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The document discusses quality control of human chorionic gonadotropin (hCG), a hormone produced during pregnancy. It describes hCG's history, functions, production methods, purification processes, formulations, assays and related quality control tests to ensure the hormone's potency, purity and sterility. Some key points are that hCG can be extracted from urine of pregnant women or produced recombinantly, and its biological activity is determined using assays that measure effects on test animals.
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3. The use of recombinant gonadotropins can offer benefits to patients through features such as pre-filled pens, which may improve compliance and reduce stress associated with treatment.
FSH, LH & Testosterone
FSH, LH, and testosterone are hormones that regulate reproductive functions. FSH acts on the ovaries and testes to stimulate gamete production. LH triggers ovulation in females and supports testosterone production in males. Testosterone promotes male sexual development and secondary sex characteristics. The hormones work by binding to receptors on target cells and activating intracellular signaling cascades. Abnormal levels can cause diseases like polycystic ovarian syndrome or Klinefelter syndrome.
Bioassay techniques
An Over view on Bioassay, structure & principles, types & methods of bioassay. Also mention of other assay's like biotechnology, microbio assay, immunoassay etc.
Beta hcg
The document provides information about beta human chorionic gonadotropin (β-HCG) levels during pregnancy. It discusses how β-HCG is the first detectable pregnancy hormone, its role in maintaining the corpus luteum and promoting progesterone secretion. Normal β-HCG level ranges are provided for different weeks of pregnancy. Blood and urine tests are used to measure β-HCG levels to diagnose and monitor pregnancy and detect potential issues.
Infertility teachback
The document discusses infertility, which is defined as the inability to become pregnant after 12 months of unprotected sex or 6 months for women over 35. About 10% of women aged 15-44 are infertile. Causes of infertility include age, ovulation issues, structural problems, immune issues, cervical fluid problems, and luteal phase defects for women. For men, causes include birth defects or issues that develop over time like low sperm count or mobility. Diagnosis and treatment options are discussed, including drugs, surgery, assisted reproductive technologies like IVF, egg freezing, and third-party reproduction methods. Emotional aspects like different types of grief and potential support systems are also covered.
Panel IUI by DR SHASHWAT JANI ( Optimizing Success in Intrauterine Inseminati...
This document discusses optimizing success with intrauterine insemination (IUI). It lists male and female factors that can indicate IUI, including issues like retrograde ejaculation or cervical hostility. Standard protocols for IUI are discussed, including using clomiphene, gonadotropins, or a combination. The timing of hCG administration and IUI is outlined. Techniques for sperm preparation and factors affecting IUI success rates are also summarized. Limitations of IUI are noted.
Azoospermia e Técnica de Extração de Espermatozóides
1. O documento descreve um curso de pós-graduação sobre reprodução humana assistida, com foco em azoospermia e técnicas de extração de espermatozoides em homens azoospérmicos.
2. As causas de azoospermia, como obstrutiva e não-obstrutiva, são explicadas, assim como os métodos de diagnóstico e opções de tratamento, incluindo cirurgia reconstrutiva e extração de espermatozoides.
3. Técnicas de extração de espermatozoides como PES
201 reproduction
1) The document discusses the endocrine system and reproduction, including sexual differentiation, gamete formation, and the roles of the hypothalamus and pituitary gland in controlling reproduction.
2) It describes the male and female reproductive systems and their functions, including spermatogenesis and the ovarian cycle.
3) Key parts of the female reproductive cycle are explained, including the follicular phase dominated by estrogen, ovulation triggered by an LH surge, and the luteal phase supported by progesterone from the corpus luteum. Changes in the endometrium driven by estrogen and progesterone in preparation for potential implantation are also summarized.
Epilepsy Myths & Misconceptions
The document discusses common myths and misconceptions about epilepsy, stating that epilepsy is not contagious, people cannot swallow their tongue during a seizure, and not all seizures involve loss of consciousness. It notes that while some people have difficulty controlling seizures, up to 70% of people with epilepsy can achieve seizure freedom with medication. The document also emphasizes that epilepsy usually does not impact employment, parenting abilities, or participation in sports.
