Organic compounds containing an electronegative atom or electron-withdrawing group bonded to a carbon undergo substitution or elimination reactions. Alkyl halides specifically undergo SN1, SN2, E1, and E2 reactions. SN1 and E1 are unimolecular reactions that proceed through a carbocation intermediate, while SN2 and E2 are bimolecular reactions. The type of reaction depends on factors like the nucleophile strength and leaving group ability.
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2. -
Organic compounds with an
electronegative atom or an
electron-withdrawing group
bonded to a sp3
carbon
undergo substitution or
elimination reactions
Organic compounds with an
electronegative atom or an
electron-withdrawing group
bonded to a sp3
carbon
undergo substitution or
elimination reactions
Substitution
Elimination
Halide ions are good leaving
groups. Substitution reaction
on these compounds are easy
and are used to get a wide
variety of compounds
Halide ions are good leaving
groups. Substitution reaction
on these compounds are easy
and are used to get a wide
variety of compounds
alkyl fluoride alkyl chloride alkyl bromide alkyl iodide
3. Alkyl Halides in Nature
Synthesized by red algae
Synthesized by sea hare
a sea hare
red algae
5. Alkyl Halides in Nature
• Several marine organisms, including sponges,
corals, and algae, synthesize organohalides
(halogen-containing organic compounds) that
they use to deterpredators. For example, red
algae synthesize a toxic,
foultastingorganohalide that keeps predators
from eating them. One predator, however,
that is not deterred is a mollusk called a sea
hare.
6. Alkyl Halides in Nature
• After consuming red algae, a sea hare
converts the original organohalide into a
structurally similar compound it uses for its
own defense. Unlike other mollusks, a sea
hare doesnot have a shell. Its method of
defense is to surround itself with a slimy
material that contains the organohalide,
thereby protecting itself from carnivorous
fish.
7. Substitution Reaction with Halides
If concentration of (1) is
doubled, the rate of the
reaction is doubled.
If concentration of (1) is
doubled, the rate of the
reaction is doubled.
bromomethane
(1)
(2)
If concentration of (2) is
doubled, the rate of the
reaction is doubled.
If concentration of (2) is
doubled, the rate of the
reaction is doubled.
If concentration of (1) and
(2) is doubled, the rate of
the reaction quadruples.
If concentration of (1) and
(2) is doubled, the rate of
the reaction quadruples.
methanol
8. Substitution Reaction with Halides
bromomethane
(1)
(2)
methanol
Rate law:
rate = k [bromoethane][OH-
]
this reaction is an example of a SN2 reaction.
S stands for substitution
N stands for nucleophilic
2 stands for bimolecular
Rate law:
rate = k [bromoethane][OH-
]
this reaction is an example of a SN2 reaction.
S stands for substitution
N stands for nucleophilic
2 stands for bimolecular
9. Mechanism of SN2 Reactions
The rate of reaction depends on the
concentrations of both reactants.
The rate of reaction depends on the
concentrations of both reactants.
When the hydrogens of bromomethane
are replaced with methyl groups the
reaction rate slow down.
When the hydrogens of bromomethane
are replaced with methyl groups the
reaction rate slow down.
The reaction of an alkyl halide in which
the halogen is bonded to an asymetric
center leads to the formation of only
one stereoisomer
The reaction of an alkyl halide in which
the halogen is bonded to an asymetric
center leads to the formation of only
one stereoisomer
Alkyl halide Relative rate
1200
40
1
≈ 0
10. Mechanism of SN2 Reactions
Hughes and Ingold proposed the following mechanism:Hughes and Ingold proposed the following mechanism:
Transition state
Increasing the concentration of either of the
reactant makes their collision more probable.
Increasing the concentration of either of the
reactant makes their collision more probable.
