Nanocarriers role in eye cancer treatment and management
•Download as PPTX, PDF•
0 likes•70 views
This document discusses the use of nanocarriers for eye cancer treatment and management. It describes some common types of eye cancer and why nanocarriers are needed due to ocular barriers and risks of damage from repeated injection. The main nanocarriers discussed are liposomes, dendrimers, and carbon nanotubes, along with their advantages such as biocompatibility and drug encapsulation abilities. However, nanocarriers also have disadvantages like limited storage conditions and potential toxicity. In conclusion, the document evaluates nanocarrier strategies for delivering drugs to the eye in a targeted manner for cancer therapy.
Report
Share
Report
Share
Recommended
Nanocarrier based strategies for eye cancer management and
This document discusses nanocarrier based strategies for eye cancer management and treatment. It begins by defining eye cancer and its common types, then discusses various nanocarriers that can be used for detection and treatment of eye cancer like quantum dots, carbon nanotubes, liposomes, dendrimers, gold nanoparticles, and nanoemulsions. The nanocarriers provide benefits like targeted delivery, bypassing biological barriers, and reduced toxicity compared to traditional methods. While nanocarriers provide advantages for drug loading and biocompatibility, they also have challenges with stability, drug release kinetics, and safety that require further research.
Use of AuNP's in image guided radiation therapy
This document summarizes a novel strategy for radiation therapy that uses gold nanoparticles targeted to tumor vasculature. The strategy aims to intensify damage to tumor tissue while sparing healthy tissue. Gold nanoparticles are conjugated with a peptide targeting receptor expressed on tumor blood vessels. Confocal imaging shows the nanoparticles cause significant vascular damage in tumors when combined with radiation. In vivo experiments in mouse models demonstrate the nanoparticles accumulate in tumors and analysis shows increased tumor damage when the targeted nanoparticles are used with radiation therapy compared to radiation alone. The dual targeting strategy could help maximize tumor damage while reducing radiation doses and limiting damage to healthy tissues.
Specialised Techniques in Oral Radiology
Specialized radiographic techniques include tomography, stereoscopy, scanography, computed tomography (CT), cone beam computed tomography (CBCT), magnetic resonance imaging (MRI), nuclear medicine techniques, and ultrasonography. CT provides cross-sectional images by using x-rays and rotational data acquisition. CBCT uses a cone-shaped beam and a 2D detector to obtain volumetric images with less radiation than medical CT. MRI uses magnetic fields and radiofrequency pulses to visualize soft tissues without exposing the patient to ionizing radiation.
NANOTECHNOLOGY IN TREATMENT OF CANCER
Nanotechnology involves engineering at the nanoscale (1-100 nanometers) and can be used in various fields including medicine. It has several applications for cancer treatment such as using nanoparticles, nanotubes, quantum dots, dendrimers, liposomes, nanoshells, silica nanoparticles, and nanorobots to more precisely deliver drugs to cancer cells, detect genetic mutations associated with cancer, and potentially diagnose and treat cancer. Nanoparticles in particular show promise for overcoming limitations of conventional cancer treatments like poor solubility, lack of targeting, and side effects by selectively targeting cancer cells and increasing drug localization.
Imaging technique in endodontics an overview
This document provides an overview of various imaging techniques used in endodontics, including their applications and advantages/disadvantages. It discusses ultrasound, radiovisiography (RVG), and computed tomography (CT) specifically. For ultrasound, it notes its ability to differentiate cystic vs. non-cystic lesions but limitations in posterior regions. For RVG, it outlines its use in detecting pathology, measuring lengths, and enhanced imaging capabilities while using less radiation than conventional radiography. For CT, it describes excellent visualization of anatomical structures, ability to detect fractures, lesions, and extra root canals, but greater radiation exposure than other methods.
Nano tech
Nanotechnology shows promise for improving oral drug delivery by increasing solubility and bioavailability of poorly soluble drugs. Nanocrystal formulations have been commercialized, such as Tricor and Emend tablets, that demonstrate higher absorption and lower dosing compared to earlier forms. However, challenges remain around fully characterizing nanoparticles, understanding their safety, ADME profiles, and environmental impacts which will require further research to fully realize the potential of this technology.
Animal biotchnology
This document discusses using gold nanoparticles for breast cancer gene therapy. It provides background on breast cancer, gene therapy, and nanoparticles. It describes how gold nanoparticles can be used to deliver tumor suppressor genes or siRNA to cancer cells via gene therapy to treat breast cancer. Gold nanoparticles are promising for cancer therapy due to their ability to bind drugs and proteins and target cancer cells. The document envisions future prospects for improving siRNA delivery and developing multifunctional gold nanoparticles for combined imaging and targeted drug/gene delivery to treat breast cancer.
Nanotech Drug Delivery System: The Perfect Physio-Chemical deal for Biologica...
Nanotechnology offers substantial prospects for the development of innovative products and applications in many in
sectors.
Recommended
Nanocarrier based strategies for eye cancer management and
This document discusses nanocarrier based strategies for eye cancer management and treatment. It begins by defining eye cancer and its common types, then discusses various nanocarriers that can be used for detection and treatment of eye cancer like quantum dots, carbon nanotubes, liposomes, dendrimers, gold nanoparticles, and nanoemulsions. The nanocarriers provide benefits like targeted delivery, bypassing biological barriers, and reduced toxicity compared to traditional methods. While nanocarriers provide advantages for drug loading and biocompatibility, they also have challenges with stability, drug release kinetics, and safety that require further research.
Use of AuNP's in image guided radiation therapy
This document summarizes a novel strategy for radiation therapy that uses gold nanoparticles targeted to tumor vasculature. The strategy aims to intensify damage to tumor tissue while sparing healthy tissue. Gold nanoparticles are conjugated with a peptide targeting receptor expressed on tumor blood vessels. Confocal imaging shows the nanoparticles cause significant vascular damage in tumors when combined with radiation. In vivo experiments in mouse models demonstrate the nanoparticles accumulate in tumors and analysis shows increased tumor damage when the targeted nanoparticles are used with radiation therapy compared to radiation alone. The dual targeting strategy could help maximize tumor damage while reducing radiation doses and limiting damage to healthy tissues.
