The document discusses the components and functions of blood. It describes the main components of blood as plasma, blood cells, and platelets. It provides details on the types of blood cells - red blood cells, white blood cells (neutrophils, eosinophils, basophils, lymphocytes, monocytes), and platelets. It also discusses hematopoiesis, the process by which blood cells are formed from stem cells in the bone marrow, and the growth factors involved in this process.

1. Komposisi dan Fungsi Darah 1 Alfian
Krisnasari,
M.Sc

2. Komponen, jumlah relatif dan fungsi darah
Protein plasma (50 % - 60 % dari vol total)
1. Air 91%- 92% dr volume plasma
Fungsi : pelarut
2. Protein plasma (albumin, globulin, fibrinogen dll) 7%-8%
Fungsi : Pertahanan, transport lipid, berperan pada pengaturan
volume cairan ekstraselluler
3. Ion, gula, lipid, asam amino, hormon, vitamin dan gas terlarut
1%-2%
Fungsi : Pengaturan cairan ekstraseluler, pH dll
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3. Composition of whole blood
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4. Konsentrasi haemoglobin
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5. Normal human erythrocytes.
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6. Red cell morphology.
Mohandas N , and Gallagher P G Blood 2008;112:3939-
3948
©2008 by American Society of Hematology
Red cell morphology. Hereditary spherocytosis
(HS; top panel); nonhemolytic hereditary
elliptocytosis (HE; middle panel); elliptocytes,
poikilocytes, and fragmented red cells in
hemolytic HE (bottom panel).

7. Normal-sickle cell

8. Five types of human leukocytes
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9. Neutrophils
• Spesifik granula
• Alkalin fosfatase
• Collagenase
• Lactoferin
• Lisosim
• Granula azurophil
• Acid fosfatase
• Arysulfatase
• Β glukoronidase
• Lisosim
• defensinCopyright © The McGraw-Hill Companies, Inc. All Rights Reserved.

10. Neutrophil ultrastructure.
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11. Fagositosis

12. Eosinophils
• Granula spesifik
• Acid fosfatase
• Arylsulfatase
• Β glukoronidase
• Cathepsin
• Fosfolipase
• RNAase
• Mayor basic protein
• Peroksidase eosinofilik
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13. Basophils
• Granula spesifik
• Eosinophilic chematactic
factor
• Heparin
• Histamin
• Peroxidase
• Phospholipase A
• Platelet activating factor
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Reserved.
Leukotrin

14. Mast cells
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Inc. All Rights Reserved.

15. Plasma cells
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Reserved.

16. Lymphocytes
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Reserved.

17. Monocytes
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Reserved.

18. Platelets
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19. Platelet
• Hyalomer (perifer)
• Granulomer (pusat)
• Selubung (GAGs & glikoprotein) adhesi
• Berkas marginal (mikrotubulus & mikrofilamen)
menjaga bentuk ovoid
• Sistem open canaliculi memfasilitasi
pengambilan serotonin & fibrinogen
• Sistem dense tubular menyimpan Ca++

20. Fibrin clot.

21. HEMATOPOIESIS (Cellular lineage- growth factors)
• Proses pembentukan sel darah  Hematopoiesis
Dapat dibedakan menjadi:
 Erythropoiesis
Proses pembentukan erythrocytus/sel darah merah
 Granulopoiesis
Proses pembentukan leucocytus/sel leucocyte
(darah putih)
 Monocytopoiesis
Proses pembentukan monocytus/lymphocytes
 Megakaryocytopoiesis
Proses pembentukan megakaryocytus
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22. Hematopoiesis tergantung
1. Growth factors (faktor pertumbuhan)
2. Faktor lingkungan (Micro)
Growth factors
 Granulocyte (G-CSF)
 menstimulasi pembentukan leucocytus
. Granulocyte+macrophage (GM-CSF)
Macrophage (M-CSF)
 Interleukin 3
 menstimulasi pembentukan sel myeloid
 Erythropoietin (EPO)
 menstimulasi pembentukan sel darah merah
(erythrocytus) Copyright © The McGraw-Hill Companies, Inc. All Rights Reserved.

23. SEL PLURIPOTENTIAL STEM
(ASAL SEL DARAH)
Berada di sumsum tulang
LYMPHOCYTUS
(Sel lymphoid)
SEL MYELOID
(Berkembang di sumsum tulang)
THYMUS
NODUS
LYMPHATICUS LIEN TONSILLA

24. Red bone marrow (active in hemopoiesis)
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25. Origin and differentiative stages of blood cells.
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26. Komponen sel darah
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27. Origin and differentiative stages of blood cells
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29. Diagram of events involving leukocytes in a postcapillary venule
at sites of inflammation.