Postoperative vision loss (POVL) is an uncommon complication associated with nonocular surgeries like cardiac surgery and spine surgery done in the prone position. It results from ischemia to the visual pathway, particularly the optic nerve and retina, which receive their blood supply from the ophthalmic artery. The posterior portion of the optic nerve is more susceptible due to less vascular supply. Causes of POVL include ischemic optic neuropathy, central retinal artery occlusion, cortical blindness, and posterior reversible encephalopathy syndrome. Risk factors for POVL after cardiac and spine surgery include low hematocrit, vascular disease, long bypass or surgery time, blood transfusions, and direct eye compression during prone positioning. Prevention strategies focus on maintaining adequate hematocrit,