11. Mechanism of SN2 Reactions
activation
energy: ∆G1
activation
energy: ∆G2
Steric effectSteric effect
Inversion of configurationInversion of configuration
(R)-2-bromobutane (S)-2-butanol
Energy
reaction coordinate reaction coordinate
12. Factor Affecting SN2 Reactions
relative rates of reaction pKa HX
HO
-
+ RCH2I RCH2OH + I
-
30 000 -10
HO
-
+ RCH2Br RCH2OH + Br
-
10 000 -9
HO
-
+ RCH2Cl RCH2OH + Cl
-
200 -7
HO
-
+ RCH2F RCH2OH + F
-
1 3.2
relative rates of reaction pKa HX
HO
-
+ RCH2I RCH2OH + I
-
30 000 -10
HO
-
+ RCH2Br RCH2OH + Br
-
10 000 -9
HO
-
+ RCH2Cl RCH2OH + Cl
-
200 -7
HO
-
+ RCH2F RCH2OH + F
-
1 3.2
The leaving group
The nucleophile
In general, for halogen substitution the
strongest the base the better the
nucleophile.
In general, for halogen substitution the
strongest the base the better the
nucleophile.
pKa Nuclephilicity
13. SN2 Reactions With Alkyl Halides
an alcohol
a thiol
an ether
a thioether
an amine
an alkyne
a nitrile
14. Substitution Reactions With Halides
If concentration of (1) is
doubled, the rate of the
reaction is doubled.
If concentration of (1) is
doubled, the rate of the
reaction is doubled.
If concentration of (2) is
doubled, the rate of the
reaction is not doubled.
If concentration of (2) is
doubled, the rate of the
reaction is not doubled.
Rate law:
rate = k [1-bromo-1,1-dimethylethane]
this reaction is an example of a SN1
reaction.
S stands for substitution
N stands for nucleophilic
1 stands for unimolecular
Rate law:
rate = k [1-bromo-1,1-dimethylethane]
this reaction is an example of a SN1
reaction.
S stands for substitution
N stands for nucleophilic
1 stands for unimolecular
1-bromo-1,1-dimethylethane 1,1-dimethylethanol
15. Mechanism of SN1 Reactions
The rate of reaction depends on the
concentrations of the alkyl halide only.
The rate of reaction depends on the
concentrations of the alkyl halide only.
When the methyl groups of 1-bromo-
1,1-dimethylethane are replaced with
hydrogens the reaction rate slow down.
When the methyl groups of 1-bromo-
1,1-dimethylethane are replaced with
hydrogens the reaction rate slow down.
The reaction of an alkyl halide in which
the halogen is bonded to an asymetric
center leads to the formation of two
stereoisomers
The reaction of an alkyl halide in which
the halogen is bonded to an asymetric
center leads to the formation of two
stereoisomers
Alkyl halide Relative rate
≈ 0 *
≈ 0 *
12
1 200 000
* a small rate is actually observed as a result of a SN2
16. Mechanism of SN1 Reactions
C-Br bond breaksC-Br bond breaks
nucleophile attacks the
carbocation
nucleophile attacks the
carbocation
Proton dissociationProton dissociation
slow
fast
18. Mechanism of SN1 Reactions
Same configuration
as the alkyl halide
Same configuration
as the alkyl halide
Inverted
configuration
relative the alkyl
halide
Inverted
configuration
relative the alkyl
halide
19. Factor Affecting SN1 reaction
Two factors affect the rate of a SN1 reaction:
• The ease with which the leaving group dissociate from the carbon
• The stability of the carbocation
Two factors affect the rate of a SN1 reaction:
• The ease with which the leaving group dissociate from the carbon
• The stability of the carbocation
The more the substituted the
carbocation is, the more
stable it is and therefore the
easier it is to form.
The more the substituted the
carbocation is, the more
stable it is and therefore the
easier it is to form.
As in the case of SN2, the
weaker base is the leaving
group, the less tightly it is
bonded to the carbon and the
easier it is to break the bond
As in the case of SN2, the
weaker base is the leaving
group, the less tightly it is
bonded to the carbon and the
easier it is to break the bond
The reactivity of the
nucleophile has no effect on
the rate of a SN1 reaction
The reactivity of the
nucleophile has no effect on
the rate of a SN1 reaction
20. Comparison SN1 – SN2
SN1 SN2
A two-step mechanism A one-step mechanism
A unimolecular rate-determining step A bimolecular rate-determining step
Products have both retained and inverted
configuration relative to the reactant
Product has inverted configuration
relative to the reactant
Reactivity order:
3o
> 2o
> 1o
> methyl
Reactivity order:
methyl > 1o
>2o
> 3o
21. Elimination Reactions
1-bromo-1,1-dimethylethane 2-methylpropene
Rate law:
rate = k [1-bromo-1,1-dimethylethane][OH-
]
this reaction is an example of a E2 reaction.
