The document discusses nuclear magnetic resonance (NMR) spectroscopy, specifically proton (1H) and carbon-13 (13C) NMR. It provides information on why NMR is used, the types of information it can provide about compounds, and the physical properties of 1H and 13C nuclei that influence their NMR spectra. It also discusses factors that affect chemical shifts, common chemical shift ranges, coupling behaviors, and how to determine the number of signals expected for given compounds from their carbon environments. The document aims to explain the fundamentals and applications of 1H and 13C NMR spectroscopy.
This presentation describes about the preparation, properties, bonding modes, classification and applications of metal Dioxygen Complexes. Also explains the MO diagram of molecular oxygen.
Two dimensional Nuclear Magnetic Resonance (2D NMR) refers to a set of multi pulse techniques which were introduced to overcome the complex spectra obtained with NMR.
It is a set of NMR methods which give data plotted in a space defined by two frequency axes rather than one.
Crown ethers
NOMENCLATURE
GENERAL SYNTHESIS OF CROWN ETHER
AZA CROWN
CRYPTAND
APPLICATIONS
1. SYNTHETIC APPLICTION
Esterification
Saponification
Anhydride formation
Potassium permanganate oxidation
Aromatic substitution reactions
Elimination reactions
Displacement reaction
Generation of carbenes
Superoxide anion
Alkylations – 1. o-alkylations
2. c-alkylations
3. n-alkylations
2. ANALYTICAL APPLICATION
Determination of gold in geological samples
Super critical fluid extraction of trace metal from solid and liquid materials
Application of ionic liquids in analytical chemistry
Oxidation and determination of aldehydes
Crown ethers are used in the laboratory as phase transfer catalyst
OTHER APPLICATION
It is used in photocynation
Resolution of racemic mixture
Benzoin condensation
Hetrocyclisation
Synthesis of furanones
Acetylation of secondary amines in presence of primary amine
This presentation describes about the preparation, properties, bonding modes, classification and applications of metal Dioxygen Complexes. Also explains the MO diagram of molecular oxygen.
Two dimensional Nuclear Magnetic Resonance (2D NMR) refers to a set of multi pulse techniques which were introduced to overcome the complex spectra obtained with NMR.
It is a set of NMR methods which give data plotted in a space defined by two frequency axes rather than one.
Crown ethers
NOMENCLATURE
GENERAL SYNTHESIS OF CROWN ETHER
AZA CROWN
CRYPTAND
APPLICATIONS
1. SYNTHETIC APPLICTION
Esterification
Saponification
Anhydride formation
Potassium permanganate oxidation
Aromatic substitution reactions
Elimination reactions
Displacement reaction
Generation of carbenes
Superoxide anion
Alkylations – 1. o-alkylations
2. c-alkylations
3. n-alkylations
2. ANALYTICAL APPLICATION
Determination of gold in geological samples
Super critical fluid extraction of trace metal from solid and liquid materials
Application of ionic liquids in analytical chemistry
Oxidation and determination of aldehydes
Crown ethers are used in the laboratory as phase transfer catalyst
OTHER APPLICATION
It is used in photocynation
Resolution of racemic mixture
Benzoin condensation
Hetrocyclisation
Synthesis of furanones
Acetylation of secondary amines in presence of primary amine
The chelate formation of thorium with 1, 2-naphthoquinone, 1-oximeIOSR Journals
Thorium chelate of 1,2-naphthoquinone, 1-oxime was synthesized. The vibrational wave numbers of thorium with 1,2-naphthoquinone, 1-oxime have been calculated using Gaussian 09 software code, employing RHF / SDD basis set and IR data is compared with experimental values. The predicted infrared intensities and Raman activities are reported. The calculated frequencies are in good agreement with the experimental values. The calculated geometrical parameters are also given. The study is extended to calculate the HOMO-LUMO energy gap, Ionization potential (I), Electron affinity ( A ), Global hardness (η ), chemical potential (μ ) and global electrophilicity ( ω ). The calculated HOMO-LUMO energies show the charge transfer occurs in the molecule. Optimized geometrical parameters of the title compound are in agreement with similar reported structures.
