This document discusses key concepts in fluid mechanics, including:
1) Fluid statics, hydrostatic equilibrium, Archimedes' principle, and buoyancy.
2) Fluid dynamics principles like conservation of mass expressed by the continuity equation, and conservation of energy expressed by Bernoulli's equation.
3) Applications of fluid dynamics concepts like calculating flow rates and velocities using the continuity equation, and calculating velocities using Bernoulli's equation.
The derivation of the equation of motion for various fluids is similar to the d derivation of Eular’s equation. However ,the tangential stresses arise during the motion of a real viscous fluid, must be considered
More: http://www.pinoybix.org
Lesson Objectives:
Phases of Matter
Density and Specific Gravity
Pressure in Fluids
Atmospheric Pressure and Gauge Pressure
Pascal’s Principle
Measurement of Pressure; Gauges and the Barometer
Buoyancy and Archimedes’ Principle
Fluids in Motion; Flow Rate and the Equation of Continuity
Bernoulli’s Equation
Applications of Bernoulli’s Principle: from Torricelli to Airplanes, Baseballs, and TIA
Viscosity
Flow in Tubes: Poiseuille’s Equation, Blood Flow
Surface Tension and Capillarity
Pumps, and the Heart
Applications and Principle of bernoulli equation (Energy Conservation)Graphic Era University.
Short explanation about Bernoulli Principle and its vast areas of application in Automobile, day to day life etc. with various forms of energy equation.
The derivation of the equation of motion for various fluids is similar to the d derivation of Eular’s equation. However ,the tangential stresses arise during the motion of a real viscous fluid, must be considered
More: http://www.pinoybix.org
Lesson Objectives:
Phases of Matter
Density and Specific Gravity
Pressure in Fluids
Atmospheric Pressure and Gauge Pressure
Pascal’s Principle
Measurement of Pressure; Gauges and the Barometer
Buoyancy and Archimedes’ Principle
Fluids in Motion; Flow Rate and the Equation of Continuity
Bernoulli’s Equation
Applications of Bernoulli’s Principle: from Torricelli to Airplanes, Baseballs, and TIA
Viscosity
Flow in Tubes: Poiseuille’s Equation, Blood Flow
Surface Tension and Capillarity
Pumps, and the Heart
Applications and Principle of bernoulli equation (Energy Conservation)Graphic Era University.
Short explanation about Bernoulli Principle and its vast areas of application in Automobile, day to day life etc. with various forms of energy equation.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
5. What new physics is involved?
• Fluids can flow from place-
to-place
• Their density can change if
they are compressible (for
example, gasses)
• Fluids are pushed around by
pressure forces
• An object immersed in a fluid
experiences buoyancy
6. Density
𝑑𝑒𝑛𝑠𝑖𝑡𝑦 =
𝑚𝑎𝑠𝑠
𝑣𝑜𝑙𝑢𝑚𝑒
𝜌 =
𝑚
𝑉
𝑈𝑛𝑖𝑡𝑠 𝑎𝑟𝑒
𝑘𝑔
𝑚3
• The density of a fluid is the concentration of mass
• Mass = 100 g = 0.1 kg
• Volume = 100 cm3 = 10-4 m3
• Density = 1 g/cm3 = 1000 kg m3
7. Pressure
• Pressure is the concentration of a force
– the force exerted per unit area
Greater pressure!
(same force, less area)
Exerts a pressure on the
sides and through the fluid
8. Pressure vs. Force
•Pressure is a scalar and force is a vector.
•The direction of the force producing a pressure
is perpendicular to the area of interest.
9.
10.
11. Pressure
𝑝 =
𝐹
𝐴
• Units of pressure are N/m2 or Pascals (Pa) – 1 N/m2 = 1
Pa
• Bar = 105 pa
• Atmospheric pressure = 13600 x 9.8 x0.76 =
1.013 x 105 pa =1.013 bar= 1 atm
12.
13.
14.
15.
16. Measuring Pressure
Atmospheric pressure can support a 10 meters high
column of water. Moving to higher density fluids
allows a table top barometer to be easily constructed.
𝑝 = 𝑝0 + 𝜌𝑔ℎ
Q. What is height of mercury (Hg)
at 1 𝑎𝑡𝑚 ?