Specialised Techniques in Oral Radiology
Specialized radiographic techniques include tomography, stereoscopy, scanography, computed tomography (CT), cone beam computed tomography (CBCT), magnetic resonance imaging (MRI), nuclear medicine techniques, and ultrasonography. CT provides cross-sectional images by using x-rays and rotational data acquisition. CBCT uses a cone-shaped beam and a 2D detector to obtain volumetric images with less radiation than medical CT. MRI uses magnetic fields and radiofrequency pulses to visualize soft tissues without exposing the patient to ionizing radiation.
NANOTECHNOLOGY IN TREATMENT OF CANCER
Nanotechnology involves engineering at the nanoscale (1-100 nanometers) and can be used in various fields including medicine. It has several applications for cancer treatment such as using nanoparticles, nanotubes, quantum dots, dendrimers, liposomes, nanoshells, silica nanoparticles, and nanorobots to more precisely deliver drugs to cancer cells, detect genetic mutations associated with cancer, and potentially diagnose and treat cancer. Nanoparticles in particular show promise for overcoming limitations of conventional cancer treatments like poor solubility, lack of targeting, and side effects by selectively targeting cancer cells and increasing drug localization.
Imaging technique in endodontics an overview
This document provides an overview of various imaging techniques used in endodontics, including their applications and advantages/disadvantages. It discusses ultrasound, radiovisiography (RVG), and computed tomography (CT) specifically. For ultrasound, it notes its ability to differentiate cystic vs. non-cystic lesions but limitations in posterior regions. For RVG, it outlines its use in detecting pathology, measuring lengths, and enhanced imaging capabilities while using less radiation than conventional radiography. For CT, it describes excellent visualization of anatomical structures, ability to detect fractures, lesions, and extra root canals, but greater radiation exposure than other methods.
Nano tech
Nanotechnology shows promise for improving oral drug delivery by increasing solubility and bioavailability of poorly soluble drugs. Nanocrystal formulations have been commercialized, such as Tricor and Emend tablets, that demonstrate higher absorption and lower dosing compared to earlier forms. However, challenges remain around fully characterizing nanoparticles, understanding their safety, ADME profiles, and environmental impacts which will require further research to fully realize the potential of this technology.
Animal biotchnology
This document discusses using gold nanoparticles for breast cancer gene therapy. It provides background on breast cancer, gene therapy, and nanoparticles. It describes how gold nanoparticles can be used to deliver tumor suppressor genes or siRNA to cancer cells via gene therapy to treat breast cancer. Gold nanoparticles are promising for cancer therapy due to their ability to bind drugs and proteins and target cancer cells. The document envisions future prospects for improving siRNA delivery and developing multifunctional gold nanoparticles for combined imaging and targeted drug/gene delivery to treat breast cancer.
Nanotech Drug Delivery System: The Perfect Physio-Chemical deal for Biologica...
Nanotechnology offers substantial prospects for the development of innovative products and applications in many in
sectors.
Cone beam computerized tomography mamita
This document discusses cone beam computed tomography (CBCT), including its history developing in 1982 for angiography and maxillofacial imaging, principles using a cone-shaped radiation source and 2D detector to acquire multiple projections, uses in assessing pathologies, deformities, implants and treatment planning, advantages of shorter scan times and improved efficiency over other techniques, and artifacts that can occur.
Shreya poster on drug delivery
Nanotechnology and nanoparticles show promise in cancer diagnosis and treatment through targeted drug delivery. Nanoparticles are well-suited for these applications due to their small size, high surface area, and ability to control and target drug delivery. This can help reduce side effects while requiring lower dosages than traditional treatments. Many nanodevices like micelles, vesicles, dendritic polymers, and quantum dots are being developed and studied for use in drug delivery systems.
Cbct
This document provides an overview of cone beam computed tomography (CBCT) including its history, components, principles, and applications in dentistry. Some key points:
- CBCT was first introduced in the 1990s and provides 3D imaging with lower radiation dose than medical CT. It works by generating a cone-shaped X-ray beam and using a detector to record attenuation data, which is then reconstructed into 3D images.
- Components include an X-ray generator, image sensor, and software for image reconstruction. Images are stored in DICOM format.
- Advantages include rapid scan time, interactive display modes, and ability to view structures in multiple planes. Disadvantages include potential artifacts and inability to view
Endodontic Radiography
This document discusses endodontic radiography and the importance of radiographs in endodontic diagnosis and treatment. It provides a brief history of radiography and describes common types of radiographs used in endodontics like intraoral periapical radiographs and cone beam computed tomography (CBCT). Intraoral periapical radiographs allow visualization of the root structure and surrounding bone. CBCT provides high quality 3D images with less radiation compared to traditional CT. The document emphasizes that radiographs are essential for endodontic diagnosis, treatment planning, working length determination, and follow-up care.
Imaging in periodontics
This document discusses various imaging techniques used in periodontics, including radiography, digital radiography, subtraction radiography, panoramic imaging, CT scans, MRI, and bone scanning. Radiography is described as the most common and important technique for assessing periodontal disease as it provides information on bone levels, furcation involvement, and other factors. Digital radiography provides advantages over traditional films such as instant viewing and reduced radiation exposure.
Specialized radiographic techniques /certified fixed orthodontic courses by I...
Specialized radiographic techniques /certified fixed orthodontic courses by I...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Advanced radiographic aids in periodontics
Digital radiography and imaging techniques like digital subtraction radiography, computer-assisted densitometric image analysis, and computed tomography provide more accurate and quantitative assessments of periodontal bone levels compared to conventional radiography. These advanced techniques allow for early detection of bone loss, longitudinal monitoring of treatment outcomes, and three-dimensional imaging. However, many require specialized equipment and high levels of standardization for calibration.
Radiographs in endodontic diagnosis
This document provides an overview of radiographic techniques and interpretations in endodontic diagnosis. It discusses the history of dental radiography and various radiographic techniques including intraoral periapical, bitewing, occlusal, tomography, computed tomography, cone beam computed tomography, scanography, stereography, magnetic resonance imaging, digital subtraction radiography and direct digital radiography. It also covers interpreting dental caries, trauma, pulpal and periapical lesions, restorations and dental materials, and root canal anatomy on radiographs. The document emphasizes that cone beam computed tomography is more accurate than conventional radiography for detecting vertical root fractures in teeth with metallic posts.
Cbct in endodontics ppt
This document provides an overview of the use of cone beam computed tomography (CBCT) in endodontics. It discusses the role of imaging in endodontics, compares 2D and 3D imaging, describes the principles and types of CBCT equipment, and reviews the clinical applications, advantages, limitations, and radiation dosage of CBCT. Key applications of CBCT in endodontics include evaluation of root canal anatomy, detection of apical periodontitis, assessment of root canal treatment outcomes, and pre-surgical planning.
