Magnesium is an essential mineral involved in hundreds of biochemical reactions in the body. It is obtained through foods like green leafy vegetables, nuts, and legumes. Magnesium acts as a cofactor for enzymes involved in energy metabolism and helps relax muscles. Deficiency can cause symptoms like fatigue, weakness, and muscle cramps initially and more severe issues like abnormal heart rhythms if deficiency worsens. Maintaining adequate magnesium levels through diet and supplementation is important for overall health and well-being.
Magnesium deficiency can cause a wide variety of features including hypocalcaemia, hypokalaemia and cardiac and neurological manifestations. Chronic low magnesium state has been associated with a number of chronic diseases including diabetes, hypertension, coronary heart disease, and osteoporosis.
As natural healthcare practitioners, we all understand the pivotal and complex role that magnesium plays. Required for over 300 biochemical reactions and metabolic functions including cellular signalling, function & energy production, it is no surprise magnesium is one of the most used supplements in a clinician’s toolbox.
Magnesium supplementation is, however, not as straightforward as we are led to believe. With considerations such as carrier, dose and bioavailability to consider, are we really doing clients (and magnesium) justice with a standard ‘go-to’ product?
In this educational webinar, Dr Nina Bailey not only discusses magnesium in clinical practice but, importantly, also uncovers the perils and pitfalls of the magnesium supplement ‘scene’, in the quest to provide clinical excellence, and the important supplemental factors that must be considered to optimise magnesium status and provide clinical efficacy.
Dr Bailey discusses:
1. A brief overview of the clinical implications of magnesium deficiency
2. Magnesium in practice:
-Supporting digestive complaints and overcoming
malabsorption
-The importance of magnesium for structural support
-Supporting energy levels and insulin sensitivity
3. How to ensure clinically effective dosing and supplementation
magnesium levels are very vitals for human beings especially for neuromuscular transmission. the purpose of the PPT is mainly to appraise the physicians; medical students
Magnesium deficiency can cause a wide variety of features including hypocalcaemia, hypokalaemia and cardiac and neurological manifestations. Chronic low magnesium state has been associated with a number of chronic diseases including diabetes, hypertension, coronary heart disease, and osteoporosis.
As natural healthcare practitioners, we all understand the pivotal and complex role that magnesium plays. Required for over 300 biochemical reactions and metabolic functions including cellular signalling, function & energy production, it is no surprise magnesium is one of the most used supplements in a clinician’s toolbox.
Magnesium supplementation is, however, not as straightforward as we are led to believe. With considerations such as carrier, dose and bioavailability to consider, are we really doing clients (and magnesium) justice with a standard ‘go-to’ product?
In this educational webinar, Dr Nina Bailey not only discusses magnesium in clinical practice but, importantly, also uncovers the perils and pitfalls of the magnesium supplement ‘scene’, in the quest to provide clinical excellence, and the important supplemental factors that must be considered to optimise magnesium status and provide clinical efficacy.
Dr Bailey discusses:
1. A brief overview of the clinical implications of magnesium deficiency
2. Magnesium in practice:
-Supporting digestive complaints and overcoming
malabsorption
-The importance of magnesium for structural support
-Supporting energy levels and insulin sensitivity
3. How to ensure clinically effective dosing and supplementation
magnesium levels are very vitals for human beings especially for neuromuscular transmission. the purpose of the PPT is mainly to appraise the physicians; medical students
fourth important cation , Second most abundant cation in intracellular fluid after K+., co- factor for more than 300 enzymes , functions of magnesium,Mg-ATP substrate , Mg-GTP substrate, ATP metabolism, muscle contraction and relaxation,normal neurological function and release of neurotransmitters are Mg dependent, green leafy vegetables are particularly rich in magnesium. Absorption in intestine and re absorption in Kidney .Paracellular -Claudin-16/-19, TRPM 6/ 7. Factor affecting for absorption and res absorption ,Action potential conduction in nodal tissue. Neuromuscular Irritability,As Constituent of Bones and Teeth: Hypomagnesemia Causes of Hypomagnesemia -Decreased intake, Redistribution from extracellular to intracellular, Increased losses -Renal Gastrointestinal. hypermagnesemia. sing and symptom of Mg deficiency, familial hypomagnesemia . Hypomagnesemia clinical manifestation, endocrinological manifestation , biochemical manifestation, method of estimations , calmagite , methylbule, Xylidyl blue, forzaman dye, enzymatic method, Magnesium Tolerance Test
Magnesium is a very important ion in the body, crucial to over 300 reactions.
