SlideShare a Scribd company logo
THYROIDITIS
Thyrotoxicosis
 hypermetabolic condition associated with elevated levels of free thyroxine
(FT4) and/or triiodo-thyronine (T3).
 Hyperthyroidism --excess synthesis and secretion of thyroid hormone by
the thyroid
Causes of thyrotoxicosis
Conditions causing hyperthyroidism
 Graves’ disease
 Toxic multinodular goitre
 Toxic adenoma
 Trophoblastic tumour
 Increased TSH secretion:
thyrotrophinoma
Conditions causing thyrotoxicosis not
associated with hyperthyroidism*
 Thyrotoxicosis factitia
 Subacute thyroiditis
 Post-partum thyroiditis
 Chronic thyroiditis with transient
toxicosis
 Ectopic thyroid tissue (struma ovarii,
functioning metastasis of Ca thyroid)
HIGH RADIO IODINE UPTAKE LOW
RADIO IODINE UPTAKE STUDY
 Reported as
Normal
 2 hour uptake- < 5%
 24 hour uptake <25%
Clinical features
System Symptom Sign
CVS Palpitation, dyspnoea Tachycardia, atrial fibrillation, cardiac failure,
wide pulse pressure
CNS Restlessness, irritability,
insomnia
Tremors, proximal muscle weakness, periodic paralysis
GIT Increased appetite,
hyperdefaecation
Exaggerated bowel sounds,
Eye Foreign body sensation,
prominence of eyes
Stare, lid lag
proptosis*, extraocular diplopia*, reduced EOM
movements *, exposure keratitis*lagophthalmos
Reproductive
system
Short menstrual cycles,loss
of libido
Gynaecomastia
Thyroid Neck swelling Goitre, bruit
General Weight loss, weakness, heat
intolerance, pruritus
onycholysis, warm and
moist skin, hyperpigmentation, palmar erythema
DIAGNOSIS OF THYROTOXICOSIS
 Elevated total and/or free T4; elevated T3
 Suppressed TSH
For example
total T4 21.8 ug/dl (6-14 ug/dl)
TSH <0.001 uIU/mL( 0.5-5.0 uIU/ml)
Diagnosis of thyrotoxicosis
Thyroid Scan
 Scintigraphy utilizes one of the radioisotopes of iodine (usually 123-I) or
technetium-99m pertechnetate.
 These radioisotopes are handled differently by thyroid follicular cells.
 Provides information on structure as well as function
Thyroid scan
Thyroid scan
THYROIDITIS
Causes of thyroiditis include
Painless
 chronic autoimmune (Hashimoto’s) thyroiditis,
 postpartum thyroiditis,
 Riedel’s thyroiditis,
 amiodarone-induced thyroiditis (
Painful
 subacute thyroiditis,
 acute infectious thyroiditis
 radiation thyroiditis
 traumatic (e.g. surgery, palpation, FNAB),
Subacute Thyroiditis (de Quervain’s Thyroiditis, Viral
Thyroiditis, Granulomatous Giant Cell Thyroiditis)
 Viral in origin.
 Neck pain, which may radiate to ear or mandible. Hoarseness, dysphagia
and signs of thyrotoxicosis may be present.
 systemic features like lassitude and weakness.
 Thyroid gland is very tender and firm.
 severe cases may require glucocorticoid therapy.
Postpartum Thyroiditis
 Thyrotoxicosis, hypothyroidism, and/or thyrotoxicosis followed by hypo-
thyroidism in the first postpartum year
 It occurs in 8% to 10% of women in postpartum period
 up to 30% of those who were anti-TPO antibody positive in pregnancy.

