Hospitals stock a variety of IV fluids including isotonic crystalloids like normal saline, hypotonic fluids like D5W, and colloids like albumin. Normal saline and D5W come in large volumes up to 1 liter while albumin and other blood products are available in smaller volumes. Pharmacists must carefully consider each fluid's tonicity and ingredients when compounding medications to avoid harming patients.
Dosage forms and routes of drug administrationFatenAlsadek
this presentation give an over review about Routes of drug administrations and dosage forms
Done by: Faten Al-Sadek , Pharmacy student at Mohammed Al-Mana college for Health Sciences -MACHS
Pharmacy compounding - Importance, Non sterile compounding and Sterile compounding, Regulations of US Pharmacoepia, Compounded Products
For any suggestions and questions regarding this ppt please comment below.
Dosage forms and routes of drug administrationFatenAlsadek
this presentation give an over review about Routes of drug administrations and dosage forms
Done by: Faten Al-Sadek , Pharmacy student at Mohammed Al-Mana college for Health Sciences -MACHS
Pharmacy compounding - Importance, Non sterile compounding and Sterile compounding, Regulations of US Pharmacoepia, Compounded Products
For any suggestions and questions regarding this ppt please comment below.
Precautions in handling pharmaceutical products containing antibioticsUniversity of Sindh
It includes precautions in handling and manufacturing pharmaceuticals containing antibiotics. all these slides have been prepared with the help of different research papers, books, and FDA guidelines.
Infection Control Guidelines for Pharmacy [compatibility mode]drnahla
Infection Control Guidelines for Pharmacy
Infection Prevention in Pharmacy
Dr. NAHLA ABDEL KADERوMD, PhD.
INFECTION CONTROL CONSULTANT, MOH
INFECTION CONTROL CBAHI SURVEYOR
Infection Control Director, KKH.
Hospital infection control programs can help healthcare organizations monitor and improve practices, identify risks and proactively establish policies to prevent the spread of infections
Professional health hazards in a microbiology laboratory and Precautions to b...Abhishek Banerjee
Professional Hazards are common in a Microbiology Laboratory . So there should ways to reduce Hazards that may cause severe infections to not only the analyst but also to the community . This Presentation may just give a glimpse of the hazard and the possible way out .
Successful infection prevention program
A successful infection prevention program depends on:
1-Developing standard operating procedures.
2- Evaluating practices and providing feedback to dental health care personnel (DHCP).
3- Routinely documenting adverse outcomes (e.g., occupational exposures to blood) and work-related illnesses in DHCP.
4- Monitoring health care associated infections in patients.
Standard Precautions
Standard Precautions: are the minimum infection prevention practices that apply to all patient care, regardless of suspected or confirmed infection status of the patient, in any setting where health care is delivered. These practices are designed to both protect DHCP and prevent DHCP from spreading infections among patients.
Standard Precautions include:
1- Hand hygiene.
2- Use of personal protective equipment (e.g., gloves, masks, eyewear).
3- Respiratory hygiene / cough etiquette.
4- Sharps safety.
5- Safe injection practices (i.e., aseptic technique for parenteral medications).
6- Sterile instruments and devices.
7- Clean and disinfected environmental surfaces.
Each element of Standard Precautions is described in the following sections. Education and training are critical elements of Standard Precautions, because they help DHCP make appropriate decisions and comply with recommended practices.
1- HAND HYGIENE:
1- Perform hand hygiene.
a. When hands are visibly soiled.
b. After bare hand touching of instruments, equipment, materials, and other objects likely to be contaminated by blood, saliva, or respiratory secretions.
C. Before and after treating each patient.
d. Before putting on gloves and again immediately after removing gloves.
2. Use soap and water when hands are visibly soiled (e.g., blood, body fluids); otherwise, an alcohol-based hand rub may be used.
2- PERSONAL PROTECTIVE EQUIPMENT (PPE):
1- Provide sufficient and appropriate PPE and ensure it is accessible to DHCP.
2- Educate all DHCP on proper selection and use of PPE.
3- Wear gloves whenever there is potential for contact with blood, body fluids, mucous membranes, non-intact skin or contaminated equipment.
a- Do not wear the same pair of gloves for the care of more than one patient.
b- Do not wash gloves. Gloves cannot be reused.
c- Perform hand hygiene immediately after removing gloves.
4- Wear protective clothing that covers skin and personal clothing during procedures or activities where contact with blood, saliva, or OPIM (other potential infectious materials) is anticipated.
5- Wear mouth, nose, and eye protection during procedures that are likely to generate splashes or spattering of blood or other body fluids.
6- Remove PPE before leaving the work area.