Its disorders are underdiagnosed and can help improve healthcare if appropriately treated
Calcium,magnesium,phosphate and chloride imbalances Jyothi Swaroop
Calcium,magnesium,phosphate and chloride imbalances
Their treatment,my main reference is Eric strong's lectures in youtube,and some of the websites.Hope everyone finding Serum electrolytes find atleast some use of it .
Thank you
Inborn errors of amino acid metabolismRamesh Gupta
Inherited disorders of amino acid metabolism e.g. phenylketonuria, maple syrup urine disease, alkaptonuria, homocystinuria, Hartnup disease etc for medical, biochemistry and biology undergraduates
INTRODUCTION
SOURCES OF CALCIUM
RDA OF CALCIUM
FUNCTIONS OF CALCIUM
CALCIUM BALANCE
ABSORPTION OF CALCIUM
EXCHANGE OF CALCIUM BETWEEN BONE AND ECF
EXCRETION OF CALCIUM
REGULATION OF PLASMA CALCIUM LEVEL
APPLIED ASPECTS
fourth important cation , Second most abundant cation in intracellular fluid after K+., co- factor for more than 300 enzymes , functions of magnesium,Mg-ATP substrate , Mg-GTP substrate, ATP metabolism, muscle contraction and relaxation,normal neurological function and release of neurotransmitters are Mg dependent, green leafy vegetables are particularly rich in magnesium. Absorption in intestine and re absorption in Kidney .Paracellular -Claudin-16/-19, TRPM 6/ 7. Factor affecting for absorption and res absorption ,Action potential conduction in nodal tissue. Neuromuscular Irritability,As Constituent of Bones and Teeth: Hypomagnesemia Causes of Hypomagnesemia -Decreased intake, Redistribution from extracellular to intracellular, Increased losses -Renal Gastrointestinal. hypermagnesemia. sing and symptom of Mg deficiency, familial hypomagnesemia . Hypomagnesemia clinical manifestation, endocrinological manifestation , biochemical manifestation, method of estimations , calmagite , methylbule, Xylidyl blue, forzaman dye, enzymatic method, Magnesium Tolerance Test
Magnesium is a very important ion in the body, crucial to over 300 reactions.
Its disorders are underdiagnosed and can help improve healthcare if appropriately treated
Calcium,magnesium,phosphate and chloride imbalances Jyothi Swaroop
Calcium,magnesium,phosphate and chloride imbalances
Their treatment,my main reference is Eric strong's lectures in youtube,and some of the websites.Hope everyone finding Serum electrolytes find atleast some use of it .
Thank you
Inborn errors of amino acid metabolismRamesh Gupta
Inherited disorders of amino acid metabolism e.g. phenylketonuria, maple syrup urine disease, alkaptonuria, homocystinuria, Hartnup disease etc for medical, biochemistry and biology undergraduates
INTRODUCTION
SOURCES OF CALCIUM
RDA OF CALCIUM
FUNCTIONS OF CALCIUM
CALCIUM BALANCE
ABSORPTION OF CALCIUM
EXCHANGE OF CALCIUM BETWEEN BONE AND ECF
EXCRETION OF CALCIUM
REGULATION OF PLASMA CALCIUM LEVEL
APPLIED ASPECTS
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1. Metabolism of magnesium
and it’s disorder
Submitted by
ABDUL MUHEEM
M.PHARMA 2ND SEM.
(PHARMACEUTICS)
JAMIA HAMDARD
2. Content –
• Introduction
• Sources
• Diet intake
• Biochemical functions
• Action of Mg
• Transport of Mg
• Disorders
• References
3. Introduction
• Inorganic elemental atoms that are essential nutrients.
• Not changed by digestion or metabolism.
• The adult body contains about 20gm Mg ,70% of which
is found in bones in combination with Ca &
phosphorous.
• Soft tissue magnesium functions as a cofactor of many
enzymes involved in energy metabolism, protein
synthesis, RNA and DNA synthesis.
• Magnesium is an essential mineral used for hundreds
of biochemical reactions, making it crucial for health.
