The formulary system is a method by which physicians and pharmacists, working through a Pharmacy and Therapeutics Committee of the medical staff, evaluate and select medications for use in a hospital.
the hospital formulary system provides the information for procuring,prescribing,dispencing and administrative of drug under non proprietary names and instance where drugs have both names.
hospital formulary is developed under the guidance of pharmacy and therapeutic commitee of the hospital.pharmacist working in a hospital should play an important role in the preparation of the hospital formulary
hospital formulary is developed under the guidance of pharmacy and therapeutic commitee of the hospital.pharmacist working in a hospital should play an important role in the preparation of the hospital formulary
2. Hospital Pharmacy and its Organisation.pptxMangeshBansod2
Hospital pharmacy and its organization
Definition, functions of hospital pharmacy, Organization structure, Location, Layout and staff requirements, and Responsibilities and
functions of hospital pharmacists.
Hospital Formulary - presentation gives the detail idea about Hospital formulary, its advantage, disadvantage, how to prepare Hospital formulary and much more. this will be useful for Pharm.D-IV YEAR students, which was in their Hospital pharmacy subject. regards APOLLOJAMES
Definition, Types of drug distribution systems, Dispensing of drugs to ambulatory (outdoor) patients, Distribution of controlled drug, Novel drug distribution methods
Pharmacy and therapeutic committee, PTC, Organization of PTC, Functions of PTC, Automatic stop order, Emergency drug list, ADR and safety monitoring, Role of Pharmacy and therapeutic committee
In this slides included clinical pharmacy introduction and pharmaceutical care, also explanation about the goals and objectives of the clinical pharmacy requirements
2. Hospital Pharmacy and its Organisation.pptxMangeshBansod2
Hospital pharmacy and its organization
Definition, functions of hospital pharmacy, Organization structure, Location, Layout and staff requirements, and Responsibilities and
functions of hospital pharmacists.
Hospital Formulary - presentation gives the detail idea about Hospital formulary, its advantage, disadvantage, how to prepare Hospital formulary and much more. this will be useful for Pharm.D-IV YEAR students, which was in their Hospital pharmacy subject. regards APOLLOJAMES
Definition, Types of drug distribution systems, Dispensing of drugs to ambulatory (outdoor) patients, Distribution of controlled drug, Novel drug distribution methods
Pharmacy and therapeutic committee, PTC, Organization of PTC, Functions of PTC, Automatic stop order, Emergency drug list, ADR and safety monitoring, Role of Pharmacy and therapeutic committee
In this slides included clinical pharmacy introduction and pharmaceutical care, also explanation about the goals and objectives of the clinical pharmacy requirements
Definition, contents of hospital formulary, Differentiation of hospital formulary and Drug list, preparation and revision, and addition and deletion of a drug from hospital formulary.
2. Hospital Formulary.pdf unit 2 sem 7 b.pharmacyVedika Narvekar
Hospital formulary
Definition, contents of hospital formulary, Differentiation of hospital formulary and
Drug list, preparation and revision, and addition and deletion of drug from hospital
formulary
Formulary is an official or authorised publication of an approved list of medicines for use in a hospital, a group of hospitals a society a state or a region a country or a number of countries.
Hospital Formulary is a continually revised compilation of pharmaceuticals dosage agents and their forms that reflects the current clinical view of the medical staff.
The hospital formulary is a continuously revised compilation of pharmaceutical dosage agent and their forms etc. which reflects the current clinical judgment of the medical staff.
A hospital exists mainly to provide therapeutic services to the patients.
Drugs are an integral part of patient care. In every hospital, medicines are crucial to the hospital services.
Appropriate use of medicines in the hospital is a multidisciplinary responsibility that includes doctors, nurses, pharmacists, administrators, support personnel and patients.
The availability of medicines in the hospitals depends not only on good supplies, but also on efficient use through good distribution system, rational prescribing, and dispensing practices.
"When a drug is required, the appropriate drug must be chosen. It must be available at the right time, at the right price. It must be dispensed correctly, must be delivered in a right dose, at the right intervals and for the right length of time".
Herbal formulation shall mean a dosage form consisting of one or more herbs in specified quantities to provide specific nutritional, cosmetic benefits, or other benefits meant for use to diagnose treat, mitigate diseases of human beings or animals.
Herbal preparations are obtained by subjecting herbal substances to treatments such as extraction, distillation, expression, fractionation, purification, concentration or fermentation.
These include comminuted or powdered herbal substances, tinctures, extracts, essential oils, expressed juices and processed exudates.
