This document provides key information about the endothelial cell-specific molecule 1 (ESM1) for selecting the best ESM1 antibody. ESM1 is a ~25 kDa protein expressed in endothelial cells and tissues involved in angiogenesis. Western blots of ESM1 show a band around 20-25 kDa. ESM1 promotes angiogenesis and tumor progression, making it a potential cancer biomarker.

1. www.bosterbio.com
ESM1 IN 3 MINUTES
Quick facts, control designs, Western Blot MW.
Info you can use to find the best ESM1 antibody.

2. FACTS
01.
Function, structure, etc.
TISSUES
02.
Expressing tissues/cells
WESTERN BLOT
03.
Expected band sizes
SIGNIFICANCE
04.
Clinical potential
TABLE OF CONTENTS

3. ● Endothelial cell-specific molecule
1 (ESM1), aka Endocan
● Total chain length is 184 amino
acids
○ Signal peptide (19 amino acids)
is cleaved to form the active
protein (165 amino acids)
● Active form: ~25 kDa
01. FACTS
AlphaFold predicted structure
Image source: https://alphafold.ebi.ac.uk/entry/Q9NQ30

4. 02. TISSUES
Image source: https://www.proteinatlas.org/ENSG00000164283-ESM1/tissue

5. 03. ESM1 WESTERN BLOT
19 images available on PMC:
https://www.ncbi.nlm.nih.gov/pmc?term=esm1%20western%20blot&report
=imagesdocsum
After reviewing several WB images, we observe ESM1 at ~20-25 kDa.
PMC8105853 Figure 2
Boster Bio ESM1
Antibody (A04169-1,
Rabbit Polyclonal)
PMC6392130 Figure 3
PMC5710926 Figure 5

6. ESM1 is involved in
angiogenesis and promotes
angiogenic sprouting.
04. HISTORY
Overexpression of ESM1 is
observed in human tumors and
tumor progression, indicating its
potential as a cancer biomarker.
ANGIOGENESIS ROLE IN TUMOR

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