 Women with postpartum thyroiditis have increased risk of developing
permanent primary hypothyroidism in the 5- to 10-year
 An annual TSH level should be performed in these women.
Riedel’s Thyroiditis
 Rare cause of thyroiditis
 Fibrosis of the thyroid
 Stony hard, immobile goitre resulting in pressure symptoms due
 Manifestation of IgG4 related disease :

More Related Content

Similar to Thyrotoxicosis.pptx

Thyroid disease in pregnancy
Thyroid disease in pregnancyThyroid disease in pregnancy
Thyroid disease in pregnancy
rajeev sood
 
Thyroid disease in dental
Thyroid disease in dentalThyroid disease in dental
Thyroid disease in dental
Mary Nasr
 
03. diseases of thyroid gland
03. diseases of thyroid gland03. diseases of thyroid gland
03. diseases of thyroid gland
Fahad Zakwan
 
Endocrinology - Archer USMLE step 3
Endocrinology - Archer USMLE step 3Endocrinology - Archer USMLE step 3
Endocrinology - Archer USMLE step 3
Archer Review USMLE and NCLEX
 
Thyroiditis by Dr Shahjada Selim
Thyroiditis by Dr Shahjada SelimThyroiditis by Dr Shahjada Selim
Thyroiditis by Dr Shahjada Selim
Bangabandhu Sheikh Mujib Medical University
 
Thyrotoxicosis and other thyroid diseases
Thyrotoxicosis and other thyroid diseasesThyrotoxicosis and other thyroid diseases
Thyrotoxicosis and other thyroid diseases
Ivan Luyimbazi
 
Thyroid
ThyroidThyroid
Thyroid
ThyroidThyroid
MATERIAL.ppt
MATERIAL.pptMATERIAL.ppt
23. diseases of thyroid gland kk
23. diseases of thyroid gland kk23. diseases of thyroid gland kk
23. diseases of thyroid gland kk
krishnakoirala4
 
Thyrotoxicosis
ThyrotoxicosisThyrotoxicosis
Thyrotoxicosis
Anant Layall
 
Thyroid pharmacotherapeutics - definition, aetiology, clinical manifestations...
Thyroid pharmacotherapeutics - definition, aetiology, clinical manifestations...Thyroid pharmacotherapeutics - definition, aetiology, clinical manifestations...
Thyroid pharmacotherapeutics - definition, aetiology, clinical manifestations...
Rajeshwari Netha
 
Endocrinology archer step3 lectures
Endocrinology   archer step3 lecturesEndocrinology   archer step3 lectures
Endocrinology archer step3 lectures
Archer Review USMLE and NCLEX
 
Thyroid disorders
Thyroid disordersThyroid disorders
Thyroid disorders
Hrudi Sahoo
 
Thyroid
ThyroidThyroid
management of Hyperthyroidism
management of Hyperthyroidism  management of Hyperthyroidism
management of Hyperthyroidism
Zelalem Semegnew
 
L2-5.Disorders of THE Thyroid gland.. PPX
L2-5.Disorders of THE Thyroid gland.. PPXL2-5.Disorders of THE Thyroid gland.. PPX
L2-5.Disorders of THE Thyroid gland.. PPX
Dr Bilal Natiq
 
Thyroid in pregnancy
Thyroid in pregnancyThyroid in pregnancy
Thyroid in pregnancy
Dr. Preksha Jain
 
Class thyroid and antithyroid drugs
Class thyroid and antithyroid drugsClass thyroid and antithyroid drugs
Class thyroid and antithyroid drugs
Raghu Prasada
 
goiter 2-170 323180 82 2 (1).pdf
goiter         2-170 323180 82 2 (1).pdfgoiter         2-170 323180 82 2 (1).pdf
goiter 2-170 323180 82 2 (1).pdf
deborayilma
 

Similar to Thyrotoxicosis.pptx (20)

Thyroid disease in pregnancy
Thyroid disease in pregnancyThyroid disease in pregnancy
Thyroid disease in pregnancy
 
Thyroid disease in dental
Thyroid disease in dentalThyroid disease in dental
Thyroid disease in dental
 
03. diseases of thyroid gland
03. diseases of thyroid gland03. diseases of thyroid gland
03. diseases of thyroid gland
 
Endocrinology - Archer USMLE step 3
Endocrinology - Archer USMLE step 3Endocrinology - Archer USMLE step 3
Endocrinology - Archer USMLE step 3
 
