This is a detailed PPT of Mucopolysaccharide for MBBS students. PPT is fully animated! To save your precious time i have included link of Canva Template which you can easily customise as per your wish.

1. A Brief Overview
11/01/2023

2. These are polymerized products of many
monosaccharide units, held together by
glycosidic bonds.

3. 1. Homopolysaccharide or Homoglycans
These are composed of single kind of monosaccharide.
e.g. Starch, Cellulose
2. Heteropolysaccharides or Heteroglycans
These are composed of two or more different kind of
monosaccharides.
e.g. Mucopolysaccharide

4. • These are heteropolysaccharides made up of
repeating units of amino sugars and uronic acids.
• They are also called Glycosaminoglycans(GAG)
• Acetylated amino groups, sulfate and carboxyl
groups are generally present in GAG structure.
• Mucopolysaccharides in combination with
proteins form mucoprotines or proteoglycans.

5. • They are major components of the extracellular
matrix or ground substance.
• They lubricate joints both at the surface of
cartilage and in synovial fluid.
• The viscous lubricating properties of mucous
secretions are also due to the presence of
• glycosaminoglycans, which led to the original
naming of these compounds as
mucopolysaccharides

6. • Heparan Sulfate
• Heparin
• Hyaluronic Acid
• Keratan Sulfate
• Chondroitin Sulfate
• Dermatan Sulfate
H
H
H
K
C
D

7. Amino sugar :
Uronic acid :
N-glucosamine
Glucuronic acid

8. • It is associated with the plasma membrane of cells.
• It may act as receptors and may also participate in
the mediation of the cell growth and cell
communication.
• It is also found in the basement membrane of the kidney.

9. N-glucosamine
L-iduronic acid
Amino sugar :
Uronic acid :

10. • It is an anticoagulant widely used when taking
blood in vitro for clinical studies.
• It is also used in vivo in suspected
thromboembolic conditions to prevent
intravascular coagulation.
• It activates antithrombin III, which in turn
inactivates thrombin, factor IX and factor X.
• Heparin is present in liver, lungs, spleen and
monocytes.

11. Amino sugar :
Uronic acid :
N-acetylglucosamine
D-Glucuronic acid

12. • Serves as lubricant and shock absorber,
facilitates cell migration in embryogenesis,
morphogenesis, wound healing.
• It is present in connective tissues, tendons,
synovial fluid and vitreous humor of eye.
• It is also forms a gel around the ovum which is
cleared by hyaluronidase enzyme.

13. Amino sugar :
Uronic acid :
N-acetyl-D-glucosamine
6-sulphate
D-galactose

14. • It is the only GAG, which does not contain any
uronic acid.
• Instead of uronic acid it contains galactose
• It is found in cartilage, cornea and connective
tissues.
• It keeps cornea transparent.

15. Amino sugar :
Uronic acid :
N-acetyl-D-
galactosamine
D-Glucuronic acid

16. • It is present in ground substance of connective
tissues.
• It is widely distributed in cartilage, bone,
tendons, cornea and skin.
• It helps to maintain the structure and shapes
of tissues.
• It is structurally comparable with
hyaluronic acid.

17. Amino sugar :
Uronic acid :
N-acetylgalactosamine
4-sulfate
L-iduronic acid

18. • It is found in skin, blood vessels and heart valves.
• It is also found in intracellular locations such as
the nucleus.
• It is structurally similar to chondroitin 4-sulfate
• Only difference is that in place of D-glucuronic,
L-iduronic acid is present.
• It maintains the shape of tissues.

19. • Memonic - The savior of medicos! :)
H
H
H
K
C
D
Heparan
Sulfate
Hepari
n
Hyaluronic Acid
Keratan
Sulfate
Chondroitin Sulfate
Dermatan Sulfate
Uronic Acid
Glucuronic
Acid
Iduronic
Acid
Glucuronic
Acid
Glucuronic
Acid
Iduronic
Acid
Galactose
Amino sugar
N-
glucosamine
N-
glucosamine
N-acetylglucosamine
N-acetylglucosamine
N-acetylgalactosamine
N-acetylgalactosamine

20. Thank You!
By
-
AMAN SINGH

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