Radiations classified as ionizing and non-ionizing radiations. ionizing includes ultraviolet, alpha, gamma and x-ray radiations. non-ionizing consists of infrared, microwave, radio wave and power line electromagnetic radiations
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
6. Biological effect of UV
• High ultraviolet
kills bacterial and other infectious agents
sun burn – increased risk of skin cancer
• Pigmentation that results in suntan
Suntan lotions contain chemicals that absorb UV radiation ( e.g Vitocare sun
protection )
• Reaction in the skin to produce Vitamin D that
prevents rickets.
disease of childhood, characterized by softening of the bones as a result of inadequate intake of vitamin and
insufficient exposure to sunlight, also associated with impaired calcium and phosphorus metabolism
8. Microwaves & Radio Waves
• Wave length between 0.1 cm to 1 kilometer
• Varity of industrial and home uses for heating
and information transfer (radio, TV, mobile
phones)
• Health effects – heating, cataracts
9. Microwave heating
Many molecules (such as those of water) are electric
dipoles, meaning that they have a partial positive charge at
one end and a partial negative charge at the other, and
therefore rotate as they try to align themselves with the
alternating electric field of the microwaves.
Rotating molecules hit other molecules and put them into
motion, thus dispersing energy. This energy, when
dispersed as molecular vibration in solids and liquids
10. Ionizing Radiation
Ionization Defined
Radiation capable for producing ions when interacting
with matter – in other words enough energy to remove
an electron from an atom.
Sources
x-rays, radioactive material produce alpha, beta, and
gamma radiation, cosmic rays from the sun and space.
11. Radioactive Material
• Either natural or created in nuclear reactor or accelerator
• Radioactive material is unstable and emits energy in order to return to
a more stable state (particles or gamma-rays)
• Half-life – time for radioactive material to decay by one-half
15. Alpha Particles
• Two neutrons and two protons
• Charge of +2
• Emitted from nucleus of radioactive atoms
• Transfer energy in very short distances (10 cm in air)
• Shielded by paper or layer of skin
• Primary hazard from internal exposure
• Alpha emitters can accumulate in tissue (bone, kidney,
liver, lung, spleen) causing local damage
16. Beta Particles
• Small electrically charged particles similar to electrons
• Charge of -1
• Ejected from nuclei of radioactive atoms
• Emitted with various kinetic energies
• Shielded by wood, body penetration 0.2 to 1.3 cm depending
on energy
• Can cause skin burns or be an internal hazard of ingested
17.
18. • Beta particles are electrons or positrons (electrons with positive electric
charge, or antielectrons).
• Beta decay occurs when, in a nucleus with too many protons or too many
neutrons, one of the protons or neutrons is transformed into the other.
• In beta minus decay, a neutron decays into a proton, an electron, and an
antineutrino
• In beta plus decay, a proton decays into a neutron, a positron, and a
neutrino:
19. Electron capture
one of the orbital electrons, usually from the K or L electron
shell (K-electron capture, also K-capture, or L-electron
capture, L-capture), is captured by a proton in the nucleus,
forming a neutron and an electron neutrino.
20. Gamma-rays
• Electromagnetic photons or radiation (identical to x-rays
except for source)
• Emitted from nucleus of radioactive atoms – spontaneous
emission
• Emitted with kinetic energy related to radioactive source
• Highly penetrating – extensive shielding required
• Serious external radiation hazard
21.
22.
23.
24. Since the proton is changed to a neutron in electron capture,
the number of neutrons increases by 1, the number of
protons decreases by 1, and the atomic mass number remains
unchanged. By changing the number of protons, electron
capture transforms the nuclide into a new element. The atom,
although still neutral in charge, now exists in an
energetically excited state with the inner shell missing an
electron. While transiting to the ground state, the atom will
emit an X-ray photon (a type of electromagnetic radiation)
and/or Auger electrons. Often the nucleus exists in an excited
state as well, and emits a gamma ray in order to reach the
ground state energy of the new nuclide just formed.
25.
26. PET
• Positron emission tomography (PET) is a test that uses a special type of camera
and a tracer (radioactive chemical) to look at organs in the body. The tracer usually
is a special form of a substance (such as glucose) that collects in cells that are using
a lot of energy, such as cancer cells.
• During the test, the tracer liquid is put into a vein (intravenous, or IV) in your arm.
The tracer moves through your body, where much of it collects in the specific
organ or tissue. The tracer gives off tiny positively charged particles (positrons).
The camera records the positrons and turns the recording into pictures on a
computer.
• PET scan pictures do not show as much detail as computed tomography (CT)
scans or magnetic resonance imaging (MRI) because the pictures show only the
location of the tracer. The PET picture may be matched with those from a CT scan
to get more detailed information about where the tracer is located.
• A PET scan is often used to evaluate cancer, check blood flow, or see how organs
are working.
27.
28. X-rays
• Overlap with gamma-rays
• Electromagnetic photons or radiation
• Produced from orbiting electrons or free electrons – usually machine
produced
• Produced when electrons strike a target material inside and x-ray
tube
• Emitted with various energies & wavelengths
29. Ionizing Radiation Health Effects
We evolved with a certain level of naturally occurring
ionizing radiation from cosmic radiation, radioactive
materials in the earth.
We have mechanisms to repair damage.
30. Dose Response Tissue
Examples of tissue Sensitivity
Very High White blood cells (bone marrow)
Intestinal epithelium
Reproductive cells
High Optic lens epithelium
Esophageal epithelium
Mucous membranes
Medium Brain – Glial cells
Lung, kidney, liver, thyroid,
pancreatic epithelium
Low Mature red blood cells
Muscle cells
Mature bone and cartilage
31. Time
Reduce the spent near the source of radiation.
Distance
Increase the distance from the source of radiation.
Shielding
Place shielding material between you and the source of
radiation.
Reducing Exposure
32. Biological Effects of Radiation
•Somatic
–Affects cells originally
exposed (cancer)
–Affects blood, tissues,
organs, possibly entire
body
–Effects range from slight
skin reddening to death
(acute radiation
poisoning)
•Genetic
–Affects cells of future
generations
–Keep levels as low as
possible (wear lead)
–Reproductive cells most
sensitive
32
33. 33
Units of Measurement
• Effect of ionizing radiation is determined by:
– Energy of radiation
– Material irradiated
– Length of exposure
– Type of effect
– Delay before effect seen
– Ability of body to repair itself
34. 34
Radiation Units of Measurement
Roentgen (R) - expression of exposure to x-
rays/gamma rays
Radiation Adsorbed Dose (rad) – amt of energy released to
/ absorbed by matter when radiation comes into contact
with it
Radiation Equivalent Man (rem) - Injury from
radiation (depends on amt of energy imparted to matter)
35. 35
Permissible exposure radiation doses
Body Part
Exposed
Permissible Dose
(rem per quarter)
Whole body 1.25
Hands, forearms, feet,
ankles
18.75
37. 37
Basic Safety Factors
• Keep exposures As Low As Reasonably
Achievable (ALARA)
– Time - Keep exposure times to a minimum
– Distance - Inverse square law: by doubling distance
from a source, exposure is dec by a factor of 4
– Shielding – wear lead, use lead wall