Thyroiditis by Dr Shahjada Selim
Thyroiditis by Dr Shahjada SelimThyroiditis by Dr Shahjada Selim
Thyroiditis by Dr Shahjada Selim
 
Thyrotoxicosis and other thyroid diseases
Thyrotoxicosis and other thyroid diseasesThyrotoxicosis and other thyroid diseases
Thyrotoxicosis and other thyroid diseases
 
Thyroid
ThyroidThyroid
Thyroid
 
Thyroid
ThyroidThyroid
Thyroid
 
MATERIAL.ppt
MATERIAL.pptMATERIAL.ppt
MATERIAL.ppt
 
23. diseases of thyroid gland kk
23. diseases of thyroid gland kk23. diseases of thyroid gland kk
23. diseases of thyroid gland kk
 
Thyrotoxicosis
ThyrotoxicosisThyrotoxicosis
Thyrotoxicosis
 
Thyroid pharmacotherapeutics - definition, aetiology, clinical manifestations...
Thyroid pharmacotherapeutics - definition, aetiology, clinical manifestations...Thyroid pharmacotherapeutics - definition, aetiology, clinical manifestations...
Thyroid pharmacotherapeutics - definition, aetiology, clinical manifestations...
 
Endocrinology archer step3 lectures
Endocrinology   archer step3 lecturesEndocrinology   archer step3 lectures
Endocrinology archer step3 lectures
 
Thyroid disorders
Thyroid disordersThyroid disorders
Thyroid disorders
 
Thyroid
ThyroidThyroid
Thyroid
 
management of Hyperthyroidism
management of Hyperthyroidism  management of Hyperthyroidism
management of Hyperthyroidism
 
L2-5.Disorders of THE Thyroid gland.. PPX
L2-5.Disorders of THE Thyroid gland.. PPXL2-5.Disorders of THE Thyroid gland.. PPX
L2-5.Disorders of THE Thyroid gland.. PPX
 
Thyroid in pregnancy
Thyroid in pregnancyThyroid in pregnancy
Thyroid in pregnancy
 
Class thyroid and antithyroid drugs
Class thyroid and antithyroid drugsClass thyroid and antithyroid drugs
Class thyroid and antithyroid drugs
 
goiter 2-170 323180 82 2 (1).pdf
goiter         2-170 323180 82 2 (1).pdfgoiter         2-170 323180 82 2 (1).pdf
goiter 2-170 323180 82 2 (1).pdf
 

More from Sheik4

men syndrome. ppt genomic and genetics
men syndrome.   ppt genomic and geneticsmen syndrome.   ppt genomic and genetics
men syndrome. ppt genomic and genetics
Sheik4
 
INVESTIGATION IN THE RHEUMATOLOGY.pptx
INVESTIGATION IN THE   RHEUMATOLOGY.pptxINVESTIGATION IN THE   RHEUMATOLOGY.pptx
INVESTIGATION IN THE RHEUMATOLOGY.pptx
Sheik4
 
Pancytopenia approach.pptx medicine in india
Pancytopenia approach.pptx medicine in indiaPancytopenia approach.pptx medicine in india
Pancytopenia approach.pptx medicine in india
Sheik4
 
Infections in medicine . Tropical infection
Infections in medicine . Tropical infectionInfections in medicine . Tropical infection
Infections in medicine . Tropical infection
Sheik4
 
epidemiologyofcommunicablediseases-181016035019 (1_240126_224322.pptx
epidemiologyofcommunicablediseases-181016035019 (1_240126_224322.pptxepidemiologyofcommunicablediseases-181016035019 (1_240126_224322.pptx
epidemiologyofcommunicablediseases-181016035019 (1_240126_224322.pptx
Sheik4
 
5- Introduction to Communicable Disease.ppt
5- Introduction to Communicable Disease.ppt5- Introduction to Communicable Disease.ppt
5- Introduction to Communicable Disease.ppt
Sheik4
 