The FTIR and FT Raman spectra of 1-4-Dichloro-2-NitroBenzene (14DC2NB) have been recorded in the region 4000-400 cm-1 and 3500-50 cm-1 respectively. The optimized geometry ,frequency and intensity of the vibrational bands of 1-4-Dichloro-2-NitroBenzene (14DC2NB) was obtained by the Density functional theory (DFT)using the basis set 6-31g(d,p). The harmonic vibrational frequencies were calculated and scaled values have been compared with experimental FT-IR and FT-Raman spectra. The Calculated and Observed frequencies are found to be in good agreement. UV-Visible spectrum of the compound was recorded, the electronic properties and HOMO - LUMO energies were calculated by Time Dependent DFT (TD-DFT) approach. A detailed interpretation of the infrared and Raman spectra were also reported based on Potential Energy Distribution (PED). The 1H and 13C nuclear magnetic resonance (NMR) chemical shifts of 14DC2NB were calculated using the GIAO approach by applying B3LYP method. The calculated HOMO and LUMO energies show that charge transfer occurs within the molecule. The Chemical reactivity and Thermodynamic properties of 14DC2NB at different temperatures were also calculated
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
BÀI TẬP BỔ TRỢ TIẾNG ANH GLOBAL SUCCESS LỚP 3 - CẢ NĂM (CÓ FILE NGHE VÀ ĐÁP Á...
M.Sc. 13 c nmr
1. Why NMR
Why is it needed? What is it used for?
To find out the required and side products in the reactions.
To analysis and confirm the structures of the natural products.
We use a variety of spectroscopic techniques-
UV spectroscopy :-
Gives the information about Chromospheres & conjugated systems
IR spectroscopy : -
Gives the information about the Functional groups
Mass spectroscopy : -
Gives the information about exact mass of the compounds.
A + B Product
3/9/2022 1
2. 1H NMR spectroscopy :
Gives the information about no. of hydrogen's & the types of
hydrogen atoms.
Gives the more detailed structural information & the most powerful
spectroscopic method used by organic chemists
13C NMR spectroscopy :-
Gives the information about no. of carbon & the types of carbon
atoms.
It gives direct information about carbon skeleton in the
molecule.
One Dimensional NMR
The NMR spectra which have one frequency axis and one
intensity axis is known as One Dimensional NMR spectrum .
3/9/2022 2
3. History of 13C NMR
First CMR by Lanterbur and Holm, 1957
PND (Proton Noise Decoupled) by Ernst, 1965
F T CMR (Fourier Transform) by Ernst, Anderson,
1966
ORD (Off Resonance Decoupled)
APT (Attached Proton Test)
DEPT (Distortionless Enhancement by
Polarization Transfer)
INEPT (Insensitive Nuclei Enhanced
Polarization Transfer)
3/9/2022 3
4. Physical Properties of 13C & 1H nucleus and its Spectrum
S. N. Nuclei 13C 1H
1 Relative abundance 1.11 99.98
2 Spin Q. N. (I) 1/2 1/2
3 Magnetic moment (μ) 0.7 2.8
4 Gyro magnetic ratio (γ) 1/4 1
5 Chemical shift (δ) Range 0-220 ppm 0-15 ppm
6 Relative sensitivity at natural
abundance
1.11/99.98
= 1/90
99.98/99.98
=1
Spectrum 13C 1H
7 Integration Signals can not
integrated
Signals can be
integrated
8 Spectrum Multi Scan
spectrum
Single Scan spectrum
9 Spectrum Simple spectrum Complex spectrum
10 Spectrum Well separated Less separated
3/9/2022 4
5. Difference Between Physical Properties of 13C & 12C nucleus
S. N. 13C 12C
1 The relative natural abundance
is 1.11%
The relative natural abundance is
98.99 %.
2 It has magnetic moment
(I)=1/2
It has magnetic moment (I)= 0
3 It is magnetic in nature. It is non-magnetic in nature.
4 It is used for recording CMR. It is not used for recording CMR.
Number of CMR signals -
The number of signals in CMR spectrum is equal to number of Sets/
kinds/types of carbon. (which depends on chemical environment)
Similar to 1H NMR, Chemically equivalent carbon gives one sharp
signals
While Chemically non-equivalent carbons gives different signals.