𝜌 𝐻𝑔 = 13.6 𝑔/𝑐𝑚3
𝑃 = 𝑃0 + 𝜌𝑔ℎ → ℎ = 𝑃/𝜌𝑔
ℎ =
1 × 105
1.36 × 104 × 9.8
= 0.75 𝑚
17.
18.
19.
20. 0%0%0%0%0%
1 2 3 4 5
The three open containers are now filled with oil,
water and honey respectively. How do the pressures
at the bottoms compare ?
1. 𝑷 𝑨 = 𝑷 𝑩 = 𝑷 𝑪
2. 𝑷 𝑨 < 𝑷 𝑩 = 𝑷 𝑪
3. 𝑷 𝑨 < 𝑷 𝑩 < 𝑷 𝑪
4. 𝑷 𝑩 < 𝑷 𝑨 < 𝑷 𝑪
5. Not enough information
A. B. C.
oil water
honey
22. 0%0%0%0%
1. 2. 3. 4.
𝑣𝑎𝑐𝑢𝑢𝑚
What is responsible for
the force which holds
urban climber B in place
when using suction cups.
A
B
1. The force of friction
2. Vacuum pressure exerts a pulling
force
3. Atmospheric pressure exerts a
pushing force
4. The normal force of the glass.
23. Calculating Crush Depth of a Submarine
Q. A nuclear submarine is rated to withstand a pressure difference
of 70 𝑎𝑡𝑚 before catastrophic failure. If the internal air pressure
is maintained at 1 𝑎𝑡𝑚, what is the maximum permissible depth ?
720 𝑚
24. Gauge Pressure
Gauge Pressure is the pressure difference from atmosphere. (e.g. Tyres)
𝑃𝑎𝑏𝑠𝑜𝑙𝑢𝑡𝑒 = 𝑃𝑎𝑡𝑚𝑜𝑠𝑝ℎ𝑒𝑟𝑒 + 𝑃𝑔𝑎𝑢𝑔𝑒
25.
26. Pascal’s Law
Q. A large piston supports a car.
The total mass of the piston and
car is 3200 𝑘𝑔. What force must
be applied to the smaller piston ?
Pressure at the same height is the same! (Pascal’s Law)
𝐹1
𝐴1
=
𝐹2
𝐴2
𝐹1 =
𝐴1
𝐴2
𝑚𝑔 =
𝜋 × 0.152
𝜋 × 1.202
× 3200 × 9.8 = 490 𝑁
A1
A2
F2
• Pressure force is transmitted through a fluid
28. Archimedes’ Principle and Buoyancy
The Buoyant Force is equal to the weight of the displaced fluid !
𝐹 𝐵 = 𝑚𝑤 𝑎𝑡𝑒𝑟 𝑔 = 𝜌 𝑤𝑎𝑡𝑒𝑟 𝑉𝑔
𝑊 = 𝑚𝑠𝑜𝑙𝑖𝑑 𝑔 = 𝜌 𝑠𝑜𝑙𝑖𝑑 𝑉𝑔
Objects immersed in a fluid experience a Buoyant Force!
29. Archimedes’ Principle and Buoyancy
The hot-air balloon
floats because the
weight of air displaced
(= the buoyancy force)
is greater than the
weight of the balloon
The Buoyant Force is equal to the weight of the displaced fluid !
30. Example Archimedes’ Principle and Buoyancy
The Buoyant Force is equal to the weight of the displaced fluid.
Q. Find the apparent weight of a 60 𝑘𝑔 concrete block when you lift
it under water, 𝜌 𝑐𝑜𝑛𝑐𝑟𝑒𝑡𝑒 = 2200 𝑘𝑔/𝑚3
mgw
bF
Develop
Assess
Interpret
Water provides a buoyancy force
Evaluate
Apparent weight should be less
apparentbnet wFmgF
gmF waterdispb Vgwater
V
m
con
con
water
app
mg
mgw
con
m
V
)1(
con
water
app mgw
N321)
2200
1000
1(8.960
31. Floating Objects
Q. If the density of an iceberg is 0.86
that of seawater, how much of an
iceberg’s volume is below the sea?