Specialized radiographic technique Prof naglaa shawki el kilani
Specialized radiographic technique Prof naglaa shawki el kilani Faculty of Dental Medicine, Al Azhar University
This document discusses various specialized radiographic techniques used in dentistry, including tomography, computed tomography (CT), cone beam computed tomography (CBCT), and magnetic resonance imaging (MRI). It provides details on the principles, advantages, disadvantages, and applications of each technique. Tomography aims to blur structures outside the focal plane. CT produces cross-sectional images using X-rays. CBCT uses a cone-shaped beam and has advantages of lower dose and cost compared to medical CT. MRI uses magnetic fields and radio waves to distinguish tissues without ionizing radiation. Each modality has indications for examining dental and craniofacial structures.CBCT IN ORTHODONTICS
principles, applications, advantages, disadvantages, guidelines, uses of cone beam computed tomography in the field of orthodontics and dentistry in general
Nanotechnology for targeted cancer therapy
Nanotechnology is manipulation of matter on an atomic, molecular and supramolecular scale. Nanotechnology useful for targeting the cancer cells and destroy them based on the surface receptor molecule or markers present on the cancer cells helpful for targeted therapy. The two process by which the drug concentrated around cancer cell is passive diffusion and targeted cellular uptake and destroy cancer cell by active drug.nanotechnology opens a new era in cancer therapy
Radio CBCT present
(1) Cone Beam Computed Tomography (CBCT) provides 3D imaging that can be used for evaluating dental anatomy, complex root morphologies, and assessing endodontic treatment complications. (2) The American Association of Endodontists (AAE) and American Association of Oral and Maxillofacial Radiology (AAOMR) have listed potential uses of CBCT in selected cases including differential diagnosis, presurgical case planning, and evaluation of dental trauma or resorptive lesions. (3) CBCT can provide improved visualization over traditional 2D imaging for tasks like locating fractures, separated instruments, root perforations, and resorptive defects.
3D diagnostics in dental medicine - CBCT
This document discusses 3D diagnostics in orofacial medicine using cone-beam computed tomography (CBCT). It begins by providing background on the development of 3D diagnostics and its limitations in dentistry due to high radiation exposure from traditional CT. The advent of CBCT enabled wider use of 3D diagnostics in dentistry by using a cone-shaped beam and lower radiation doses. CBCT provides high-resolution 3D images, allows for improved surgical planning, and greater understanding of procedures for patients. The document then describes the technical principles and components of CBCT scanning.
MULTIMODAL DIAGNOSTIC SEGREGATION OF ORAL LEUKOPLAKIA AND CANCER
This document proposes a multimodal diagnostic approach to differentiate between oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC). It explores using liquid-based exfoliative cytology (LBEC) imaging, optical coherence tomography (OCT) imaging, and Fourier-transform infrared (FTIR) spectroscopy. LBEC analysis of cell and nuclear features achieved 100% and 89.9% sensitivity respectively. Ex vivo OCT analysis achieved 81.3% sensitivity and 92% specificity. FTIR spectroscopy using selected wavenumbers achieved 81.3% sensitivity and 91.3% specificity. The approach aims to provide non-invasive and low-cost diagnostic tools to distinguish OLK and OSCC
CBCT in dental practice
This document discusses cone-beam computed tomography (CBCT) and its applications in dental practice. CBCT provides sub-millimeter resolution images of the maxillofacial skeleton in a fraction of the time and radiation dose of conventional CT. It allows reconstruction of 3D volumetric data into multiplanar reformatted images. Specific applications discussed include implant planning, pathology assessment, temporomandibular joint imaging, and orthodontics. Advanced display modes like curved planar reformation and volume rendering provide familiar views useful for clinical evaluation and measurement.
The corneal universe - mission possible by in vivo confocal microscopy
The document discusses the history and applications of in vivo confocal microscopy of the cornea. It describes how confocal microscopy has advanced from early tandem scanning techniques to current laser scanning models. The summary provides:
1) In vivo confocal microscopy allows real-time microscopic examination of the living cornea and has evolved from early tandem scanning to current laser scanning models.
2) It has both research applications as a descriptor, discriminator, and reconstructor of corneal structures in 3D and 4D, and clinical applications in describing, differentiating, diagnosing, and monitoring corneal conditions.
3) Examples discussed include using in vivo confocal microscopy to characterize cystinosis crystal deposits and differentiate Scheie's syndrome from
CBCT
CBCT stands for cone beam computed tomography. It is a 3D imaging technique that uses a cone-shaped X-ray beam to capture volumetric images of the teeth, jaws, and surrounding structures. CBCT provides more detailed views than conventional 2D X-rays and exposes patients to less radiation than traditional medical CT scans. It has various applications in dentistry, including implant planning, endodontics, surgery, and orthodontics by allowing visualization of hard tissues and their relationship to anatomical structures.
Cbct
Cone beam computed tomography (CBCT) uses a cone-shaped x-ray beam projected through the area of interest and a 2D detector to acquire multiple 2D radiographic images at different angles. These images are then used to reconstruct 3D volumetric images. CBCT has applications in dentistry for implant planning, endodontics, orthodontics and TMJ imaging due to its ability to provide high contrast images of bony structures at a lower radiation dose compared to medical CT. Some limitations include artifacts from metallic restorations, lower soft tissue contrast and isotropic resolution compared to medical CT.
nanobiotecnology in medical side
1. Nanobiotechnology involves engineering at the atomic or molecular scale to develop nanomaterials and devices typically less than 100nm in size for applications in medicine.
2. Nanoparticles show promise for targeted drug delivery, reducing side effects and improving bioavailability of drugs. They can be designed to target specific cells and tissues.
3. Nanoparticles are being used for imaging and detection purposes, such as quantum dots for cancer imaging and magnetic nanoparticles for MRI. They provide improved contrast and sensitivity.
MUDASIR MALIK
This document discusses the properties and medical applications of nanoparticles. It begins by defining nanoparticles and nanotechnology. It then discusses various methods for synthesizing nanoparticles and their unique properties at the nanoscale. The document outlines several medical applications of nanoparticles, including drug delivery, cancer treatment, surgery, and antibiotic resistance. It provides examples of how nanoparticles can be used for targeted drug delivery, photodynamic therapy, MRI contrast agents, and more. The conclusion reiterates that nanoparticles have increased surface area and novel properties that can benefit medical applications.