3/9/2022 5
7. S N No. of sets
of Carbon
No. of CMR
signals
S N No. of sets
of Carbon
No. of CMR
signals
i 4 4 vii 7 7
ii 7 7 viii 3 3
iii 8 8 ix 4 4
iv 5 5 x 7 7
v 6 6 xi 6 6
vi 7 7 xii 2 2
3/9/2022 7
8. Indicate the Number of Signals expected in the CMR spectrum of
the following Compounds
O O
O
CH3
Cl
Cl
a b
c
d
e f
g h i
j k
N
N
l
3/9/2022 8
9. S N No. of sets
of Carbon
No. of CMR
signals
S N No. of sets
of Carbon
No. of CMR
signals
a 1 1 g 8 8
b 1 1 h 4 4
c 5 5 i 3 3
d 7 7 j 4 4
e 3 3 k 5 5
f 4 4 l 1 1
3/9/2022 9
10. Indicate the number of signals expected in the CMR spectrum of the
following isomeric compounds
X X
X
X
X
X
X
X
Y
X
Y
X
Y
X
X X
X
X
X
X
X
X
X
X
Y
X
X
Y
X
X
Y
X
Y
X
X
X
X
X
X
X
X
X
1 2 3 4 5 6 7
8 9 10 11 12 13
14 15 16
3/9/2022 10
11. S N No. of sets
of Carbon
No. of CMR
signals
S N No. of sets
of Carbon
No. of CMR
signals
1 4 4 9 4 4
2 3 3 10 6 6
3 4 4 11 4 4
4 2 2 12 6 6
5 4 4 13 6 6
6 6 6 14 6 6
7 6 6 15 2 2
8 2 2 16 4 4
3/9/2022 11
12. Position of CMR signals :-Chemical shifts
Chemical shifts values to different carbons
S. N. Hybridization Nature of Carbon Chemical shift
in δ or ppm
1 SP3 C-C 0-30 δ
C-X (O, N, S, Halogen)
C-C=,
30-60 δ
2 SP 60-100 δ
100-120 δ
3 SP2 C=C, C=N, C=S 100-150 δ
C=O 160-220 δ
Amide, Acid, Ester & Acid
Chloride, Acid anhydride
(C=O)
160-190 δ
Aldehyde & Ketone (C=O) 190-220 δ
Benzene C=C 128.5 δ
C C
C N
3/9/2022 12
13. Comparison of 1H and 13C- Chemical Shifts
Group 1H 13C
Cyclopropyl- 0.5-1.5 3-10
CH3C 0.8-1.2 10-30
CH3C=C 1.6-2.0 18-35
H-C-C=O 2.5-2.7 35-52
CH3 –O 3.3-4.2 53-75
H-C ≡ C 2.5-3.0 65-95
H-C ≡ N 3-3.2 115
=CH2 4.5-5.0 100-120
Aromatic 7-8 110-150
R-CHO 9.7 182-205
3/9/2022 13
15. Chemical shifts of Alcohols & Ethers
OH
61.4
35
21.1
13.6
OH
23.6
32
9.9 68.7 OH
31.8
68.4
O
10.7
67.9
57.6
O
17.1
67.4
O
24
73.2
11.1
O O
O
O
O
24.9
27.7
69.5
66.5
92.8
64.9
28.6
3/9/2022 15
17. Chemical shifts of carbon functional group
3/9/2022 17
H3C
O
OH
178.1
H3C
O
Cl
169.5
H3C
O
O
CH3
173.3
167.7
H3C
O
NH2
172.7
H3C
O
H H3C
O
CH3
199.8 206.4
H3C
O
O CH3
O
18. Types of Coupling in 13CMR
1) 13C-13C coupling-
Not observed due low natural
abundance of 13C nuclei.
2) 13C-Ha coupling-
It is most commonly observed type of coupling.
It is also known as Residual Coupling
( J r =100-250 Hz)
3) 13C-Hb coupling- Long Range Coupling
Also commonly observed. ( J =1-20 Hz)
4) 13C-Hc coupling-Long Range Coupling
Also commonly observed. ( J =1-5 Hz)
C
OH
H
H
H
H
H
13
a
b
c
X
H
H
C
OH
H
H
H
H
H
13
a
b
c
H
H
C
OH
H
H
H
H
H
13
a
b
c
H
H
C
OH
H
H
H
H
H
13
a
b
c
H
H
3/9/2022 18
19. • In PND technique, all singlet are observed because all interactions between
protons and 13C nuclei are completely disappeared.
• This technique simplifies the spectrum & avoids overlapping multiplets.
• It has disadvantage that the information on attached hydrogen's is lost.
• In decoupling experiment, all the protons in the molecule are irradiating
simultaneously using second radiofrequency in the proper range.
• Due to double irradiation, each proton undergo rapid upward and downward
transition.
• Because of the rapid transition, spin interactions between protons and 13C
nuclei are completely disappeared
• Hence all singlets are appeared for all sets of carbon.
Proton Noise Decoupled Spectra (PND)
3/9/2022 19
20. Proton Noise Decoupled Spectra of 2-bromo butane
H3C
1
C
2
C
3
CH3
4
Br
H
H
H C1=12.6
C4=26.5
C2=35.3
C3=53.2
TMS
3/9/2022 20
21. Off- Resonance Decoupled Spectra
In many cases of the proton coupled spectrum, the information about
attached hydrogen is obtained, but the spectrum becomes highly
complex due to residual and long range couplings. Hence it is very
difficult to resolve and assign correctly.