Hypercalcemia ppt.pdf
Hypercalcemia ppt.pdfHypercalcemia ppt.pdf
Hypercalcemia ppt.pdf
Sheik4
 
Anaemia_ppt[1].pptx
Anaemia_ppt[1].pptxAnaemia_ppt[1].pptx
Anaemia_ppt[1].pptx
Sheik4
 
LEPTO.pptx
LEPTO.pptxLEPTO.pptx
LEPTO.pptx
Sheik4
 
Anaemia classification .pdf
Anaemia classification .pdfAnaemia classification .pdf
Anaemia classification .pdf
Sheik4
 
Anaemia ppt.pdf
Anaemia ppt.pdfAnaemia ppt.pdf
Anaemia ppt.pdf
Sheik4
 
Approach to anaemia .pdf
Approach to anaemia .pdfApproach to anaemia .pdf
Approach to anaemia .pdf
Sheik4
 
Hepatology - 2018 - Terrault - Update on prevention diagnosis and treatment...
Hepatology - 2018 - Terrault - Update on prevention  diagnosis  and treatment...Hepatology - 2018 - Terrault - Update on prevention  diagnosis  and treatment...
Hepatology - 2018 - Terrault - Update on prevention diagnosis and treatment...
Sheik4
 
Hypercalcemia ppt.pptx
Hypercalcemia ppt.pptxHypercalcemia ppt.pptx
Hypercalcemia ppt.pptx
Sheik4
 
helicobacterpylori-120616225853-phpapp01.pdf
helicobacterpylori-120616225853-phpapp01.pdfhelicobacterpylori-120616225853-phpapp01.pdf
helicobacterpylori-120616225853-phpapp01.pdf
Sheik4
 
Hyperkalemia ppt.pdf
Hyperkalemia ppt.pdfHyperkalemia ppt.pdf
Hyperkalemia ppt.pdf
Sheik4
 
Heart Failure.ppt
Heart Failure.pptHeart Failure.ppt
Heart Failure.ppt
Sheik4
 
manoj THYROTOXIC CRISIS.pptx
manoj THYROTOXIC CRISIS.pptxmanoj THYROTOXIC CRISIS.pptx
manoj THYROTOXIC CRISIS.pptx
Sheik4
 
manoj THYROTOXIC CRISIS.pptx
manoj THYROTOXIC CRISIS.pptxmanoj THYROTOXIC CRISIS.pptx
manoj THYROTOXIC CRISIS.pptx
Sheik4
 
PEP_Prophylaxis_guideline_15_12_2014.pdf
PEP_Prophylaxis_guideline_15_12_2014.pdfPEP_Prophylaxis_guideline_15_12_2014.pdf
PEP_Prophylaxis_guideline_15_12_2014.pdf
Sheik4
 

More from Sheik4 (20)

men syndrome. ppt genomic and genetics
men syndrome.   ppt genomic and geneticsmen syndrome.   ppt genomic and genetics
men syndrome. ppt genomic and genetics
 
INVESTIGATION IN THE RHEUMATOLOGY.pptx
INVESTIGATION IN THE   RHEUMATOLOGY.pptxINVESTIGATION IN THE   RHEUMATOLOGY.pptx
INVESTIGATION IN THE RHEUMATOLOGY.pptx
 
Pancytopenia approach.pptx medicine in india
Pancytopenia approach.pptx medicine in indiaPancytopenia approach.pptx medicine in india
Pancytopenia approach.pptx medicine in india
 
Infections in medicine . Tropical infection
Infections in medicine . Tropical infectionInfections in medicine . Tropical infection
Infections in medicine . Tropical infection
 
epidemiologyofcommunicablediseases-181016035019 (1_240126_224322.pptx
epidemiologyofcommunicablediseases-181016035019 (1_240126_224322.pptxepidemiologyofcommunicablediseases-181016035019 (1_240126_224322.pptx
epidemiologyofcommunicablediseases-181016035019 (1_240126_224322.pptx
 