Herbal cosmetic is defined as “ the beauty products, which possess desirable physiological activities such as skin healing, smoothening, appearance enhancing properties with the help of herbal ingredients.”
almond oil
olive oil
rosemarry oil
sandalwood oil
Fibers are elongated thick walled cells with pointed ends, cell walls of which may consist of cellulose and may or may not contain lignin
Plant fibers
Jute
Flax
Cotton
Banana
Hemp
Animal fiber
Silk
wool
Minerals
Glass
Asbestos
Surgical dressings are the materials used alone or in combination for protection and healing of wound
e.g. cotton, wool, rayon
Official requirements of surgical dressings are as;
They should be sterilized before use
They should be stored in dry-ventilated place at temperature not exceeding 250c
They should not be dyed unless mentioned in the monograph
There should not be any loose threads fibres-ends in dressings
They should be used with permitted prescribed concentrations only.
Sutures
Sutures are threads used for stiching the tissues like skin, muscles by using needle.
Two types of sutures;
Absorbable sutures: these are absorbed in the body
E.g catgut, kangaroo tendon and some synthetic polymers
Non-absorbable sutures: these are not absorbed by skin.
E.g silk, nylon
Requirements of sutures;
They must be sterile and cause no irritation
They should be stored in dry place
They are intended for one use.
A diuretic is any substance that increases production of urine.
Sometimes called water pills, help rid your body of salt (sodium) and water.
Gokharu
Synonym: Puncture vine, devil’s thorn, Caltrops fruit.
B.S.: Gokhru is the dried ripe seeds of Tribulus terrestris Linn., Family: Zygophyllaceae.
Morphological characters:
Color: fruits are yellowish in colour
Odor: odorless
Taste: slightly bitter
Shape: globose, 1.2 cm in diameter containing five woody, densely hairy, spiny cocci
Size: 1-1.5cm in diameter and 8.5mm thick
Chemical Constituents
consist of steroidal saponins as the major constituents.which are;
terestrosins A, B, C, D and E,.
F-gitonin and gitonin.
Certain other steroidal such as terestroside F, tribulosin, trillin, gracillin, dioscin
Therapeutic uses
The fruit has cooling, anti inflammatory, antiarthritic, diuretic, tonic, properties.
It is used in building immune system, in painful micturition, calculus affections and impotency.
Improves and prolongs the duration of erection
It exerts a stimulating effect on reproductary organs.
Punarnava
Synonym: rakta punarnava, hog-weed
B.S.: freh dried herb of Boerhhavia diffusa
Family: Nyctagineacea.
Morphological characters:
Color: green on upper surface,
Odor: odorless
Taste: slightly bitter
Shape: ovate
Size: 25-30mm long
Therapeutic uses
In the treatment of urogenital disorders
In the renal diseases
Fever, cough, dysponea and bronchial complaints
The term "Nutraceutical" was coined by combining the terms "Nutrition" and "Pharmaceutical" in 1989 by Dr. Stephen De Felice.
Definition Of Nutraceuticals...
A nutraceutical is any substance considered as a food, or its part which, in addition to its normal which, in addition to its normal nutritional value provides health benefits including the prevention of disease or promotion of health.
Antioxidants are substance that can prevent or minimize cell damage caused by free radicals.
These are live microbial feed supplement which improves intestinal microbial balance when administered
E.g. lactobacilli such as L. acidophilus, gram +ve cocci such as enterococcus foecium etc.
A non- digestible food ingredient that stimulates the growth or activity of number of bacteria in colon.
what is TSM?
WHO defines traditional medicine as including diverse health practices, approaches, knowledge and beliefs incorporating plant, animal, and/or mineral based medicines, spiritual therapies, manual techniques and exercises which can be used to maintain well-being, as well as to treat, diagnose or prevent illness.
TYPES OF TSM (AYUSH)
A-AYURVEDA
Y-YOGA & NATUROPATHY
U-UNANI
S-SIDDHA
H-HOMEOPATHY
Classification of Ayurvedic dosage form
POINTS TO BE INCLUDED
Definition, scope,
Technical definitions, common terminologies used in clinical
settings
Daily activities of clinical pharmacists
Ward round participation
Treatment Chart Review
Adverse drug reaction monitoring
Interprofessional collaboration
Introduction
Pharmacy & therapeutic committee (PTC)
Hospital formulary
Infection control committee
In these days of modern medicine, a large number of drugs are available for the treatment of a disease.
Considering the complexities surrounding their effective use, it is necessary for the hospital to establish a system to bring the best medicinal agents to the attention of the medical staff and help them in proper selection of therapeutic substances.