Nanoparticles and their medical applications
This document discusses the properties and medical applications of nanoparticles. It begins by defining nanoparticles and nanotechnology. It then discusses various methods for synthesizing nanoparticles and their unique properties at the nanoscale. The document outlines several medical applications of nanoparticles, including drug delivery, cancer treatment, surgery, and antibiotic resistance. It provides examples of how nanoparticles can be used for targeted drug delivery, photodynamic therapy, MRI contrast agents, and more. The conclusion reiterates that nanoparticles have increased surface area and novel properties that can benefit medical applications.
More Related Content
What's hot
Cone beam computerized tomography mamita
This document discusses cone beam computed tomography (CBCT), including its history developing in 1982 for angiography and maxillofacial imaging, principles using a cone-shaped radiation source and 2D detector to acquire multiple projections, uses in assessing pathologies, deformities, implants and treatment planning, advantages of shorter scan times and improved efficiency over other techniques, and artifacts that can occur.
Shreya poster on drug delivery
Nanotechnology and nanoparticles show promise in cancer diagnosis and treatment through targeted drug delivery. Nanoparticles are well-suited for these applications due to their small size, high surface area, and ability to control and target drug delivery. This can help reduce side effects while requiring lower dosages than traditional treatments. Many nanodevices like micelles, vesicles, dendritic polymers, and quantum dots are being developed and studied for use in drug delivery systems.
Cbct
This document provides an overview of cone beam computed tomography (CBCT) including its history, components, principles, and applications in dentistry. Some key points:
- CBCT was first introduced in the 1990s and provides 3D imaging with lower radiation dose than medical CT. It works by generating a cone-shaped X-ray beam and using a detector to record attenuation data, which is then reconstructed into 3D images.
- Components include an X-ray generator, image sensor, and software for image reconstruction. Images are stored in DICOM format.
- Advantages include rapid scan time, interactive display modes, and ability to view structures in multiple planes. Disadvantages include potential artifacts and inability to view
Endodontic Radiography
This document discusses endodontic radiography and the importance of radiographs in endodontic diagnosis and treatment. It provides a brief history of radiography and describes common types of radiographs used in endodontics like intraoral periapical radiographs and cone beam computed tomography (CBCT). Intraoral periapical radiographs allow visualization of the root structure and surrounding bone. CBCT provides high quality 3D images with less radiation compared to traditional CT. The document emphasizes that radiographs are essential for endodontic diagnosis, treatment planning, working length determination, and follow-up care.
Imaging in periodontics
This document discusses various imaging techniques used in periodontics, including radiography, digital radiography, subtraction radiography, panoramic imaging, CT scans, MRI, and bone scanning. Radiography is described as the most common and important technique for assessing periodontal disease as it provides information on bone levels, furcation involvement, and other factors. Digital radiography provides advantages over traditional films such as instant viewing and reduced radiation exposure.
Specialized radiographic techniques /certified fixed orthodontic courses by I...
Specialized radiographic techniques /certified fixed orthodontic courses by I...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Advanced radiographic aids in periodontics
Digital radiography and imaging techniques like digital subtraction radiography, computer-assisted densitometric image analysis, and computed tomography provide more accurate and quantitative assessments of periodontal bone levels compared to conventional radiography. These advanced techniques allow for early detection of bone loss, longitudinal monitoring of treatment outcomes, and three-dimensional imaging. However, many require specialized equipment and high levels of standardization for calibration.
Radiographs in endodontic diagnosis
This document provides an overview of radiographic techniques and interpretations in endodontic diagnosis. It discusses the history of dental radiography and various radiographic techniques including intraoral periapical, bitewing, occlusal, tomography, computed tomography, cone beam computed tomography, scanography, stereography, magnetic resonance imaging, digital subtraction radiography and direct digital radiography. It also covers interpreting dental caries, trauma, pulpal and periapical lesions, restorations and dental materials, and root canal anatomy on radiographs. The document emphasizes that cone beam computed tomography is more accurate than conventional radiography for detecting vertical root fractures in teeth with metallic posts.
Cbct in endodontics ppt
This document provides an overview of the use of cone beam computed tomography (CBCT) in endodontics. It discusses the role of imaging in endodontics, compares 2D and 3D imaging, describes the principles and types of CBCT equipment, and reviews the clinical applications, advantages, limitations, and radiation dosage of CBCT. Key applications of CBCT in endodontics include evaluation of root canal anatomy, detection of apical periodontitis, assessment of root canal treatment outcomes, and pre-surgical planning.
Specialized radiographic technique Prof naglaa shawki el kilani
Specialized radiographic technique Prof naglaa shawki el kilani Faculty of Dental Medicine, Al Azhar University
This document discusses various specialized radiographic techniques used in dentistry, including tomography, computed tomography (CT), cone beam computed tomography (CBCT), and magnetic resonance imaging (MRI). It provides details on the principles, advantages, disadvantages, and applications of each technique. Tomography aims to blur structures outside the focal plane. CT produces cross-sectional images using X-rays. CBCT uses a cone-shaped beam and has advantages of lower dose and cost compared to medical CT. MRI uses magnetic fields and radio waves to distinguish tissues without ionizing radiation. Each modality has indications for examining dental and craniofacial structures.CBCT IN ORTHODONTICS
principles, applications, advantages, disadvantages, guidelines, uses of cone beam computed tomography in the field of orthodontics and dentistry in general
Nanotechnology for targeted cancer therapy
Nanotechnology is manipulation of matter on an atomic, molecular and supramolecular scale. Nanotechnology useful for targeting the cancer cells and destroy them based on the surface receptor molecule or markers present on the cancer cells helpful for targeted therapy. The two process by which the drug concentrated around cancer cell is passive diffusion and targeted cellular uptake and destroy cancer cell by active drug.nanotechnology opens a new era in cancer therapy
Radio CBCT present
(1) Cone Beam Computed Tomography (CBCT) provides 3D imaging that can be used for evaluating dental anatomy, complex root morphologies, and assessing endodontic treatment complications. (2) The American Association of Endodontists (AAE) and American Association of Oral and Maxillofacial Radiology (AAOMR) have listed potential uses of CBCT in selected cases including differential diagnosis, presurgical case planning, and evaluation of dental trauma or resorptive lesions. (3) CBCT can provide improved visualization over traditional 2D imaging for tasks like locating fractures, separated instruments, root perforations, and resorptive defects.