5- Introduction to Communicable Disease.ppt
5- Introduction to Communicable Disease.ppt5- Introduction to Communicable Disease.ppt
5- Introduction to Communicable Disease.ppt
 
Hypercalcemia ppt.pdf
Hypercalcemia ppt.pdfHypercalcemia ppt.pdf
Hypercalcemia ppt.pdf
 
Anaemia_ppt[1].pptx
Anaemia_ppt[1].pptxAnaemia_ppt[1].pptx
Anaemia_ppt[1].pptx
 
LEPTO.pptx
LEPTO.pptxLEPTO.pptx
LEPTO.pptx
 
Anaemia classification .pdf
Anaemia classification .pdfAnaemia classification .pdf
Anaemia classification .pdf
 
Anaemia ppt.pdf
Anaemia ppt.pdfAnaemia ppt.pdf
Anaemia ppt.pdf
 
Approach to anaemia .pdf
Approach to anaemia .pdfApproach to anaemia .pdf
Approach to anaemia .pdf
 
Hepatology - 2018 - Terrault - Update on prevention diagnosis and treatment...
Hepatology - 2018 - Terrault - Update on prevention  diagnosis  and treatment...Hepatology - 2018 - Terrault - Update on prevention  diagnosis  and treatment...
Hepatology - 2018 - Terrault - Update on prevention diagnosis and treatment...
 
Hypercalcemia ppt.pptx
Hypercalcemia ppt.pptxHypercalcemia ppt.pptx
Hypercalcemia ppt.pptx
 
helicobacterpylori-120616225853-phpapp01.pdf
helicobacterpylori-120616225853-phpapp01.pdfhelicobacterpylori-120616225853-phpapp01.pdf
helicobacterpylori-120616225853-phpapp01.pdf
 
Hyperkalemia ppt.pdf
Hyperkalemia ppt.pdfHyperkalemia ppt.pdf
Hyperkalemia ppt.pdf
 
Heart Failure.ppt
Heart Failure.pptHeart Failure.ppt
Heart Failure.ppt
 
manoj THYROTOXIC CRISIS.pptx
manoj THYROTOXIC CRISIS.pptxmanoj THYROTOXIC CRISIS.pptx
manoj THYROTOXIC CRISIS.pptx
 
manoj THYROTOXIC CRISIS.pptx
manoj THYROTOXIC CRISIS.pptxmanoj THYROTOXIC CRISIS.pptx
manoj THYROTOXIC CRISIS.pptx
 
PEP_Prophylaxis_guideline_15_12_2014.pdf
PEP_Prophylaxis_guideline_15_12_2014.pdfPEP_Prophylaxis_guideline_15_12_2014.pdf
PEP_Prophylaxis_guideline_15_12_2014.pdf
 

Recently uploaded

June 2024 Oncology Cartoons By Dr Kanhu Charan Patro
June 2024 Oncology Cartoons By Dr Kanhu Charan PatroJune 2024 Oncology Cartoons By Dr Kanhu Charan Patro
June 2024 Oncology Cartoons By Dr Kanhu Charan Patro
Kanhu Charan
 
NARCOTICS- POLICY AND PROCEDURES FOR ITS USE
NARCOTICS- POLICY AND PROCEDURES FOR ITS USENARCOTICS- POLICY AND PROCEDURES FOR ITS USE
NARCOTICS- POLICY AND PROCEDURES FOR ITS USE
Dr. Ahana Haroon
 
CBL Seminar 2024_Preliminary Program.pdf
CBL Seminar 2024_Preliminary Program.pdfCBL Seminar 2024_Preliminary Program.pdf
CBL Seminar 2024_Preliminary Program.pdf
suvadeepdas911
 
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
Medical Quiz ( Online Quiz for API Meet 2024 ).pdfMedical Quiz ( Online Quiz for API Meet 2024 ).pdf
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
Jim Jacob Roy
 
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
19various
 
Chapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptxChapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptx
Earlene McNair
 
Efficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in AyurvedaEfficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in Ayurveda
Dr. Jyothirmai Paindla
 