Eficácia Clínica da Gonadotrofina Coriônica Humana Recombinante (hCG-rec) pa...
Este estudo avaliou a eficácia e segurança da gonadotrofina coriônica humana recombinante (hCG-rec) na restauração da espermatogênese e produção de andrógenos em homens com hipogonadismo hipogonadotrófico. Após 12 semanas de tratamento com injeções semanais de hCG-rec, 10 dos 11 pacientes apresentaram espermatozóides na ejaculação e aumento dos níveis de testosterona, com poucos efeitos adversos relatados. O hCG-rec mostrou-se uma alternativa e
Aromatase inhibitors or gonadotropin-releasing hormone agonists for the manag...
Aromatase inhibitors or gonadotropin-releasing hormone agonists for the management of uterine adenomyosis:
A randomized controlled study
Gonadal function
The document discusses the gonads and sex hormones. It states that the gonads are the organs that produce gametes (sex cells) and steroid hormones. In males the gonads are the testes and in females they are the ovaries. Sex steroids control the development of sex organs and secondary sexual characteristics. Their production is regulated by hormones from the hypothalamus and pituitary gland. The document then discusses factors that can affect sex hormone production and various conditions related to abnormal hormone levels.
4 mechanism of action of testosteron
4 mechanism of action of testosteronDr. Alamzeb Associate professor ,HOD Physiology Saidu Medical College saidu Sharif Swat Pakistan
Testosterone's effects occur through binding to androgen receptors or by aromatization to estradiol. It stimulates protein synthesis in target tissues like the prostate. Gonadotropin-releasing hormone from the hypothalamus stimulates the pituitary to secrete LH and FSH, controlling testosterone and sperm production. Negative feedback loops regulate these processes. Abnormalities can include prostate diseases and hypogonadism.Viewers also liked (19)
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Placental endocrinology
The placenta acts as an endocrine organ around 6-8 weeks of pregnancy, producing hormones like hCG, HPL, and estrogen. These hormones help maintain the corpus luteum, promote fetal growth, prevent rejection of the fetus, and prepare the uterus for pregnancy and birth. The placenta synthesizes hormones through pathways integrated between the mother, fetus, and placenta itself. Levels of hormones like hCG, HPL, and estrogen provide information about fetal and placental health.
BASIC STEPS IN IN VITRO FERTILIZATION (IVF)
The document summarizes the basic steps in in vitro fertilization (IVF). It begins with pituitary suppression and ovarian hyperstimulation to develop multiple follicles. Mature eggs are then retrieved from the ovaries through transvaginal ultrasound-guided needle aspiration. Sperm is collected and prepared for fertilization through sperm washing. The eggs and sperm are then fertilized through either insemination or intracytoplasmic sperm injection. The fertilized eggs are cultured for 2-6 days until embryo transfer into the uterus. Success rates vary based on factors like maternal age but average live birth rates in the US range from about 30-40% per cycle for women under 35.
The Role of Recombinant hCG in IVF
This presentation discusses the role of recombinant human chorionic gonadotropin (hCG) in in vitro fertilization (IVF). It begins by outlining the learning objectives and providing background on hCG and its native and recombinant forms. The document then compares urinary and recombinant hCG, noting the higher purity and consistency of recombinant hCG. Several studies are summarized showing similar or improved outcomes with recombinant hCG compared to urinary hCG in terms of fertility measures like fertilization rates and pregnancy rates, as well as reduced risk of ovarian hyperstimulation syndrome.
1_HYPOTHALAMUS PIThbUITARY HORMONES.pdf
The summary is as follows:
1. The hypothalamus produces releasing and inhibiting hormones that regulate the pituitary gland, which secretes hormones that control other endocrine glands and tissues.
2. Pituitary hormones include growth hormone, thyroid-stimulating hormone, adrenocorticotropic hormone, gonadotropins, prolactin, oxytocin, and antidiuretic hormone.
