One test can save your life. Know what a Follicle Stimulating Hormone(FSH) is, why you should have it, who should get it, and where can you get tested as well as get your results fast. If you want to read more about Follicle Stimulating Hormone(FSH), click the link below.
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As a component of the endocrine system, both male and female gonads produce sex hormones. Male and female sex hormones are steroid hormones and as such, can pass through the cell membrane of their target cells to influence gene expression within cells. Gonadal hormone production is regulated by hormones secreted by the anterior pituitary in the brain. Hormones that stimulate the gonads to produce sex hormones are known as gonadotropins. The pituitary secretes the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These protein hormones influence reproductive organs in various ways. LH stimulates the testes to secrete the sex hormone testosterone and the ovaries to secrete progesterone and estrogens. FSH aids in the maturation of ovarian follicles (sacs containing ova) in females and sperm production in males.
One test can save your life. Know what a Follicle Stimulating Hormone(FSH) is, why you should have it, who should get it, and where can you get tested as well as get your results fast. If you want to read more about Follicle Stimulating Hormone(FSH), click the link below.
Visit: https://www.labfinder.com/labexams/follicle-stimulating-hormone-fsh/ and get tested now!
As a component of the endocrine system, both male and female gonads produce sex hormones. Male and female sex hormones are steroid hormones and as such, can pass through the cell membrane of their target cells to influence gene expression within cells. Gonadal hormone production is regulated by hormones secreted by the anterior pituitary in the brain. Hormones that stimulate the gonads to produce sex hormones are known as gonadotropins. The pituitary secretes the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These protein hormones influence reproductive organs in various ways. LH stimulates the testes to secrete the sex hormone testosterone and the ovaries to secrete progesterone and estrogens. FSH aids in the maturation of ovarian follicles (sacs containing ova) in females and sperm production in males.
Fertilization of the ovum prevents the regression of the corpus luteum. Instead, the corpus luteum enlarges, stimulated by the glycoprotein hormone, hCG, produced by the trophoblast (the developing placenta).
Hormonal control of the testicular function, with emphasis made on the role played by hormones or the endocrine system on the function of the testis and its importance in reproduction.
Fertilization of the ovum prevents the regression of the corpus luteum. Instead, the corpus luteum enlarges, stimulated by the glycoprotein hormone, hCG, produced by the trophoblast (the developing placenta).
Hormonal control of the testicular function, with emphasis made on the role played by hormones or the endocrine system on the function of the testis and its importance in reproduction.
LH activity for Gonadotrphin in controlled ovarian hyperstimulation : LH or j...Hesham Al-Inany
LH like activity is claimed to be of importance for COH in IVF/ ICSI cycles. is this real. Does addition of LH make GN more superior? this talk may answer this
Presentation for Progesterone Amp. 100 mg/ml and Progesterone pessaries 400mg for treatment of PTB, Recurrent miscarriage, Threatened abortion, Post-natal psychosis.
An idea which helps to know about both male and female sex hormones known as androgens, estrogens and progesterones and the differences between them. And basic information regarding sexual functionality helps us to know their necessity in our body
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
2. PREVIEW
1. DEFINITION OF HORMONES
2. BIOCHEMICAL CLASSIFICATION OF HORMONES
3. CASE STUDIED
- Structure & classification
- Origin of production
- Target tissues/organ(s) and functions
- Mechanism of action
- DISEASES
3. DEFINITION: Hormones are chemical substances synthesized
in small amounts by endocrine tissues and carried by blood
stream to another tissue, where it acts as a messenger to
regulate the function of the target tissue or organ.
CLASSIFICATION OF HORMONES
CLASSES OF HORMONES CHEMICAL COMPOSITION EXAMPLES
AMINO ACIDS DERIVATIVES C, H and N, AMINE GROUP CATECHOLAMINES
POLYPEPTIDES
LONG CHAINS OF AMINO
ACIDS
INSULIN, GLUCAGON
GLYCOPROTEINS
LARGE PROTEINS COMBINED
WITH CARBOHYDRATES
FSH, LH etc
STEROIDS LIPIDS CORTICOIDS, SEX HORMONES
FATTY ACID DERIVATIVES
(EICOSANOIDS)
LONG HYDROCARBON ACID
CHAINS
PROSTAGLANDINS,
LEUKOTRIENES
&THROMBOXANES
4. CASE STUDY I: FOLLICLE STIMULATING
HORMONE (FSH)
A. STRUCTURE AND CLASSIFICATION.
FSH is a glycoprotein composed of 2
monomeric subunits proteins to which
is attached a sugar. The dimer contains
2 polypeptides; Alpha subunit made up
of 92 amino acids and a beta subunit
made up of 111 amino acids. This beta
subunit confers the hormone its
specific biologic action and is
responsible for interaction with FSH
receptors.
The sugar part of FSH is composed
of fucose, galactose, mannose, galacto
samine, glucosamine, and sialic acid
Normal level: 3mIU/ml – 10mIU/ml
5. ORIGIN OF PRODUCTION
The hormone is produced in
the pituitary gland(anterior)
under the influence of
Gonadotropic hormone
releasing hormone (GnRH)
produced in the
hypothalamus, inhibited by
inhibin and enhanced by
activin.