6. • Bioavailability influenced by: Calcium, Phosphorous.
• Even the magnesium inside whole grains and fresh
vegetables has been declining steadily in recent years
because of depletion of minerals in our soils, making
magnesium supplementation necessary for most people.
7. The modern diet, with an overabundance of refined
grains, processed foods and sugars, contains very little
magnesium.
8. Diet intake-
• ADULT MEN (19 to 30) 400mg
• 31 yrs. and older 420mg
• ADULT WOMEN (19 to 30) 310mg
• 31 yrs. and older 320mg
9.
10. Biochemical functions of Mg-
• Magnesium is the most critical mineral required for
electrical stability of every cell in the body.
• Mg is required for the formation of bones & teeth.
11. • Mg serves as a cofactor for several enzymes
requiring ATP eq- glucokinase ,
phosphofructokinase, hexokinase.
12. Magnesium is considered the “anti-stress” mineral. It
is a natural tranquilizer that functions to relax skeletal
muscles as well as the smooth muscles of blood
vessels and the gastrointestinal tract
13. Action of magnesium –
• Initially much of this magnesium is readily
exchangeable with serum and therefore
represents a moderately accessible magnesium
store which can be drawn on in times of
deficiency.
• Neutralizes negatively charged ions
• Energy metabolism
14. • In plants, magnesium is necessary for synthesis of
chlorophyll and photosynthesis.
16. Transport of Mg-
• Magnesium ions (Mg2+) in cellular biology
are usually in almost all senses opposite to
Ca2+ ions, because they are bivalent too, but
have greater electronegativity and thus hold
on to water molecules stronger, preventing
passage through the channel (even though
magnesium is smaller). Thus Mg2+ ions block
Ca2+ channels (NMDA channels) for example,
etc.
17. • Thus Mg2+ ions block Ca2+ channels (NMDA
channels) for example, etc.
19. Signs of severe magnesium deficiency include:
Extreme thirst
Extreme hunger
Frequent urination
Sores or bruises that heal slowly
Dry, itchy skin
Unexplained weight loss
Blurry vision that changes from day to day
Unusual tiredness or drowsiness
Tingling or numbness in the hands or feet
Frequent or recurring skin, gum, bladder or vaginal yeast
infections
20. • first symptoms of deficiency can be subtle – as
most magnesium is stored in the tissues, leg
cramps, foot pain, or muscle ‘twitches’ can be
the first sign.
21. • Magnesium deficiency will disturb sleep and
background stress levels.
• Other early signs of deficiency include loss of
appetite, nausea, vomiting, fatigue, and weakness.
22. • Magnesium deficiency worsens, numbness, tingling,
seizures, personality changes, abnormal heart
rhythms, and coronary spasms can occur at resulted
lead to death
23. • Persons only slightly deficient in magnesium become
irritable, highly-strung, and sensitive to noise, hyper-
excitable, apprehensive and belligerent.
• A magnesium deficiency can affect virtually every
system of the body.
24. • Symptoms or signs of the cardiovascular system include
palpitations, heart arrhythmias, and angina due to
spasms of the coronary arteries, high blood pressure and
mitral valve prolapse.
• Anxiety and panic attacks are addressed by magnesium by
keeping adrenal stress hormones under control so it really
helps in dealing with stressful emergencies.
26. • Magnesium deficiency is also associated with low
levels of potassium in the blood (hypokalemia).
27. Possible manifestations of magnesium deficiency:
Low energy Fatigue
Weakness Confusion
Nervousness Anxiousness
Irritability Seizures (and tantrums)
Poor digestion PMS and hormonal imbalances
Inability to sleep Muscle tension, spasm/cramps
Calcification of organs Weakening of the bones
Abnormal heart rhythm
28. References –
• Therapeutic use of Mg in anesthesiology, intensive
care and emer med: a review ,Laurent Dubé, Jean-
Claude, Can J intensive care 2003
• Review of functions of calcium, phosphorus and
magnesium, Shashank Joshi, JAPI Aug 2008
• Magnesium and the anaesthetist,David
Gambling,Laird Birmingham; Can J Anaesth 1988 /
35: 6 / pp644-54.
• Biochemistry by U.Satyanarayana,U.Chakrapani,third
edition ,arunabha sen books & allied(p) ltd.