High tibial osteotomy (HTO) is a common and widely accepted procedure in orthopaedic surgery. In the literature, we find descriptions of the technique dating back to the 50s, with Jackson (Jackson, 1958). However, it was not until the 70s, with the publications of Conventry (Coventry, 1969 and 1973) and Insall (Insall, 1975), that proximal tibial osteotomy became common practice as a treatment option for medial compartment osteoarthritis of the knee usually associated to varus deformity. At that time, closing wedge osteotomies were performed, despite the greater technical difficulty and risks involved, as there were no fixation materials available that could enable opening wedge osteotomy. Only after the development of medial wedge plate fixation that opening wedge osteotomy became applicable (Puddu, 2004).
The goals of HTO are:
1. To reduce knee pain by transferring weight-bearing loads to the relatively unaffected compartment;
2. To increase the life span of the knee joint, by slowing or stopping the destruction of the medial joint compartment. This could delay the need of a joint replacement.
a simplified version of periprosthetic fractures, easy to learn and understand with lots of images and classification. It includes hip, shaft of femur, knee, shoulder
Deformity: It’s the position of a limb/Joint, from which it cannot be brought back to its normal anatomical position.
Described as abnormalities of :
Length
Angulation
Rotation
Translation
Combination
Hip dysplasia in adults, types, radiographs and management!
Useful for Orthopaedic residents and Surgeons.
Include most of the basics from reliable sources, pardon for any mistakes. Contact at singh_prabhjeet@yahoo.com for any corrections.
High tibial osteotomy (HTO) is a common and widely accepted procedure in orthopaedic surgery. In the literature, we find descriptions of the technique dating back to the 50s, with Jackson (Jackson, 1958). However, it was not until the 70s, with the publications of Conventry (Coventry, 1969 and 1973) and Insall (Insall, 1975), that proximal tibial osteotomy became common practice as a treatment option for medial compartment osteoarthritis of the knee usually associated to varus deformity. At that time, closing wedge osteotomies were performed, despite the greater technical difficulty and risks involved, as there were no fixation materials available that could enable opening wedge osteotomy. Only after the development of medial wedge plate fixation that opening wedge osteotomy became applicable (Puddu, 2004).
The goals of HTO are:
1. To reduce knee pain by transferring weight-bearing loads to the relatively unaffected compartment;
2. To increase the life span of the knee joint, by slowing or stopping the destruction of the medial joint compartment. This could delay the need of a joint replacement.
a simplified version of periprosthetic fractures, easy to learn and understand with lots of images and classification. It includes hip, shaft of femur, knee, shoulder
Deformity: It’s the position of a limb/Joint, from which it cannot be brought back to its normal anatomical position.
Described as abnormalities of :
Length
Angulation
Rotation
Translation
Combination
Hip dysplasia in adults, types, radiographs and management!
Useful for Orthopaedic residents and Surgeons.
Include most of the basics from reliable sources, pardon for any mistakes. Contact at singh_prabhjeet@yahoo.com for any corrections.
Principle of Deformity Correction in lower Limb Kaushal Kafle
A brief summary about the priniciple of deformity correction in paediatrics and adults with the effects of deformity, etiology, physiological deformity, clinical and radiological assessment, measurements of various lines and angles, various terminologies, preoperative templating, acute and gradual correction , osteotomy principle and techniques, methods of fixation and stabilization.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
1. HTO
Planning : How to do it
Dr Abhishek Kaushik
AO Fellow (Austria)
AO National Faculty
FJR (USA, UK and Germany)
2. Learning objectives
• Historical aspects
• Physiological axis and anomalies
• Indications
• Principle of osteotomy
• Planning (Medial Open Wedge)
• Techniques
• Complications
• Take home
3. History
Those who cannot remember the past, are condemned to repeat it
• First modern osteotomy
was done by American
John Rhea Barton (1794–
1871) on sub-trochanteric
femur.
• Bernhard Heine (1800–
1846) from Germany
designed first working
osteotome
4. • Bernhard Rudolf Konrad von
Langenbeck (1810–1887)
professor in Göttingen, Kiel, and
Berlin, Germany, was the first to
describe a subcutaneous
osteotomy technique
• Theodor Billroth (1829–1894)
Professor in Zürich, Switzerland
and Wien, Austria designend a
chisel.
5. • Sir William Macewen (1848–1924),
Professor in Glasgow, performed
the first antiseptic osteotomy in
Great Britain on April 11, 1875.
• In 1884, he presented his series of
1,800 cases without major
complications.
• His major work was on
supracondylar region of humerus.
6. • Jackson, Waugh, Gariépy,
Coventry were first to perform
proximal tibial osteotomy for
osteoarthritis knee.
• Jackson did it distal to tibial
tubercle
• Coventry “Classical” lateral
closed wedge valgization type
with fibular osteotomy done
proximal to tibial tubercle.
7. • Open-wedge osteotomy was
first described by Lexer (1931).
• In 1969 the AO advocated
fixation using an angular plate
for either varization or
valgization osteotomy on the
distal femur
8. Knee Axis
• The knee joint is the
largest and most
complex joint in the
human body and has
the longest lever
arms.
