The document provides an overview of LSTM (Long Short-Term Memory) networks. It first reviews RNNs (Recurrent Neural Networks) and their limitations in capturing long-term dependencies. It then introduces LSTM networks, which address this issue using forget, input, and output gates that allow the network to retain information for longer. Code examples are provided to demonstrate how LSTM remembers information over many time steps. Resources for further reading on LSTMs and RNNs are listed at the end.
This is a presentation I gave as a short overview of LSTMs. The slides are accompanied by two examples which apply LSTMs to Time Series data. Examples were implemented using Keras. See links in slide pack.
This Edureka Recurrent Neural Networks tutorial will help you in understanding why we need Recurrent Neural Networks (RNN) and what exactly it is. It also explains few issues with training a Recurrent Neural Network and how to overcome those challenges using LSTMs. The last section includes a use-case of LSTM to predict the next word using a sample short story
Below are the topics covered in this tutorial:
1. Why Not Feedforward Networks?
2. What Are Recurrent Neural Networks?
3. Training A Recurrent Neural Network
4. Issues With Recurrent Neural Networks - Vanishing And Exploding Gradient
5. Long Short-Term Memory Networks (LSTMs)
6. LSTM Use-Case
Brief introduction on attention mechanism and its application in neural machine translation, especially in transformer, where attention was used to remove RNNs completely from NMT.
Introduction For seq2seq(sequence to sequence) and RNNHye-min Ahn
This is my slides for introducing sequence to sequence model and Recurrent Neural Network(RNN) to my laboratory colleagues.
Hyemin Ahn, @CPSLAB, Seoul National University (SNU)
This is a presentation I gave as a short overview of LSTMs. The slides are accompanied by two examples which apply LSTMs to Time Series data. Examples were implemented using Keras. See links in slide pack.
This Edureka Recurrent Neural Networks tutorial will help you in understanding why we need Recurrent Neural Networks (RNN) and what exactly it is. It also explains few issues with training a Recurrent Neural Network and how to overcome those challenges using LSTMs. The last section includes a use-case of LSTM to predict the next word using a sample short story
Below are the topics covered in this tutorial:
1. Why Not Feedforward Networks?
2. What Are Recurrent Neural Networks?
3. Training A Recurrent Neural Network
4. Issues With Recurrent Neural Networks - Vanishing And Exploding Gradient
5. Long Short-Term Memory Networks (LSTMs)
6. LSTM Use-Case
Brief introduction on attention mechanism and its application in neural machine translation, especially in transformer, where attention was used to remove RNNs completely from NMT.
Introduction For seq2seq(sequence to sequence) and RNNHye-min Ahn
This is my slides for introducing sequence to sequence model and Recurrent Neural Network(RNN) to my laboratory colleagues.
Hyemin Ahn, @CPSLAB, Seoul National University (SNU)
Recurrent Neural Networks have shown to be very powerful models as they can propagate context over several time steps. Due to this they can be applied effectively for addressing several problems in Natural Language Processing, such as Language Modelling, Tagging problems, Speech Recognition etc. In this presentation we introduce the basic RNN model and discuss the vanishing gradient problem. We describe LSTM (Long Short Term Memory) and Gated Recurrent Units (GRU). We also discuss Bidirectional RNN with an example. RNN architectures can be considered as deep learning systems where the number of time steps can be considered as the depth of the network. It is also possible to build the RNN with multiple hidden layers, each having recurrent connections from the previous time steps that represent the abstraction both in time and space.
This presentation on Recurrent Neural Network will help you understand what is a neural network, what are the popular neural networks, why we need recurrent neural network, what is a recurrent neural network, how does a RNN work, what is vanishing and exploding gradient problem, what is LSTM and you will also see a use case implementation of LSTM (Long short term memory). Neural networks used in Deep Learning consists of different layers connected to each other and work on the structure and functions of the human brain. It learns from huge volumes of data and used complex algorithms to train a neural net. The recurrent neural network works on the principle of saving the output of a layer and feeding this back to the input in order to predict the output of the layer. Now lets deep dive into this presentation and understand what is RNN and how does it actually work.