3. Hypothalamic hormones and pituitary hormones are used clinically for various purposes such as diagnosing endocrine disorders, stimulating growth, and controlling hormone-secreting tumors.
Woolsey & Goff - The Effects of hCG Diet Injections on Common Pregnancy Tests
This study examined whether injections of the hormone hCG used in hCG diets could cause unreliable positive results on pregnancy tests in non-pregnant women. 15 non-pregnant women were tested before and during their hCG diet injections. All 15 women tested positive on blood pregnancy tests during the injections, and 14 tested positive on urine tests, indicating the injections caused false positive results. This shows hCG diet injections can lead to inaccurate positive pregnancy test results in non-pregnant women. Physicians and those on hCG diets should be aware of this effect.
Principles and Practices of LH Administration in Controlled Ovarian Stimulation
The document discusses principles of LH supplementation during controlled ovarian stimulation (COS) cycles. It begins by outlining how the author practices LH supplementation in different patient populations during COS using either recombinant human LH (rec-LH) or human menopausal gonadotropin (hMG), which contains LH activity from hCG. It then reviews the principles of LH supplementation, molecular differences between LH and hCG, and clinical outcomes when using preparations containing LH activity.
Early diagnosis of pregnancy
The document discusses several methods used to diagnose pregnancy through the measurement of hormones like hCG, progesterone, and early pregnancy factor in blood and urine samples. It explains that hCG levels rise steadily in the first trimester and doubling every 2-3 days can confirm a viable pregnancy. Different hormone assays and ultrasound examination can determine viability and location of the pregnancy. Home pregnancy tests detect hCG in urine but accuracy depends on hormone levels and test sensitivity.
Salivaryhormonetesting
SHT (saliva hormone testing) was developed as a non-invasive alternative to traditional female hormone blood panels. It maps estrogen and progesterone levels throughout the menstrual cycle using 11 saliva samples. This frequent monitoring can help detect hormonal imbalances, luteal phase deficits, and customize hormone therapy. Saliva testing is marketed as easier, cheaper, and more accurate than blood tests due to more frequent sampling. While advantageous for being non-invasive and convenient, saliva testing also has disadvantages like lower sensitivity and potential contamination issues.
Salivaryhormonetesting
SHT (saliva hormone testing) was developed as a non-invasive alternative to traditional female hormone blood panels. It maps estrogen and progesterone levels throughout the menstrual cycle using 11 saliva samples. This frequent monitoring can help detect hormonal imbalances, luteal phase deficits, and customize hormone therapy. Saliva testing is marketed as easier, cheaper, and more accurate than blood tests due to more frequent sampling. While advantageous for being non-invasive and convenient, saliva testing also has disadvantages like lower sensitivity and potential contamination issues.
Endcrinological changes during pregnancy
After fertilization, the zygote implants in the uterus by day 5 and the corpus luteum secretes progesterone and hCG to maintain pregnancy until week 8. The placenta becomes fully functional by week 10, taking over hormone production. Pregnancy causes changes in maternal endocrine glands, including increased production of progesterone, estrogens, hCG, hPL, and other placental hormones by the corpus luteum and placenta. Levels of pituitary, thyroid, adrenal, and other hormone levels also increase during pregnancy to support development.
POLYCYSTIC OVARIAN SYNDROME
This document describes a study on the quality of life and effects of CoQ10 in patients with polycystic ovarian syndrome. The study aims to assess quality of life, study the effect of CoQ10 in PCOS patients, and examine treatment outcomes in lean and obese patients treated with CoQ10 or clomiphene citrate. A prospective comparative study was conducted involving 40 PCOS patients, with 20 receiving CoQ10 and 20 receiving clomiphene citrate. Quality of life, hormone levels, follicle numbers, and improvement in anovulation and irregular cycles were evaluated before and after 45 days of treatment.
OHSS Management - Dr Dhorepatil Bharati
The achievement of a pregnancy with no OHSS, leading to a singleton live term birth of a healthy child.
Recombinant hCG: state-of -art formulation for a patient-centered management ...
