This industrial training report summarizes Rohit Yadav's one month internship at Navkar Lifesciences Pvt. Ltd. The report outlines the key production sections of the pharmaceutical plant including tablet components and additives. It describes common equipment used such as sifters, mass mixers, fluidized bed dryers and tray dryers. Processing problems like capping, lamination, and mottling are also discussed. Finally, the report provides a flow chart of the tablet manufacturing process from raw materials to final packaging.

1. INDUSTRIAL TRAINING REPORT
PRESENTATION
DEPARTMENT OF PHARMACY,
DR. BHIMRAO AMBEDKAR UNIVERSITY,
AGRA- 282002
Submitted by: Submitted to:
ROHIT YADAV Mrs. PRATIBHA
B. Pharma VIII-Sem MISHRA
(Asst. Professor)

2. ACKNOWLEDGEMENT
First of all, I praise God, the almighty, merciful and passionate, for providing
me this opportunity granting me the capability to proceed successfully.
There are no word to express the feeling of gratitude I have in my heart for
respected H.O.D. Prof. Brijesh Kumar Tiwari sir and other faculty of Dept. of
Pharmacy, Dr. B. R. Ambedkar University, Agra.
I am hearty thankful to the staff of NAVKAR LIFESCIENCES Pt. Ltd. Mr.
Arvind Yadav, Mr. Manoj Kumar, Mr. Pankaj Yadav a and others Staffs,
who helped and teached me about all progress in the plant during complete
session of one month .
I am also thankful to Mr. Kamlesh Mishra, Managing Director to allow me to
join his esteemed plant.
I am also thankful to Anoop Singh, Jitendar Sagar & Krishna kumar we
worked as a team and guided me completing this work.
ROHIT YADAV
ROLL No: 158287361020
B. Pharma VII SEM

3. PRODUCTION SECTION:
TABLET COMPONENTSANDADDITIVES:
A. ACTIVE INGREDIENTS: PURE DRUG (SALT)
B. Non-active Ingredients: six major excipientcategories:
a. Diluents: lactose, starch, mannitol, Sorbitol
b. Binders:Acacia, Gelatin, Tragacanth, Calcium lactate trihydrate granular
N. F., starch.
c. Lubricants: stearic acid, magnesium stearate, calcium stearate. andtalc
d. Disintegrants: Starches are the most common disintegratingagents
e. Colors: D&Cand FD&Cdyes and lakes,and
f. Flavors and Sweeteners: mannitol, lactose, sucrose, saccharin and dextrose
There are three methods of preparing tablet granulations.Theseare
 Wet granulation,
 Dry granulation (also called "slugging")
 Direct compression.

5. EQUIPMENTS
1. Sifter: An instrument used to sieve the ingredients of a tablet with a replaceable
mess ware. In this technique, particles of power massare placed on a screen made
of uniform aperture.

6. 3. Mass Mixer: This is also mixing equipment used to mix dry aswell is wet
ingredients. The mixer has blades that are alternately arranged and is allows uniform
mixing. The massmixer is emptied by inverting it and scrapping off its ingredients.
The planetary mixer can mix a material of 100kg.

7.  Multi-mill: This is a hammer mill that usesa high speed rotor to which a number
of swinging hammers are fixed. The unit is enclosed with chamber containing a grid
or removable screen through which the material can pass.

8. 5. Fluidized bed dryer: In a fluidized bed dryer, the fluidized air stream is introduced
by a fan or blower mounted at the top of the apparatus. The air is heated to the
required temperature in an air heater and flows upwards through the wet
materials, which remains in a drying chamber fitted with a wire mesh supported at
the bottom.

9. 6.Tray dryer: It consists of a chamber, containing
horizontal arrangements of trays on which granules
are dried.

10. 7.Compressor: For increased production, Rotary machines offer a great advantage.A
head carrying a number of sets of punches and dies revolves continuously while the
tablet granulation runs from the hopper, through a feed frame and into the dies
placed in a large, steel plate revolving under it.

11.  Coating machine:

12.  Tablet Packing machine:

13. PROCESSING PROBLEMS
1. Capping:- It is the partial or complete separation of
top or ttom crowns of Tablet from the main body of
Tablet.
2. Lamination:- It is the separation of a Tablet in to two
or more distinct layers. Usually these processing
problems are readily apparent immediately after
compression.
3. Picking & Sticking:- ‘Picking' is used to describe the
surface material from a Tablet that sticking to and
being removed from the Tablet's surface by a punch.
4. Mottling:- It is an unequal distribution of colour on a
Tablet, with light or dark areas standing out in an
otherwise uniform surface.

14. TABLET COATING
Two common methods:-
1. Pan coating
a. The Standard Coating pan is circular metal pane mounted
angularly on a stand.
b. Pan is 8 to 60 inches in diameter and rotated on its
horizontal axis by a motor
c. Coating solution is applied to the Tablets by ladling or
spraying the material on to the rotating Tablet bed.
2. Press coating
a. The Coating process is the last critical step in tablet
production cycle.
b. The type of process chosen depends on type of coating
that is to be applied.

15. FLOW CHART
RAW MATERIAL
SIFTINO BY SIFTER
MIXING BY OCTAGONAL BLENDER
MASS MINER (binding materials added)
FLUID BED DRYER
MULTI MILL
FLUID BED DRYER
MULTI MILL
LUBRICATION
COMPRESSION
COATING
PACKING (Blister, strip)
GOODS TRANSFERRED TO STORE