Dr. T.V. Rao provides an overview of Helicobacter pylori (H. pylori), the bacterium associated with peptic ulcer disease and gastric cancer. Some key points:
- H. pylori was discovered in 1983 by Warren and Marshall and linked to gastritis and ulcers. They received the 2005 Nobel Prize in Physiology or Medicine.
- H. pylori colonizes the stomach of about half of individuals worldwide. It is a gram-negative, spiral-shaped bacterium that lives in the mucus layer of the stomach.
- H. pylori infection can cause chronic gastritis, peptic ulcers, and in rare
CHRONIC DYSPEPSIA
Seminar Prepared by :-
Ali Abdulazeem
Shilan Adnan Abdulrahman
Alaa Shamil
Guldan Hameed
Internal Medicine
College of Medicine - University of Kirkuk
Helicobactor pylori,gram negative ,fastidious bacteria,important cause for Gastritis as well as gastric carcinoma.Early diagnosis and treatment are necessary to prevent carcinoma.
Histology
H.pylori can be detected on Giemsa staining of sections of gastric mucosa
Sensitivity affected by PPIs
Culture
Enables testing for antibiotic sensitivity
Often reserved for patients with refractory H. Pylori
ERADICATION OF H.PYLORIS
Reinfection occurs in less than 1% in developed countries
In developing countries reinfection is higher owing to less compliance and metronidazole resistance.
Common drugs used: clarithromycin, metronidazole, bismuth chelates, amoxicillin, tetracycline.
Quinolones (Cipro, furazolidone) and rifabutin may be used as “rescue therapy” when standard regimens fails
Helicobacter Pylori infect more than 50% of worlds population.HP causes gastritis,PUD,gastric cancer and MALT lymphoma.Variable invasive and noninvasive diagnostic modilities are available.Eradication of H.Pylori is possible with proper therapy.
Helicobacter pylori and Peptic Ulcer diseaseDiaa Srahin
Case Study
Clinical Case Summary
History
Helicobacter pylori
Biochemical characteristics
Transmission
Epidemiology
Global incidence of H. pylori infection
risk factors for acquisition of H.pylori
Immune responses
Pathogenesis
Helicobacter pylori Virulence Factors
Clinical Presentation
Complications
Peptic Ulcer
Diagnosis
Treatment
Prevention
Morphology and structure of H. pylori
Diagnosis of H. pylori infection
Transmission of H. pylori
Symptoms of H. pylori infection
Treatment and prevention
Pathogenesis of H. pylori
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
2. HISTORY OF H. PYLORI
• 1890’s: Spirochetes in animal stomachs
• 1900’s: Spirochetes in human stomachs
• 1954: No bacteria in gastric biopsies of 1000 patients
• 1975: Gram negative bacteria in 80% of GU’s
(Pseudomonas)
• 1983: Warren and Marshall characterize H. pylori
• 2005 Nobel prize in 2005
3. HELICOBACTER PYLORI
Background
Human stomach long considered inhospitable for
bacteria
Spiral shaped organisms occasionally visualized in
gastric mucous layer, but no evidence of disease
association
Organism classified first as Campylobacter pylori
Now Helicobacter pylori
Other species of Helicobacter isolated from
stomach, intestine of other animals
Marshall and Warren culture organism from human
gastric mucosa and show association with gastric
inflammation
DR.T.V.RAO MD 3
4. HELICOBACTER
( WARREN AND MARSHAL )
• Campylobacter like organisms
• Spiral shaped colonizes Gastric mucosa
• Etiological agent in Gastritis and peptic ulcer
• Most important bacteria.
Helicobacter pylori
Colonizes 50 % of the Individuals
DR.T.V.RAO MD 4
6. GENERAL CHARACTERISTICS OF
HELICOBACTER
DR.T.V.RAO MD 6
• Helicobacter pylori is major human pathogen associated with
gastric antral epithelium in patients with active chronic gastritis
• Stomach of many animal species also colonized
• Urease (gastric strains only), mucinase, and catalase positive
highly motile microorganisms
• Other Helicobacters: H. cinnaedi and H. fenneliae
• Colonize human intestinal tract
• Isolated from homosexual men with proctitis, proctocolitis,
enteritis, and bacteremia and are often transmitted through
sexual practices
7. A silver stain of H. pylori on gastric mucus-
secreting epithelial cells (x1000).
From Dr. Marshall's stomach biopsy taken 8 days
after he drank a culture of H. pylori (1985).