This document discusses the use of recombinant human chorionic gonadotropin (rec-hCG) compared to urinary hCG (u-hCG) for oocyte maturation triggering in in vitro fertilization (IVF). Recombinant hCG is produced from cultured cells and has higher purity than u-hCG extracted from urine. It has consistent characteristics that allow precise dosing and a better safety profile. Studies show rec-hCG results in higher fertilization rates and pregnancy rates compared to u-hCG when used for oocyte triggering in IVF. Recombinant hCG also allows for subcutaneous administration using pre-filled syringes or pens, providing more convenient treatment compared to u
الحمل.pdf
Pregnancy tests detect human chorionic gonadotropin (hCG) hormone produced by the placenta from early pregnancy. hCG levels rise quickly in the first weeks and are excreted in urine, allowing urine tests to detect pregnancy before a missed period. Urine tests are based on inhibition or direct binding of hCG to antibodies on test strips or latex/red blood cells. A positive test shows no agglutination or color change, indicating the presence of hCG bound the antibodies. Factors like time since conception, urine concentration, and interferences can affect accuracy.
Physiology of the Endocrine System
The endocrine system is composed of organs positioned throughout the body in widely separated locations. Endocrinology is the study of the structure and functioning of the endocrine system.
Novel treatments to trigger final follicular maturation and luteal phase support
This document summarizes novel strategies for triggering final follicular maturation and supporting the luteal phase in fertility treatments. It discusses evaluating the quality of trigger and luteal phase support methods based on indicators of safety, effectiveness, and patient-centeredness. Specific strategies used at Androfert clinic are presented, including individualizing triggers and support according to patient risk factors. Recombinant hCG is shown to have advantages over urinary hCG in terms of effectiveness, safety, and patient preferences. GnRH agonist triggering avoids risk of ovarian hyperstimulation syndrome but needs additional luteal phase support.
Fertility tests
The semen analysis is the most important test for male fertility. It examines semen volume, sperm count, motility, morphology, and other factors. Abnormal results may indicate infertility issues. Hormone tests of blood and urine examine reproductive hormone levels which are important for ovulation. Ultrasound can check the ovaries, uterus, and fallopian tubes for issues like endometriosis that impact fertility. Other tests include hysterosalpingography which uses dye and x-rays to examine the fallopian tubes for blockages. Together these tests provide information to diagnose and treat fertility problems.
Pregnancy Testing In Clinical Chemistry
This document provides information about pregnancy testing using human chorionic gonadotropin (hCG) detection. It discusses the history and development of pregnancy tests, the biochemistry of hCG, common testing methods, factors affecting test accuracy, and recommendations for use and interpretation of results. Modern pregnancy tests are immunoassays that use antibodies to detect hCG in urine or blood to determine if a woman is pregnant.
A STUDY ON QOL & EFFECTOF COQ10 IN PCOS
The document summarizes a study on quality of life and the effect of CoQ10 in patients with polycystic ovarian syndrome. It describes the objectives, methodology, and results of the study. The study involved 40 PCOS patients divided into two groups - one treated with standard medication and the other treated with CoQ10. Various quality of life and clinical parameters were assessed before and after treatment and compared between the two groups. The results suggest CoQ10 may help improve quality of life and clinical outcomes in PCOS patients.
Infertility investigation tests
This document provides information about various tests used in infertility investigations, including hormone levels, semen analysis, and genetic testing. It discusses hormones like FSH, LH, estradiol, progesterone, and hCG, explaining their functions and normal ranges. Semen analysis is outlined as measuring volume, sperm count, morphology, motility, and white blood cells. The tests aim to evaluate reproductive function in both males and females in order to identify potential causes of infertility.