3D diagnostics in dental medicine - CBCT
This document discusses 3D diagnostics in orofacial medicine using cone-beam computed tomography (CBCT). It begins by providing background on the development of 3D diagnostics and its limitations in dentistry due to high radiation exposure from traditional CT. The advent of CBCT enabled wider use of 3D diagnostics in dentistry by using a cone-shaped beam and lower radiation doses. CBCT provides high-resolution 3D images, allows for improved surgical planning, and greater understanding of procedures for patients. The document then describes the technical principles and components of CBCT scanning.
MULTIMODAL DIAGNOSTIC SEGREGATION OF ORAL LEUKOPLAKIA AND CANCER
This document proposes a multimodal diagnostic approach to differentiate between oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC). It explores using liquid-based exfoliative cytology (LBEC) imaging, optical coherence tomography (OCT) imaging, and Fourier-transform infrared (FTIR) spectroscopy. LBEC analysis of cell and nuclear features achieved 100% and 89.9% sensitivity respectively. Ex vivo OCT analysis achieved 81.3% sensitivity and 92% specificity. FTIR spectroscopy using selected wavenumbers achieved 81.3% sensitivity and 91.3% specificity. The approach aims to provide non-invasive and low-cost diagnostic tools to distinguish OLK and OSCC
CBCT in dental practice
This document discusses cone-beam computed tomography (CBCT) and its applications in dental practice. CBCT provides sub-millimeter resolution images of the maxillofacial skeleton in a fraction of the time and radiation dose of conventional CT. It allows reconstruction of 3D volumetric data into multiplanar reformatted images. Specific applications discussed include implant planning, pathology assessment, temporomandibular joint imaging, and orthodontics. Advanced display modes like curved planar reformation and volume rendering provide familiar views useful for clinical evaluation and measurement.
The corneal universe - mission possible by in vivo confocal microscopy
The document discusses the history and applications of in vivo confocal microscopy of the cornea. It describes how confocal microscopy has advanced from early tandem scanning techniques to current laser scanning models. The summary provides:
1) In vivo confocal microscopy allows real-time microscopic examination of the living cornea and has evolved from early tandem scanning to current laser scanning models.
2) It has both research applications as a descriptor, discriminator, and reconstructor of corneal structures in 3D and 4D, and clinical applications in describing, differentiating, diagnosing, and monitoring corneal conditions.
3) Examples discussed include using in vivo confocal microscopy to characterize cystinosis crystal deposits and differentiate Scheie's syndrome from
CBCT
CBCT stands for cone beam computed tomography. It is a 3D imaging technique that uses a cone-shaped X-ray beam to capture volumetric images of the teeth, jaws, and surrounding structures. CBCT provides more detailed views than conventional 2D X-rays and exposes patients to less radiation than traditional medical CT scans. It has various applications in dentistry, including implant planning, endodontics, surgery, and orthodontics by allowing visualization of hard tissues and their relationship to anatomical structures.
Cbct
Cone beam computed tomography (CBCT) uses a cone-shaped x-ray beam projected through the area of interest and a 2D detector to acquire multiple 2D radiographic images at different angles. These images are then used to reconstruct 3D volumetric images. CBCT has applications in dentistry for implant planning, endodontics, orthodontics and TMJ imaging due to its ability to provide high contrast images of bony structures at a lower radiation dose compared to medical CT. Some limitations include artifacts from metallic restorations, lower soft tissue contrast and isotropic resolution compared to medical CT.
nanobiotecnology in medical side
1. Nanobiotechnology involves engineering at the atomic or molecular scale to develop nanomaterials and devices typically less than 100nm in size for applications in medicine.
2. Nanoparticles show promise for targeted drug delivery, reducing side effects and improving bioavailability of drugs. They can be designed to target specific cells and tissues.
3. Nanoparticles are being used for imaging and detection purposes, such as quantum dots for cancer imaging and magnetic nanoparticles for MRI. They provide improved contrast and sensitivity.
What's hot (20)
Specialized radiographic techniques /certified fixed orthodontic courses by I...
Specialized radiographic techniques /certified fixed orthodontic courses by I...
Specialized radiographic technique Prof naglaa shawki el kilani
Specialized radiographic technique Prof naglaa shawki el kilani
MULTIMODAL DIAGNOSTIC SEGREGATION OF ORAL LEUKOPLAKIA AND CANCER
MULTIMODAL DIAGNOSTIC SEGREGATION OF ORAL LEUKOPLAKIA AND CANCER
The corneal universe - mission possible by in vivo confocal microscopy
The corneal universe - mission possible by in vivo confocal microscopy
Similar to Nanocarriers role in eye cancer treatment and management
MUDASIR MALIK
This document discusses the properties and medical applications of nanoparticles. It begins by defining nanoparticles and nanotechnology. It then discusses various methods for synthesizing nanoparticles and their unique properties at the nanoscale. The document outlines several medical applications of nanoparticles, including drug delivery, cancer treatment, surgery, and antibiotic resistance. It provides examples of how nanoparticles can be used for targeted drug delivery, photodynamic therapy, MRI contrast agents, and more. The conclusion reiterates that nanoparticles have increased surface area and novel properties that can benefit medical applications.
Nanoparticles and their medical applications
This document discusses the properties and medical applications of nanoparticles. It begins by defining nanoparticles and nanotechnology. It then discusses various methods for synthesizing nanoparticles and their unique properties at the nanoscale. The document outlines several medical applications of nanoparticles, including drug delivery, cancer treatment, surgery, and antibiotic resistance. It provides examples of how nanoparticles can be used for targeted drug delivery, photodynamic therapy, MRI contrast agents, and more. The conclusion reiterates that nanoparticles have increased surface area and novel properties that can benefit medical applications.
NANOPARTICLES IN CANCER DIAGNOSIS AND TREATMENT
This document discusses the use of nanoparticles in cancer diagnosis and treatment. It introduces several types of nanoparticles that can be used, including nanoshells, dendrimers, quantum dots, superparamagnetic nanoparticles, nanowires, nanodiamonds, and nanosponges. Nanoshells and dendrimers are highlighted as promising for targeted drug delivery. The document also discusses magnetic resonance imaging contrast agents, including both paramagnetic gadolinium agents and superparamagnetic iron oxide nanoparticles, which can enhance MRI images and improve cancer diagnosis.