FSH is then released to the
blood stream towards the
target tissues.
It has a plasma half life of 3-4
hours
6. TARGET TISSUES AND FUNCTIONS
• FSH regulates the development, growth, pubertal
maturation, and reproductive processes of the
human body.
• In both males and females, FSH stimulates the
maturation of germ cells.
• In males, FSH induces Sertoli cells to
secrete inhibin and stimulates the formation of
sertoli-sertoli tight junctions (zonula occludens).
• In females, FSH initiates follicular growth,
specifically affecting granulosa cells
7. MECHANISM OF ACTION
• FSH binds to FSH-R on the cell
membrane.
• This occupied receptor causes
replacement of GDP bound to Gs
protein by GTP, activating this Gs
protein.
• Gs alpha subunit moves to
ADENYLATE CYCLASE. This cyclase
then catalyzes formation of cAMP
(second messenger) from ATP
• The CAMP then activates protein
kinase (third messenger), which in
turn by phosphorylation of cellular
proteins influences on mRNA
synthesis.
8. DISEASES
1.HIGH LEVELS OF FSH
• Premature menopause also known as Premature
Ovarian Failure
• Poor ovarian reserve also known as Premature
Ovarian Aging
• Gonadal dysgenesis, Turner syndrome (XO)
• Castration
• Swyer syndrome(46XY but externally female)
• Certain forms of CAH
• Testicular failure.
• Klinefelter syndrome(XXY)
10. CASE STUDY II: LUTEINIZING
HORMONE(LH)
A.STRUCTURE AND CLASSIFICATION
LH is a heterodimeric glycoprotein.
Each monomeric unit is
a glycoprotein molecule; one alpha and one
beta subunit make the full, functional
protein. The alpha subunit is similar in all
glycoprotein hormones but it’s beta subunit
consists of 120 amino acids, that confers its
specific biologic action and is responsible
for the specificity of the interaction with
the LH receptor. The carbohydrate part
consist of different oligosaccharides
The biologic half-life of LH is 20 minutes.
During the reproductive years, typical levels
of LH are between 1-20 IU/L.
In males over 18 years of age, reference
ranges have been estimated to be 1.8-8.6 IU/L
11. ORIGIN OF PRODUCTION
LUTEINIZING HORMONE is produced in the
pituitary gland under the regulation of
GONADOTROPIC HORMONE RELEASING
HORMONE(GnRH). It is then released to the
blood stream towards the target tissues
12. TARGET TISSUES AND FUNCTIONS
In females, LH supports theca cells in the ovaries that
provide androgens and hormonal precursors for estradiol
production.
-"LH surge" triggers ovulation, thereby not only releasing
the egg from the follicle, but also initiating the conversion of
the residual follicle into a corpus luteum that, in turn,
produces progesterone to prepare theendometrium for a
possible implantation.
In the male, LH acts upon the Leydig cells of the testis and
is responsible for the production of testosterone,
an androgen that exerts both endocrine activity and
intratesticular activity on spermatogenesis.
13.
14. MECHANISM OF ACTION
• The mechanism of action is basically similar to
that seen in FSH and the diseases observed
too.
16. HIGH LEVEL OF LH (low level of FSH) in female and male
17. CASE STUDY III: TESTOSTERONE
STRUCTURE AND CLASSIFICATION
Testosterone is made up of
CYCLOPENTANEPERHYDROPH
ENANTHRENE ring which is a
characteristics of most steroid
hormones.
Therefore testosterone is
considered to be a steroid
hormone with molecular
weigh (MW) = 288,4
18. ORIGIN OF PRODUCTION
TESTOSTERONE is primarily produced in the
testes by the INTERSTITIAL CELLS OF LEYDIG.
Precursor of testosterone is Progesterone
which is first converted to androstenedione
which is then hydrolyzed to form
testosterone. This is how testosterone is
produced in females.
Testosterone is also produced in small
amount in the zona reticularis of the adrenal
gland.
Testosterone level is regulated by FSH and
LH.
LH stimulates an increase in number of leydig
cells , hence increasing testosterone level, and
vice versa.
Testosterone is transported together with
specific plasma protein binding globulin or
testosterone-estrogen binding globulin
19. TARGET TISSUES AND FUNCTIONS
Testosterone acts on several tissues of the body
where it carries out the following functions:
1. It is responsible for gonadal development in the male
embryo.
2. This hormone is responsible for "brain masculinization"
in infant boys.
3. It is responsible for secondary sexual characteristics in
male.
4. It increases energy metabolism, thereby helping men to
shed extra pounds, lower their body fat, and acquire a
leaner and fitter physique.
5. Testosterone is also believed to stimulate erythropoeisis
21. DISEASES
• LACK OF TESTOSTERONE: this induces
hypogonadism (primary- testicular failure)
• Normal level of testosterone but defective
receptors induces “ testicular feminization” I.e
genotype is XY but phenotype is female (swyer
syndrom).
Kallmann syndrome is a genetic condition which results in the failure to commence or the non-completion of puberty. It is characterised by hypogonadism and by a total lack of sense of smell (anosmia) or a heavily reduced sense of smell (hyposmia). The term hypogonadism describes a low level of circulating sex related hormones; (testosterone in men and oestrogen and progesterone in women).