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Do elements of globalization, such as Foreign Direct Investment (FDI), negatively affect the ability of countries in the Global South to preserve their culture? This research aims to answer this question by employing a cross-sectional comparative case study analysis utilizing methods of difference. Thailand and Cambodia are compared as they are in the same region and have a similar culture. The metric of difference between Thailand and Cambodia is their ability to preserve their culture. This ability is operationalized by their respective attitudes towards FDI; Thailand imposes stringent regulations and limitations on FDI while Cambodia does not hesitate to accept most FDI and imposes fewer limitations. The evidence from this study suggests that FDI from globally influential countries with high gross domestic products (GDPs) (e.g. China, U.S.) challenges the ability of countries with lower GDPs (e.g. Cambodia) to protect their culture. Furthermore, the ability, or lack thereof, of the receiving countries to protect their culture is amplified by the existence and implementation of restrictive FDI policies imposed by their governments.
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WhatsPump Thriving in the Whirlwind of Biden’s Crypto Roller Coaster
WhatsPump Thriving in the Whirlwind of Biden’s Crypto Roller Coaster
Who Is the Largest Producer of Soybean in India Now.pdf
This blog explores the current largest producer of soybean in India and the factors contributing to their dominance.
Abhay Bhutada Leads Poonawalla Fincorp To Record Low NPA And Unprecedented Gr...
Under the leadership of Abhay Bhutada, Poonawalla Fincorp has achieved record-low Non-Performing Assets (NPA) and witnessed unprecedented growth. Bhutada's strategic vision and effective management have significantly enhanced the company's financial health, showcasing a robust performance in the financial sector. This achievement underscores the company's resilience and ability to thrive in a competitive market, setting a new benchmark for operational excellence in the industry.
Bridging the gap: Online job postings, survey data and the assessment of job ...
Bridging the gap: Online job postings, survey data and the assessment of job ...Labour Market Information Council | Conseil de l’information sur le marché du travail
OJP data from firms like Vicinity Jobs have emerged as a complement to traditional sources of labour demand data, such as the Job Vacancy and Wages Survey (JVWS). Ibrahim Abuallail, PhD Candidate, University of Ottawa, presented research relating to bias in OJPs and a proposed approach to effectively adjust OJP data to complement existing official data (such as from the JVWS) and improve the measurement of labour demand.Does teamwork really matter? Looking beyond the job posting to understand lab...
Does teamwork really matter? Looking beyond the job posting to understand lab...Labour Market Information Council | Conseil de l’information sur le marché du travail
Vicinity Jobs’ data includes more than three million 2023 OJPs and thousands of skills. Most skills appear in less than 0.02% of job postings, so most postings rely on a small subset of commonly used terms, like teamwork.
Laura Adkins-Hackett, Economist, LMIC, and Sukriti Trehan, Data Scientist, LMIC, presented their research exploring trends in the skills listed in OJPs to develop a deeper understanding of in-demand skills. This research project uses pointwise mutual information and other methods to extract more information about common skills from the relationships between skills, occupations and regions.How Non-Banking Financial Companies Empower Startups With Venture Debt Financing
How Non-Banking Financial Companies Empower Startups With Venture Debt Financing
Independent Study - College of Wooster Research (2023-2024)
"Does Foreign Direct Investment Negatively Affect Preservation of Culture in the Global South? Case Studies in Thailand and Cambodia."
Do elements of globalization, such as Foreign Direct Investment (FDI), negatively affect the ability of countries in the Global South to preserve their culture? This research aims to answer this question by employing a cross-sectional comparative case study analysis utilizing methods of difference. Thailand and Cambodia are compared as they are in the same region and have a similar culture. The metric of difference between Thailand and Cambodia is their ability to preserve their culture. This ability is operationalized by their respective attitudes towards FDI; Thailand imposes stringent regulations and limitations on FDI while Cambodia does not hesitate to accept most FDI and imposes fewer limitations. The evidence from this study suggests that FDI from globally influential countries with high gross domestic products (GDPs) (e.g. China, U.S.) challenges the ability of countries with lower GDPs (e.g. Cambodia) to protect their culture. Furthermore, the ability, or lack thereof, of the receiving countries to protect their culture is amplified by the existence and implementation of restrictive FDI policies imposed by their governments.