Below topics are explained in this recurrent neural networks tutorial:
1. What is a neural network?
2. Popular neural networks?
3. Why recurrent neural network?
4. What is a recurrent neural network?
5. How does an RNN work?
6. Vanishing and exploding gradient problem
7. Long short term memory (LSTM)
8. Use case implementation of LSTM
Simplilearn’s Deep Learning course will transform you into an expert in deep learning techniques using TensorFlow, the open-source software library designed to conduct machine learning & deep neural network research. With our deep learning course, you'll master deep learning and TensorFlow concepts, learn to implement algorithms, build artificial neural networks and traverse layers of data abstraction to understand the power of data and prepare you for your new role as deep learning scientist.
Why Deep Learning?
It is one of the most popular software platforms used for deep learning and contains powerful tools to help you build and implement artificial neural networks.
Advancements in deep learning are being seen in smartphone applications, creating efficiencies in the power grid, driving advancements in healthcare, improving agricultural yields, and helping us find solutions to climate change. With this Tensorflow course, you’ll build expertise in deep learning models, learn to operate TensorFlow to manage neural networks and interpret the results.
And according to payscale.com, the median salary for engineers with deep learning skills tops $120,000 per year.
You can gain in-depth knowledge of Deep Learning by taking our Deep Learning certification training course. With Simplilearn’s Deep Learning course, you will prepare for a career as a Deep Learning engineer as you master concepts and techniques including supervised and unsupervised learning, mathematical and heuristic aspects, and hands-on modeling to develop algorithms. Those who complete the course will be able to:
Learn more at: https://www.simplilearn.com/
Much of data is sequential – think speech, text, DNA, stock prices, financial transactions and customer action histories. Modern methods for modelling sequence data are often deep learning-based, composed of either recurrent neural networks (RNNs) or attention-based Transformers. A tremendous amount of research progress has recently been made in sequence modelling, particularly in the application to NLP problems. However, the inner workings of these sequence models can be difficult to dissect and intuitively understand.
This presentation/tutorial will start from the basics and gradually build upon concepts in order to impart an understanding of the inner mechanics of sequence models – why do we need specific architectures for sequences at all, when you could use standard feed-forward networks? How do RNNs actually handle sequential information, and why do LSTM units help longer-term remembering of information? How can Transformers do such a good job at modelling sequences without any recurrence or convolutions?
In the practical portion of this tutorial, attendees will learn how to build their own LSTM-based language model in Keras. A few other use cases of deep learning-based sequence modelling will be discussed – including sentiment analysis (prediction of the emotional valence of a piece of text) and machine translation (automatic translation between different languages).
The goals of this presentation are to provide an overview of popular sequence-based problems, impart an intuition for how the most commonly-used sequence models work under the hood, and show that quite similar architectures are used to solve sequence-based problems across many domains.
The slides includes an introduction to Long Short-term Memory (LSTM ) >> A novel approach in dealing with vanishing gradients in deep neural networks. Made for students, and anyone out there who'd love to learn about recurrent artificial neural networks, specifically of the LSTMs architecture.
Reference material has been attached to further your reading.
Deep Learning: Recurrent Neural Network (Chapter 10) Larry Guo
This Material is an in_depth study report of Recurrent Neural Network (RNN)
Material mainly from Deep Learning Book Bible, http://www.deeplearningbook.org/
Topics: Briefing, Theory Proof, Variation, Gated RNNN Intuition. Real World Application
Application (CNN+RNN on SVHN)
Also a video (In Chinese)
https://www.youtube.com/watch?v=p6xzPqRd46w
Attention Mechanism in Language Understanding and its ApplicationsArtifacia
This is the presentation from our AI Meet March 2017 on Attention Mechanism in Language Understanding and its Applications.