Nano materials for cancer therapy.pptx (seminar).pptx by me
Nano materials show promise for more targeted cancer treatments with fewer side effects. Nanoparticles can be programmed to selectively destroy cancer cells without harming healthy cells, allowing patients to recover more quickly. Various nano structures under research include gold-coated silica nano shells for targeted drug delivery, dendrimers that can combine imaging, targeting and drug functions, and superparamagnetic nanoparticles for magnetic resonance imaging and targeting via magnetic fields. Applications include using quantum dots for optical detection, carbon nanotubes for biomarker detection, and nano sponges for sustained drug release at tumor sites. Overall, nano technologies may enable more effective cancer diagnostics and treatments with less toxicity.
Nanotechnology to detect cancer
This document discusses how nanotechnology can be used to detect cancer. It describes how nanoparticles like gold nanoparticles, quantum dots, and nanorobots could be engineered to target cancer cells for detection and treatment. Gold nanoparticles in particular can accumulate in tumors due to leaky vasculature and be used for imaging. Quantum dots consisting of materials like cadmium selenide can be conjugated to biomarkers to image different parts of cells. Future nanorobots may help distinguish cell types, deliver targeted radiation treatment, and be retrieved after their task is complete, representing a promising new approach to medicine.
Medical science using nano technology
Ultimate goal of nanomedicine is to integrate disease detection, diagnostics, treatment and prevention into a single personalized platform. Nanoparticles can be used for targeted drug delivery and detection of pathogens and cancer. For example, gold nanoparticles have been functionalized with oligonucleotides to detect specific RNA sequences through fluorescence. Nanoparticles less than the size of cancer cell pores can pass through tumor interstitial spaces, delivering therapeutic payloads directly inside tumors. While promising applications are under development, regulatory issues around safety, ethics, and artificial intelligence must be addressed for nanomedicine to realize its potential for widespread health improvements.
Nanomedicine cure
This document discusses the potential applications of nanotechnology in medicine. It describes how nano-scale devices smaller than 50nm can enter cells and those under 20nm can pass out of blood vessels, allowing them to be used as contrast agents and drug delivery systems. The major areas of nanomedicine development are prevention, early detection, imaging diagnostics, and multifunctional therapeutics. Several types of nanoparticles under investigation are described, including quantum dots, photonic crystals, nanoshells, nanowires, and nanoscale cantilevers, which could help diagnose and treat cancer at the cellular level with fewer side effects. While nanomedicine shows great promise, more research is still needed to fully realize its benefits
Adapting nano structures
This document discusses organic nanoparticles and their applications in nanomedicine. It defines nanoparticles as small objects between 1-100 nanometers that behave as single units. In nanomedicine, nanoparticles are used for targeted drug delivery, controlled release applications, and nanoimaging. Examples provided include gold nanorods and quantum dots for molecular imaging and cancer therapy, iron oxide nanoparticles for cancer detection, and the potential future use of nanorobots as miniature surgeons to repair cells or alter DNA.
1nanomedicine
This document discusses nanomedicine and its potential applications for diagnosis and treatment of diseases like Alzheimer's disease. It begins by explaining how nanotechnology allows analysis and repair of the body at the molecular level similarly to how machines are repaired today. It then discusses various nanoscale structures and materials that can be used for nanomedicine, such as liposomes, dendrimers, mesoporous silica, quantum dots, carbon nanotubes, and polymers. Examples are given of current nanomedicine products and applications being researched include drug delivery, imaging, and regenerative medicine. However, challenges are also noted around manufacturing nanoparticles for medical use, assessing their toxicity, ensuring targeted delivery, and removing nanoparticles from the body
Nanotechnoloy in Cancer.pptx
The document discusses the applications of nanotechnology in cancer diagnosis and treatment. It describes how nanoparticles can be engineered for passive and active tumor targeting via the enhanced permeability and retention effect or by attaching targeting ligands. Various nanocarriers including dendrimers, liposomes, quantum dots, iron oxide nanoparticles, and multifunctional nanoparticles are summarized. The document also discusses how nanotechnology enables targeted delivery of drugs, genes, photosensitizers and hyperthermia for cancer therapy. Nanoparticles can also be used as contrast agents for improved cancer imaging and detection. While nanotechnology has made progress in oncology, more clinical studies are still needed to prove the efficacy and safety of nanomedicine applications for cancer patients.
Use of nanotechnology in medical science (pros and cons)
here in this presentation I had shared the basic information regarding use of nanotechnology in medical science and what wonders and improvements that nano technology did in the field of medical science.
NanoBiotechnology, applications, nanoethics
Introduction
Nano
Nanoscale
Nanoparticles & Nanomaterials
Applications
Biological pores
Nanomedicine
Diagnostic & Therapeutic Applications
Nanoethics
Introduction to Nanobiotechnology note.pdf
Nanobiotechnology combines nanotechnology and biotechnology to build and manipulate devices at the nanoscale for studying and engineering biological systems. It allows characterization of biological structures and functions at the nanoscale level. Key applications of nanobiotechnology include developing nanoprobes, nanoparticles, and nanodevices for applications in diagnostics, therapeutics, drug delivery, and tissue engineering in the fields of biology and medicine. Some examples discussed are using nanoparticles for imaging and drug delivery, developing nanosensors for cancer detection, and exploring the use of nanorobots for targeted drug delivery and tissue repair.
Metallic nanoparticle
Metallic NPs and their differenttypes used in the field of medicine, surgery, diagnosis therapeutics and the advantages associated with it.
Nanotechnology
nanotechnology is one of the most advance technology
biotechnology techniques for treatment of different diseases
Use of Nanotechnology in Diagnosis and Treatment of Cancer
The document discusses how nanotechnology can be used for cancer diagnosis and treatment. It describes several nanoscale devices such as nanopores, nanotubes, quantum dots, dendrimers, liposomes, nanoshells, and nanorobots that can help detect genetic mutations associated with cancer, target delivery of drugs to cancer cells, and enable non-invasive cancer diagnosis and treatment with localized heat therapy. The manipulation of matter at the nanoscale allows more precise cancer detection and targeted therapy with fewer side effects than traditional approaches.
Nanotech1
1. Nanotechnology involves manipulating matter at the nanoscale, roughly the size of 2-3 atoms. It has applications in dentistry including improving dental materials and treatments.