My study abroad in Bali, Indonesia, inspired this research topic as I noticed how globalization is changing the culture of its people. I learned their language and way of life which helped me understand the beauty and importance of cultural preservation. I believe we could all benefit from learning new perspectives as they could help us ideate solutions to contemporary issues and empathize with others.
Pensions and housing - Pensions PlayPen - 4 June 2024 v3 (1).pdf
Wayhome's analysis of the UK market and how pension schemes can help solve the problems it presents younger people
Tax System, Behaviour, Justice, and Voluntary Compliance Culture in Nigeria -...
Tax System, Behaviour, Justice, and Voluntary Compliance Culture in Nigeria -...Godwin Emmanuel Oyedokun MBA MSc PhD FCA FCTI FCNA CFE FFAR
Lecture slide titled Tax System, Behaviour, Justice, and Voluntary Compliance Culture in Nigeria - Prof Oyedokun.pptxRecently uploaded (20)
This assessment plan proposal is to outline a structured approach to evaluati...
This assessment plan proposal is to outline a structured approach to evaluati...
Tdasx: Unveiling the Trillion-Dollar Potential of Bitcoin DeFi
Tdasx: Unveiling the Trillion-Dollar Potential of Bitcoin DeFi
Sources of Revenue for State Government - Prof Oyedokun.pptx
Sources of Revenue for State Government - Prof Oyedokun.pptx
Independent Study - College of Wooster Research (2023-2024) FDI, Culture, Glo...
Independent Study - College of Wooster Research (2023-2024) FDI, Culture, Glo...
^%$Zone1:+971)581248768’][* Legit & Safe #Abortion #Pills #For #Sale In #Duba...
^%$Zone1:+971)581248768’][* Legit & Safe #Abortion #Pills #For #Sale In #Duba...
WhatsPump Thriving in the Whirlwind of Biden’s Crypto Roller Coaster
WhatsPump Thriving in the Whirlwind of Biden’s Crypto Roller Coaster
Who Is the Largest Producer of Soybean in India Now.pdf
Who Is the Largest Producer of Soybean in India Now.pdf
Abhay Bhutada Leads Poonawalla Fincorp To Record Low NPA And Unprecedented Gr...
Abhay Bhutada Leads Poonawalla Fincorp To Record Low NPA And Unprecedented Gr...
Bridging the gap: Online job postings, survey data and the assessment of job ...
Bridging the gap: Online job postings, survey data and the assessment of job ...
Does teamwork really matter? Looking beyond the job posting to understand lab...
Does teamwork really matter? Looking beyond the job posting to understand lab...
How Non-Banking Financial Companies Empower Startups With Venture Debt Financing
How Non-Banking Financial Companies Empower Startups With Venture Debt Financing
Independent Study - College of Wooster Research (2023-2024)
Independent Study - College of Wooster Research (2023-2024)
Pensions and housing - Pensions PlayPen - 4 June 2024 v3 (1).pdf
Pensions and housing - Pensions PlayPen - 4 June 2024 v3 (1).pdf
Tax System, Behaviour, Justice, and Voluntary Compliance Culture in Nigeria -...
Tax System, Behaviour, Justice, and Voluntary Compliance Culture in Nigeria -...
Presentation2
- 1. QUALITY CONTROLE OF CHORIONIC GONADOTROPHIN BY S.RAVINDER REDDY ROLL NO:1008-10-885-011 M.PHARMACY 1 ST YEAR 1 ST SEM PHARMACEUTICAL ANALYSIS AND Q.A.
- 3. ABSTRACT Gonadotropins are hormones which target the gonads , structures involved in fertility and reproduction. In women, gonadotropins are directed at the ovaries , where they play in a role in the production of eggs and eventual ovulation , while in men, these hormones are involved in sperm production in the testes . Abnormalities in gonadotropin levels can lead to infertility, which can sometimes be treated with hormone injections . crude preparation of hCG, deriving from a concentrated sample of a culture medium obtained after the recombinant process or from a crude concentrate of urine of pregnant women , can be purified such that the resulting hCG is practically free from proteins or other contaminants contained in the crude hCG preparation.