E stands for elimination
2 stands for bimolecular
Rate law:
rate = k [1-bromo-1,1-dimethylethane][OH-
]
this reaction is an example of a E2 reaction.
E stands for elimination
2 stands for bimolecular
22. The E2 Reaction
A proton is
removed
A proton is
removed
Br-
is eliminatedBr-
is eliminated
The mechanism shows that an E2
reaction is a one-step reaction
The mechanism shows that an E2
reaction is a one-step reaction
23. Elimination Reactions
If concentration of (1) is
doubled, the rate of the
reaction is doubled.
If concentration of (1) is
doubled, the rate of the
reaction is doubled.
If concentration of (2) is
doubled, the rate of the
reaction is not doubled.
If concentration of (2) is
doubled, the rate of the
reaction is not doubled.
Rate law:
rate = k [1-bromo-1,1-dimethylethane]
this reaction is an example of a E1
reaction.
E stands for elimination
1 stands for unimolecular
Rate law:
rate = k [1-bromo-1,1-dimethylethane]
this reaction is an example of a E1
reaction.
E stands for elimination
1 stands for unimolecular
1-bromo-1,1-dimethylethane 2-methylpropene
24. The E1 Reaction
The alkyl halide
dissociate, forming a
carbocation
The alkyl halide
dissociate, forming a
carbocation
The base
removes a
proton
The base
removes a
proton
The mechanism shows that an E1
reaction is a two-step reaction
The mechanism shows that an E1
reaction is a two-step reaction
25. Products of Elimination Reaction
2-bromobutane
2-butene
1-butene
80%
20%
The most stable alkene is the
major product of the reaction
for both E1 and E2 reaction
The most stable alkene is the
major product of the reaction
for both E1 and E2 reaction
The greater the number of
alkyl substituent the more
stable is the alkene
The greater the number of
alkyl substituent the more
stable is the alkene
For both E1 and E2 reactions, tertiary alkyl halides
are the most reactive and primary alkyl halides
are the least reactive
For both E1 and E2 reactions, tertiary alkyl halides
are the most reactive and primary alkyl halides
are the least reactive
30% 50%
26. Competition Between
SN2/E2 and SN1/E1
rate = k1[alkyl halide] + k2[alkyl halide][nucleo.] + k3[alkyl halide] + k2[alkyl halide][base]rate = k1[alkyl halide] + k2[alkyl halide][nucleo.] + k3[alkyl halide] + k2[alkyl halide][base]
SN1SN1 SN2SN2 E1E1 E2E2
• SN2 and E2 are favoured by a high concentration of a good
nucleophile/strong base
• SN1 and E1 are favoured by a poor nucleophile/weak base, because a
poor nucleophile/weak base disfavours SN2 and E2 reactions
• SN2 and E2 are favoured by a high concentration of a good
nucleophile/strong base
• SN1 and E1 are favoured by a poor nucleophile/weak base, because a
poor nucleophile/weak base disfavours SN2 and E2 reactions
27. Competition Between
Substitution and Elimination
• SN2/E2 conditions:
In a SN2 reaction: 1o
>2o
> 3o
In a E2 reaction: 3o
> 2o
> 1o
In a SN2 reaction: 1o
>2o
> 3o
In a E2 reaction: 3o
> 2o
> 1o
90% 10%
25% 75%
100%
28. Competition Between
Substitution and Elimination
• SN1/E1 conditions:
All alkyl halides that react under SN1/E1 conditions will give
both substitution and elimination products (≈50%/50%)
All alkyl halides that react under SN1/E1 conditions will give
both substitution and elimination products (≈50%/50%)
29. Summary
• Alkyl halides undergo two kinds of nucleophilic subtitutions:
SN1 and SN2, and two kinds of elimination: E1 and E2.
• SN2 and E2 are bimolecular one-step reactions
• SN1 and E1 are unimolecular two step reactions
• SN1 lead to a mixture of stereoisomers
• SN2 inverts the configuration od an asymmetric carbon
• The major product of a elimination is the most stable alkene
• SN2 are E2 are favoured by strong nucleophile/strong base
• SN2 reactions are favoured by primary alkyl halides
• E2 reactions are favoured by tertiary alkyl halides