2. Specific nanostructures used in dentistry include nanoparticles, nanorods, nanospheres, nanotubes, and dendrimers which are incorporated into materials like composites, adhesives, and impression materials to enhance their properties.
3. Nanotechnology could enable localized anesthesia via nanobots, hypersensitivity treatment by selectively occluding dentinal tubules, continuous cleaning via nanorobotic toothpaste, and improved cosmetics using stronger materials at the nanoscale. It may also transform procedures like orthodontics, implants, cancer diagnosis and
Nano pharmacology
This document discusses nanopharmacology and its applications. It begins with a brief history of nanotechnology and defines nanopharmacology as applying nanomedicine and nanotechnology to living systems at the nanoscale. Various nanomaterials that can be used as drug carriers are described, including liposomes, polymers, dendrimers, metal oxides, quantum dots, fullerenes, and carbon nanotubes. The document outlines how nanotechnology can provide targeted drug delivery, reduce toxicity, and increase efficacy. Applications discussed include cancer treatment, heart disease, diabetes, skin creams, and COVID-19 diagnostic tests and vaccines. In conclusion, the document states that nanopharmacology will significantly change disease diagnosis, treatment and prevention
Nanobiotechnology role in nanomedicine field
This document discusses the role of nanobiotechnology in molecular diagnostics, drug discovery, and drug delivery. It describes how nanoparticles like gold particles, magnetic nanoparticles, and quantum dots can be used for molecular diagnostics applications such as cancer detection, genotyping, and detecting pathogens. Nanoparticles and other nanotechnologies are also discussed as tools for drug discovery and monitoring drug interactions. The document outlines how nanotechnologies enable targeted drug delivery for improved treatment of diseases like cancer through intracellular drug delivery and controlled drug release.
nanotechnology in drug delivery and diagnostic
Nanotechnology is increasingly being used in drug delivery and diagnostics due to advantages like targeted drug delivery, improved solubility and stability, and constant drug release kinetics. Key nanomaterials used include nanoparticles, liposomes, dendrimers, nanoshells, and nanosensors. These materials can incorporate drugs for delivery or be functionalized for diagnostic applications like detecting biomarkers or pathogens. Advanced nanotechnologies like atomic force microscopy and cantilever arrays also provide powerful tools for precision diagnostics. Overall, nanotechnology is enhancing drug delivery methods and enabling highly sensitive disease detection.
Similar to Nanocarriers role in eye cancer treatment and management (20)
Nano materials for cancer therapy.pptx (seminar).pptx by me
Nano materials for cancer therapy.pptx (seminar).pptx by me
Use of nanotechnology in medical science (pros and cons)
Use of nanotechnology in medical science (pros and cons)
Use of Nanotechnology in Diagnosis and Treatment of Cancer
Use of Nanotechnology in Diagnosis and Treatment of Cancer
More from RajdeepaKundu
Self-nano emulsifying drug delivery systems.pptx
This document summarizes a presentation on self-nanoemulsifying drug delivery systems (SNEDDS). SNEDDS are mixtures that spontaneously form nanoemulsions of approximately 200 nm or less upon dilution with water. They consist of oil, surfactant, drug, and co-surfactant or solubilizer. SNEDDS can improve oral bioavailability of hydrophobic drugs by enhancing dissolution rate and permeability as well as reducing first-pass metabolism. Key factors in formulating SNEDDS include selecting oils, surfactants, and co-emulsifiers that enable nanoemulsification as well as considering the drug properties. SNEDDS provide benefits like increased bioavailability, reduced variability, and a potential for
Dissolution model.pptx
The proper diffrence between dissolution and dissolution rate and detailed description of dissolution model with application
Construction and working of silverson emulsifier
The document describes the construction and working of a Silverson emulsifier. It consists of a head attached to a central shaft powered by a motor. The head contains turbine blades surrounded by a perforated mesh. Liquids are sucked into the head and subjected to intense mixing by the high-speed blades. This creates small emulsion globules that exit through the mesh openings, producing a fine emulsion. The Silverson emulsifier provides advantages like rapid mixing, particle size reduction, and homogenization through its high-shear action. Occasional clogging of the mesh pores is its main disadvantage.
Application of buffers,buffers equation and buffer capacity
This document discusses buffers, buffer capacity, and buffer equations. It defines a buffer as an aqueous solution of a weak acid and its conjugate base that resists changes in pH when a small amount of strong acid or base is added. The key points are:
- Buffers work by maintaining an equilibrium between an acid and its conjugate base
- Buffer capacity is a measure of a buffer's ability to resist pH changes upon addition of acid or base
- The buffer equation relates pH, pKa, and relative concentrations of the acid and conjugate base
- Buffers have important applications in drug formulations, fermentation, blood plasma, and more to maintain stable and optimal pH levels.
Suppositories the semi solid dosage form
This document discusses suppositories, which are semisolid dosage forms inserted into body cavities like the rectum. It defines suppositories and describes their types, including rectal, vaginal, nasal, urethral, and ear suppositories. New trends in suppository formulation and packaging are presented, such as tablet, layered, capsule, coated, and disposable suppositories. The mechanisms of local and systemic drug action from suppositories are explained. Advantages include easy administration to children, localized effects, and sustained release of medication. Disadvantages include irritation from some drugs and potential embarrassment for patients.
Alpha-amylase inhibitors: alternative approach for the treatment of type 2 di...
This document discusses alpha-amylase inhibitors as an alternative treatment for type 2 diabetes. It begins by introducing diabetes and its causes and symptoms. It then discusses the different types of diabetes and current diabetes medication options. Finally, it focuses on alpha-amylase inhibitors, explaining that they work by inhibiting the alpha-amylase enzyme involved in starch digestion, which helps control post-meal blood sugar spikes for type 2 diabetes patients.
More from RajdeepaKundu (6)
Application of buffers,buffers equation and buffer capacity
Application of buffers,buffers equation and buffer capacity
Alpha-amylase inhibitors: alternative approach for the treatment of type 2 di...
Alpha-amylase inhibitors: alternative approach for the treatment of type 2 di...
Recently uploaded
Adhd Medication Shortage Uk - trinexpharmacy.com
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Cosmetology and Trichology Courses at Kosmoderma Academy PRP (Hair), DR Growt...
