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Higuchi And Peppas Plot

The document presents the Higuchi and Peppas models for drug release from polymer matrices, highlighting their mathematical formulations and applications. The Higuchi plot, developed in 1961, describes drug release as a diffusion process that is proportional to the square root of time, while the Korsmeyer-Peppas model, introduced in 1983, categorizes drug release mechanisms based on the release exponent. Both models are utilized to analyze the kinetics of drug release from various pharmaceutical formulations, particularly for water-soluble and poorly soluble drugs.

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THE HIGUCHI AND PEPPAS PLOT Presented By Simran M.Pharmacy 1st year GGSCOP, YNR
The Higuchi Plot • In 1961 Higuchi developed a mathematical model for the study of the release of drugs from its matrix. • For studying the release of water-soluble and poorly soluble drugs from a variety of matrices, including semisolid and solids. • Initial drug concentration in the matrix is much higher. • As the drug is released, the distance for diffusion progressively increases. • Drug is leached out polymer matrix by the entrance of medium.
• The Equation Of Higuchi model: Q= [D(2A-Cs)Cs x t]1/2 or Q=(2ADCst)¹/2 • By differentiating the above equation we get, dQ/dt=(ADCs/2t)1/2 • Release of the drug is proportional to the square root of time. • The Drug release from the granular matrix is given by
Applications of Higuchi Plot • Higuchi describes the drug release as a diffusion process based on Fick's law, square root time dependent. • This model is useful for studying the release of water-soluble and poorly soluble drugs from a variety of matrices, including solids and semi-solids.
Korsmeyer’s-Peppa’s model • A simple relationship that described drug release from a polymeric system equation was derived by Korsmeyer-Peppa in 1983. • To understand the mechanism of drug release and to compare the release profile differences among these matrix formulations , the percent drug released time versus time were fitted using this equation:
• The n value characterizes different releases from matrix and specify release mechanisms as shown below: Release Exponent (n) Drug transport mechanism 0.5 Fickian diffusion 0.5<n=0.89 Non Fickian transport 0.89 Case II transport Higher than 0.89 Super case II transport
• To study release kinetic data obtained plotted as log cumulative % drug release versus time.
Applications of Peppas Plot • This equation has been used for the linearization of release data from several formulations of microcapsules or microspheres. • Use to analyze the release of pharmaceutical polymeric dosage form. • When the release mechanism is not known or when more than one type of release phenomena could be involved. • To study the modified release dosage form and release phenomenon of drugs.
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