9. • The mechanical axis of the leg (Mikulicz
line) runs from the center of the
femoral head to the center of the ankle
joint.
• Under physiological conditions this line
runs on average 4 (± 2) mm medial to
the center of the knee joint. (MAD)
• The anatomical and mechanical femoral
axes form an angle of 6° (± 1°) (aMFA).
10. • The tibial plateau is
slightly shifted in a
posterior direction in
relation to the axis of the
femoral diaphysis
• Tilted caudally by 10° in
relation to the horizontal
line in the sagittal plane
(tibial slope).
11. Deformed Leg / Knee
• Deformities of the lower limb are defined as a
deviation of the physiological axes
• Can be pathologically altered in the frontal,
sagittal or transverse or torsional plane.
• The most frequent pathologies and therefore
those of greatest clinical relevance are varus-
valgus deformities in the frontal plane.
12. Varus
• Anatomical femorotibial
angle > 173–175°
• Mikulicz line runs medial
to the 4 mm point,
significant in MAD >
15mm medial to the
center of the knee joint
• Increased intercondylar
distance
13. Valgus
• Anatomical femorotibial
angle < 173–175°
• Mikulicz line runs lateral to
the 4 mm point, significant
in MAD > 10 mm lateral to
the center of the knee
joint
• Increased inter-malleolar
distance
14. Causes
• Congenital deformities
• Constitutional deformities
• Growth disorders with premature partial closure
of the epiphyseal plate
• Metabolic diseases (eg, rachitis)
• Osteopathies (eg, renal osteopathy)
• Posttraumatic deformities
• Secondary deviation due to destruction of the
joint surface (infection, Tumors)
• Degenerative
16. • Clinical evaluation for ligaments, skin and soft
tissues.
• Examination of Hips, knee and spine must be
done.
• X-rays standing and Stress views and patella
views.
• CT scannogram for measurement of angles.
• MRI for evaluating cartilage, ligaments.
19. Indications
• Oseoarthritis Patients With Varus Limb
Alignment
• Oseoarthritis Patients With Valgus Limb
Alignment
• Adult Osteochondritis Dissecans.
• Osteonecrosis
• Postero-lateral Instability
• Chondral Resurfacing
20. Planning
• Selection of patient: Most Important
• Determining the deformity (Plane , Angle)
• Determine the amount of correction desired
• Choice of osteotomy
• Implant selection
• Develop a surgical plan
• Execute
21. Patient Selection Guidelines
• Stage of osteoarthritis (Uni / Bi/Advanced)
• Ligamentous status
• Type of deformity and reducibility
• Age
• Range of motion
• Obesity
• General medical status
• Activity levels
• Patient’s expectations.
22. The Ideal patient for a HTO
• Younger than 65 years (male) respectively 55
years (female)
• Metaphyseal varus deformity of the tibia (TBVA >
5°)
• Intact lateral compartment
• Normal range of motion (<10° extension deficit)
• Non-smoker (better healing)
• Has a certain pain tolerance
• May have ACL or PCL deficiency (can be
addressed by the surgery by correcting slope)
• BMI under 30
23. The ideal candidate for a UKA
• Older than 55 years
• Has no osseous deformity and mere intra-
articular wear.
• Intact ligaments ( ACL, MCL)
• Has a deformity which reduces completely in 20°
of flexion under valgus stress
• Has an intact lateral compartment
• Has an almost normal range of motion
• Has no inflammatory disease
• Should preferably have a BMI under 30
24. The ideal candidate for a TKA
• Is older than 75 years
• Has generalized and manifest osteoarthritis of the
knee
• Has significant and continuous pain during
activities of daily life
• May have extension or flexion deficits
• May have axis deviation and bone deficiencies
• Has limited expectations regarding activity and
range of motion
• May have ligament balance issues.
27. Nature and localization
• Prerequisites for the planning process are
• A good quality weight-bearing x-ray of the
entire lower extremity
• Definition of the type and localization of the
deformity
• Knowledge of any associated ligament
instability
28. Nature of Deformity
• Varus deformity with
• No loss of med cartilage
• 1/3 loss of medial cartilage
• 2/3 loss of medial cartilage
• Bone on bone arthrosis
• ACL Deficiency
• PCL deficiency
• Axial Rotation components
• Femoral deformity
components
29. Localization
• Frontal and sagittal plane evaluation
• a. Weight-bearing line
b. Mechanical axis of femur and tibia
c. Joint orientation angles
d. Location of deformity (CORA)
• Bowing of femur or tibia may coexist
• Deformity in distal femur may coexist
• Deformity in ankle
30. • Effect of ankle joint line
inclination on HTO
• Ankle joint inclined:
corrects to normal after
closed Wedge HTO
• Ankle joint parallel to
knee: gets inclined after
surgery.
31. Planning
• Level of osteotomy:
• Should be performed at the apex of the
deformity for optimal correction.
• The metaphysis of a long bone is the region of
best healing capacity; Healing time favors tibia
over femur.
• Double osteotomy may sometime be needed
in complex deformities.
32. Planning
• Open v/s Closed:
• Open-wedge are generally easier and more
precise to perform.