3- RESPIRATORY HYGIENE / COUGH ETIQUETTE:
1- Implement measures to contain respiratory secretions in patients and accompanying individuals who have signs and symptoms of a respiratory infection, beginning at point of entry to the facility and conti
Announcement about my previous presentations - Thank youAreej Abu Hanieh
ANNOUNCEMENT Thank you for all of you, my followers who sent me messages with a lot of love and appreciations, I finally graduated after 6 years of studying in Birzeit University , In doctor of Pharmacy department I hope all of you benefited from all the presentations posted before Thank you a new PharmD GraduatedAreej ^^
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
2. Background
The pharmacist all medication preparation:
- non-sterile creams, ointments;
- sterile compounds e.g. eye drops;
- sterile products e.g. TPN, IV admixtures and Cytotoxic drugs.
The pharmacist knowledge of:
- ingredients,
- equipment,
- compatibility,
- stability,
- technique needed to compound sterile and non-sterile
extemporaneous prescriptions.
3. Background
Personnel
- proficiency in the art of compounding,
- knowledge,
- experience,
- ability to assume the responsibility.
- continuing competency and training programs.
Apparel
- clean clothing.
- protective apparel, e.g. lab coats/jackets, apron or gloves.
- to protect drug products from contamination during processing or
packaging.
- to help protect employees.
4. Background
Area
- specifically designated area.
- adequate lighting and ventilation.
- the compounding area for sterile products shall be
separate and distinct from the area used for
compounding of non-sterile drug products.
Equipment
- appropriate design, composition, size and suitably
located.
- cleaned and sanitized to prevent contamination.
5. Background
Packaging
- containers used in compounding shall be stored in a manner
to prevent contamination.
- bagged or boxed containers shall be stored off the floor.
- containers shall not be reactive, additive or absorptive.
- containers shall provide adequate protection against
foreseeable external factors in storage.
Expiration date
- Expiration dates should be derived using any of the following:
a) the manufacturer’s expiry date of the product with the shortest expiration,
b) pharmaceutical compendia,
c) professional literature,
d) in-house stability and/or sterility studies.
6. Cytotoxic Drug Preparation
Personnel
- All pharmacy personnel involved in any aspect of Cytotoxic
agent handling shall be trained in:
- appropriate handling techniques,
- preparation,
- reconstitution,
- administration,
- disposal of Cytotoxic agents.
- All pharmacy staff shall be informed:
- health hazards of working with Cytotoxic agents,
- handling of Cytotoxic agents by pregnant, breastfeeding women or
individuals actively try to conceive should be prohibited.
- the effect of exposure to hazardous drugs on human reproduction is
not fully understood.
7. Cytotoxic Drug Preparation
Apparel
- wear protective clothing “special clean, low particulate generating
disposable garments, with a back closing, long sleeves, tight fitting cuffs
and neck”.
- remove wristwatches, and jewelry.
- wash hands and arms up to the elbows with antimicrobial skin cleanser.
- wash hands before and after the preparation session.
- wear sterile, powder free gloves and disinfect regularly with 70% isopropyl
alcohol.
- change the disposable gloves every 30-60 minutes or when contaminated
or punctured.
- wear head and facial hair coverings, covering the ears and all the hair to
minimize particulate shedding.
- wear face mask.
- wear garments prior to entering the aseptic preparation area, and remove
upon exiting the area.
9. Cytotoxic Drug Preparation
Area
- dedicated solely to the preparation of sterile products.
- limited access.
- secluded from general traffic to minimize air turbulence.
- well lit.
- nonporous washable floors, walls and counters.
- untrained personnel shall not enter the aseptic
preparation area unless they are supervised .
- an eyewash station should be located within 7 meters of
the work area.
10. Cytotoxic Drug Preparation
Equipment
- laminar air flow hood equipped with a HEPA filter to prevent
contamination with microorganisms and particulate matter.
- the hood should be kept running continuously.
- if turned off, it should not be used for at least 30 minutes after
being turned on, or as specified by the manufacturer.
- a qualified technician shall certify the hood at least annually.
- Biological Safety Cabinets shall be cleaned and disinfected
before and after each preparation session:
- water for injection or irrigation and a small amount of cleaner,
- 70% isopropyl alcohol.
15. Cytotoxic Drug Preparation
Definition of Hazardous Drugs:
Carcinogenic
Teratogenic
Reproductive toxicity
Organ toxicity at low doses
Genotoxic
By definition; a drug is deemed hazardous if it causes
harm to organs:
Liver damage was reported in the literature on three nurses
(working 6, 8 and 16 years) with chemotherapeutic agents.
Cardiotoxicity related to the use of anthracyclines.
16. Cytotoxic Drug Preparation
Cancer Risk in Workers
Leukemia in nurses (Skov et al, 1992) (RR = 10.65)
Cyclophosphamide (Sessink et al, 1993) (1.4-10 excess cases/million)
NHL & skin cancer (Hansen & Olsen, 1994) (SIR = 3.7)
Overall increased cancer risk (Martin, 2005) (OR = 3.27)
Reproductive Risks in Workers
Fetal abnormalities (Hemminki et al, 1985)
Spontaneous Abortions (Stucker, 1990)
Infertility (Valanis et al, 1997)
Miscarriages (Valanis et al, 1999)
Infertility, premature labor, low-birth weight, learning disabilities in offspring
(Martin, 2005)
Infertility (Fransman, 2007)
Teratogenicity
Conflicting opinion on exposure during 2nd and 3rd trimesters.
