This document provides guidance on how to give effective scientific presentations. It discusses preparing the presentation by using the right tools to tell a story and communicate the big idea. Presentations should incorporate story elements like a beginning, middle and end, and use techniques like analogies to persuade the audience. The document also recommends including a memorable "STAR moment" and valuing brevity by reducing excessive content on slides. An example discussed is Steve Jobs introducing the Macbook Air by surprising the audience by pulling it out of an envelope on stage.