You can join Artifacia AI Meet Bangalore Group: https://www.meetup.com/Artifacia-AI-Meet/
Word Embeddings, Application of Sequence modelling, Recurrent neural network , drawback of recurrent neural networks, gated recurrent unit, long short term memory unit, Attention Mechanism
Recurrent Neural Network
ACRRL
Applied Control & Robotics Research Laboratory of Shiraz University
Department of Power and Control Engineering, Shiraz University, Fars, Iran.
Mohammad Sabouri
https://sites.google.com/view/acrrl/
Recurrent Neural Networks have shown to be very powerful models as they can propagate context over several time steps. Due to this they can be applied effectively for addressing several problems in Natural Language Processing, such as Language Modelling, Tagging problems, Speech Recognition etc. In this presentation we introduce the basic RNN model and discuss the vanishing gradient problem. We describe LSTM (Long Short Term Memory) and Gated Recurrent Units (GRU). We also discuss Bidirectional RNN with an example. RNN architectures can be considered as deep learning systems where the number of time steps can be considered as the depth of the network. It is also possible to build the RNN with multiple hidden layers, each having recurrent connections from the previous time steps that represent the abstraction both in time and space.
This presentation on Recurrent Neural Network will help you understand what is a neural network, what are the popular neural networks, why we need recurrent neural network, what is a recurrent neural network, how does a RNN work, what is vanishing and exploding gradient problem, what is LSTM and you will also see a use case implementation of LSTM (Long short term memory). Neural networks used in Deep Learning consists of different layers connected to each other and work on the structure and functions of the human brain. It learns from huge volumes of data and used complex algorithms to train a neural net. The recurrent neural network works on the principle of saving the output of a layer and feeding this back to the input in order to predict the output of the layer. Now lets deep dive into this presentation and understand what is RNN and how does it actually work.
Below topics are explained in this recurrent neural networks tutorial:
1. What is a neural network?
2. Popular neural networks?
3. Why recurrent neural network?
4. What is a recurrent neural network?
5. How does an RNN work?
6. Vanishing and exploding gradient problem
7. Long short term memory (LSTM)
8. Use case implementation of LSTM
Simplilearn’s Deep Learning course will transform you into an expert in deep learning techniques using TensorFlow, the open-source software library designed to conduct machine learning & deep neural network research. With our deep learning course, you'll master deep learning and TensorFlow concepts, learn to implement algorithms, build artificial neural networks and traverse layers of data abstraction to understand the power of data and prepare you for your new role as deep learning scientist.
Why Deep Learning?
It is one of the most popular software platforms used for deep learning and contains powerful tools to help you build and implement artificial neural networks.
Advancements in deep learning are being seen in smartphone applications, creating efficiencies in the power grid, driving advancements in healthcare, improving agricultural yields, and helping us find solutions to climate change. With this Tensorflow course, you’ll build expertise in deep learning models, learn to operate TensorFlow to manage neural networks and interpret the results.
And according to payscale.com, the median salary for engineers with deep learning skills tops $120,000 per year.
You can gain in-depth knowledge of Deep Learning by taking our Deep Learning certification training course. With Simplilearn’s Deep Learning course, you will prepare for a career as a Deep Learning engineer as you master concepts and techniques including supervised and unsupervised learning, mathematical and heuristic aspects, and hands-on modeling to develop algorithms. Those who complete the course will be able to:
Learn more at: https://www.simplilearn.com/
Much of data is sequential – think speech, text, DNA, stock prices, financial transactions and customer action histories. Modern methods for modelling sequence data are often deep learning-based, composed of either recurrent neural networks (RNNs) or attention-based Transformers. A tremendous amount of research progress has recently been made in sequence modelling, particularly in the application to NLP problems. However, the inner workings of these sequence models can be difficult to dissect and intuitively understand.
This presentation/tutorial will start from the basics and gradually build upon concepts in order to impart an understanding of the inner mechanics of sequence models – why do we need specific architectures for sequences at all, when you could use standard feed-forward networks? How do RNNs actually handle sequential information, and why do LSTM units help longer-term remembering of information? How can Transformers do such a good job at modelling sequences without any recurrence or convolutions?