DR.T.V.RAO MD 7
8. HELICOBACTER PYLORI
• Gram –ve spiral
shaped , motile
with unipolar tuft
of lopotrichus
flagella
DR.T.V.RAO MD 8
9. H. PYLORI BACTERIA
• Gram negative
• Spiral rod
• Unipolar flagella
• Microaerophilic
• Urease positive*
*Most important
character
*Scanning microscopic view of H. pylori
10. MORPHOLOGY & PHYSIOLOGY OF
HELICOBACTER
DR.T.V.RAO MD 10
• Gram-negative; Helical (spiral or curved) (0.5-1.0 um X
2.5-5.0 um); Blunted/rounded ends in gastric biopsy
specimens; Cells become rod-like and coccoid on
prolonged culture
• Produce urease, mucinase, and catalase
• H. pylori tuft (lophotrichous) of 4-6 sheathed flagella
(30um X 2.5nm) attached at one pole
• Single polar flagellum on H. fennellae & H. cinaedi
• Smooth cell wall with unusual fatty acids
11. • Transmissible
• Oral-oral and oral-
fecal
• Infects the human
stomach
• Produces inflammatory
response
• This brings up the point
of the importance of
“hand washing”
H. PYLORI INFECTION
TRANSMISSION
13. CULTURING AND BIOCHEMICAL
CHARACTERS
• Grows on chocolate agar, Campylobacter media
• Grows under Microaerophilic conditions
• With presence of 5 – 20% co2
• Oxidase +
• Catalase –
• Urease strongly +++
• H2S
DR.T.V.RAO MD 13
14. H. PYLORI PATHOGENESIS
BACTERIAL VIRULENCE FACTORS
(CAG- PAI)( 37000 B-P – 29 GENES)
• Type IV secretions apparatus(1) (translocate cag A)
• Possible insertion by needle like organelle coated with a sheath (Cag 7
protein) [Rohde et al]
• Phosphorylated + binds to SHP-2 tyrosine Phosphates
Cytokine Production Growth Factor
IL- 8+ chemokines Like cellular response
(1) Odenbreit S, et al. Science 2000;287:1497-1500
15. H. PYLORI PATHOGENESIS
BACTERIAL VIRULENCE FACTORS
Ingestion Evasion + Entrance of Mucus
1 Layer (Motility + Urea I)
2 Binding
3 Insertion
4 Intra cellular pathway
18. H. PYLORI PATHOGENESIS
THE ROLE OF CYTOKINES
I. Alter secretion of mucus
II. TNF–α IL–Iß, INF- 1Y
• ↑ Gastrin release Stimulate parietal cells
↑ Acid secretion
I. TNF–α ↓ D cells number
↓ Somatostatin
↑ Acid secretion
19. PATHOLOGY AND PATHOGENESIS
• H.pylori colonizes gastric mucosa
• Spread by oral – oral contact
• Feco oral spread prominent
• Poverty and overcrowding predisposes
• Poor Hygiene
• Causes mild to acute gastritis
• Gastric antrum - causes gastric metaplasia
• Any part of the stomach can be involved
• Colonizes overlying mucosa but donot invade mucosa
DR.T.V.RAO MD 19
21. Colonize mucosal lining of stomach & duodenum in
man & animals
• Adherent to gastric surface epithelium or pit epithelial
cells deep within the mucosal crypts adjacent to gastric
mucosal cells
• Mucosa protects the stomach wall from its own gastric
milleu of digestive enzymes and hydrochloric acid
• Mucosa also protects Helicobacter from immune
response
Most gastric adenocarcinomas and lymphomas are
concurrent with or preceded by an infection with H.
pylori
Pathogenesis of Helicobacter Infections
29. H. Pylori Pathogenesis and Application of
Cutting Edge Technologies
Molecular
biology
Genetics Imaging Cell culture
models
30. INDICATIONS FOR NONINVASIVE
TESTING FOR H. PYLORI *
• Strongly Recommended
• Dyspepsia
• History of/active peptic ulcer disease
• Gastric MALT lymphoma
• Following gastric cancer resection
• Following peptic ulcer surgery
• First-degree relative with gastric cancer
• Long-term Non-steroidal anti-inflamatory drugs (NSAID)
therapy
* In the absence of alarm signs for gastric cancer or ulcer disease
1. Malfertheiner P, et al. Aliment Pharmacol Ther. 2002;16:167. 2. Talley NJ et al. Aliment Pharmacol Ther.
1999;12:1135.