Greatest danger during 1st trimester.
18. Cytotoxic Drug Preparation
Policies and Procedures
- Ensuring Cytotoxic ampoule heads are clear of liquid.
- Wrapping the ampoule neck with an alcohol swab before cracking.
- Dissolving powders in ampoules and vials by introducing diluents slowly
down the wall (wetting minimizes dusting) “but it’s not always possible”.
- Measuring final volumes before removing the needle from the vial.
- Wrapping the needle and vial top with an alcohol swab before withdrawing
the needle to minimize aerosol escape and removes last drop from needle
tip.
19. Cytotoxic Drug Preparation
- Using syringes and IV infusion administration sets with luer-loc fittings.
- Attaching and priming IV infusion administration sets prior to adding Cytotoxic
agent.
- Needles shall not be recapped or clipped after use, but discarded directly into a
designated Cytotoxic sharps container to prevent accidental skin punctures.
- Using a negative pressure technique by injecting a small amount of air into a vial
permitting the removal of the required volume.
20. Cytotoxic Drug Preparation
- All cases of exposure to Cytotoxic agents must be reported and documented.
- An incident report must be completed documenting the cause and corrective action taken.
- Detailed treatments shall be developed and available in the event of Cytotoxic exposure via skin
puncture, skin or eye contact or inhalation.
- A clearly defined, formal procedure for handling Cytotoxic agent spills must be developed.
- Clearly labeled spill kits must be kept in or near all preparation, administration and storage
areas.
- All broken containers, contaminated packaging and cleanup materials must be disposed of
appropriately in Cytotoxic waste containers.
21. Cytotoxic Drug Preparation
Vinca Alkaloid Administration
- In setting where a patient has an order for a lumbar puncture and a
combination of intrathecal and intravenous therapy, the following
procedures must be in place:
a) ensure that vinca alkaloids (vincristine, vinblastine, vindesine, etc..) are NEVER in the same
treatment area where a lumbar puncture is being performed.
b) prevent cross labeling in the pharmacy by physically separating intrathecal and intravenous
doses during all stages of preparation and labeling.
c) clear the hood of all intravenous medications prior to mixing drugs for intrathecal use.
d) prominently warn that vincristine and other vinca alkaloids are fatal if given intrathecally.
Ensure the warning label is affixed DIRECTLY to the label on the syringe barrel (i.e.
WARNING: FATAL IF GIVEN INTRATHECALLY).
22. Potassium Chloride Injections
Potassium chloride (KCl) injection infused too rapidly or given by direct
IV can cause cardiac arrest.
KCl poly-ampoules have been mistaken for normal saline, sterile water
and heparin.
KCl concentrate shall be removed from all nursing units, including
medication storage sites, medication carts, unit dose carts, and after
hours cabinets.
23. Potassium Chloride Injections
Strategies to reduce risk of KCl concentrate:
a) educating prescribers and nursing staff about the risks and
potentially fatal consequences of KCl medication errors,
b) encourage prescribers to use oral KCl whenever possible,
c) premixed KCl large volume Parenteral and minibags are
commercially available. The increased cost far outweighs the
potential consequences of a KCl error.
d) prohibit the addition of KCl concentrate to premixed KCl
solutions. KCl concentrate can pool at the injection port,
effectively delivering a “bolus” of KCl to the patient.
24.
25. Double Check
Critical work Risk management Double check.
Double check: negative/positive sides.
Double check problems:
- the process takes extra time.
- staffing shortages and other time resource issues plaguing healthcare.
- could lead to more mistakes as staff learn to rely upon others to catch
problems.
- the checker may, based upon his colleague’s past performance, assume
that the work is sound, and so be less observant during the double-check
process.
- many facilities have experienced errors that reached patients despite
double-checks !
26. Double Check
Double check importance:
- Double-checks identify a higher rate of errors than people
realize.
- The average “checking error rate” (errors missed during a
double-check) is about 5%.
- It’s hard to find your own mistakes “In a pharmacy
simulation, for example, participants were significantly
better at finding other’s mistakes rather than their own”.
27. Double Check
- Limit checks to high-risk situations:
- certain high-alert medications, very complex processes, and high-
risk patient populations “ e.g. IV chemotherapy, IV and epidural
opioids, IV insulin, IV heparin, neonatal parenteral medications,
TPN compounding, and manual compounding of electrolyte
solutions”.
- Double-checks work best when they are conducted
independently:
- e.g. the independent double-check that occurs when a pharmacist
dispenses medication and a nurse checks the accuracy,
- or when certain designated drugs are returned un-administered
and pharmacy staff investigate to learn why the drug wasn’t given.
28.
29.
30.
31.
32.
33. Assignment
What kind of IV fluids are present in the hospital?
Classify according to: tonicity, type (crystalloid vs.
colloid), composition, quantity of the ingredients
(per 100 ml), total volumes available.