While in proton noise decoupling (PND) technique, all singlet are
observed. Hence unfortunately much useful information about the
attached hydrogen is lost.
A second compromise method called off-resonance decoupling can often
provide multiplet information while keeping the spectrum relatively
simple.
Similar to PND, in off-resonance technique also second radio-frequency
source is used for double irradiation. But in ORD, the decoupler is
set(held) to avoid complete decoupling.
The off-resonance decoupled spectrum retains the coupling between
each carbon and directly attached proton but effectively removes long
range couplings.
3/9/2022 21
22. Multiplicity/Spin-spin splitting:-
In the off resonance decoupling technique
Multiplicity (N)= (2nI + 1)
where n = No. of protons directly bonded to carbon
I = Spin Q. N. of coupling Partner
For Hydrogen (I =1/2)
N = [(2n x 1/2) +1]
N = [n+1]
S
N
Nature of carbon No. of
coupling
partners (n)
Multiplicity
N = [n+1]
Known as
1 -C- (Quaternary Carbon ) 0 (0+1)=1 singlet
2 -CH- (Methine Carbon) 1 (1+1)=2 doublet
3 -CH2- (Methylene Carbon) 2 (2+1)=3 triplet
4 -CH3 (Methyl Carbon) 3 (3+1)=4 quartet
Off- Resonance Decoupled Spectra
3/9/2022 22
24. Examples on Multiplicity/ Splitting of CMR signals :-
According to the off resonance decoupling technique
Multiplicity (N)= (2nI + 1)
where n = No. of protons directly bonded to carbon
I = Spin Q. N. of coupling Partner
For Hydrogen I =1/2
N = [(2n x 1/2) +1]
= [n+1]
S N Example Set a Set b Set c Set d
1 d d s --
2 s s quartet Triplet
3 s -- -- --
a
b
c
a
a
a
b
b
b
c
O
O
d
c
a
a
b
b
c
d
d
d
a
N
N
a
a
a a
a
3/9/2022 24
25. S N Example Set a Set b Set c Set d
4 q d s --
5 q t d --
6 q t d q
7 t t t --
3/9/2022 25
H3C
1
C
2
C
3
CH3
4
Br
H
H
H
1
2
O
3
2
O
26. Chemical Shifts of Common Solvents
Position of the signal in ppm
(No. of lines in carbon signal, multiplicity N= ( 2nI + 1)
where n = No. of coupling Partners
I= Spin Q. N. of Deuterium=1
1. CD3COOD (Deuterated Acetic acid) 20(7), 178.4(1)
2. CD3CN (Deuterated Acetonitrile ) 1.3(7), 111.7(1)
3. CD3COCD3 (Deuterated Acetone) 29.8(7), 206(1)
4. (CD3)2SO (Deuterated dimethyl methoxide) 39.5(7)
5. CD3OD (Deuterated Methanol) 49(7)
6. CD3NO2 (Deuterated Nitromethane) 57.7(7)
7. CCl4 (Carbon Tetrachloride) 96(1)
8. CDCl3 (Deuterated Chloroform) 77(3)
9. CD2Cl2 (Deuterated Dichloromethane) 53.8(5)
10. Dioxane-d8 67.4(5)
11. CS2 (Carbon disulfide) 192.8(1)
12. C6D6 (Deuterated Benzene) 128.5(3)
13. Pyridine-d5 149.9(3), 129.3(3), 135.3(3)
C C C
3/9/2022 26
27. 3/9/2022 27
The attached proton test is a 1D 13C NMR experiment that is
used to assignment for separating quaternary carbons & CH2 signals
from CH & CH3 signals.
The APT experiment gives positive signals for methine (CH)
and methyl (CH3) carbons and negative signals quaternary (C) and
methylene (CH2) carbons.
It is slightly less sensitive than DEPT but a single experiment
shows all carbon signals at one time.
In DEPT experiment signals of quaternary carbons suppresses
and requires up to three different acquisitions to get clear and full
information of all the carbons.
APT (Attached Proton Test)
28. 3/9/2022 28
APT spectrum of Ethylbenzene showing signals of CH &
CH3 positive while CH2 & quaternary C are negative
H2
C
CH3
a
b
c
d
d
e
e
f
a
b
c
Solvent Peaks
d, e, f
29. DEPT (Distortionless Enhancement by Polarization Transfer)
• DEPT technique is used for determining the presence of primary, secondary
& tertiary carbon atoms signals from quaternary carbons & other carbons
with no attached protons in three steps.
