Menthol is the active ingredient in Rowachol, a cholagogue herbal drug used to treat gallstones and biliary disorders. Rowachol works by increasing bile production and relaxing the bile ducts, helping to reduce painful spasms and allowing gallstones to pass more easily. It also reduces the cholesterol content of bile and can help break up cholesterol-based gallstones. Each capsule of Rowachol contains menthol and other terpenes that work to relax the bile ducts and increase biliary secretion. Common side effects include headache and gastric irritation.

1. CHOLAGOGUE HERBAL
DRUG
BY . MOHAMMAD ALY AHMED 😎😎
FAKHRY ANDRAWS 👨🔬👨🔬👨🔬

2. MENTHOL (C10H20O):
Menthol is an organic compound, more
specifically a monoterpenoid, made
synthetically or obtained from the oils of
corn mint, peppermint, or other mints.
It is a waxy, clear or white crystalline
substance, which is solid at room
temperature and melts slightly above.

3. Structure of MENTHOL :
NATURAL MENTHOL EXISTS AS
ONE
PURE STEREOISOMER, NEARLY
ALWAYS
THE (1R,2S,5R) FORM (BOTTOM
LEFT
CORNER OF THE DIAGRAM
BELOW).

4. Trade form

5. Example: ROWACHOL

6. MECHANISM :
Increases bile production and relaxes the bile
ducts. This helps reduce painful spasms of bile
ducts. It also makes it easier for any gallstones
present to be passed out (expelled) with the bile.
Note : Rowachol somehow has none known
contraindications 🤔
🤔
🤫
!!

7. Uses and Actions:
●reduces the cholesterol content of bile.
●break up cholesterol-based gallstones.
●relaxes the bile ducts.
●Hepatic disorders.
●Biliary disorders.
●Gall stones disorders.
●Increase Biliary secretion.

8. ■Each Capsule contains:
●Pinene (α+β) 17 mg
●Camphene 5 mg
●Cineol 2 mg
●Menthone 6 mg
●Menthol 32 mg
●Borneol 5 mg
●Olive Oil 33 mg

9. ■Side effects:
●Headache
●Stomach upset (Gastric Irritation)
• Runny stools (Diarrhoea).
Storage:
Do not store above 25˚C.
Store in a dry place.

10. Marketing Authorisation Holder and Manufacturer
Rowa Pharmaceuticals Ltd.
EDA Reg. No.: 200/2021
Packed by :
Amoun Pharmaceutical Co.
Price :
39 L.E per carton box
13 L.E per strip

11. Alternatives gurd
...
BILICHOL :
Which have
(MENTHOL ) as
active Ingredient...
And has the same
effect on patients👍
👍

12. Alternative drug..
URINEX :
Although URINEX has
the an effect semi like
ROWACHOL 😲😲but the
active ingredient in it is (
Alpha-pinene and
Anethole …)

13. General USES For MENTHOL..
1. Reduce the cough .
2. Reduce throat irritation .
3. Reduce gingival irritation .
4. Relieves body‘s pain.

14. MECHANISM in ditail
 NAVIdentificationPharmacologyIndicationAssociated ConditionsContraindications &
Blackbox WarningsPharmacodynamicsMechanism of actionAbsorptionVolume of
distributionProtein bindingMetabolismRoute of eliminationHalf-lifeClearanceAdverse
EffectsToxicityPathwaysPharmacogenomic
Effects/ADRsInteractionsProductsCategoriesChemical IdentifiersReferencesClinical
TrialsPharmacoeconomicsPropertiesSpectraTargets (2)Menthyl salicylateBrand
NamesMax-freezeGeneric NameMenthyl salicylateDrugBank Accession
NumberDB11201BackgroundMenthyl salicylate is an ester of menthol and salicylic acid
1.This product is used to treat minor aches and pains of the muscles/joints (e.g.,
arthritis, backache, sprains) 2.TypeSmall
MoleculeGroupsApprovedStructureWeightAverage: 276.376Monoisotopic:
276.172544633Chemical FormulaC17H24O3Synonyms1-Menthyl
salicylatePHARMACOLOGYIndicationFor the temporary relief of pain associated with
rheumatism, arthritis, neuralgia, sprains and strains of joints and muscles, lumbago and
fibrositis 7.Build, train, & validate predictive machine-learning models with structured
datasets.Associated ConditionsBack painContusionsJoint PainMuscle
StrainMusculoskeletal PainSprainsArticular inflammationContraindications & Blackbox
WarningsAvoid life-threatening adverse drug events & improve clinical decision
support.

15. Cont. MECHANISM in ditail
 PharmacodynamicsMenthol and methyl salicylate are known as counterirritants.
They work by causing the skin to feel cool and then warm. Used together, they
provide symptomatic relief for mild to moderate muscular and joint aches and
pains, muscle cramps, shoulder aches and stiff neck.2.Mechanism of
actionMenthol dilates the blood vessels causing a sensation of coldness, followed
by an analgesic effect. Menthol also acts as a penetration enhancer, increasing the
penetration of drugs when applied on the skin, to give a faster onset of action
6.Methyl salicylate is a salicylic acid derivative, and when combined with menthol,
produces menthyl salicylate 6.Salicylates inhibit cyclooxygenase, thereby
reducing the formation of prostaglandins, and cause platelet dysfunction Methyl
salicylate is used topically as a counter-irritant. Upon application, it is absorbed
through the skin and is applied for the relief of pain in rheumatic conditions and
painful muscle or joints 6.The menthol dilates blood vessels, why the salicylate
portion provides a topical anesthetic and analgesic action on the affected area.
The cooling and warning action may interfere with the transmission of pain
signals through nerves 6.

16. References
1. https://www.amoun.com/leap-portfolio-project/rowachol/
2. https://www.drugs.com/uk/rowachol-capsules-leaflet.html
3. https://www.mims.com/malaysia/drug/info/rowachol?type=fu
ll
4. livertoxic.nih.gov

17. Slide share web site…

18. Thank you