Acute Gout Care & Urate Lowering Therapy .pdf
Acute Gout Care & Urate Lowering Therapy .pdfAcute Gout Care & Urate Lowering Therapy .pdf
Acute Gout Care & Urate Lowering Therapy .pdf
Jim Jacob Roy
 
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPromoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
PsychoTech Services
 
Physical demands in sports - WCSPT Oslo 2024
Physical demands in sports - WCSPT Oslo 2024Physical demands in sports - WCSPT Oslo 2024
Physical demands in sports - WCSPT Oslo 2024
Torstein Dalen-Lorentsen
 
The Nervous and Chemical Regulation of Respiration
The Nervous and Chemical Regulation of RespirationThe Nervous and Chemical Regulation of Respiration
The Nervous and Chemical Regulation of Respiration
MedicoseAcademics
 
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
FFragrant
 
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptxEar and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Dr. Rabia Inam Gandapore
 
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
rishi2789
 
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptxVestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Dr. Rabia Inam Gandapore
 
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.GawadHemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
NephroTube - Dr.Gawad
 
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxDoes Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
walterHu5
 
Pharmacology of 5-hydroxytryptamine and Antagonist
Pharmacology of 5-hydroxytryptamine and AntagonistPharmacology of 5-hydroxytryptamine and Antagonist
Pharmacology of 5-hydroxytryptamine and Antagonist
Dr. Nikhilkumar Sakle
 
Histololgy of Female Reproductive System.pptx
Histololgy of Female Reproductive System.pptxHistololgy of Female Reproductive System.pptx
Histololgy of Female Reproductive System.pptx
AyeshaZaid1
 
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptxREGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
LaniyaNasrink
 

Recently uploaded (20)

June 2024 Oncology Cartoons By Dr Kanhu Charan Patro
June 2024 Oncology Cartoons By Dr Kanhu Charan PatroJune 2024 Oncology Cartoons By Dr Kanhu Charan Patro
June 2024 Oncology Cartoons By Dr Kanhu Charan Patro
 
NARCOTICS- POLICY AND PROCEDURES FOR ITS USE
NARCOTICS- POLICY AND PROCEDURES FOR ITS USENARCOTICS- POLICY AND PROCEDURES FOR ITS USE
NARCOTICS- POLICY AND PROCEDURES FOR ITS USE
 
CBL Seminar 2024_Preliminary Program.pdf
CBL Seminar 2024_Preliminary Program.pdfCBL Seminar 2024_Preliminary Program.pdf
CBL Seminar 2024_Preliminary Program.pdf
 
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
Medical Quiz ( Online Quiz for API Meet 2024 ).pdfMedical Quiz ( Online Quiz for API Meet 2024 ).pdf
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
 
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
 
Chapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptxChapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptx
 
Efficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in AyurvedaEfficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in Ayurveda
 
Acute Gout Care & Urate Lowering Therapy .pdf
Acute Gout Care & Urate Lowering Therapy .pdfAcute Gout Care & Urate Lowering Therapy .pdf
Acute Gout Care & Urate Lowering Therapy .pdf
 
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPromoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
 
Physical demands in sports - WCSPT Oslo 2024
Physical demands in sports - WCSPT Oslo 2024Physical demands in sports - WCSPT Oslo 2024
Physical demands in sports - WCSPT Oslo 2024
 
The Nervous and Chemical Regulation of Respiration
The Nervous and Chemical Regulation of RespirationThe Nervous and Chemical Regulation of Respiration
The Nervous and Chemical Regulation of Respiration
 
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
 
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptxEar and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
 
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
 
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptxVestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
 
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.GawadHemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
 
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxDoes Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
 
Pharmacology of 5-hydroxytryptamine and Antagonist
Pharmacology of 5-hydroxytryptamine and AntagonistPharmacology of 5-hydroxytryptamine and Antagonist
Pharmacology of 5-hydroxytryptamine and Antagonist
 