In order to ensure proper rationality in the use of drugs a “PHARMACY AND THERAPEUTIC COMMITTEE” need to be organized and constituted in a hospital.
It is an advisory group of medical staff and the administration of hospital on matters related to the therapeutic use of drugs.
FUNCTIONS
To advise the medical staff on usage of drugs.
To develop and compile formulary of drugs accepted for use in the hospital.
To plan/establish suitable educational programs.
To review adverse drug reactions.
To make recommendations concerning drugs to be stocked in hospital patient care areas.
To advise the pharmacy in the implementation of effective drug distribution and control procedures.
HOSPITAL FORMULARY
Hospital Formulary is defined as a list of drugs used in the hospital.
Formulary system is method whereby the medical staff of an institution, working through the PTC, evaluates, appraises, and selects from among the numerous available drug entities & drug products those that considered most useful in patient care.
The list of drugs guides to detect medications that require special precautions to reduce risk of errors
Precautions may include limiting access to certain drugs.
The list of drugs categorised into
High risk drugs
Emergency drugs
Schedule H1 drugs
NDPS drugs
Reserved antibiotics
High risk medications are drugs that have a heightened risk of causing significant patient harm when they are misused.
List of high risk drugs
Adrenaline 1mg/ml inj
Cobra antivenom inj
Dextrose 30% and 50% inj
Digoxin 0.5 mg inj
Dopamine 200mg/ 20ml inj
Heparin 5000unit/ml inj
Actrapid1000 unit/10ml inj
Morphine 10mg/ml inj
Noradrenaline inj
All high medication containers or loose vials/ampoules stored must be labelled as high risk medicines
Use TALL-man lettering to emphasize difference in medication name e.g. DOPamine abd DOButamine
Prescribing: do not use abbreviations when prescribing
Do not use trailing zero when prescribing e.g. 5.0mg can be mistaken as 50mg
Administration: the following particulars shall be checked before administration;
Patient’s name
Strength of medication
Dose
Route and expiry
Drug distribution is defined as, "Physical transfer of drugs from storage area in the hospital to the patient's bedside".
This involves two types of drug distribution. They are:
In-patient distribution
Out-patient distribution
The drug distribution to the in patient department can be carried out from the out patient dispensing area.
The pharmacists involved in dispensing the drugs for out patient can dispense drugs for in patients too.
The pharmacist employed for drug distribution to the in patient wards should be well skilled and qualified staff.
Out patient refers to the patients not occupying beds in hospital or in clinics, health centers and other places where out patients usually go for health care.
No medicaments should be issued without the prescription.
After the issue has been made the quantities supplied must be recorded.
In short form the out patient department was called as OPD.
CLASSIFICATION OF PATIENTS
EMERGENCY
TERTIARY CARE
PRIMARY CARE
AMBULATORY.
A hospital pharmacy is a department within a hospital that prepares, compounds, stocks and dispenses inpatient medications.
What is the role of hospital pharmacist?
Hospital pharmacists work in hospital pharmacy services belong to the MOH as well as the private sector. Pharmacists work in this field are responsible for dispensing of medications, quality testing, formulating and re-formulating dosage forms, monitoring and reporting drug safety, and preparing budges for medications.
Rheumatism is characterized by increased level of uric acid in blood , recurrent attacks of inflammation of joints due to deposition of monosodium urate crystals in the cartilage & tendons
The drugs used to relieve or used in the treatment of rheumatism.
Colchicum consists of dried ripe seeds and corms of Colchi-cum autumnale Linn., belonging to family Liliaceae
They are used mainly in the treatment of gout and rheumatic complaints,
They are radioactive substances or radioactive medications for diagnostic & therapeutic intervention
Radiopharmaceutical are medicinal formulations containing radioisotopes which are safe for organization in people for analysis or for treatment
Usually radiopharmaceuticals contain at least 2major components;
Radionuclide that provides the desired radiation characteristics &
Chemical compound with structural or chemical properties that determine the physiological behavior of radiopharmaceutical
"Pharmaceutical aids are the drugs or substances which have no or little pharmacological.but they are essentially used in the preparation of pharmaceutical dosage form
Antimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria,
Cinchona bark
Artemisia
nticancer drug, also called antineoplastic drug, any drug that is effective in the treatment of malignant, or cancerous, disease.
Vinca have been used to treat diabetes, high blood pressure and have been used as disinfectants and anti-cancer.
