This document classifies myasthenia gravis into different categories based on the muscles affected and severity of symptoms. Category I involves only ocular muscles with negative tests on other muscles, while Category Ia includes ocular involvement and positive peripheral muscle tests without symptoms. Categories II-IV classify generalized myasthenia gravis as mild, moderate, acute fulminating, or late severe based on impact. Repetitive nerve stimulation and single fiber electromyography are described as electrophysiological tests used in diagnosis.

12. CLASSIFICATION
Muscle
specific
kinase

16. CLASS NAME DESCRIPTION
I Ocular myasthenia Involves ocular muscles
only(Ptosis and diplopia)
Electrophysological tests
of other muscles negative
Ia Ocular MG with peripheral involvement Ocular muscles involves
(Ptosis and diplopia)
Peripheral muscles show
NO SYMPTOMS( EMG
positive)
GENERALIZED MG
IIa MILD
IIB MODERATE
III ACUTE FULMINATING MG
IV LATE SEVERE MG

31. REPITITIVE NERVE STIMULATION TEST SINGLE FIBRE ELECTROMYOGRAPHY
Rapid decrease in amplitude of CMAP Selective recording of action potentials from 2
adjacent muscles fibres from same motor unit
Single dose edrophonium prevents decremental
response
Evaluates time interval between 2 muscle fibre Aps
in same motor unit
Senitivity 75% Sensitive(92-100%) but not specific