This document defines important statistical terms used in medical research: sensitivity measures the probability a test is positive when the disease is present, while specificity measures the probability a test is negative when the disease is absent. It also defines precision, accuracy, confidence intervals, risk ratios, odds ratios, incidence, prevalence, and provides examples of how these terms are used and interpreted.
Excelsior College PBH 321 Page 1 CASE-CONTROL STU.docxgitagrimston
Excelsior College PBH 321
Page 1
CASE-CONTROL STUD IES
A case-control study is an observational design that involves studying a population in which cases of disease
are identified and enrolled, and a sample of the population that produced the cases is identified and enrolled
(controls). Exposures are determined for individuals in both groups.
Let’s say that we want to test the hypothesis that pesticide exposure increases the risk of breast cancer.
Consider a hypothetical prospective cohort study of 89,949 women aged 34-59; 1,439 breast cancer cases
were identified over 8 years of follow-up. Blood was drawn on all 89,949 at beginning of follow-up and
samples were frozen. The exposure was defined as the level of pesticides (e.g. DDE) in blood, characterized as
high or low. We compare women with high or low exposures to see if they got breast cancer or not by the end
of follow-up.
Breast Cancer
Yes No Total
DDE
exposure High 360 13,276 13,636
Relative Risk = RR = (360/13,636) / (1,079/76,313) = 1.9
Low 1,079 75,234 76,313
Women with high pesticide levels in the blood have 1.9
times the risk of developing breast cancer after 8 years
than women with low levels
Total 1,439 88,510 89,949
Conducting this study presents a practical problem: quantifying pesticide levels in the blood is very expensive -
-it's not feasible to analyze all 89,949 blood samples (this would cost many thousands of dollars).
To be efficient, we could instead analyze blood on all breast cancer cases (N=1,439) but take only a sample of
the women who did not get breast cancer, say two times as many cases (N=2,878) (controls). This is a case-
control study! Specifically, because we sampled cases and controls from within a complete cohort, we refer to
this as a nested case-control study.
Breast Cancer
Cases Controls
DDE
exposure
High 360 432
Low 1,079 2,446
Total 1,439 2,878
Excelsior College PBH 321
Page 2
Timing and Set Up of a Case-Control Study
Cases
When identifying cases, the criteria for the case definition should lead to accurate classification of disease.
This means the investigator must have efficient and accurate sources to identify cases, such as existing disease
registries or hospitals.
In our standard 2 x 2 table, the number of cases gives you the numerators of the rates of disease in exposed
and unexposed groups being compared.
Disease
Yes
(cases)
No
(controls)
Total
Exposure Yes a ? ? Rate of disease in exposed: a/?
No c ? ?
Rate of disease in
unexposed: c/?
Total a+c ? ?
What is missing? The denominators! If this were a cohort study, you would have the total population (if you
were calculating cumulative incidence) or total person-years (if you were calculating incidence rates) for both
the exposed and non-exposed groups, which would provide the c ...
Consider the following hypothet-ical scenario and results .docxdonnajames55
C
onsider the following hypothet-
ical scenario and results that are
formatted in evidence-based
practice (EBP) language such as those
that you might see in the Cochrane
Collaboration,1 a primary resource for
evidence-based systematic reviews.
Scenario: How effective is a daily
dose of 500 mg of vitamin C in
the prevention of ulcers on the heels of
bedridden elderly clients? Results: With
an NNT of 5, vitamin C is effective (OR,
0.10; 95% CI, 0.05-0.20).
If there are some abbreviations
or values in this situation that are un-
familiar to you, you will find explana-
tions and examples in this article that
will help you in reading, interpreting,
and understanding them as you use
evidence-based literature for your best
practices. Nurses always rise to the
occasion to learn the latest research
information that may improve patient
care and outcomes.
An obstacle to involvement in EBP
is lack of skill in understanding the
‘‘bottom line’’ of systematic reviews
and accompanying risk-related num-
bers.
2-4
Content and research experts
conduct systematic reviews using strict
criteria for inclusion of primary re-
search studies and statistical analysis.
5
The Cochrane Collaboration is a major
resource for more than 1,000 system-
atic reviews of randomized clinical
trials for the effects of healthcare inter-
ventions created through collaboration
of more than 50 worldwide review and
methods teams.6
The systematic review teams basi-
cally seek the response to 1 question:
how many people have a bad outcome
in the experimental group compared
with the control group? Bad outcomes
refer to the undesirable outcomes in a
study, such as development of a heel
ulcer. Noteworthy in EBP statistics is
the simplicity of using a head count
rather than group averages. Even when
individual study results are not statisti-
cally significant, if the experimental
group has fewer bad outcomes than the
control group, the nurse or other pro-
vider might want to apply the results
anyway. Seven terms and their abbre-
viations and formulas are common in
the reported results,7,8 as summarized
in Table 1. In this article, hypothetical
examples and their derivations de-
scribe these 7 terms. At the end, you
can derive these values for a clinical
scenario toward a better understanding
when teaching these terms to others.
Absolute Risk Reduction
Absolute risk reduction (ARR) is the
absolute arithmetic difference (abso-
lute means that one ignores plus and
minus signs) in percentages of bad
outcomes between the experimental
and control groups. Absolute risk reduc-
tion means that more people in the
control group than in the experimen-
tal group develop a bad outcome. To
calculate the ARR, you need to know
just 2 things: the experimental event
rate (EER), or the percentage of the
bad outcome in the experimental group;
and the control group event rate (CER),
or the percentage of the bad outcome in
the control group. Let us look at an ex-
ample: 13% of patients with diabetes
receiv.
