Morphine and related drugs.pptx

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The document discusses several opioid drugs derived from morphine, including morphine sulfate, codeine, meperidine hydrochloride, anilerdine hydrochloride, diphenoxylate hydrochloride, loperamide hydrochloride, fentanyl citrate, methadone hydrochloride, propoxyphene hydrochloride, pentazocine, and levorphanol tartrate. For each drug, it describes their mechanism of action and medical uses, such as for pain relief. The document also introduces morphine and its chemical structure, as well as opioid receptors and antagonists like naloxone.

Education

MORPHINE AND RELATED
DRUGS
Submitted by: Rahul Pal, Prachi Pandey
M. PHARM (PHARMACEUTICS)
DEPARTMENT OF PHARMACEUTICS, NIMS INSTITUTE OF PHARMACY, NIMS UNIVERSITY
JAIPUR, RAJASTHAN INDIA

Introduction
raw opium
Uses of Morphine
10kg 1kg

Opioid Receptors
Naloxone Naltrexone
Ethylketazocine Bremazocine
DADLE DPDPE

MORPHINE DERIVATIVES
Naloxone Naltraxon nalorphine

Morphine Sulphate
Mechanism of Action
Uses

Meperidine hydrochloride
Mechanism of Action
Uses:

Anilerdine hydrochloride
Mechanism of Action
Uses

Diphenoxylate Hydrochloride
Mechanism of Action
Uses

Loperamide Hydrochloride
Mechanism of Action
Uses:

Fentanyl citrate
Mechanism of Action
Uses

Methadone Hydrochloride
Mechanism of Action
Uses

Propoxyphene Hydrochloride
Mechanism of Action
Uses

LevorphanolTartrate
Mechanism of Action
6 to 8 times
Uses

The core AIM of the present study is to develop a novel, rapid, precise and accurate RP-HPLC method for simultaneous separation and quantification of six fluoroquinolones OF LEVOFLOXACIN (LEVO), PRULIFLOXACIN (PRFX), GATIFLOXACIN (GATI), SPARFLOXACIN (SPAR), MOXIFLOXAXIN (MOXI) AND BALOFLOXACIN (BALO) for the the day to day analysis. The author felt that a novel single method for separation and quantification of all the above said drugs on single chromatographic system without any minor changes in detection wavelength and mobile phase composition. To develop rapid, sensitive and economical analytical method based on HPLC for separation and estimation of six fluoroquinolones pharmaceutical dosage forms. To develop method with shorter run time and better sensitivity. Reducing the solvent consumption to make it more eco-friendly. Avoid the column damage by minimizing the buffer strength and pH of mobile phase than reported methods. To validate the method for different parameters like Accuracy, Precision, Linearity, specificity, Robustness International Conference on Harmonization ICH Q2(R1) guidelines.. To apply the developed RP-HPLC method in the analysis of pharmaceutical formulations.

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