This paper presents the design and implementation of a 2-bit multiplier using transmission gate logic in both fully automatic and semi-custom designs. The study finds that the semi-custom approach offers a 25.45% reduction in power consumption and a 20% reduction in chip area compared to the fully automatic design while maintaining high performance. The results highlight the significance of optimizing power and area in VLSI design, emphasizing the effectiveness of transmission gates in minimizing CMOS usage.