Does your next experiment involve Tau (microtubule-associated protein tau, MAPT)? This is a presentation about tau, intended for scientists who are designing controls and performing immunoassays detecting tau. It contains information about western blot band size, protein tissue expression, and interesting facts. Anti-Tau/MAPT Antibody Picoband™ (A00097-3) https://www.bosterbio.com/anti-tau-mapt-picoband-trade-antibody-a00097-3-boster.html References: Uniprot, Proteinatlas.org Learn more about Tau (infographic and discussion): https://www.bosterbio.com/bosterbio-gene-info-cards/MAPT Boster Biological Technology Website: www.bosterbio.com Email: support@bosterbio.com

1. www.bosterbio.com
TAU IN 3 MINUTES
Quick facts, control designs, Western Blot MW.
Info you can use to find the best TAU antibody.

2. FACTS
01.
Function, structure, etc.
TISSUES
02.
Expressing tissues/cells
WESTERN BLOT
03.
Expected band sizes
HISTORY
04.
…and medical significance
TABLE OF CONTENTS

3. 3
● Microtubule-associated protein
tau (Tau)
● Single chain protein
● Isoforms
○ Isoform PNS-tau (Big tau) is
758 AAs long
○ 6 isoforms between 352–441
AAs long
● In WB, tau is observed to be
several bands spanning from 50
kDa to 80 kDa
01. FACTS
AlphaFold predicted structure
Image source: https://alphafold.ebi.ac.uk/entry/P10636

4. 4
02. TISSUES
Image source: https://www.proteinatlas.org/ENSG00000186868-MAPT/tissue

5. 5
03. TAU WESTERN BLOT
After reviewing the
selected images, we
observe Tau shows in
WB as a collection of
bands from 50 kDa to
80 kDa.
PMC5675734 Figure 1
PMC4294473 Figure 10
PMC5895994
Figure 2
Boster Bio Tau Antibody
(A00097-3) WB image
2861 images available on PMC:
https://www.ncbi.nlm.nih.gov/pmc/?term=tau+western+blot&report=imagesdocsum

6. 6
Marc Kirschner identified the first
microtubule-stabilizing protein tau in
1975 at Princeton.
04. HISTORY
Tau aggregation is observed in
tauopathies and other
neurodegenerative diseases, such
as Alzheimer’s disease.
1975 CLINICAL POTENTIAL

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