This document summarizes the results of the NOR-TEST trial, which compared the intravenous thrombolytics tenecteplase and alteplase for the treatment of acute ischemic stroke. The trial found that tenecteplase was not superior to alteplase in achieving excellent functional outcomes or in rates of intracranial hemorrhage. Both intention-to-treat and per-protocol analyses showed similar efficacy and safety profiles between the two drugs. While tenecteplase has theoretical advantages, this large phase 3 trial did not demonstrate it to be clearly better than the current standard treatment of alteplase.