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
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This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Triangles of Neck and Clinical Correlation by Dr. RIG.pptx
Important definitions in statistics
1. Important definitions in statistics
ABOUBAKR ELNASHAR
Benha University Hospital, Egypt
ABOUBAKR ELNASHAR
2. Sensitivity:
Probability of test to be positive when the disease
is present
True positive test
Specificity
Probability of the test to be negative when the
disease is absent
True negative test
Systematic review
is qualitative reports
Meta-analysis
Qualitative analysis of systematic review
ABOUBAKR ELNASHAR
3. Precision
a description of a level of measurement that
yields consistent results when repeated. It is
associated with the concept of "random error", a
form of observational error that leads to
measurable values being inconsistent when
repeated.
ABOUBAKR ELNASHAR
4. Precision or positive predictive value
the proportion of the true positives against all the
positive results (both true positives and false
positives)
ABOUBAKR ELNASHAR
5. Accuracy
two definitions:
a level of measurement with no inherent
limitation (i.e. free of systematic error, another
form of observational error).
ISO definition
a level of measurement that yields true (no
systematic errors) and consistent (no random
errors) results.
ABOUBAKR ELNASHAR
6. Accuracy
used as a statistical measure of how well a binary
classification test correctly identifies or excludes a
condition.
Accuracy
is the proportion of true results (both true
positives and true negatives) among the total
number of cases examined.
To make the context clear by the semantics, it is
often referred to as the "Rand accuracy" or "Rand
index".It is a parameter of the test.
ABOUBAKR ELNASHAR
7. Accuracy may be determined from sensitivity and specificity,
provided prevalence is known, using the equation:
The accuracy paradox for predictive analytics states that
predictive models with a given level of accuracy may have
greater predictive power than models with higher accuracy. It
may be better to avoid the accuracy metric in favor of other
metrics such as precision and recall.
In situations where the minority class is more important, F-
measuremay be more appropriate, especially in situations
with very skewed class imbalance.
ABOUBAKR ELNASHAR
8. Another useful performance measure is the balanced
accuracy
which avoids inflated performance estimates on imbalanced
datasets.
It is defined as the arithmetic mean of sensitivity and
specificity, or the average accuracy obtained on either class:
ABOUBAKR ELNASHAR
9. Confidence interval
A way of expressing certainty about the findings
from a study or group of studies, using statistical
techniques.
A confidence interval describes a range of
possible effects (of a treatment or intervention)
that is consistent with the results of a study or
group of studies.
I am confident 95% that the range is between so
and so
If the range cross 1 , it is insignificant
95% CI (1.05-1.15)= I am 95% confident that the
risk between 1.05 and 1.15
ABOUBAKR ELNASHAR
10. A wide confidence interval indicates a lack of
certainty or precision about the true size of the
clinical effect and is seen in studies with too few
patients.
Where confidence intervals are narrow they
indicate more precise estimates of effects and a
larger sample of patients studied.
It is usual to interpret a ‘95%’ confidence interval
as the range of effects within which we are 95%
confident that the true effect lies
ABOUBAKR ELNASHAR
11. In case control study
It is better to have more controls than cases
In clinical studies
It is better for cases and control to be the same
For numbers: t test
For %: chi square
ABOUBAKR ELNASHAR
12. RR
If 1: no association
<1: negative association
>1: positive association
RR= 2 i.e. risk is doubled
= 5 i.e. risk is 5 times
= 0.5 i.e. negative association ad the risk is
halfed
OR
Is like RR and interpreted as it
ABOUBAKR ELNASHAR
13. Very common 1/1-1/10 A person in family
Common 1/10-1/100 A person in street
Uncommon 1/100-1/1000 A person in village
Rare 1/1000-1/10,000 A person in small town
Very rare <1/10,000 A person in large town
Royal College of Obstetricians and
Gynaecologists
ABOUBAKR ELNASHAR
14. Incidence
The rate of new (or newly diagnosed) cases of
the disease.
It is generally reported as the number of new
cases occurring within a period of time (e.g.,
per month, per year).
It is more meaningful when the incidence rate
is reported as a fraction of the population at risk
of developing the disease (e.g., per 100,000 or
per million population).
ABOUBAKR ELNASHAR
15. The accuracy of incidence data depends upon
the accuracy of diagnosis and reporting of the
disease.
In some cases (including ESRD) it may be
more appropriate to report the rate of treatment
of new cases since these are known, whereas
the actual incidence of untreated cases is not.
Incidence rates can be further categorized
according to different subsets of the population
– e.g., by gender, by racial origin, by age group
or by diagnostic category.
ABOUBAKR ELNASHAR
16. Prevalence
The actual number of cases alive, with the
disease either during a period of time (period
prevalence) or at a particular date in time (point
prevalence).
Period prevalence provides the better measure
of the disease load since it includes all new cases
and all deaths between two dates
Point prevalence only counts those alive on a
particular date.
Prevalence is also most meaningfully reported as
the number of cases as a fraction of the total
population at risk and can be further categorized
according to different subsets of the population.
ABOUBAKR ELNASHAR