A drug that stimulates contraction of the myometrium. Oxytocics are used to induce labour, obstetric at term, to prevent or control postpartum or postabortion haemorrhage, and to assess foetal status in high risk pregnancies.
crude drug used is Ergot
ergot life cycle
1. over wintering stage
2. sexual reproduction
3. asexual reproduction
Vitamins can be soluble in fat or water, that effect allows classifying them on liposoluble or water-soluble.
In the first classification are the vitamins A, D, E and K. Due to the ease of their solution in body fat they stored and need not consume daily.
In the water-soluble group are B Complex and Vitamin C that can not be stored since they´re easily removed by body fluids and should be consumed daily preferably, with some exceptions.
useful for D>Pharm as per PCI syllabus
The human body does not synthesize vitamins and should be acquired by the daily intake of food, the lack of any of them can cause various diseases.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. DEFINITION:
Hospital Formulary is defined as a list of drugs
used in the hospital.
Formulary system is method whereby the medical
staff of an institution, working through the PTC,
evaluates, appraises, and selects from among the
numerous available drug entities & drug products
those that considered most useful in patient care.
3. THE NEED FOR HOSPITAL FORMULARY:
The increasing no. of new drugs manufactured
and marketed by drug companies
Increasing complexity of untoward effects of
modern potent drugs
Newer sales promotion strategies of
pharmaceutical industry.
The public interest in getting possible health
care at lowest possible cost.
4. GUIDELINE PRINCIPLES OF HOSPITAL
FORMULARY
A multidisciplinary PTC is appointed for
organization of various hospital day to day
activities.
The formulary system shall be sponsored by the
medical staff based upon the recommendations of
the PTC.
The medical staff should adopt the principles of the
system to the needs of the particular institution.
The PTC shall adopt written policies & procedures
governing the formulary system.
5. Non proprietary names should be included in the
formulary
Limiting the number of drug entities and drug products
routinely available from the pharmacy can produce
substantial patient care and financial benefits.
The formulary system is informed to the entire medical
and nursing staff.
The pharmacist shall be responsible for the
specification as to the quality, & source of supply of all
drugs, chemicals, biological & pharmaceutical
preparations.
6. GUIDING PRINCIPLE FOR ADMISSION OR
DELETION OF DRUGS IN THE FORMULARY
Drugs must be recognised by the pharmacopeia
and formularies approved under D&C act.
The manufacturer of drug should have license
for manufacturing.
Preparation of secrete composition should not be
admitted in the formulary
Preparation containing many ingredients should
be admitted if the similar therapeutic effect can
be obtained by the use of single ingredient.
9. 2. BASIC INFORMATION OF THE DRUG
Generic name, dosage form, strength
Indications
Pharmacological action
Precautions
Side effects
Dosage – form, frequency
Instructions
Drug interactions
10. 3. SUPPLEMENTARY INFORMATION ON
EACH DRUG
Price
Regulatory category
Storage guidelines
Patient counselling information
Brand names
11. 4. PRESCRIBING AND DISPENSING
GUIDELINES
Principles of prescription writing
Name and address of the patient
Prescribed drug should be written in formulary
terminology
Strength of prescribed medication must be given in
accepted metric system.
Correct dispensing guidelines
Prevention and reporting of ADRs
12. 5. GENERAL DRUG USE ADVICE
Use of IV additives
Prescribing in special situations
Poisoning and antidotes
13. 6. OTHER COMPONENTS
Formulas for various diagnostic stains, diagnostic
aids
Table of common Lab-values
Posological tables
Index of the drugs included in the formulary
Metric units
Indexes(by generic name, brand name, therapeutic
category)
14. 7. THE FORMAT
Pharmacist decides the format before commencing
work on printing and publishing in the hospital.
He has to collect formularies of some leading
hospitals as well as their format.
Copies of finally published formulary may be sent to
bodies like directorate general of health services,
Govt of India, PCI etc.
15. 8. SIZE
It is sufficiently small in size so that it could be
easily carried by clinicians, nurses etc, in the
pockets of their uniform or lab coats.
The hospitals may determine their own size of the
formulary.
16. 9. TYPE OF FORMAT
Loose leaf or Bound
Printed or Mimeographed
Indexing and Assigning categories
17. PRIVATE FORMULARY & NATIONAL
FORMULARY
Private formulary National formulary
Prepared by hospital’s own staff Prepared by nation’s outstanding
clinicians, pharmacologists and
pharmacists
Information given under each
monograph is subject to local
needs
Each monograph contains physical and
chemical properties, pharmacologic
responses, uses,toxicology,posology
etc.
Published in a more convenient
size & format
Since too many drugs are listed the
size of formulary is big.
Drugs may be added or deleted
with greater frequency
Drugs are added or deleted with less
frequency.