𝐵𝑢𝑜𝑦𝑎𝑛𝑐𝑦 𝑓𝑜𝑟𝑐𝑒 𝐹𝐵 = 𝑤𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 𝑤𝑎𝑡𝑒𝑟 𝑑𝑖𝑠𝑝𝑙𝑎𝑐𝑒𝑑
𝑉 𝑠𝑢𝑏 = 𝑠𝑢𝑏𝑚𝑒𝑟𝑔𝑒𝑑 𝑣𝑜𝑙𝑢𝑚𝑒
𝐹 𝐵 = 𝑚𝑤𝑎𝑡𝑒𝑟 𝑔 = 𝜌 𝑤𝑎𝑡𝑒𝑟 𝑉 𝑠𝑢𝑏 𝑔
𝐼𝑛 𝑒𝑞𝑢𝑖𝑙𝑖𝑏𝑟𝑖𝑢𝑚, 𝐹𝐵 = 𝑤𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 𝑖𝑐𝑒𝑏𝑒𝑟𝑔
𝐹 𝐵 = 𝑚𝑖𝑐𝑒 𝑔 = 𝜌𝑖𝑐𝑒 𝑉𝑖𝑐𝑒 𝑔
𝜌 𝑤𝑎𝑡𝑒𝑟 𝑉 𝑠𝑢𝑏 𝑔 = 𝜌𝑖𝑐𝑒 𝑉𝑖𝑐𝑒 𝑔 →
𝑉 𝑠𝑢𝑏
𝑉𝑖𝑐𝑒
=
𝜌 𝑤𝑎𝑡𝑒𝑟
𝜌𝑖𝑐𝑒
= 0.86
35. Conservation of Mass: The Continuity Eqn.
Q. A river is 40m wide, 2.2m deep and flows at 4.5 m/s. It passes
through a 3.7-m wide gorge, where the flow rate increases to 6.0
m/s. How deep is the gorge?
𝐴1 = 𝑤1 𝑑1
𝐴2 = 𝑤2 𝑑2
𝐶𝑜𝑛𝑡𝑖𝑛𝑢𝑖𝑡𝑦 𝑒𝑞𝑢𝑎𝑡𝑖𝑜𝑛 ∶ 𝐴1 𝑣1 = 𝐴2 𝑣2 → 𝑤1 𝑑1 𝑣1 = 𝑤2 𝑑2 𝑣2
𝑑2 =
𝑤1 𝑑1 𝑣1
𝑤2 𝑣2
=
40 × 2.2 × 4.5
3.7 × 6.0
= 18 𝑚
36.
37.
38.
39.
40. Conservation of Energy: Bernoulli’s Eqn.
Q. Find the velocity of water leaving a tank through a hole in the
side 1 metre below the water level.
𝑃 + 1
2
𝜌𝑣2 + 𝜌𝑔𝑦 = 𝑐𝑜𝑛𝑠𝑡𝑎𝑛𝑡
𝐴𝑡 𝑡ℎ𝑒 𝑡𝑜𝑝: 𝑃 = 1 𝑎𝑡𝑚, 𝑣 = 0, 𝑦 = 1 𝑚
𝐴𝑡 𝑡ℎ𝑒 𝑏𝑜𝑡𝑡𝑜𝑚: 𝑃 = 1 𝑎𝑡𝑚, 𝑣 =? , 𝑦 = 0 𝑚
𝑃 + 𝜌𝑔𝑦 = 𝑃 + 1
2 𝜌𝑣2
𝑣 = 2𝑔𝑦 = 2 × 9.8 × 1 = 4.4 𝑚/𝑠
42. Lift on a wing is often explained in textbooks by Bernoulli’s Principle: the air over the
top of the wing moves faster than air over the bottom of the wing because it has further
to move (?) so the pressure upwards on the bottom of the wing is smaller than the
downwards pressure on the top of the wing.
Is that convincing? So why can a plane fly upside down?
Bernoulli’s Effect and Lift
Newton’s 3rd law
(air pushed downwards)𝑃 + 1
2 𝜌𝑣2 + 𝜌𝑔𝑦 = 𝑐𝑜𝑛𝑠𝑡𝑎𝑛𝑡