• It is now much more widely used than proton coupling to determine the
number of hydrogens attached to a carbon.
• DEPT 13C spectrum does not show a signal for a quaternary carbons (carbon
that is not attached to a hydrogen).
• For Ex: 13CMR of 2-butanone shows 4 signals, as it has four sets of carbons,
whereas the DEPT shows only three signals because the quaternary carbonyl
carbon is not bonded to a hydrogen, so it will not produce a signal.
3/9/2022 29
H3C
1
2
3
CH3
4
O
30. 13C DEPT spectra enable different carbon
(CH3, CH2, CH, and quaternary)
Types to be identified-
DEPT 135: -CH2 peaks negative
-CH and CH3 peaks positive
DEPT 90: only CH peaks visible.
DEPT 45 : -CH2 and quaternary peaks negative
-CH3 and CH peaks positive
3/9/2022 30
DEPT (Distortionless Enhancement by Polarization
Transfer)
31. DEPT 13C NMR Spectra of Ipsenol
In CDCl3 at 75.6 MHz:
DEPT-90(A)-CH up.
DEPT-135(B),-CH3 & CH up, CH2 down.
At Bottom-PND13C NMR
3X CH-
3X CH, 2X CH3
4X CH2
3/9/2022 31
C2
C4
C7
C1
HO
1'
2
3
4
5
6
7
8
1
9
32. Insensitive nuclei enhancement by polarization transfer (INEPT) is a
signal resolution enhancement method used in NMR spectroscopy.
It is used to improve the sensitivity of NMR experiments on the nuclei
which have low abundance & low gyromagnetic ratio.
The gyromagnetic ratio of 13C is 4 times lower than that of the proton, so
the signal intensity it produces will be 64 times lower than one produced
by a proton.
The net effect in INEPT is the non-selective polarizarion transfer from
protons to 13C nuclei with the appropriate 1H-13C coupling.
3/9/2022 32
INEPT (Insensitive Nuclei Enhancement by
Polarization Transfer)
37. 3/9/2022 37
S. N. Structure S. N. Structure
01 07
02 08
03 09
04 10
05 11
06 12
C N H
H3C
CH3
14.3
21.5 155.2
C C CH2
H OH
74 84 50
27
40
174
Br OH
O
Br
16
46 202
H
O
14
153.7 134.9 193.4
H
O
18.2
O
O
28
178
22
69
150
25
170
O CH3
O
100
O
O
136.6
164.3
O
N
O
30.3
183.6
O
H
60.4
20.2
170.7
O
H3C
O
14.4
65
14
161
O
C
O
90
Cl
Cl
Cl
127,8 131 32.9
Br
17.5
39. 3/9/2022 39
01 08
02 09
03 10
04 11
05 12
06 13
07 14
CH2 105
150
33
33
17
H C C C
OH
CH3
CH3
31
64
90
70
32
40
45
H3C
H
N
H
N
CH3
41
25
43
Cl CH3
CH3
22
H2C
OCH3
O
H3C
125
137
18
168
53
26
34
21 67
75
H3C
H2
C
C
H2
HC
CH2
O
130
166
129 60
14
H2C
O
O
25.5
27.6 47.8
NH
47.8
27.6
22
13
H C C
H2
C
H2
C
18
31
84
68
H2
C CH3
26
24
36
24
OH
36
70
219
46
31
38
20
O CH3
32
63
28
34
35
27
43
H2N
OH
136
N
NH2
O
147
123
167
130
152
152.3
H3C C
H
C
H
C
H
C
H
193
141.6 130.4
130.2
C H
19
41. 3/9/2022 41
01 02
03 04
05 06
07 08
22 67.6
41
7
OH
H3C
OH
CH3
29.6
14.2 32.5
23.2
a
a
b
b
c
c
d
d
30.2
a
b
c
d
C
CH
H3C CH3
CH3
CH3
H3C
a
a
e
31.2
CH2
e
33.4
25
25.5
34.1
114.7 32.2
139.2
a
h
g
b
c
f
e
d
i j
29.6
29
14
29.8
29.4
23
142
104
15.4
54
20
173
15.2
O
O
CH3
CH3
OCH3
O
OH
135
130
119
117.9
112.9
162.4
170
52
128
128.4
125.4
137
O
50.8
52.1
NH2
CH3
118.6
128
115.4
126
128.4
144.3
23.9
13