• Opening procedure allows for intraoperative
“fine-tuning” by adjusting the opening.
• Open wedge may require bone grafting. ( not
in angle stable devices)
• Open may have more chances of delay union.
33. Open v/s Closed
• Patella baja (Rel
elevation of Joint line)
• Insufficient medial
collateral ligament
(open-wedge technique
allows tensioning)
• Simultaneous medial
arthrotomy is required.
• Patella alta (Relative
lowering of joint)
• Intact medial collateral
ligament
• Simultaneous lateral
arthrotomy is required
34. • Open-wedge HTO
• Faster surgery
• Bone graft necessary in
case of high correction
• Higher precision
• Risk of saphenus nerve
lesion
• Gain in Limb length ( av
5.5 mm)
• Longer consolidation
• Closed-wedge HTO
• Longer surgery
• No graft necessary
• Lower precision
• Risk of peroneus nerve
lesion
• Shorter consolidation
• Loss of limb length (2.4
mm)
35. • Correction of Sagittal Plane:
• If anterior knee instability ( ACL insufficiency)
is present, the tibial slope should be
decreased (<5ᴼ ) to minimize anterior force.
• Posterior cruciate ligament (PCL insufficiency)
the slope should be increased (up to 12ᴼ) to
reduce posterior force vector.
37. • Correction at transverse plane
• Should be corrected at the level of deformity
to achieve optimal patellar tracking
• Location of Hinge points:
• Importance of choosing correct hinge points
of osteotomies in open or closed wedge
procedures can’t be overemphasized.
38. Amount of correction
• Goal is to normalize the mechanical axis or to
overcorrect it to valgus side.
• Determination of the correction depending on
residual cartilage thickness in the involved
compartment : Fujisawa Scale
39. Fujisawa Point
• Its an imaginary point
on lateral tibial condyle
at 62% of scale of tibia
from medial to lateral (
0 to 100%) or at 31% of
lateral tibial plateau
from center.
40. Fujisawa scale
• In a well-aligned knee,
load distribution is not
well-balanced but
physiologically 60% in the
medial and 40% in the
lateral compartment
41. • Overcorrection by shifting
the weight-bearing line
slightly to the lateral
compartment is required.
• The correction between
10% and 35% laterally on
the Fujisawa-scale is adv.
42. Angle of Correction required
• Mathematical method
• c × (ΔS)
β= -------------
TW
• C constant 76.4
• ∆ S : incremental
lateral joint separation
43. • In the given case.
• TW 80 mm
• ∆S is 4 mm (7-3 mm)
• So the angle required will be 3.8 ∘
44. Amount of Wedge required
• It depends upon width of proximal tibia and
angle of correction required.
• Length = Diameter of tibia X 0.02 X Angle
46. Correction Angle
• On paper tracings of
x-rays
• Draw a line from Head
of femur to Fujisawa
point.
• Second line from just
above tip of fibula to
center of ankle
47. • Calculate the angle
between two lines.
• Draw that angle on
proximal tibia with
apex at just above tip
of fibula.
• Cut the line and open
the wedge to see the
correction.
51. • Superficial MCL is
identified and
divided
• And pes is identified.
52. • Osteotomy is marked in
an reverse L shaped line
with horizontal limb
parallel to Pes anserinus
and then turning the
vertical limb to an angle
of 110 ᴼ just medial to
tibial tuberosity and
then going anteriorly
across.
55. • Length is measured to
know the length of
osteotomy
56. • Osteotomy is
performed using saw or
osteotome with desired
angle using markings or
angle guides.
• Do not pierce the lateral
cortex.
57. • Anterior part of
osteotomy completed
taking care not to injure
tibial tuberosity or
patellar tendon.
58. • Lateral cortex s not fully
broken while
performing osteotomy
to keep the medial
hinge intact.
• Chisels are inserted one
over other to distract
the osteotomy
59. • Osteotomy further
opened up using
spreader chisel to
desired correction angle
and also advanced till
lateral cortex to open it
fully.
60. • Finally using laminar
spreader the osteotomy
is opened up and fine
tuning can be done
here.
61. • Osteotomy tuned to see
the axis correction using
long rods and C arm
62. • When desired
correction is achieved ,
osteotomy kept open
and plate fixation starts.
• Proximal parallel screws
guide pins inserted
• Plate is pre-loaded by
putting spacer screws in
proximal and distal
holes
64. • After applying proximal
locking screws one
cortical screw is applied
in first distal hole.
65. • Cortical screw should
be applied little
obliquely to avoid
interfering with lock
screw to be used later
66. • Tightening of cortical
screw would cause the
compression of lateral
cortex
• This is caused by pre-
loading effect of
block/spacer screws
used previously.
67. Sagittal correction
• Concept of sagittal
correction
• Neutral
• Flexion( for Posterior
instabilities)
• Extension (for Anterior
Instability)
75. Take home message
• Lateral Opening wedge osteotomy is a useful
procedure in addressing medial joint arthritis
in young adults
• Requires suitable patient selection and
meticulous planning
• Long term Results are good and can be easily
converted to total knee whenever required.