Weka is a collection of machine learning algorithms for data mining tasks. It contains tools for data preprocessing, classification, regression, and clustering. The document discusses using Weka to explore a contact lenses dataset, including preprocessing the data using filters, running classifiers like ZeroR, and evaluating classifier performance using metrics like true positive rate, precision, and recall. It also covers using cross-validation to evaluate classifiers, where changing the number of folds alters the percentage of data used for training versus testing.