-51-
1031-6, InTech, DOI: 10.5772/54234.
3. Johnson GA, Tramaglini DM, Levine RE, Ohno K, Choi NY, Woo SL. Tensile
and viscoelasticfckLRproperties of human patellar tendon. J Orthop Res,
1994; 12(6): 796–803.
4. Maganaris CN, Paul JP. In vivo human tendon mechanical properties. J
Physiol, 1999; 521 (Pt 1): 307–313.
5. Wang, JHC. Mechanobiology of Tendon. Journal of Biomechanics, 2006; 39:
1563–1582.
6. Maganaris CN. Tensile properties of in vivo human tendinous tissue. Journal
of Biomechanics, 2002; 35: 1019–1027.
15. 7. Komi PV, Fukashiro S, Jarvinen M. Biomechanical loading of Achilles tendon
during normal locomotion. Clinics in Sports Medicine, 1992; 11: 521–531.
8. Schuind F, Garcia-Elias M, Cooney WP, An KN. fckLRFlexor tendon forces: in
vivo measurements. Journal of Hand Surgery [American], 1992; 17: 291–298.
9. Kellis E. Quantification of quadriceps and hamstring antagonist activity.
Sports Medicine, 1998; 25: 37–62.
10.Korvick DL, Cummings JF, Grood ES, Holden JP, Feder SM, Butler DL. The
use of an implantable force transducer to measure patellar tendon forces in
goats. Journal of Biomechanics, 1996; 29: 557–561.
11. Finni T, Komi PV, Lukkariniemi J. Achilles tendon loading during walking:
application of a novel optic fiber technique. European Journal of Applied
Physiology and Occupational Physiology, 1998; 77: 289–291.
12.Kyrolainen H, Finni T, Avela J, Komi PV. Neuromuscular behaviour of the
triceps surae muscle-tendon complex during running and jumping.
International Journal of Sports Medicine, 2003; 24: 153–155.
13.Samuel D Rosengarten1, Jill L Cook, Adam L Bryant, Justin T Cordy, John
Daffy, Sean I Docking. Australian football players’ Achilles tendons respond to
game loads within 2 days: an ultrasound tissue characterisation (UTC) study.
Br J Sports Med 2015;49:183-187
14.Docking SI, Rosengarten SD, Cook J1. Achilles tendon structure improves on
UTC imaging over a 5-month pre-season in elite Australian football players.
Scand J Med Sci Sports. 2015 May 5.
for more info:
www.c7physio.in