In the practical portion of this tutorial, attendees will learn how to build their own LSTM-based language model in Keras. A few other use cases of deep learning-based sequence modelling will be discussed – including sentiment analysis (prediction of the emotional valence of a piece of text) and machine translation (automatic translation between different languages).
The goals of this presentation are to provide an overview of popular sequence-based problems, impart an intuition for how the most commonly-used sequence models work under the hood, and show that quite similar architectures are used to solve sequence-based problems across many domains.
The slides includes an introduction to Long Short-term Memory (LSTM ) >> A novel approach in dealing with vanishing gradients in deep neural networks. Made for students, and anyone out there who'd love to learn about recurrent artificial neural networks, specifically of the LSTMs architecture.
Reference material has been attached to further your reading.
Deep Learning: Recurrent Neural Network (Chapter 10) Larry Guo
This Material is an in_depth study report of Recurrent Neural Network (RNN)
Material mainly from Deep Learning Book Bible, http://www.deeplearningbook.org/
Topics: Briefing, Theory Proof, Variation, Gated RNNN Intuition. Real World Application
Application (CNN+RNN on SVHN)
Also a video (In Chinese)
https://www.youtube.com/watch?v=p6xzPqRd46w
Attention Mechanism in Language Understanding and its ApplicationsArtifacia
This is the presentation from our AI Meet March 2017 on Attention Mechanism in Language Understanding and its Applications.
You can join Artifacia AI Meet Bangalore Group: https://www.meetup.com/Artifacia-AI-Meet/
Word Embeddings, Application of Sequence modelling, Recurrent neural network , drawback of recurrent neural networks, gated recurrent unit, long short term memory unit, Attention Mechanism
Recurrent Neural Network
ACRRL
Applied Control & Robotics Research Laboratory of Shiraz University
Department of Power and Control Engineering, Shiraz University, Fars, Iran.
Mohammad Sabouri
https://sites.google.com/view/acrrl/
Learn Recurrent Neural Networks (RNN), GRU and LSTM networks and their architecture. This was one of the lectures of a full course I taught in University of Moratuwa, Sri Lanka on 2024 first half of the year.
Presentation on Neural Networks in Tensorflow. Code available at https://github.com/nfmcclure/tensorflow_cookbook . Presentation for Open Source Bridge, Portland, 2016.
This is a slide deck from a presentation, that my colleague Shirin Glander (https://www.slideshare.net/ShirinGlander/) and I did together. As we created our respective parts of the presentation on our own, it is quite easy to figure out who did which part of the presentation as the two slide decks look quite different ... :)
For the sake of simplicity and completeness, I just copied the two slide decks together. As I did the "surrounding" part, I added Shirin's part at the place when she took over and then added my concluding slides at the end. Well, I'm sure, you will figure it out easily ... ;)
The presentation was intended to be an introduction to deep learning (DL) for people who are new to the topic. It starts with some DL success stories as motivation. Then a quick classification and a bit of history follows before the "how" part starts.
The first part of the "how" is some theory of DL, to demystify the topic and explain and connect some of the most important terms on the one hand, but also to give an idea of the broadness of the topic on the other hand.
After that the second part dives deeper into the question how to actually implement DL networks. This part starts with coding it all on your own and then moves on to less coding step by step, depending on where you want to start.
The presentation ends with some pitfalls and challenges that you should have in mind if you want to dive deeper into DL - plus the invitation to become part of it.
As always the voice track of the presentation is missing. I hope that the slides are of some use for you, though.
This is a slide deck from a presentation, that my colleague Uwe Friedrichsen (https://www.slideshare.net/ufried/) and I did together. As we created our respective parts of the presentation on our own, it is quite easy to figure out who did which part of the presentation as the two slide decks look quite different ... :)
For the sake of simplicity and completeness, Uwe copied the two slide decks together. As he did the "surrounding" part, he added my part at the place where I took over and then added concluding slides at the end. Well, I'm sure, you will figure it out easily ... ;)
The presentation was intended to be an introduction to deep learning (DL) for people who are new to the topic. It starts with some DL success stories as motivation. Then a quick classification and a bit of history follows before the "how" part starts.