Histololgy of Female Reproductive System.pptx
Histololgy of Female Reproductive System.pptxHistololgy of Female Reproductive System.pptx
Histololgy of Female Reproductive System.pptx
 
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptxREGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
 

Thyrotoxicosis.pptx

  • 2. Thyrotoxicosis  hypermetabolic condition associated with elevated levels of free thyroxine (FT4) and/or triiodo-thyronine (T3).  Hyperthyroidism --excess synthesis and secretion of thyroid hormone by the thyroid
  • 3. Causes of thyrotoxicosis Conditions causing hyperthyroidism  Graves’ disease  Toxic multinodular goitre  Toxic adenoma  Trophoblastic tumour  Increased TSH secretion: thyrotrophinoma Conditions causing thyrotoxicosis not associated with hyperthyroidism*  Thyrotoxicosis factitia  Subacute thyroiditis  Post-partum thyroiditis  Chronic thyroiditis with transient toxicosis  Ectopic thyroid tissue (struma ovarii, functioning metastasis of Ca thyroid) HIGH RADIO IODINE UPTAKE LOW
  • 4. RADIO IODINE UPTAKE STUDY  Reported as Normal  2 hour uptake- < 5%  24 hour uptake <25%
  • 5. Clinical features System Symptom Sign CVS Palpitation, dyspnoea Tachycardia, atrial fibrillation, cardiac failure, wide pulse pressure CNS Restlessness, irritability, insomnia Tremors, proximal muscle weakness, periodic paralysis GIT Increased appetite, hyperdefaecation Exaggerated bowel sounds, Eye Foreign body sensation, prominence of eyes Stare, lid lag proptosis*, extraocular diplopia*, reduced EOM movements *, exposure keratitis*lagophthalmos Reproductive system Short menstrual cycles,loss of libido Gynaecomastia Thyroid Neck swelling Goitre, bruit General Weight loss, weakness, heat intolerance, pruritus onycholysis, warm and moist skin, hyperpigmentation, palmar erythema
  • 6. DIAGNOSIS OF THYROTOXICOSIS  Elevated total and/or free T4; elevated T3  Suppressed TSH For example total T4 21.8 ug/dl (6-14 ug/dl) TSH <0.001 uIU/mL( 0.5-5.0 uIU/ml)
  • 8.
  • 9. Thyroid Scan  Scintigraphy utilizes one of the radioisotopes of iodine (usually 123-I) or technetium-99m pertechnetate.  These radioisotopes are handled differently by thyroid follicular cells.  Provides information on structure as well as function
  • 12. THYROIDITIS Causes of thyroiditis include Painless  chronic autoimmune (Hashimoto’s) thyroiditis,  postpartum thyroiditis,  Riedel’s thyroiditis,  amiodarone-induced thyroiditis ( Painful  subacute thyroiditis,  acute infectious thyroiditis  radiation thyroiditis  traumatic (e.g. surgery, palpation, FNAB),
  • 13. Subacute Thyroiditis (de Quervain’s Thyroiditis, Viral Thyroiditis, Granulomatous Giant Cell Thyroiditis)  Viral in origin.  Neck pain, which may radiate to ear or mandible. Hoarseness, dysphagia and signs of thyrotoxicosis may be present.  systemic features like lassitude and weakness.  Thyroid gland is very tender and firm.  severe cases may require glucocorticoid therapy.
  • 14. Postpartum Thyroiditis  Thyrotoxicosis, hypothyroidism, and/or thyrotoxicosis followed by hypo- thyroidism in the first postpartum year  It occurs in 8% to 10% of women in postpartum period  up to 30% of those who were anti-TPO antibody positive in pregnancy.   Women with postpartum thyroiditis have increased risk of developing permanent primary hypothyroidism in the 5- to 10-year  An annual TSH level should be performed in these women.
  • 15. Riedel’s Thyroiditis  Rare cause of thyroiditis  Fibrosis of the thyroid  Stony hard, immobile goitre resulting in pressure symptoms due  Manifestation of IgG4 related disease :