Cosmetology and Trichology Courses at Kosmoderma Academy PRP (Hair), DR Growt...Kosmoderma Academy Of Aesthetic Medicine
Kosmoderma Academy, a leading institution in the field of dermatology and aesthetics, offers comprehensive courses in cosmetology and trichology. Our specialized courses on PRP (Hair), DR+Growth Factor, GFC, and Qr678 are designed to equip practitioners with advanced skills and knowledge to excel in hair restoration and growth treatments.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
Fallopian tube blockage may cause female infertility. For treatment, herbal medicine Fuyan Pill can be a solution.
Ketone bodies and metabolism-biochemistry
This slide consists of all the topics of ketone . This can be used for exam purpose for writing about Diabetic keto acidosis etc . Thank you
Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS). Parc Taulí. Sabadell
Top Travel Vaccinations in Manchester
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
It includes regulation of combination products and medical devices. FDA and industry liaisons.
Acute Gout Care & Urate Lowering Therapy .pdf
In this document , the management of acute gout attacks and a description of urate lowering therapy is mentioned.
NARCOTICS- POLICY AND PROCEDURES FOR ITS USE
This document outlines policies and procedures for handling narcotic and controlled drugs in NABH accredited hospitals.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
June 2024 Oncology Cartoons By Dr Kanhu Charan Patro
une 2024 Oncology Cartoons By Dr Kanhu Charan Patro
Post-Menstrual Smell- When to Suspect Vaginitis.pptx
Do you have abnormal smell after periods? It may be vaginitis. Do not worry, herbal medicine Fuyan Pill can help you get a cure.
Cervical Disc Arthroplasty ORSI 2024.pptx
Indication and installation of a mobile cervical disc prosthesis. Benefits of the PRODISC C VIVO mobile disc prosthesis (Centinel Spine)
CLEAR ALIGNER THERAPY IN ORTHODONTICS .pptx
Dr. ZANAB FARHEEN FAYAZ ,MDS(ORTHODONTICS & DENTOFACIAL ORTHOPEDICS ).
Recently uploaded (20)
Cosmetology and Trichology Courses at Kosmoderma Academy PRP (Hair), DR Growt...
Cosmetology and Trichology Courses at Kosmoderma Academy PRP (Hair), DR Growt...
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
Outbreak management including quarantine, isolation, contact.pptx
Outbreak management including quarantine, isolation, contact.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
June 2024 Oncology Cartoons By Dr Kanhu Charan Patro
June 2024 Oncology Cartoons By Dr Kanhu Charan Patro
Post-Menstrual Smell- When to Suspect Vaginitis.pptx
Post-Menstrual Smell- When to Suspect Vaginitis.pptx
Nanocarriers role in eye cancer treatment and management
- 1. Nanocarrier based strategies for the eye cancer management and treatment Submitted by – Rajdeepa kundu (11810697) Supervised by –Kalvatala Sudhakar
- 2. Eye Cancer Eye cancer is a general term used to describe many types of tumors that can start in various parts of the eye. The basic symptoms for eye cancers are - lump on the eyelids or around the eye, seeing spots or flashes of light, or wiggly lines in front of your eyes. Blinkered vision, a dark spot on the colored part of the eye (the iris) that is getting bigger are the symptoms of ocular cancer The most common parts where the cancer starts are – 1. The Eye Ball ( sclera, Uvea and Retina ) 2. The Orbit (the tissues surrounding the eyeball) 3. The adnexal (accessory) structures such as the eyelids and tear glands.
- 3. Classification of eye cancer Retinoblastoma Ocular Melanoma
- 4. Why do we need nanocarriers for ocular malignancy? • Due to the presence of different types of ocular barriers. • Repeated Intravitreal injection can cause retinal damage. • conventional methods like – Ultrasound, Fluorescein angiography, Fine needle biopsy, Magnetic resonance imaging (MRI), CT scan, etc but these methods can also be a cause of cancer.
- 5. Types of nanocarriers used in Ocular cancer therapy
- 6. Liposome • A liposome is a circular formed vesicle that is made out of at least one phospholipid bilayers extraordinarily phosphatidylcholine which intently looks like the construction of cell layers it has the capacity to epitomize hydrophilic or lipophilic medications have permitted these vesicles to become valuable medication conveyance frameworks.
- 7. Dendrimers • The dendrimers acts as a unimolecular micelle by encapsulating a pharmaceutical through the formation of a dendrimer drug supramolecular assembly. • drug delivery gene transfection, catalysis, size determination rheology modification, It have been explored for the encapsulation of hydrophobic compounds and for the delivery of anticancer drug
- 8. Carbon Nanotube • Carbon nanotube, also called buckytube, nanoscale hollow tubes composed of carbon atoms. • They can design tags that seeks out specific mutation in DNA .Once the mutation has been tagged researchers use a nanotube tip resembling the needle on a record player to trace the physical shape of DNA and the mutation region.
- 9. Advantages and disadvantages of Nanocarriers Advantages Liposome • Biocompatible • Biodegradable • Nontoxic • Prolonged half-life • High carrying capacity Dendrimers • Good carrying capacity • Physical properties and size can be controlled at molecular level Inorganic /Metal NP • Nontoxic • Good tissue penetration • High carrying capacity Microemulsion • Good tissue permeability Disadvantages Liposome • Limited storage condition • Blurring of vision Dendrimers • Conjugates low amount of drugs • Safety is unclear in vivo Inorganic /Metal NP • Difficult for engineering • Non degradable • Rapid uptake by cell • Rapid removal from blood. Microemulsion • Unsuitable for long term sustained drug release.
- 10. Reference • What Is Cancer? - National Cancer Institute.” https://www.cancer.gov/aboutcancer/understanding/what-is-cancer • “Advances in Leukemia Research - National Cancer Institute.” https://www.cancer.gov/types/leukemia/research • Vu, Trang et al. 2017. “Piecing Together the Puzzle: Nanopore Technology in Detection and Quantification of Cancer Biomarkers.” RSC Advances • Yu, Jin Gang et al. 2012. “Irradiation-Mediated Carbon Nanotubes’ Use in Cancer Therapy.” Journal of Cancer Research and Therapeutics • Vasalaki, Marina et al. 2017. “Ocular Oncology: Advances in Retinoblastoma, Uveal Melanoma and Conjunctival Melanoma.” British Medical Bulletin • “Properties and Applications of Gold Nanoshells - CD Bioparticles.” https://www.cdbioparticles.com/support/properties-and-applications-of-gold- nanoshells.html