The first part of the "how" is some theory of DL, to demystify the topic and explain and connect some of the most important terms on the one hand, but also to give an idea of the broadness of the topic on the other hand.
After that the second part dives deeper into the question how to actually implement DL networks. This part starts with coding it all on your own and then moves on to less coding step by step, depending on where you want to start.
The presentation ends with some pitfalls and challenges that you should have in mind if you want to dive deeper into DL - plus the invitation to become part of it.
As always the voice track of the presentation is missing. I hope that the slides are of some use for you, though.
Generating Natural-Language Text with Neural NetworksJonathan Mugan
Automatic text generation enables computers to summarize text, to have conversations in customer-service and other settings, and to customize content based on the characteristics and goals of the human interlocutor. Using neural networks to automatically generate text is appealing because they can be trained through examples with no need to manually specify what should be said when. In this talk, we will provide an overview of the existing algorithms used in neural text generation, such as sequence2sequence models, reinforcement learning, variational methods, and generative adversarial networks. We will also discuss existing work that specifies how the content of generated text can be determined by manipulating a latent code. The talk will conclude with a discussion of current challenges and shortcomings of neural text generation.
As a data science Intern at Leapcheck Services private limited, I have developed a naive chatbot using sequence to sequence model by LSTM of RNN. Sharing the tutorial which I made explicitly for the deep learning enthusiasts to
provide them a basic insight on how chatbot can be developed with the help of recurrent neural network.
Houston machine learning meetup, two papers are discussed:
- A Contextual-Bandit Approach to Personalized News Article Recommendation
http://rob.schapire.net/papers/www10.pdf
- An efficient bandit algorithm for realtime multivariate optimization
https://www.kdd.org/kdd2017/papers/view/an-efficient-bandit-algorithm-for-realtime-multivariate-optimization
Sr. Architect Pradeep Reddy, from Qubole, presents the state of Data Science in the enterprise industries today, followed by deep dive of an end-to-end real world machine learning use case. We'll explore the best practices and challenges of big data operations when developing new machine learning features and advanced analytics products at scale in the cloud.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
2. • We are the sum total of our experiences. None of us are the same as
we were yesterday, nor will be tomorrow. (B.J. Neblett)
• memorization: every time we gain new information, we store it for
future reference.
• combination: not all tasks are the same, so we couple our analytical
skills with a combination of our memorized, previous experiences to
reason about the world.
Human Learning
3. Outline
• Review of RNN
• SimpleRNN
• LSTM (forget, input and output gates)
• GRU (reset and update gates)
• LSTM
• Motivation
• Introduction
• Code example
4. Review of RNN
• Jack Ma is a Chinese business magnate, and his native language is ____
5. Review of RNN
• Jack Ma is a Chinese business magnate, and his native language is ____
13. Summary
• Hidden state can be viewed as “memory”, which tries to capture
previous information.
• Output is determined by current input and all the “memory”
• Hidden stage cannot capture all the information
• Unlike CNN, RNN shares the same parameters W
45. • Sample may refer to individual training examples. A “batch_size” variable is
hence the count of samples you sent to the neural network. That is, how
many different examples you feed at once to the neural network.
• Time Steps are ticks of time. It is how long in time each of your samples
are. For example, a sample can contain 128 time steps, where each time
steps could be a 30th of a second for signal processing. In Natural Language
Processing (NLP), a time step may be associated with a character, a word,
or a sentence, depending on the setup.
• Features are simply the number of dimensions we feed at each time steps.
For example in NLP, a word could be represented by 300 features
using word2vec. In the case of signal processing, let’s pretend that your
signal is 3D. That is, you have a X, a Y and a Z signal, such as an
accelerometer’s measurements on each axis. This means you would have
3 features sent at each time step for each sample.