32. • Detects active infection
• Sensitive and specific
• Non-radioactive
• No special handling
requirements
• Easy to collect and handle
sample
• Not indicated in pediatric
population
13C UREA BREATH TEST
1. Graham DY et al. Am J Gastroenterol. 2001;96:1741. 2. Leodolter A et al. Am J Gastroenterol. 1999;94:2100.
33. LABORATORY DIAGNOSIS
• Diagnosed by Invasive and Non Invasive tests
• Invasive, Endoscopic Biopsy of Gastric mucosa
• Microscopy – Biopsy
• Culture
• Staining by special stains
• Gram staining
• Culture more sensitive 3 – 7 days
• Biopsy testing for urease detection in urea medium
DR.T.V.RAO MD 33
34. Laboratory Identification
Recovered from or detected in endoscopic antral
gastric biopsy material; Multiple biopsies are taken
Many different transport media
Culture media containing whole or lysed blood
Microaerophilic
Grow well at 37oC, but not at 25 nor 42oC
Like Campylobacter, does not use carbohydrates,
neither fermentatively nor oxidatively
35. DIAGNOSIS BY NON INVASIVE
METHODS
• Serology ELISA
• Urea breath test patient
swallows urea solution
In this test patient drinks
urea solutions labeled with
an isotope carbon
If H.pylori is present in the
urea is converted to
ammonia and co2 in the
breath measured.
DR.T.V.RAO MD 35
36. SUGGESTED GUIDELINES FOR
TREATMENT OF PATIENTS WITH GI OR ULCER
DISEASE
History & Physical Exam
Peptic ulcer
disease
Undifferentiated
dyspepsia
Symptoms
of GERD
Use of NSAIDs
or aspirin
Positive
Eradication
therapy
Confirmation of cure
Test for H. pylori
Malfertheiner P, et al. Aliment Pharmacol Ther. 2002;16:167.
37. SUGGESTED GUIDELINES FOR
TREATMENT OF PATIENTS WITH GI OR ULCER
DISEASE
History & Physical Exam
Peptic ulcer
disease
Undifferentiated
dyspepsia
Symptoms
of GERD
Use of NSAIDs
or aspirin
Positive
Eradication
therapy
Confirmation of cure
Negative
Treat for PUD,
Initiate PPI therapy,
or discontinue NSAIDs
Test for H. pylori
Malfertheiner P, et al. Aliment Pharmacol Ther. 2002;16:167.
38. TREATMENT
• Use of antibiotics, bismuth salts
• Ingestion of Bismuth subsalicylate
• Antibiotics Tetracycline's and metronidazole for two
weeks
• Use of Omeprazole
• Clarithromycin
• Do not treat for Asymptomatic colonization
• Drug resistance is a growing problem
DR.T.V.RAO MD 38
39. • Antibiotic treatment does not always
completely inhibit or kill H. pylori
with potential for antibiotic
resistance. Resistance to antibiotics
is the single most important factor
for declining H. pylori eradication
rates.
• In Japan, resistance to antibiotic
drugs has increased 400% while in
Taiwan, it is 500%. This means that
those who are infected while in
these countries may find the
bacterium rather resistant to their
antibiotic treatments.
EMERGING DRUG RESISTANCE IN H.PYLORI
DR.T.V.RAO MD 39
40. EPIDEMIOLOGY OF HELICOBACTER INFECTIONS
DR.T.V.RAO MD 40
• Developed Countries:
• United States: 30% of total population infected
• Of those, ~1% per year develop duodenal ulcer
• ~1/3 eventually have peptic ulcer disease(PUD)
• 70% gastric ulcer cases colonized with H. pylori
• Low socioeconomic status predicts H. pylori infection
• Developing Countries:
• Hyperendemic
• About 10% acquisition rate per year for children between 2 and 8 years
of age
• Most adults infected but no disease
• Protective immunity from multiple childhood infections
41. H.PYLORI CONTINUES TO BE AN
IMPORTANT PATHOGEN
• H. pylori is a transmissible, infectious disease with
potentially serious outcomes
• H. pylori infection may be asymptomatic or cause
dyspepsia
• Eradication therapy can cure H. pylori infection and
prevent morbidity and downstream events such as PUD
and gastric cancer
• Patients with symptoms of upper-GI disease, and who
use aspirin or NSAIDs should be tested for H. pylori
infection
42. • Programme Created by Dr.T.V.Rao MD
for Medical and Health Care Workers in
the Developing World
• Email
• doctortvrao@gmail.com
DR.T.V.RAO MD 42